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Disease on EC 7.4.2.3 - mitochondrial protein-transporting ATPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Missed
Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions.
Abortion, Spontaneous
A comparison in concentration of heat shock proteins (HSP) 70 and 90 on chorionic villi of human placenta in normal pregnancies and in missed miscarriages.
Early changes of the heat-shock protein 60 to 70 ratio as prediction of miscarriage in pregnancy.
Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion.
Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions.
The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion.
Abortion, Threatened
Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions.
Acidosis
Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis.
Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats.
Heat-shock proteins expression in fish central nervous system and its possible relation with water acidosis resistance.
Acquired Immunodeficiency Syndrome
Hsp70 clears misfolded kinases that partitioned into distinct quality control compartments.
Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions.
Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3.
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos.
The translation machinery and 70 kd heat shock protein cooperate in protein synthesis.
Acute Coronary Syndrome
Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Variants of HSPA1A in Combination with Plasma Hsp70 and Anti-Hsp70 Antibody Levels Associated with Higher Risk of Acute Coronary Syndrome.
Acute Kidney Injury
Association between heat shock protein 72 gene polymorphism and acute renal failure in premature neonates.
Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.
Induction of heat shock protein 70 inhibits ischemic renal injury.
Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.
Temporal alterations in regional gene expression after nephrotoxic renal injury.
Acute Lung Injury
Alanyl?glutamine prophylactically protects against lipopolysaccharide?induced acute lung injury by enhancing the expression of HSP70.
Dioscin prevents LPS?induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70.
Enhanced Hsp70 expression protects against acute lung injury by modulating apoptotic pathways.
Expression of heat shock protein 70 in lung tissues of acute paraquat poisoned rats and intervention of ulinastatin.
Fluoro-edenite Fibers Induce Expression of Hsp70 and Inflammatory Response.
Heat shock response and acute lung injury.
High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning.
Hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70.
Addison Disease
Major histocompatibility complex class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility.
Adenocarcinoma
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
Effects of combined treatment of chemotherapeutics and hyperthermia on survival and the regulation of heat shock proteins in Dunning R3327 prostate carcinoma cells.
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.
Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma--immunohistochemistry and Western blot analysis.
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
HSP70 peptidembearing and peptide-negative preparations act as chaperokines.
Immunocytochemical expression of the 70 kD heat shock protein in ischaemic bowel disease.
MUC1 expression and its association with other aetiological factors and localization to mitochondria in preneoplastic and neoplastic gastric tissues.
Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
PS2 and HSP70 Expression in Rectal Adenocarcinomas: An Immunohistochemical Investigation of 45 cases.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Role of Helicobacter pylori infection in pathogenesis of gastric adenocarcinoma.
Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells.
[Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma]
Adenocarcinoma of Lung
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.
Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry.
[Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma]
Adenocarcinoma, Mucinous
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Adenoma
Glucocorticoid receptor and molecular chaperones in the pathogenesis of adrenal incidentalomas: potential role of reduced sensitivity to glucocorticoids.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Adenomatous Polyposis Coli
Protein disulfide bond formation in the cytoplasm during oxidative stress.
Adenomyosis
Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.
Adenoviridae Infections
Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells.
Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells.
Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.
Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12S E1A product.
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.
Agranulocytosis
Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups.
Airway Obstruction
Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients.
Albuminuria
Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy.
Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study.
Alkalosis
Extracellular pH changes activate the p38-MAPK signalling pathway in the amphibian heart.
Alkalosis, Respiratory
Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat-stressed pigs.
Altitude Sickness
High altitude hypoxia on brain ultrastructure of rats and Hsp70 expression changes.
Alzheimer Disease
Association of HSP70 and its Co-Chaperones with Alzheimer's Disease.
Engineered Hsp70 chaperones prevent A?42-induced memory impairments in a Drosophila model of Alzheimer's disease.
Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.
Heat shock proteins: a history of study in Russia.
Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease.
Hsp70 and its molecular role in nervous system diseases.
Hsp70 molecular chaperones and Parkinson's disease.
Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment.
Involvement of Heat Shock Protein 70 in the DNA Protective Effect From Estrogen.
Modulation of Amyloid-? Protein Precursor Expression by HspB1.
Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.
Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection.
Screening strategies to identify HSP70 modulators to treat Alzheimer's disease.
Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway.
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
The Effect of Human HSP70 Administration on a Mouse Model of Alzheimer's Disease Strongly Depends on Transgenicity and Age.
The Possible Involvement of HLA Class III Haplotype (RAGE, HSP70 and TNF Genes) in Alzheimer's Disease.
Therapeutic Effect of Exogenous Hsp70 in Mouse Models of Alzheimer's Disease.
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and A? accumulation via enhancement of ERK phosphatase VHR activity.
Ameloblastoma
HSP70 expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma.
Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas.
Amyloidosis
Aggregation interplay between variants of the RepA-WH1 prionoid in Escherichia coli.
RepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles.
Amyotrophic Lateral Sclerosis
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis.
Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment.
Hsp70 molecular chaperones and Parkinson's disease.
Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.
Anemia
A peptide derived from apoptin inhibits glioma growth.
Novel players in ?-thalassemia dyserythropoiesis and new therapeutic strategies.
Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-?B activation.
The haem-regulated eukaryotic initiation factor 2alpha kinase: a molecular indicator of lead-toxicity anaemia in rabbits.
Anemia, Hypochromic
Low Genetic Diversity Suggests a Single Introduction and Recent Spread of Tomato chlorosis virus in Brazil
Anemia, Sideroblastic
Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.
Aneurysm
Heat shock proteins HSP70 and HSP27 in the cerebral spinal fluid of patients undergoing thoracic aneurysm repair correlate with the probability of postoperative paralysis.
Angina, Stable
Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Angina, Unstable
Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Intense immunostaining of heat shock protein 70 within renal interstitium associates with long-term renal survival in an ANCA-associated vasculitis cohort.
