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(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O
(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala + Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2
-
among the fluorescent peptide substrates analyzed, 7-amido-4-methylcoumaryl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 displays the highest specificity constant
-
-
?
(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Gly-Leu-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O
?
-
-
-
-
?
(7-methoxycoumarin-4-yl)acetyl-PKPLAL-Dpa-AR-NH2 + H2O
?
(7-methoxycoumarin-4-yl)acetyl-PLAQAV-Dpa-RSSSR-NH2 + H2O
?
synthetic fluorogenic peptide derived of tumor necrosis factor-alpha converting enzyme
-
?
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Cha-Gly-norvaline-His-Ala-Dpa-NH2 + H2O
?
synthetic fluorogenic substrate
-
?
(7-methoxycoumarin-4-yl)acetyl-RPKPVA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O
?
synthetic fluorogenic peptide, catalytic domain of the enzyme
-
?
(7-methoxycoumarin-4-yl)acetyl-RPKPVE-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O
?
synthetic fluorogenic peptide derived of matrix metalloproteinases
-
?
(7-methoxycoumarin-4-yl)acetyl-RPKPYA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O
?
activated pro-MMP-9 + H2O
?
-
-
-
?
alpha1-antitrypsin + H2O
?
alpha1-proteinase inhibitor + H2O
?
casein + H2O
?
-
zymography
-
-
?
denatured collagen + H2O
?
-
-
?
denatured collagen type I + H2O
?
-
-
-
?
denatured collagen type II + H2O
?
-
-
-
?
denatured collagen type III + H2O
?
-
-
-
?
denatured collagen type IV + H2O
?
-
-
-
?
DQ-gelatin + H2O
?
fluorescein conjugated substrate from pig skin
-
-
?
insulin-like growth factor binding protein 1 + H2O
?
-
-
-
?
insulin-like growth factor-binding protein-1 + H2O
?
-
cleaves His140Val141 in insulin-like growth factor-binding protein-1, probably rendering the substrate inactive
-
-
?
peptide + H2O
?
-
the optimal cleavage motifs for MMP-26 are Lys-Pro-Ile(Leu)-Ser-/-Leu(Met)-Ile(Thr)-Ser(Ala)-Ser. The strongest preference is observed at the P1' and P2 sites where hydrophobic residues are favored. Proline is preferred at P3, and serine is preferred at P1
-
-
?
pro-MMP-9 + H2O
MMP-9 + MMP-9 propeptide
progelatinase B + H2O
gelatinase B
substrate becomes activated, both enzymes can act as coordinately as part of a proteolytic cascade
-
?
type I gelatin + H2O
?
-
-
?
vibronectin + H2O
?
-
-
-
-
?
additional information
?
-
(7-methoxycoumarin-4-yl)acetyl-PKPLAL-Dpa-AR-NH2 + H2O
?
synthetic fluorogenic peptide derived of matrix metalloproteinases
-
?
(7-methoxycoumarin-4-yl)acetyl-PKPLAL-Dpa-AR-NH2 + H2O
?
synthetic fluorogenic peptide, catalytic domain of the enzyme
-
?
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O
?
synthetic fluorogenic substrate
-
?
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O
?
-
synthetic fluorogenic peptide
-
?
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O
?
synthetic fluorogenic peptide derived of matrix metalloproteinases
-
?
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O
?
synthetic fluorogenic peptide, derived from the catalytic domain of the enzyme
-
?
(7-methoxycoumarin-4-yl)acetyl-RPKPYA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O
?
synthetic fluorogenic peptide derived of matrix metalloproteinases
-
?
(7-methoxycoumarin-4-yl)acetyl-RPKPYA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O
?
synthetic fluorogenic peptide, catalytic domain of the enzyme
-
?
alpha1-antitrypsin + H2O
?
-
MMP-26 by cleaving and inactivating the alpha1-antitrypsin serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasm. Involvement of MMP-26 in inflammation and malignant progression of estrogen-dependent tumor
-
-
?
alpha1-antitrypsin + H2O
?
-
the enzyme is highly efficient in cleaving the the serpin alpha1-antitrypsin at the positions Gln135-/-Leu136, Glu223-/-Val224, Phe376-/-Leu377, and Pro381-/-Met382
-
-
?
alpha1-proteinase inhibitor + H2O
?
