EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.188 | prostaglandin-F synthase |
squamous cell carcinoma cell |
AKR1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism |
740413 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
squamous cell carcinoma cell |
positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction |
725153 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
squamous cell carcinoma cell |
positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction |
725153 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
squamous cell carcinoma cell |
positive AKR1C3 immunoreactivity is extensively present in both adenocarcinoma and squamous cell carcinoma arising from the lung and the gastroesophageal junction |
725153 |
1.14.16.4 | tryptophan 5-monooxygenase |
squamous cell carcinoma cell |
- |
658187 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
squamous cell carcinoma cell |
- |
691603 |
1.4.3.13 | protein-lysine 6-oxidase |
squamous cell carcinoma cell |
- |
673118 |
1.8.1.9 | thioredoxin-disulfide reductase |
squamous cell carcinoma cell |
- |
711672 |
2.1.1.1 | nicotinamide N-methyltransferase |
squamous cell carcinoma cell |
- |
719027 |
2.1.1.37 | DNA (cytosine-5-)-methyltransferase |
squamous cell carcinoma cell |
cell lines TE-3 and TE-12 |
720441 |
2.1.1.45 | thymidylate synthase |
squamous cell carcinoma cell |
- |
703257 |
2.3.1.85 | fatty-acid synthase system |
squamous cell carcinoma cell |
oral squamous carcinoma cell lines SCC-4, SCC-9, SCC-15, SCC-25, differential expression of enzyme being highest in SCC-9 followed by SCC-25 |
663001 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
squamous cell carcinoma cell |
- |
729520 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
squamous cell carcinoma cell |
- |
736069 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
squamous cell carcinoma cell |
- |
759839 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
squamous cell carcinoma cell |
- |
688782 |
2.4.2.3 | uridine phosphorylase |
squamous cell carcinoma cell |
- |
658264 |
2.5.1.46 | deoxyhypusine synthase |
squamous cell carcinoma cell |
- |
739208 |
2.7.1.32 | choline kinase |
squamous cell carcinoma cell |
- |
759595 |
2.7.1.40 | pyruvate kinase |
squamous cell carcinoma cell |
squamous cell carcinoma of tongue |
708759 |
2.7.10.1 | receptor protein-tyrosine kinase |
squamous cell carcinoma cell |
head and neck |
661551 |
2.7.11.10 | IkappaB kinase |
squamous cell carcinoma cell |
- |
662516 |
2.7.11.10 | IkappaB kinase |
squamous cell carcinoma cell |
in human acantholytic squamous cell carcinoma IKKalpha and E-cadherin are strongly expressed, with absence of keratins K1 and K10, usually co-expressed with IKKalpha and E-cadherin |
691676 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
squamous cell carcinoma cell |
high PDK expression |
662948 |
2.7.11.20 | elongation factor 2 kinase |
squamous cell carcinoma cell |
cell lines of head and neck cancer |
664507 |
2.7.11.21 | polo kinase |
squamous cell carcinoma cell |
- |
703103 |
2.7.7.49 | RNA-directed DNA polymerase |
squamous cell carcinoma cell |
- |
694504 |
3.1.1.4 | phospholipase A2 |
squamous cell carcinoma cell |
high levels of expression of 1-CysPrx/aiPLA2 |
714370 |
3.1.3.1 | alkaline phosphatase |
squamous cell carcinoma cell |
non-carcinoma tissue. Liver type alkaline phosphatesse AP is detected in the heavy and light surfactant aggregates from both non-carcinoma and squamous carcinoma tissues, but not in heavy surfactant aggregates from adenocarcinoma tissues. A larger amount of bone type alkaline phosphatase is found in light surfactant aggregate fractions from squamous cell carcinomas than those from adenocarcinoma tissues or noncarcinoma tissues from patients with either type of cancer |
679113 |
3.1.3.3 | phosphoserine phosphatase |
squamous cell carcinoma cell |