Aortic Aneurysm, Thoracic
Antiapoptotic Effect of ?1 Blockers in Ascending Thoracic Aortic Smooth Muscle Cells: The Role of HSP70 Expression.
Aortic Valve Stenosis
Antiapoptotic Effect of ?1 Blockers in Ascending Thoracic Aortic Smooth Muscle Cells: The Role of HSP70 Expression.
Apnea
Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients.
Arrhythmias, Cardiac
Intermittent hypoxia exposure-induced heat-shock protein 70 expression increases resistance of rat heart to ischemic injury.
Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.
Arterial Occlusive Diseases
HSP70 expression in skeletal muscle of patients with peripheral arterial occlusive disease.
Arteriosclerosis
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Arthritis
A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis.
An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA-Restricted T Cell Responses.
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Heat Shock Protein 70 as a Double Agent Acting Inside and Outside the Cell: Insights into Autoimmunity.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis.
Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes.
In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide.
Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins.
Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.
Protective effects of overexpression TCR Vbeta5.2-HSP70 and TCR Vbeta8.2-HSP70 against collagen-induced arthritis in rats.
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.
The anti-inflammatory mechanisms of Hsp70.
Arthritis, Experimental
A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis.
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Strain differences and the role for HSP47 and HSP70 in adjuvant arthritis in rats.
Arthritis, Juvenile
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
Arthritis, Rheumatoid
A novel variant of the MHC-linked hsp70, hsp70-hom, is associated with rheumatoid arthritis.
Aberrant stress-induced Hsp70 expression in immune cells in multiple sclerosis.
An allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression.
Autologous extracellular Hsp70 exerts a dual role in rheumatoid arthritis.
Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissue.
Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis.
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.
Experimental immunization with anti-rheumatic bacterial extract OM-89 induces T cell responses to heat shock protein (hsp)60 and hsp70; modulation of peripheral immunological tolerance as its possible mode of action in the treatment of rheumatoid arthritis (RA).
Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints.
Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.
Heat Shock Protein 70 as a Double Agent Acting Inside and Outside the Cell: Insights into Autoimmunity.
Heat shock protein 70 gene polymorphisms in rheumatoid arthritis.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis.
HLA-D region and Hsp70 genes in rheumatoid arthritis.
Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis.
Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes.
Serum levels of free heat shock protein 70 and anti-HSP70 are elevated in Behçet's disease.
The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats.
Aspergillosis
Stress proteins in fungal diseases.
Asthenozoospermia
Supplementation of freezing media with alpha lipoic acid preserves the structural and functional characteristics of sperm against cryodamage in infertile men with asthenoteratozoospermia.
Asthma
Analysis of hsp70 gene polymorphism in allergic asthma.
Bronchial gamma delta T-lymphocytes and expression of heat shock proteins in mild asthma.
Heat Shock Protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.
Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids.
Heat shock proteins mRNA expressions by peripheral blood mononuclear cells in asthma and chronic bronchitis.
Heat shock proteins' mRNA expression in asthma.
Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.
Increased circulating heat shock protein 70 levels in pregnant asthmatics.
Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients.
Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma.
The Role of Heat Shock Protein 70 kDa in Asthma.
Astrocytoma
Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours.
Heat shock protein expression in human gliomas.
Hsp27 (HSPB1): a possible surrogate molecular marker for loss of heterozygosity (LOH) of chromosome 1p in oligodendrogliomas but not in astrocytomas.
Ataxia
The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]
Atherosclerosis
A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit.
Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats.
Anti-heat-shock protein 70 kDa antibodies in vascular patients.
Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease.
Atherosclerosis alters the localization of HSP70 in human and macaque aortas.
Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.
Changes in heat shock protein 70 localization and its content in rabbit aorta at various stages of experimental atherosclerosis.
Chaperone duality: the role of extracellular and intracellular HSP70 as a biomarker of endothelial dysfunction in the development of atherosclerosis.
Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats.
Effect of dyslipidemia on intima-media thickness of intra- and extracranial atherosclerosis by regulating the expression of hsp70 in rabbits.
Effects of oxidant-induced injury on heme oxygenase and glutathione in cultured aortic endothelial cells from atherosclerosis-susceptible and -resistant Japanese quail.
Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis.
Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis.
Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population.
Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.
Heat shock protein 70 and antibodies to heat shock protein 60 are associated with cerebrovascular atherosclerosis.
Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
HSP 70 and atherosclerosis--protector or activator?
HSP70 increases extracellular matrix production by human vascular smooth muscle through TGF-?1 up-regulation.
HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo.
Human endothelial cells exposed to oxidized LDL express hsp70 only when proliferating.
Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration.
Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation.
Oxidized LDL induce hsp70 expression in human smooth muscle cells.
Pentoxifylline administration changes protein expression profile of coronary artery disease patients.
Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Proteomic analysis and comparison of intra? and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits.
Regulatory effects of 1,25-dihydroxyvitamin D(3) on vascular smooth muscle cells.
Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.
Serum level of soluble Hsp70 is associated with vascular calcification.
Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris.
Soy isoflavones reduce heat shock proteins in experimental atherosclerosis.
Temporal expression of heat shock proteins 60 and 70 at lesion-prone sites during atherogenesis in ApoE-deficient mice.
Trimethylamine-N-oxide, as a risk factor for atherosclerosis, induces stress in J774A.1 murine macrophages.
Two Hsp70 family members expressed in atherosclerotic lesions.
Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice.
Atrial Fibrillation
Association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fibrillation.
Association of Met439Thr Substitution in Heat Shock Protein 70 Gene with Postoperative Atrial Fibrillation and Serum HSP70 Protein Levels.
Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation.
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.
Low preoperative HSP70 atrial myocardial levels correlate significantly with high incidence of postoperative atrial fibrillation after cardiac surgery.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions.