-
-
?
alpha1-proteinase inhibitor + H2O
?
-
MMP-26 cleaves Phe352Leu353 and Pro357Met358 in the reactive loop of alpha1-proteinase inhibitor, probably rendering the substrate inactive
-
-
?
Fibrinogen + H2O
?
-
-
-
?
Fibrinogen + H2O
?
complete degradation
-
?
Fibrinogen + H2O
?
complete degradation, cleavage sequenced of the peptide chains, overview
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
?
Fibronectin + H2O
?
-
-
?
Fibronectin + H2O
?
cleavage sequence is PVA44-V45SQS
-
?
Gelatin + H2O
?
-
-
-
-
?
pro-MMP-9 + H2O
MMP-9 + MMP-9 propeptide
-
-
-
-
?
pro-MMP-9 + H2O
MMP-9 + MMP-9 propeptide
-
MMP-26 can activate MMP-9 by cleavage of some sites in pro-MMP-9
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
?
proteins + H2O
peptides
wide substrate specificity
-
?
proteins + H2O
peptides
wide substrate specificity
-
?
proteins + H2O
peptides
enzyme might be rsponsible for inactivation of cytokins and serpins
-
?
proteins + H2O
peptides
enzyme plays an important specific role in tumor progression and angiogenesis
-
?
proteins + H2O
peptides
potentially implicated in tumor progression
-
?
Type IV collagen + H2O
?
-
-
-
-
?
Type IV collagen + H2O
?
-
-
-
?
Type IV collagen + H2O
?
-
-
?
Vitronectin + H2O
?
-
-
-
?
Vitronectin + H2O
?
complete degradation, cleavage sequence is PPEG134-I135DSR
-
?
additional information
?
-
no activity with collagens, laminin, elastin, beta-casein, plasminogen, soybean trypsin inhibitor, Bowman-Birk inhibitor
-
?
additional information
?
-
-
no activity with collagens, laminin, elastin, beta-casein, plasminogen, soybean trypsin inhibitor, Bowman-Birk inhibitor
-
?
additional information
?
-
-
increased level and activation of MMP-26 in gingival crevicular fluid is associated with an enhanced severity of periodontal inflammation, suggesting that MMP-26 can participate in the progression of periodontal diseases
-
-
?
additional information
?
-
-
the enzyme exhibits an unconventional PH81CGVPD Cys switch motif
-
-
?
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epithelium and stroma of adenomatoid odontogenic tumors, overview
brenda
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epithelium and stroma of amelobastomas, overview
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astrocytic gliom tissue
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an immortalized cytotrophoblast-like cell line
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elevated MMP-26 expression level
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-
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elevated MMP-26 expression level
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-
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decending and transverse, gene expression
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beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells
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elevated MMP-26 expression level
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primary cell culture
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-
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-
brenda
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-
brenda
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-
brenda
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apical epithelial conjunctiva cells of the human eye
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-
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-
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slightly enhanced MMP-26 staining in HIV+ gingival tissue samples in comparison with controls
brenda
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from patients with aggressive periodontitis, with chronic periodontitis, with gingivitis and periodontally healthy subjects. Patients with aggressive periodontitis and patients with chronic periodontitis have elevated MMP-26 levels and degrees of activation compared with the gingivitis and healthy groups. The gingivitis group has higher MMP-26 levels and degree of activation compared to the healthy group
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in intact skin MMP-26 is expressed only in hair follicles
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-
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elevated MMP-26 expression level
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promyelocytic leukemia, gene expression
brenda
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-
brenda
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-
brenda
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a choriocarcinoma cell line
brenda
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matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis. MMP-26 is expressed by laminin-5-positive keratinocytes in the migrating area during wound repair, in benign skin disorders characterized by inflammation and microdisruptions of basement membrane. MMP-26 may be upregulated in basal keratinocytes even without tumorigenesis because of altered cell-matrix interactions and inflammation
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of peripheral blood, gene expression
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-
brenda
gene expression
brenda
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-
brenda
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in the course of further disease progression through stages I to III, the expression of MMP-26 decreases. The expression of MMP-26 in ductal carcinomas correlates with a longer patient survival
brenda
