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Information on EC 7.4.2.3 - mitochondrial protein-transporting ATPase

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IUBMB Comments
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cpHsc70-1, cpHsc70-2, DnaK, DnaK chaperone, HIKESHI, Hsc70 ATPase, Hsp70, HSP70 ATPase, Hsp70 chaperone, inner mitochondrial membrane preprotein translocase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + H2O + mitochondrial-protein[side 1] = ADP + phosphate + mitochondrial-protein[side 2]
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