Autoimmune Diseases
Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease.
Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice.
Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals.
Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization.
Facets of heat shock protein 70 show immunotherapeutic potential.
Heat shock proteins and allograft rejection.
Hsp70 and its molecular role in nervous system diseases.
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
HSP70, a Novel Regulatory Molecule in B Cell-Mediated Suppression of Autoimmune Diseases.
Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus?
Molecular markers of systemic autoimmune disorders: the expression of MHC-located HSP70 genes is significantly associated with autoimmunity development.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Short-term Follow-up of Chagasic Patients after Benznidazole Treatment Using Multiple Serological Markers.
Zika E Glycan Loop Region and Guillain-Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development.
Babesiosis
Heat shock response of Babesia divergens and identification of the hsp70 as an immunodominant early antigen during ox, gerbil and human babesiosis.
Bacterial Infections
Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.
Cloning and characterization of a hsp70 gene from Asiatic hard clam Meretrix meretrix which is involved in the immune response against bacterial infection.
Cloning and identification of grass carp transcription factor HSF1 and its characterization involving the production of fish HSP70.
Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78.
Expression of HSP70 family mRNAs in albino northern snakehead, Channa argus: Response to extreme temperature stress and bacterial infection.
Extracellular Hsp70 induces inflammation and modulates LPS/LTA-stimulated inflammatory response in THP-1 cells.
Feeding Artemia franciscana (Kellogg) larvae with bacterial heat shock protein, protects from Vibrio campbellii infection.
Genome-wide identification of Hsp70 genes in channel catfish and their regulated expression after bacterial infection.
Heat shock protein profiles on the protein and gene expression levels in olive flounder kidney infected with Streptococcus parauberis.
Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL.
Hsp90, Hsp60 and sHsp families of heat shock protein genes in channel catfish and their expression after bacterial infections.
Molecular cloning and expression analysis of heat-shock protein 70 in orange-spotted grouper Epinephelus coioides following heat shock and Vibrio alginolyticus challenge.
Pathogen-associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Barrett Esophagus
Barrett's Esophagus and ?-carotene Therapy: Symptomatic Improvement in GERD and Enhanced HSP70 Expression in Esophageal Mucosa.
Blindness
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Blister
Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid.
Bone Neoplasms
Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen.
Borna Disease
Persistent borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.
Bradycardia
Adrenergic regulation of adrenal and aortic heat shock protein.
Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats.
Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke.
Brain Contusion
[A study of HSP70 and NF in brain contusion timing]
[A study on the expression of HSP70 and iNOS after human brain contusion]
Brain Death
Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70.
Effects of brain death on stress and inflammatory response in the human donor kidney.
Renal expression of heat shock proteins after brain death induction in rats.
Brain Edema
Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat.
Expression of c-fos and hsp70 mRNA after traumatic brain injury in transgenic mice overexpressing CuZn-superoxide dismutase.
Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia.
Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression.
Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.
[Effect of heat shock protein 70 on nuclear factor-KappaB/inhibitor protein-alpha of nuclear factor-KappaB in brain edema induced by infection in rat]
[Heat shock protein 70 induction by heat stress suppress interleukin-1beta and tumor necrosis factor-alpha levels in the brain tissue in rats with infectious brain edema]
[Protective effect and mechanism of pretreatment with curcumin on infectious brain edema in rats]
[Protective effects and its mechanism of panaxatriol saponins isolated from Panax notoginseng on cerebral ischemia]
Brain Infarction
The Antiapoptotic Actions of Mood Stabilizers: Molecular Mechanisms and Therapeutic Potentials.
Brain Injuries
Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury.
Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27.
Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice.
Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats.
Expression of heat shock protein after +Gz exposure and its protective effects on +Gz-induced brain injury.
Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.
In vivo heat-shock response in the brain: signalling pathway and transcription factor activation.
L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70.
Marked alteration of c-fos and c-jun but not hsp70 messenger RNA expression in rat brain after cold-induced trauma: An in situ hybridization study.
Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression.
Neuroprotective effects of food restriction in a rat model of traumatic brain injury - the role of glucocorticoid signaling.
Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury.
Protective effects of focal ischemic preconditioning and HSP70 expression on middle cerebral artery occlusion in rats.
Spatio-temporal distribution of apoptosis and the modulators thereof following a cortical microinfarct in rat brain.
Subcellular stress response after traumatic brain injury.
The expression and changes of heat shock protein 70, MDA and haemorheology in rat cortex after diffuse axonal injury with secondary insults.
The immune modulating properties of the heat shock proteins after brain injury.
Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.
[A study on expression of hsp70 mRNA in the early stage of diffuse brain injury in rats]
[Changes of HSP70, bFGF and TGF-beta1 expression in rat brain after concussion]
[The findings indicate that HSP70 expression is closely related to ischemic brain injury, and that HSP70 expression is not related to either breakdown of the blood-brain barrier or reactive axonal changes]
Brain Injuries, Diffuse
[A study on expression of hsp70 mRNA in the early stage of diffuse brain injury in rats]
Brain Injuries, Traumatic
17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia.
Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression.
Expression of c-fos and hsp70 mRNA after traumatic brain injury in transgenic mice overexpressing CuZn-superoxide dismutase.
Expression of heat shock protein 70 and Annexin A1 in serum of patients with acutely severe traumatic brain injury.
Expression of Hsp70 and Caspase-3 in rabbits after severe traumatic brain injury.
Heat shock protein signaling in brain ischemia and injury.
Hsp70 inducer, 17-allylamino-demethoxygeldanamycin, provides neuroprotection via anti-inflammatory effects in a rat model of traumatic brain injury.
Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression.
p53-independent transient p21(WAF1/CIP1) mRNA induction in the rat brain following experimental traumatic injury.
Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury.
Pharmacological induction of the 70-kDa heat shock protein protects against brain injury.
