Application | Comment | Organism |
---|---|---|
diagnostics | MMP-7 immunohistochemistry may be a valuable aid for identification of the cell proliferation center in oral carcinoma in situ and dysplasia | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | carcinoma in situ, MMP-7+ cells are spread over the whole epithelial layer | Homo sapiens | - |
epithelium | expression of MMP-7 in the normal oral mucosal epithelium is restricted mainly to the parabasal layers | Homo sapiens | - |
additional information | heparan sulfate proteoglycans, especially perlecan, are extracellular docking molecules for MMP-7 | Homo sapiens | - |
oral epithelial cell | strong expression of MMP-7 in epithelial dysplasia with a two-phase appearance: a clear demarcation of MMP-7-immunopositive (+) lower dysplastic/basaloid cells from non-positive upper keratinized cells | Homo sapiens | - |
squamous cell carcinoma cell | MMP-7 positivity is reduced from carcinoma cells but instead appears in stromal cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the enhanced metabolism of perlecan associated with MMP-7 plays an important role in the cell proliferation of oral epithelia in their malignant transformation process | Homo sapiens |