Literature summary for 1.7.3.3 extracted from

Wei, D.; Huang, X.; Qiao, Y.; Rao, J.; Wang, L.; Liao, F.; Zhan, C.
Catalytic mechanisms for cofactor-free oxidase-catalyzed reactions reaction pathways of uricase-catalyzed oxidation and hydration of uric acid (2017), ACS Catal., 7, 4623-4636 .

Crystallization (Commentary)

Crystallization (Comment)	Organism
quantum mechanical/molecular mechanical calculations based on PDB entry 4N9M. The oxidation consists of chemical transformation from 8-hydroxyxythine to an anionic radical via a proton transfer along with an electron transfer, proton transfer to the O2- anion (radical), diradical recombination to form a peroxo intermediate, and dissociation of H2O2 to generate the dehydrourate. Hydration is initiated by the nucleophilic attack of a water molecule on dehydrourate, along with a concerted proton transfer through residue Thr69 in the catalytic site. Hydration is the rate-determining step	Aspergillus flavus

Crystallization (Comment)

Organism

quantum mechanical/molecular mechanical calculations based on PDB entry 4N9M. The oxidation consists of chemical transformation from 8-hydroxyxythine to an anionic radical via a proton transfer along with an electron transfer, proton transfer to the O2- anion (radical), diradical recombination to form a peroxo intermediate, and dissociation of H2O2 to generate the dehydrourate. Hydration is initiated by the nucleophilic attack of a water molecule on dehydrourate, along with a concerted proton transfer through residue Thr69 in the catalytic site. Hydration is the rate-determining step

Aspergillus flavus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus flavus	Q00511	-	-

Synonyms

Synonyms	Comment	Organism
Uaz	-	Aspergillus flavus

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Release 2023.1 (January 2023)