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elevated MMP-26 expression level
brenda
-
-
brenda
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no elevated MMP-26 expression level
brenda
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high expression rate of MMP-26
brenda
-
brenda
-
-
brenda
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no elevated MMP-26 expression level
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
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-
brenda
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patients with metastatic lymph nodeshave increased expression of MMP-26 in tumor samples
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-
brenda
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-
brenda
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-
brenda
gene expression
brenda
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from control and preeclamptic umbilical cord blood
brenda
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matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes
brenda
gene expression
brenda
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brenda
androgen-repressed prostate cancer cell
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-
-
brenda
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-
brenda
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from control and preeclamptic umbilical cord blood
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fetal, gene expression
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-
brenda
gene expression
brenda
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from coronary artery or from prostate tissue and associated blood vessels
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gene expression
brenda
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-
brenda
chondrosarcoma cell line
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colorectal adenocarcinoma, gene expression
brenda
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-
brenda
gene expression
brenda
fetal, gene expression
brenda
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-
brenda
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-
brenda
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-
brenda
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-
brenda
MMP-26 mRNA is evenly distributed in all glandular epithelial cells and luminal epithelial cells but is absent in the stroma. The amount of MMP-26 mRNA is greater in samples at day 5 in an artificial cycle of progesterone addition than at day 7 in an artificial cycle of progesterone addition
brenda
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-
brenda
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-
brenda
lung carcinoma, gene expression
brenda
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-
brenda
fetal, gene expression
brenda
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-
brenda
gene expression
brenda
gene expression
brenda
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gene expression
brenda
-
-
brenda
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beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells
brenda
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overexpression in 24 of the 50 esophageal squamous cell carcinoma tissues. Overexpression is significantly correlated with depth of invasion, lymph node metastasis amd an advance in pathological tumor node metastasis stage
brenda
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33 out of 34 of the primary tumors express MMP-26. Most abundant expression concentrates in grade I-II tumors. In normal esophagus, the basal cells are usually negative for MMP-26, except for occasional basal cells at the top of epidermal papillae. MMP-26 is already upregulated in dysplasia. Tumor cells making contact with islets undergoing apoptosis show prominent MMP-26 staining, and inflammation upregulates MMP-26 expression. When the invasive islet escapes through the basement membrane, MMP-26 expression becomes abundant. The pushing border of the tumor only shows dispersed MMP-26 staining, and MMP-26 does not colocalize with proliferation or apoptosis. Neoplastic islands are often positive for MMP-26. In 2 out of 4 lymph nodes, MMP-26 is detected in metastatic tumor cells, where individual cancer cells expressed MMP-26 on the border of apoptotic areas non-neoplastic epithelium
brenda
-
-
brenda
-
brenda
in the outer and inner annulus and in the nucleus pulposus
brenda
constitutive expression. Protein is found in both disc cells and in the disc extracellular matrix. MMP-26 is identified in the outer and inner annulus and in the nucleus pulposus. Fewer cells show localization in the inner vs. outer annulus, and localization is sparse in the nucleus
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-
brenda
adult and fetal, gene expression
brenda
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-
brenda
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no elevated MMP-26 expression level
brenda
gene expression
brenda
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atypical hyperplasia, low expression rate of MMP-26
brenda
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elevated MMP-26 expression level
brenda
-
-
brenda
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matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes
brenda
-
-
brenda
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MMP-26 predominantly accumulates in its proenzyme form in the intracellular milieu of the transfected breast carcinoma MCF-7 cells
brenda
