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Information on EC 3.4.22.15 - cathepsin L

for references in articles please use BRENDA:EC3.4.22.15

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IUBMB Comments

A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity

Synonyms
cathepsin l, cathepsin l-like, cathepsin-l, human cathepsin l, cpl-1, cat l, cwp84, cathl, major excreted protein, smcl1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
show the reaction diagram
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Highest Expressing Human Cell Lines
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