Protective Effects of Propolis Extract in a Rat Model of Traumatic Brain Injury via Hsp70 Induction.
Serum Hsp70 as an early predictor of fatal outcome after severe traumatic brain injury in males.
Subcellular stress response after traumatic brain injury.
The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury.
Brain Ischemia
Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke.
c-fos and HSP70 gene expression in rat brains in high gravitation-induced cerebral ischemia.
Cerebral ischemia and infarction from atheroemboli <100 microm in Size.
Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia.
Different thresholds of HSP70 and HSC70 heat shock mRNA induction in post-ischemic gerbil brain.
Expression of Cu/Zn SOD protein is suppressed in hsp 70.1 knockout mice.
Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen.
Expression of hsp70 mRNA is induced in the brain of transgenic mice overexpressing human CuZn-superoxide dismutase following transient global cerebral ischemia.
Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions.
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential.
Hsp70.1 and related lysosomal factors for necrotic neuronal death.
HuR function and translational state analysis following global brain ischemia and reperfusion.
Immunohistochemical assessment of constitutive and inducible heat-shock protein 70 and ubiquitin in human cerebellum and caudate nucleus.
Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat.
Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.
Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.
Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.
Induction of the 'zinc finger' gene after transient focal ischemia in rat cerebral cortex.
Interaction between hypertension and HSP70 variants increase the risk of cerebral ischemia in Chinese Han population: an association study.
Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways.
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.
Many mechanisms for hsp70 protection from cerebral ischemia.
MicroRNAs regulate the chaperone network in cerebral ischemia.
Mild hypothermia decreases the incidence of transient ADC reduction detected with diffusion MRI and expression of c-fos and hsp70 mRNA during acute focal ischemia in rats.
Monitoring the temporal and spatial activation pattern of astrocytes in focal cerebral ischemia using in situ hybridization to GFAP mRNA: comparison with sgp-2 and hsp70 mRNA and the effect of glutamate receptor antagonists.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
Nuclear factor-kappa B activation in permanent intraluminal focal cerebral ischemia in the rat.
Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress.
Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates.
Preconditioning with +Gz acceleration (head-to-foot inertial load) produces neuroprotection against transient focal cerebral ischemia in rats.
Preferential expression of HSC70 heat shock mRNA in gerbil heart after transient brain ischemia.
Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase.
Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury.
Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.
Targeted disruption of Hsp110/105 gene protects against ischemic stress.
Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
Transient MRI-detected water apparent diffusion coefficient reduction correlates with c-fos mRNA but not hsp70 mRNA induction during focal cerebral ischemia in rats.
[Amantadine sulfate (PK-Merz) in the treatment of ischemic stroke: a clinical-experimental study]
[Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]
[Effects of afobazole on stress protein HSP70 content in brain tissue of rats with global transient ischemia]
[Effects of Naoluo Xintong Recipe on expression of HSP70 and bFGF in focal ischemia-reperfusion rats]
[Effects of Naomaitong Recipe on expressions of nuclear factor-kappaB and nitric-oxide synthases in brain tissue after focal cerebral ischemia reperfusion in aged rats.]
[Heat shock protein 70 and stimulation induced by +Gz]
[Protective effects and its mechanism of panaxatriol saponins isolated from Panax notoginseng on cerebral ischemia]
[The expression of hsp70 and BCL-2 genes in hippocampus of the rats exposed to cerebral ischemia and reperfusion]
Brain Neoplasms
Concomitant alterations in distribution of 70 kDa heat shock proteins, cytoskeleton and organelles in heat shocked 9L cells.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells.
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.
Expression of heat shock proteins in brain tumors.
Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
HSP70-based anti-cancer immunotherapy.
Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumour cells.
Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.
The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.
[Chaperone therapy in the rat model of intracranial glioblastoma].
Breast Neoplasms
19-substituted Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Biological Activity and Decreased Off-target Toxicity.
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines.
Altered expression of anti-apoptotic proteins in non-involved tissue from cancer-containing breasts.
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells.
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia.
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Chromatographic separation of eight progesterone receptor isoforms in human breast tumors, and detection by radioligand and monoclonal antibodies. Association with hsp90 and hsp70 heat shock proteins.
Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells.
Correlation of heat shock protein (HSP70) expression with cell proliferation (MIB1), estrogen receptors (ER) and clinicopathological variables in invasive ductal breast carcinomas.
Correlation of heat shock protein 70 expression with estrogen receptor levels in invasive human breast cancer.
Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.
Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy.
Enhanced immunity by NeuEDhsp70 DNA vaccine Is needed to combat an aggressive spontaneous metastatic breast cancer.
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Evaluation of a panel of tumor-associated antigens in breast cancer.
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
Expression and roles of heat shock proteins in human breast cancer.
Expression of heat shock protein 70 and c-myc protein in human breast cancer: an immunohistochemical study.
Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia.
Extracellular heat shock protein (Hsp)70 and Hsp90? assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy.
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications.
Heat shock proteins and cell proliferation in human breast cancer biopsy samples.
Heat shock proteins and drug resistance.
Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study).
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
Heat-shock protein 70 as a prognostic marker in node-negative breast cancer.
Heregulin up-regulates heat shock protein-70 expression in breast cancer cells.
High risk for cardiovascular disease in postmenopausal breast cancer survivors.
High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial.
Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.
HSP70 as a Diagnostic and Prognostic Marker in Egyptian Women With Breast Cancer.
HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness.
Immunohistochemical detection of estrogen receptor in invasive human breast cancer: correlation with heat shock proteins, pS2 and oncogene products.
Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera.
Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?
Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes.
Isolation of a Novel Thioflavin S-Derived Compound that Inhibits BAG-1-Mediated Protein Interactions and Targets BRAF Inhibitor-Resistant Cell Lines.
LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells.