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-
brenda
gene expression
brenda
gene expression
brenda
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malignant prostate tumor. Higher MMP-26 expression in high-grade prostatic intraepithelial neoplasia and cancer, compared to non-neoplastic acini. The expression level is highest in high-grade prostatic intraepithelial neoplasia, but declines in invasive cancer in the same tissue. MMP-26 may play an important role in the initial conversion of prostate cancer cells to an invasive phenotype
brenda
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elevated MMP-26 expression level
brenda
-
-
brenda
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MMP-26 may participate in stromal remodelling and regulation of inflammation in various skin disorders, such as granulomatous diseases or actinic damage
brenda
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MMP-26 is expressed in grade I and II squamous cell cancer. It is not present in dedifferentiated grade III tumors. MMP-26 becomes downregulated during histological dedifferentiation of squamous cell cancer cells
brenda
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MMP-26 is present more frequently in squamous cell carcinomas of immunosuppressed compared with immunocompetent patients. Stromal staining for MMP-26 in elastic fibers and endothelial cells does not differ between the groups
brenda
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-
brenda
-
brenda
gene expression
brenda
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gene expression
brenda
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localized to the luminal and glandular epithelium at proestrus and estrus. The expression level is decreased significantly from metestrus to dioestrus. During pre-implantation period, MMP-26 mRNA is predominantly expressed in luminal and glandular epithelium at much higher level. It switches to stroma during peri-implantation period and also appears in the blastocysts and the implantation sites. MMP-26 might play a role in the cycling changes of mouse uterus during the estrous cycle and embryo implantation
brenda
additional information
no expression in testis, heart, brain, lung, liver, thymus, and melanoma G361 cell
brenda
additional information
-
no expression in testis, heart, brain, lung, liver, thymus, and melanoma G361 cell
brenda
additional information
very restricted expression pattern
brenda
additional information
-
very restricted expression pattern
brenda
additional information
-
matrilysin-2 mRNA expression is undetectable or only faintly detected in non-tumor tissues
brenda
additional information
-
MMP-26 is not expressed in mammary epithelium
brenda
additional information
-
MMP-26 exists in the form of complexes with other extracellular matrix components and/or their tissue inhibitors in control and preeclamptic subjects, overview
brenda
additional information
-
MMP-26 expression analysis
brenda
additional information
-
MMP-26 immunohistochemic expression analysis and comparison to MMP-7 or matrilysin-1, overview
brenda
additional information
-
MMP-26 real-time PCR expression analysis, overview
brenda
additional information
-
MMP-26 shows unique but complex expression patterns in normal and abnormal tissue, RT-PCR expression analysis, overview
brenda
additional information
-
no expression rate of MMP-26 in healthy lung tissue
brenda
additional information
-
RT-PCR MMP-26 expression profiling in different human cancer tissues, several cancer tissue show elevated MMP-26 expression compared to benign tissue
brenda
additional information
no transcripts detectable in the endometrial stroma and vasculature
brenda
additional information
-
no transcripts detectable in the endometrial stroma and vasculature
brenda
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Marchenko, G.N.; Ratnikov, B.I.; Rozanov, D.V.; Godzik, A.; Deryugina, E.I.; Strongin, A.Y.
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin
Biochem. J.
356
705-718
2001
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Uria, J.A.; Lopez-Otin, C.
Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity
Cancer Res.
60
4745-4751
2000
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Park, H.I.; Ni, J.; Gerkema, F.E.; Liu, D.; Belozerov, V.E.; Sang, Q.X.
Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor
J. Biol. Chem.
275
20540-20544
2000
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Marchenko, N.D.; Marchenko, G.N.; Strongin, A.Y.
Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif
J. Biol. Chem.
277
18967-18972
2002
Homo sapiens
brenda
Park, H.I.; Turk, B.E.; Gerkema, F.E.; Cantley, L.C.; Sang, Q.X.
Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26
J. Biol. Chem.
277
35168-35175
2002
Homo sapiens
brenda
Park, H.I.; Jin, Y.; Hurst, D.R.; Monroe, C.C.; Lee, S.; Schwartz, M.A.; Sang, Q.X.
The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling
J. Biol. Chem.
278
51646-51653
2003
Homo sapiens
brenda
Li, W.; Savinov, A.Y.; Rozanov, D.V.; Golubkov, V.S.; Hedayat, H.; Postnova, T.I.; Golubkova, N.V.; Linli, Y.; Krajewski, S.; Strongin, A.Y.
Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin
Cancer Res.
64
8657-8665
2004
Homo sapiens
brenda
Savinov, A.Y.; Remacle, A.G.; Golubkov, V.S.; Krajewska, M.; Kennedy, S.; Duffy, M.J.; Rozanov, D.V.; Krajewski, S.; Strongin, A.Y.
Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients
Cancer Res.
66
2716-2724
2006
Homo sapiens
brenda
Yamamoto, H.; Vinitketkumnuen, A.; Adachi, Y.; Taniguchi, H.; Hirata, T.; Miyamoto, N.; Nosho, K.; Imsumran, A.; Fujita, M.; Hosokawa, M.; Hinoda, Y.; Imai, K.
