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Literature summary for 3.4.21.109 extracted from
- Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer (2009), J. Invest. Dermatol., 129, 1816-1823.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hepatcyte growth factor activator inhibitor-1 | in normal skin matriptase is complexed to hepatcyte growth factor activator inhibitor-1 wheras in squamous cell carcinoma the enzyme is present in an unassociated form | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
SDS-PAGE and Western blot, reducing conditions, cleaved form of the enzyme | Homo sapiens |
| 130000 | - |
SDS-PAGE and Western blot, reducing conditions, matriptase-hepatcyte growth factor activator inhibitor-1 complex | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteinase-activated receptor 2 + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| basal cell carcinoma cell | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| squamous cell carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteinase-activated receptor 2 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matriptase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | immunoreactivity of matriptase, hepatcyte growth factor activator inhibitor-1 and proteinase-activated receptor 2 is shown to be diminished in basal cell carcinomas | down |
| Homo sapiens | matriptase expression is increased with squamous cell carcinoma progression | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | both matriptase and a specific peptide agonist for proteinase-activated receptor 2 are able to induce intracellular calcium mobilization and inhibition of proliferation in cultured human HaCaT keratinocytes. Results suggest that proteinase-activated receptor 2 is a substrate for matriptase in human skin in vivo. Deregulation of these proteins delineates squamous cell carcinoma progression | Homo sapiens |
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Release 2023.1 (January 2023)
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