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Literature summary for 3.4.24.34 extracted from

  • Korpi, J.T.; Kervinen, V.; Maeklin, H.; Vaeaenaenen, A.; Lahtinen, M.; Laeaerae, E.; Ristimaeki, A.; Thomas, G.; Ylipalosaari, M.; Astroem, P.; Lopez-Otin, C.; Sorsa, T.; Kantola, S.; Pirilae, E.; Salo, T.
    Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer (2008), Br. J. Cancer, 98, 766-775.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.34

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme expression is induced by estrogen Mus musculus
additional information the enzyme expression is induced by estrogen Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of MMP-8 knockout mice by gene targeting, MMP-8-deficient female mice develop tongue squamous cell carcinoma at a significantly higher incidence than wild-type mice exposed to carcinogen 4-nitroquinoline-N-oxide, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
GM6001 an MMP inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Mus musculus
-
 ?
-
 ?
Collagen + H2O Homo sapiens
-
 ?
-
 ?
estrogen receptor alpha + H2O Mus musculus
-
 ?
-
 ?
estrogen receptor alpha + H2O Homo sapiens
-
 ?
-
 ?
estrogen receptor beta + H2O Mus musculus
-
 ?
-
 ?
estrogen receptor beta + H2O Homo sapiens
-
 ?
-
 ?
additional information Mus musculus expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview ?
-
 ?
additional information Homo sapiens expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HSC-3 cell
-
 Homo sapiens
-
OSCC cell
-
 Homo sapiens
-
squamous cell carcinoma cell induced by 4-nitroquinoline N-oxide Mus musculus
-
squamous cell carcinoma cell induced by 4-nitroquinoline N-oxide Homo sapiens
-
tongue
-
 Mus musculus
-
tongue
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Mus musculus ?
-
 ?
Collagen + H2O
-
 Homo sapiens ?
-
 ?
estrogen receptor alpha + H2O
-
 Mus musculus ?
-
 ?
estrogen receptor alpha + H2O
-
 Homo sapiens ?
-
 ?
estrogen receptor beta + H2O
-
 Mus musculus ?
-
 ?
estrogen receptor beta + H2O
-
 Homo sapiens ?
-
 ?
additional information expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview Mus musculus ?
-
 ?
additional information expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
collagenase-2
-
 Mus musculus
collagenase-2
-
 Homo sapiens
Matrix metalloproteinase-8
-
 Mus musculus
Matrix metalloproteinase-8
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Homo sapiens