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma
Carcinogenesis
25
2353-2360
2004
Homo sapiens
brenda
Marchenko, N.D.; Marchenko, G.N.; Weinreb, R.N.; Lindsey, J.D.; Kyshtoobayeva, A.; Crawford, H.C.; Strongin, A.Y.
beta-Catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells
Int. J. Biochem. Cell Biol.
36
942-956
2004
Homo sapiens
brenda
Ahokas, K.; Skoog, T.; Suomela, S.; Jeskanen, L.; Impola, U.; Isaka, K.; Saarialho-Kere, U.
Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis
J. Invest. Dermatol.
124
849-856
2005
Homo sapiens
brenda
Liu, G.; Zhang, X.; Lin, H.; Li, Q.; Wang, H.; Ni, J.; Amy Sang, Q.X.; Zhu, C.
Expression of matrix metalloproteinase-26 (MMP-26) mRNA in mouse uterus during the estrous cycle and early pregnancy
Life Sci.
77
3355-3365
2005
Mus musculus
brenda
Lee, S.; Park, H.I.; Sang, Q.X.
Calcium regulates tertiary structure and enzymatic activity of human endometase/matrilysin-2 and its role in promoting human breast cancer cell invasion
Biochem. J.
403
31-42
2007
Homo sapiens
brenda
Lee, S.; Desai, K.K.; Iczkowski, K.A.; Newcomer, R.G.; Wu, K.J.; Zhao, Y.; Tan, W.W.; Roycik, M.D.; Sang, Q.A.
Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor
Cell Res.
16
750-758
2006
Homo sapiens
brenda
Skoog, T.; Ahokas, K.; Orsmark, C.; Jeskanen, L.; Isaka, K.; Saarialho-Kere, U.
MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture
Exp. Dermatol.
15
775-783
2006
Homo sapiens
brenda
Pilka, R.; Oborna, I.; Lichnovsky, V.; Havelka, P.; Fingerova, H.; Eriksson, P.; Hansson, S.; Casslen, B.
Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patients
Hum. Reprod.
21
3146-3156
2006
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Mellanen, L.; Lahdevirta, J.; Tervahartiala, T.; Meurman, J.H.; Sorsa, T.
Matrix metalloproteinase-7, -8, -9, -25, and -26 and CD43, -45, and -68 cell-markers in HIV-infected patients saliva and gingival tissue
J. Oral Pathol. Med.
35
530-539
2006
Homo sapiens
brenda
Emingil, G.; Kuula, H.; Sorsa, T.; Atilla, G.
Gingival crevicular fluid matrix metalloproteinase-25 and -26 levels in periodontal disease
J. Periodontol.
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2006
Homo sapiens
brenda
Bister, V.; Skoog, T.; Virolainen, S.; Kiviluoto, T.; Puolakkainen, P.; Saarialho-Kere, U.
Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma
Mod. Pathol.
20
1128-1140
2007
Homo sapiens
brenda
Ahokas, K.; Karjalainen-Lindsberg, M.L.; Sihvo, E.; Isaka, K.; Salo, J.; Saarialho-Kere, U.
Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer
Tumour Biol.
27
133-141
2006
Homo sapiens
brenda
Park, H.I.; Lee, S.; Ullah, A.; Cao, Q.; Sang, Q.X.
Effects of detergents on catalytic activity of human endometase/matrilysin 2, a putative cancer biomarker
Anal. Biochem.
396
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2010
Homo sapiens
brenda
Galewska, Z.; Romanowicz, L.; Jaworski, S.; Ba?kowski, E.
Matrix metalloproteinases, MMP-7 and MMP-26, in plasma and serum of control and preeclamptic umbilical cord blood
Eur. J. Obstet. Gynecol. Reprod. Biol.
150
152-156
2010
Homo sapiens
brenda
Souza Freitas, V.; Ferreira de Araujo, C.R.; Alves, P.M.; de Souza, L.B.; Galvao, H.C.; de Almeida Freitas, R.
Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
108
417-424
2009
Homo sapiens
brenda
Zhao, Y.G.; Xiao, A.Z.; Ni, J.; Man, Y.G.; Sang, Q.X.
Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells
Ai Zheng
28
1168-1175
2009
Homo sapiens
brenda
Li, L.; Mei, T.H.; Zhou, X.D.; Zhang, X.G.
Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer
Ai Zheng
28
60-63
2009
Homo sapiens
brenda
Kuivanen, T.; Jeskanen, L.; Kylloenen, L.; Isaka, K.; Saarialho-Kere, U.
Matrix metalloproteinase-26 is present more frequently in squamous cell carcinomas of immunosuppressed compared with immunocompetent patients
J. Cutan. Pathol.
36
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2009
Homo sapiens
brenda
Deng, Y.; Li, W.; Li, Y.; Yang, H.; Xu, H.; Liang, S.; Zhang, L.; Li, Y.
Expression of Matrix Metalloproteinase-26 promotes human glioma U251 cell invasion in vitro and in vivo
Oncol. Rep.
23
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2010
Homo sapiens
brenda
Liu, J.; Cao, B.; Li, Y.; Wu, X.; Wang, Y.
GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts
Reprod. Biol. Endocrinol.
8
5
2010
Homo sapiens
brenda
Gruber, H.E.; Hoelscher, G.L.; Ingram, J.A.; Hanley, E.N.
Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro
Exp. Mol. Pathol.
92
59-63
2011
Homo sapiens, Homo sapiens (Q9NRE1)
brenda
Zhang, Y.; Zhao, H.; Wang, Y.; Lin, Y.; Tan, Y.; Fang, X.; Zheng, L.
Non-small cell lung cancer invasion and metastasis promoted by MMP-26
Mol. Med. Rep.
4
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2011
Homo sapiens
brenda
Almeida-Francia, C.C.; Keator, C.S.; Mah, K.; Holden, L.; Hergert, C.; Slayden, O.D.
Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque
Hum. Reprod.
27
1723-1734
2012
Macaca mulatta (F6QMZ1), Macaca mulatta
brenda
Yang, H.; Wang, Y.; Li, Y.; Zhang, L.; Deng, Y.; Qi, D.; Li, Y.; Li, W.
Roles of matrix metalloproteinase-26 in the growth, invasion and angiogenesis of breast cancer
Oncol. Lett.
4
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2012
Homo sapiens (Q9NRE1)
brenda
Mu, T.; Liang, W.; Ju, Y.; Wang, Z.; Wang, Z.; Roycik, M.D.; Sang, Q.X.; Yu, D.; Xiang, H.; Fang, X.
Efficient soluble expression of secreted matrix metalloproteinase 26 in Brevibacillus choshinensis
Protein Expr. Purif.
91
125-133
2013
Homo sapiens (Q9NRE1)
brenda
Xu, X.; Ma, J.; Li, C.; Zhao, W.; Xu, Y.
Regulation of chondrosarcoma invasion by MMP26
Tumour Biol.
36
365-369
2015
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Romanowicz, L.; Gogiel, T.; Galewska, Z.; Bruczko, M.; Baczyk, J.; Roszkowska-Jakimiec, W.; Sobolewski, K.
Divergent changes in the content and activity of MMP-26 and TIMP-4 in human umbilical cord tissues associated with preeclampsia
Eur. J. Obstet. Gynecol. Reprod. Biol.
231
48-53
2018
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Khamis, Z.I.; Iczkowski, K.A.; Man, Y.G.; Bou-Dargham, M.J.; Sang, Q.X.
Evidence for a proapoptotic role of matrix metalloproteinase-26 in human prostate cancer cells and tissues
J. Cancer
7
80-87
2016
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Guo, J.G.; Guo, C.C.; He, Z.Q.; Cai, X.Y.; Mou, Y.G.
High MMP-26 expression in glioma is correlated with poor clinical outcome of patients
Oncol. Lett.
16
2237-2242
2018
Homo sapiens (Q9NRE1), Homo sapiens
brenda
Zhang, G.; Zhang, J.; Li, X.; Meng, X.; Fang, X.
Identification of the endoplasmic reticulum localization sequence and N-glycosylation of matrix metalloproteinase 26
RSC Adv.
9
23053-23060
2019
Homo sapiens (Q9NRE1)
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brenda