Magnetic thermoablation stimuli alter BCL2 and FGF-R1 but not HSP70 expression profiles in BT474 breast tumors.
MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.
MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer.
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer.
Perturbation of HSP Network in MCF-7 Breast Cancer Cell Line Triggers Inducible HSP70 Expression and Leads to Tumor Suppression.
Phage display biopanning identifies the translation initiation and elongation factors (IF1?-3 and eIF-3) as components of Hsp70-peptide complexes in breast tumour cells.
Photothermal Therapeutic Response of Cancer Cells to Aptamer-Gold Nanoparticle-Hybridized Graphene Oxide under NIR Illumination.
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
Recombinant Arabidopsis HSP70 sustains cell survival and metastatic potential of breast cancer cells.
Relationship Between HSP70 and ERBB2 Expression in Breast Cancer Cell Lines Regarding Drug Resistance.
Response of human breast cancer cells to heat shock and chemotherapeutic drugs.
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Sensitizing tumor cells to radiation by targeting the heat shock response.
SerpinB3, a new prognostic tool in breast cancer patients treated with neoadjuvant chemotherapy.
Small extracellular vesicle-mediated Hsp70 intercellular delivery enhances breast cancer adriamycin resistance.
Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.
The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.
The Impact of TIMM17A on Aggressiveness of Human Breast Cancer Cells.
The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer.
The Prognostic Significance of Hsp70/Hsp90 Expression in Breast Cancer: A Systematic Review and Meta-analysis.
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised.
Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics.
Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation.
Visualizing and Quantifying the Effect of the Inhibition of HSP70 on Breast Cancer Cells Based on Laser Scanning Microscopy.
X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
[Effects of survivin antisense RNA and HSP70 double gene transfection on MCF-7 cells in vitro]
[Expression of Hsp70 and Hdj1 chaperone proteins in human tumor cells]
[Influence of HSP70 on combined method of hyperthermia and immunologic effector cells to treat cancer]
[The role of the heat shock protein in human breast cancer]
Bronchitis, Chronic
Heat shock proteins mRNA expressions by peripheral blood mononuclear cells in asthma and chronic bronchitis.
Heat shock proteins' mRNA expression in asthma.
Bulbo-Spinal Atrophy, X-Linked
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Burkitt Lymphoma
Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70.
Inhibition of JAK2/STAT3 Signaling Pathway Suppresses Proliferation of Burkitt's Lymphoma Raji Cells via Cell Cycle Progression, Apoptosis, and Oxidative Stress by Modulating HSP70.
Candidiasis
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Carcinogenesis
Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosis.
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
ChaperISM: improved chaperone binding prediction using position-independent scoring matrices.
Chaperone-dependent stabilization and degradation of p53 mutants.
Chronic stress induces CD99, suppresses autophagy, and affects spontaneous adipogenesis in human bone marrow stromal cells.
Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis.
Dual role of heat shock proteins as regulators of apoptosis and innate immunity.
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence.
Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Heat shock protein (HSP70) as a marker of epithelial dysplasia in oral dysplastic lesions: A clinicopathological study.
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties.
Heat shock proteins: endogenous modulators of apoptotic cell death.
Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.
HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.
HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis.
Hsp70 in cancer: A double agent in the battle between survival and death.
Hsp70: A Cancer Target Inside and Outside the Cell.
Hsp70: anti-apoptotic and tumorigenic protein.
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer.
In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Inhibition of HSP70: A challenging anti-cancer strategy.
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.
Is Mongolian gerbil really adequate host animal for study of Helicobacter pylori infection-induced gastritis and cancer?
Membrane HSP70: the molecule triggering gammadelta T cells in the early stage of tumorigenesis.
Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.
Overexpression of human 27 kDa heat shock protein in laryngeal cancer cells confers chemoresistance associated with cell growth delay.
p53-HSP70 complexes in oral dysplasia and cancer: potential prognostic implications.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Serum p53 antibodies in patients with oral lesions: correlation with p53/HSP70 complexes.
Similarities Between Embryo Development and Cancer Process Suggest New Strategies for Research and Therapy of Tumors: A New Point of View.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids.
Suppression of the Inflammatory Cascade is Implicated in Resveratrol Chemoprevention of Experimental Hepatocarcinogenesis.
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.
Targeting Hsp70: A possible therapy for cancer.
The Prognostic Significance of Hsp70 in Patients with Colorectal Cancer Patients: A PRISMA-Compliant Meta-Analysis.
Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex.
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.
[Expression and significance of Hsp70 and PCNA during the development of forestomach carcinoma in NIH mice]
Carcinoma
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
An immunohistochemical analysis of heat shock protein 70, p53, and estrogen receptor status in carcinoma of the uterine cervix.
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Carcinosarcoma of the urinary bladder: expression of epithelial markers and different expression of heat shock proteins between epithelial and sarcomatous elements.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Characteristics of human gastric carcinoma cell lines with induced multidrug resistance.
Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers.
Co-expression of heat shock protein 70 and glucose-regulated protein 94 in human gastric carcinoma cell line BGC-823.
Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas.
Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma.
Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue.
CYP1a1, HSP70, P53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol.
Cytoplasmic Increase in Hsp70 Protein: A Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis.
Cytotoxicity and expression of c-fos, HSP70, and GADD45/153 proteins in human liver carcinoma (HepG2) cells exposed to dinitrotoluenes.
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.
Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis.
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix.
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on HSP70 and HSP28 gene expression and thermotolerance development in human colon carcinoma cells.
Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells.
Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels.
Effects of combined treatment of chemotherapeutics and hyperthermia on survival and the regulation of heat shock proteins in Dunning R3327 prostate carcinoma cells.
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3.
Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma.
Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma.
Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity.
Expression of antisense hsp70 is a major determining factor in heat-induced cell death of P-19 carcinoma cells.
Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma--immunohistochemistry and Western blot analysis.