highly induced in squamous cell carcinoma |
715741 |
3.2.1.166 | heparanase |
squamous cell carcinoma cell |
- |
714960 |
3.4.14.5 | dipeptidyl-peptidase IV |
squamous cell carcinoma cell |
squamous lung carcinoma, enzymic activity is restricted to the connective tissue stroma surrounding the dipeptidyl peptidase IV-negative tumor foci |
732939 |
3.4.21.109 | matriptase |
squamous cell carcinoma cell |
- |
709407 |
3.4.21.26 | prolyl oligopeptidase |
squamous cell carcinoma cell |
oral cavity and larynx |
710533 |
3.4.21.75 | Furin |
squamous cell carcinoma cell |
- |
732499 |
3.4.21.B10 | neurosin |
squamous cell carcinoma cell |
KLK6 is upregulated |
679036 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
squamous cell carcinoma cell |
expressed in both premalignant and malignant forms of squamous cell carcinoma, but are lacking in normal esophageal epithelia, suggesting that the enzyme is involved in squamous cell carcinoma neoplastic progression |
694506 |
3.4.21.B41 | kallikrein 10 |
squamous cell carcinoma cell |
increased mRNA expression compared to normal cells |
667878 |
3.4.22.15 | cathepsin L |
squamous cell carcinoma cell |
mandibular |
712921 |
3.4.22.38 | cathepsin K |
squamous cell carcinoma cell |
- |
709307 |
3.4.24.11 | neprilysin |
squamous cell carcinoma cell |
- |
709805 |
3.4.24.22 | stromelysin 2 |
squamous cell carcinoma cell |
- |
-, 708422 |
3.4.24.22 | stromelysin 2 |
squamous cell carcinoma cell |
head and neck squamous cell carcinoma (HNSCC) |
718291 |
3.4.24.22 | stromelysin 2 |
squamous cell carcinoma cell |
in situ detection, overview |
708422 |
3.4.24.23 | matrilysin |
squamous cell carcinoma cell |
- |
707905 |
3.4.24.23 | matrilysin |
squamous cell carcinoma cell |
MMP-7 positivity is reduced from carcinoma cells but instead appears in stromal cells |
709655 |
3.4.24.24 | gelatinase A |
squamous cell carcinoma cell |
- |
684054 |
3.4.24.24 | gelatinase A |
squamous cell carcinoma cell |
tissue samples of oral squamous cell carcinomas |
669567 |
3.4.24.34 | neutrophil collagenase |
squamous cell carcinoma cell |
induced by 4-nitroquinoline N-oxide |
683311 |
3.4.24.35 | gelatinase B |
squamous cell carcinoma cell |
of larynx |
683512 |
3.4.24.65 | macrophage elastase |
squamous cell carcinoma cell |
16-50 SCCs, in situ detection, overview |
708422 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
squamous cell carcinoma cell |
from the oral cavity, SCC9, SCC25 and SCC68 cells |
669263 |
3.4.24.B4 | matrix metalloproteinase-13 |
squamous cell carcinoma cell |
enzyme expression is related to tumor aggresiveness |
650906 |
3.4.24.B4 | matrix metalloproteinase-13 |
squamous cell carcinoma cell |
induced tumors, stromal MMP13 is associated with vascular endothelial growth factor receptor-2 on endothelial cells in invasive areas. Tumour invasion was downregulated in Mmp13-/- animals. Kinetics of angiogenesis and tumour growth in surface transplants, overview |
711684 |
3.4.24.B7 | matrix metalloproteinase-26 |
squamous cell carcinoma cell |
MMP-26 is expressed in grade I and II squamous cell cancer. It is not present in dedifferentiated grade III tumors. MMP-26 becomes downregulated during histological dedifferentiation of squamous cell cancer cells |
669750 |
3.4.24.B7 | matrix metalloproteinase-26 |
squamous cell carcinoma cell |
MMP-26 is present more frequently in squamous cell carcinomas of immunosuppressed compared with immunocompetent patients. Stromal staining for MMP-26 in elastic fibers and endothelial cells does not differ between the groups |
712585 |
3.4.24.B9 | ADAM9 endopeptidase |
squamous cell carcinoma cell |
- |
712114 |
4.1.1.17 | ornithine decarboxylase |
squamous cell carcinoma cell |
- |
-, 680214, 708200, 747963 |
4.3.2.9 | gamma-glutamylcyclotransferase |
squamous cell carcinoma cell |
- |
487987 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
squamous cell carcinoma cell |
- |
677862 |