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Expression of heat shock protein 70 and c-myc protein in human breast cancer: an immunohistochemical study.
Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study.
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells.
General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors.
Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells.
Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver.
Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer.
Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes.
Heat Shock Protein 70 Membrane Expression in Oral Cancer: A Possible New Target in Antineoplastic Therapy?
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
Heat shock protein expression independently predicts survival outcome in schistosomiasis-associated urinary bladder cancer.
Heat shock proteins and cell proliferation in human breast cancer biopsy samples.
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC?3 cells.
HSP27 and HSP70 expression in squamous cell carcinoma: An immunohistochemical study.
Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Hsp70 in oncology.
HSP70 induces TLR4 signaling in oral squamous cell carcinoma: an immunohistochemical study.
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin.
Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma.
In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody.
Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway.
Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells.
Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia.
Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma.
Inhibition of heat shock protein expression by Helicobacter pylori.
Investigation on the effect of peptides mixture from tumor cells inducing anti-tumor specific immune response.
Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer.
Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.
Label-Free Nondestructive Discrimination of Colon Carcinoma Sublines and Biomolecular Insights into their Differential Hsp70 Expression: DNA/RNA Nucleobase Specific Changes.
Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
mRNA levels of molecular chaperones hsp27, hsp60 and hsp70 in cisplatin resistant squamous cell carcinomas.
Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-?B activation and HSP70 up-regulation.
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.
Phospholipse c inhibitor, u73122, stimulates release of hsp-70 stress protein from A431 human carcinoma cells.
Possible involvement of HSP70 in pancreatic cancer cell proliferation after heat exposure and impact on RFA postoperative patient prognosis.
Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone.
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
PS2 and HSP70 Expression in Rectal Adenocarcinomas: An Immunohistochemical Investigation of 45 cases.
Repression of thermotolerance in Dunning R3327 prostate carcinoma cells by 2-deoxy-glucose.
Role of membrane Hsp70 in radiation sensitivity of tumor cells.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
SKOV-3 and Me45 cell response to cisplatin-based chemotherapy: an in vitro study.
Stress responses of mammalian cells to high hydrostatic pressure.
The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer.
The Heat-Shock Protein Apg-2 Binds to the Tight Junction Protein ZO-1 and Regulates Transcriptional Activity of ZONAB.
The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma.
The human HSP70 family of chaperones: where do we stand?
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis.
The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.
The study on the expression of membrane HSP70 protein in H22 cell and its immunoprotective mechanism against carcinoma.
Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells.
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3.
[Adenovirus-mediated antisense HSP70 cDNA transfection inhibits the growth of laryngeal carcinoma Hep-2 cells]
[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues]
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression and significance of heat shock proteins in esophageal squamous cell carcinoma]
[Expression and significance of Hsp70 and PCNA during the development of forestomach carcinoma in NIH mice]
[Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma]
[Expression of heat shock protein (HSP70) in normal endometrium and endometrial carcinomas]
[Expression of heat shock protein-70, estrogen receptor and progesterone receptor in ovarian carcinomas and the correlation between HSP70 and sex steroid receptor]
[Expression of heat shock proteins in laryngeal carcinoma]
[Expression of Hsp70 Grp94 and IgG in human lung carcinoma.]
[Heat shock proteins and malignancies of the female genital tract]
[Induction of apoptosis in ovarian carcinoma cells by HSP70 antisense oligodeoxynucleotides]
[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy]
[Prognostic significances of natural killer cells and dendritic cells infiltrations in esophageal squamous cell carcinoma]
Carcinoma in Situ
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Carcinoma, Ductal
Altered expression of ERK, Cytochrome-c, and HSP70 triggers apoptosis in Quinacrine-exposed human invasive ductal carcinoma cells.
Carcinoma, Endometrioid
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
Carcinoma, Hepatocellular
A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma.
A Fixed Human Umbilical Vein Endothelial Cell Vaccine With 2 Tandem Repeats of Microbial HSP70 Peptide Epitope 407-426 As Adjuvant for Therapy of Hepatoma in Mice.
Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells.
Analysis of stress-induced gene expression in fish cell lines exposed to heavy meals and heat shock.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Dendritic cells pulsed with Hsp70 and HBxAg induce specific antitumor immune responses in hepatitis B virus?associated hepatocellular carcinoma.
Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells.
Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma.
Effects of HSP70 antisense oligonucleotide on the proliferation and apoptosis of human hepatocellular carcinoma cells.
Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine.
Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma.
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
Expression of P53 and HSP70 in Chronic Hepatitis, Liver Cirrhosis, and Early and Advanced Hepatocellular Carcinoma Tissues and Their Diagnostic Value in Hepatocellular Carcinoma: An Immunohistochemical Study.
Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma.
Expressions of HSP70 and HSP27 in hepatocellular carcinoma.
Gel-based proteomics of liver cancer progression in rat.
Glucose regulates heat shock factor 1 transcription activity via mTOR pathway in HCC cell lines.
Heat shock protein 70 positively regulates transforming growth factor-?-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Human hepatoma cell line (HepG2) cellular response to hypothermic stress with recovery. Induction of Hsp70, Hsp60 and Hsf1 expression.
Hyperthermia-associated carboplatin resistance: Differential role of p53, HSF1 and Hsp70 in hepatoma cells.
Identification of a Promiscuous Epitope Peptide Derived From HSP70.
Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432.
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Increased heat shock protein 70 expression following toxicant-mediated cytotoxicity: a ubiquitous marker of toxicant exposure?
Insulin-induced expression of human heat-shock protein gene hsp70.
Is hypothermia a stress condition in HepG2 cells? Expression and localization of Hsp70 in human hepatoma cell line.
Molecular diagnosis of multistage hepatocarcinogenesis.
Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells.
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter.
Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma.
Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values.
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models.
The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma.
The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer.
[Downregulation of HSP70 gene expression and apoptosis in human hepatocellular carcinoma SMMC-7721 cells induced by nimesulide in vitro].
[Effects of 5-aza-2'-deoxycytidine on the amount of exosomes and secreted immuno-associated proteins by hepatoma cells]
[Immunotherapy with a chimeric AFP and HSP70 gene DNA vaccine targeting on a murine hepatocellular carcinoma]
[Interaction between p53 and HSP70 in human hepatocellular carcinoma tissues]
[Purification of hsp70 and its immunoprotective effect against mouse hepatoma]
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
Carcinoma, Lobular
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Carcinoma, Merkel Cell
The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma.
Carcinoma, Non-Small-Cell Lung
Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients.
Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC).
Concentrations of SP-A and HSP70 are associated with polarization of macrophages in pleural effusions of non-small cell lung cancer.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study.
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study.
Heat shock protein antagonists in early stage clinical trials for NSCLC.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells.
Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption.
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions.
Carcinoma, Ovarian Epithelial
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
The HSP70 gene predicts prognosis and response to chemotherapy in epithelial ovarian cancer.
Carcinoma, Renal Cell
Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
Carcinoma, Squamous Cell
Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers.
Cytoplasmic Increase in Hsp70 Protein: A Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis.
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix.
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
HSP27 and HSP70 expression in squamous cell carcinoma: An immunohistochemical study.
Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma.
mRNA levels of molecular chaperones hsp27, hsp60 and hsp70 in cisplatin resistant squamous cell carcinomas.
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy]
Carcinoma, Transitional Cell
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Cardiomegaly
Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy.
Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy.
Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2.
Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice.
Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin-Induced Heart Failure Through Resolution of Toll-Like Receptor 2-Mediated Myocardial Inflammation.
[Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy: potential role of HSF1 and NF-?B p65 signaling].
[Progress in research on heat shock proteins in cardiovascular system]
Cardiomyopathies
Heat shock protein 70 expression protects against sepsis-associated cardiomyopathy by inhibiting autophagy.
Oxidative parameters and expression of 70kDa heat shock proteins in pig heart tissue after transport and slaughter.
Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.
The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions.
Cardiomyopathy, Dilated
Antibodies against stress proteins in sera of patients with dilated cardiomyopathy.
BAG3 plays a central role in proteostasis in the heart.
Cardiotoxicity
Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions.
Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity.
Cardiovascular Diseases
32nd national medicinal chemistry symposium - medicinal chemistry developments for neurodegeneration, diabetes and cancer.
A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.
Cardiovascular disease delay in centenarian offspring: role of heat shock proteins.
Diesel exhaust inhalation induces heat shock protein 70 expression in vivo.
[Anti-heat shock protein 70 (anti - Hsp 70) antibodies in alcohol use disorder patients].
Carotid Artery Diseases
Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation.
Serum level of soluble Hsp70 is associated with vascular calcification.
Social Determinants and Heat Shock Protein-70 Among African American and Non-Hispanic White Women With Atherosclerosis: A Pilot Study.
Carotid Artery Thrombosis
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling.
Carotid Stenosis
Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration.
Cataract
A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice.
Genetic polymorphisms of HSP70 in age-related cataract.
Heat shock protein expression in human conjunctiva.
Cauda Equina Syndrome
Experimental cauda equina compression induces HSP70 synthesis in dog.
Celiac Disease
Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease.
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Cerebral Hemorrhage
Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats.
Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage.
Cerebral Infarction
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion.
[Study on plasma antibodies against heat shock protein 70 in the hypertensive patients with cerebral infarction]
Cerebrovascular Disorders
Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases.
Cervical Intraepithelial Neoplasia
HSP70 and ER expression in cervical intraepithelial neoplasia and cervical cancer.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Chagas Disease
A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection.
Human humoral immunity to hsp70 during Trypanosoma cruzi infection.
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
Mapping of the linear antigenic determinants of the Leishmania infantum hsp70 recognized by leishmaniasis sera.
Multilocus PCR-RFLP profiling in Trypanosoma cruzi I highlights an intraspecific genetic variation pattern.
Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients.
Short-term Follow-up of Chagasic Patients after Benznidazole Treatment Using Multiple Serological Markers.
The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection.
Charcot-Marie-Tooth Disease
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
Chlamydia Infections
RNAi Screen in Drosophila Cells Reveals the Involvement of the Tom Complex in Chlamydia Infection.
Cholangiocarcinoma
Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma.
Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma.
Cholangitis
Plasma autoantibodies against heat shock protein 70, enolase 1 and ribonuclease/angiogenin inhibitor 1 as potential biomarkers for cholangiocarcinoma.
Cholangitis, Sclerosing
Ursodeoxycholic acid reduces expression of heat shock proteins in primary biliary cirrhosis.
Cholera
Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins.
Cholesteatoma
Heat shock proteins in middle ear cholesteatoma.
Chondrosarcoma
Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas.
Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma.
Chorioamnionitis
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.
Chronic Periodontitis
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis.
Chronic Urticaria
Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria.
Classical Swine Fever
Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol.
[Hsp70 Fused with the Envelope Glycoprotein E0 of Classical Swine Fever Virus Enhances Immune Responses in Balb/c Mice].
Cleft Palate
Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis.
Coccidiosis
Heat shock-like polypeptides of the sporozoites and merozoites of Eimeria bovis.
Molecular cloning, sequencing, and expression of Eimeria tenella HSP70 partial gene.
Coinfection
Co-expression of human chaperone Hsp70 and Hsdj or Hsp40 co-factor increases solubility of overexpressed target proteins in insect cells.
Giardia and Cryptosporidium infections in Danish cats: risk factors and zoonotic potential.
Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.
Colic
Morphological data indicate a stress response at the oral border of strangulated small intestine in horses.
Colitis
Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB.
Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases.
Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis.
Histological and immunohistochemical effects of L-arginine and silymarin on TNBS-induced inflammatory bowel disease in rats.
Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.
Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice.
Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice.
Protective role of HSF1 and HSP70 against gastrointestinal diseases.
Protective role of HSP70 against various gastrointestinal diseases.
The anti-inflammatory mechanisms of Hsp70.
Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Colitis, Ulcerative
Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins.
Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases.
Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.
Immunocytochemical expression of the 70 kD heat shock protein in ischaemic bowel disease.
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases.
Colonic Neoplasms
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro.
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.
Heat-shocked tumor cell lysate-pulsed dendritic cells induce effective anti-tumor immune response in vivo.
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer.
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins.
HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells.
Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines.
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.
Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia.
Isorhamnetin in Tsoong blocks Hsp70 expression to promote apoptosis of colon cancer cells.
Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells.
Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia.
Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone.
Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor.
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma.
Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
ShRNA-mediated gene silencing of Heat shock protein 70 inhibits human colon cancer cell growth in vitro and in vivo.
ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth.
Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.
Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer, current status and perspectives.
Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
Colorectal Neoplasms
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.
Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-?. In Vitro Synergy Quantification of Pifithrin-? Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949.
Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer.
Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer.
Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma--immunohistochemistry and Western blot analysis.
Heat shock protein derived from a non-autologous tumour can be used as an anti-tumour vaccine.
High levels of acute phase proteins and soluble 70 kDa heat shock proteins are independent and additive risk factors for mortality in colorectal cancer.
High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort.
Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT.
Hsp70 inhibitors: Implications for the treatment of colorectal cancer.
Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44.
Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells.
Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia.
Multi-panel assay of serum autoantibodies in colorectal cancer.
NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells.
Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-?. In Vitro Synergy Quantification of Pifithrin-? Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.
P53 and heat shock protein 70 expressions in colorectal adenocarcinoma.
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter.
Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.
Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer.
Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages.
RP11-462C24.1 suppresses proliferation and invasion of colorectal carcinoma cells by regulating HSP70 through PI3K/AKT signaling pathway.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression.
The Natural Compound Cantharidin Induces Cancer Cell Death through Inhibition of Heat Shock Protein 70 (HSP70) and Bcl-2-associated Athanogene Domain 3 (BAG3) Expression by Blocking Heat Shock Factor 1 (HSF1) Binding to Promoters.
The Prognostic Significance of Hsp70 in Patients with Colorectal Cancer Patients: A PRISMA-Compliant Meta-Analysis.
Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer, current status and perspectives.
[Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]
[Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM]
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics.]
Coma
Persistently elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker in post-cardiac-arrest patients.
Survival rate and expression of Heat-shock protein 70 and Frost genes after temperature stress in Drosophila melanogaster lines that are selected for recovery time from temperature coma.
Communicable Diseases
A non-receptor-mediated mechanism for internalization of molecular chaperones.
Heat shock protein 70-associated peptides elicit specific cancer immunity.
Heat shock proteins in immune response to cancer: the Fourth Paradigm.
Seasonal changes in gene expression and polymorphism of hsp70 in cultivated oysters (Crassostrea gigas) at extreme temperatures.
Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
Congenital Abnormalities
Assessing toxicity of the insecticide thiacloprid on Chironomus riparius (Insecta: Diptera) using multiple end points.
The effect of heat and cold exposure on HSP70 expression and development of deformities during embryogenesis of Atlantic salmon (Salmo salar)
Transcriptional responses, metabolic activity and mouthpart deformities in natural populations of chironomus riparius larvae exposed to environmental pollutants.
Contracture
Serum levels of heat shock protein 70, a biomarker of cellular stress, are elevated in patients with systemic sclerosis: association with fibrosis and vascular damage.
The role of hsp70 and IP3-DAG mechanism in the adaptive stabilization of structures and heart protection.
Corneal Injuries
Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.
Coronary Artery Disease
Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease.
Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease.
Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation.
Coronary Disease
Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits.
Expression of heat shock proteins and nitrotyrosine in small arteries from patients with coronary heart disease.
Functional SNPs in HSPA1A gene predict risk of coronary heart disease.
Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.
Klotho overexpression suppresses apoptosis by regulating the Hsp70/Akt/Bad pathway in H9c2(2-1) cells.
Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Coronary Occlusion
Cardiac adaptation to ischemia-reperfusion injury.
Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function.
Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion.
COVID-19
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients.
Craniocerebral Trauma
Neuronal changes in the arcuate and hypoglossal nuclei of brain stem induced by head injury.
Crohn Disease
Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70.
Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins.
Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.
Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases.
Immunocytochemical expression of the 70 kD heat shock protein in ischaemic bowel disease.
Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease.
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases.
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
Tumour necrosis factor-alpha production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn's disease.
Cryptococcosis
A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary cryptococcosis.
Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis.
The heat shock protein (Hsp) 70 of Cryptococcus neoformans is associated with the fungal cell surface and influences the interaction between yeast and host cells.
Cryptorchidism
Effects of Moringa oleifera Lam Extract (MOLE) in the heat shock protein 70 expression and germ cell apoptosis on experimentally induced cryptorchid testes of rats.
Cystic Fibrosis
4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells.
BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner.
Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast.
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70.
The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels.
Cysticercosis
Cloning, expression and serodiagnostic potential of HSP70 of Taenia multiceps in sheep.
Cysts
Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.
Anti-HSP70 autoantibody formation by B-1 cells in Toxoplasma gondii-infected mice.
Cloning, expression and serodiagnostic potential of HSP70 of Taenia multiceps in sheep.
Comparisons of stress proteins and soluble carbohydrate in encysted embryos of Artemia franciscana and two species of Parartemia.
Cyst viability and stress tolerance upon heat shock protein 70 knockdown in the brine shrimp Artemia franciscana.
Giardia duodenalis: Improved detection of viable cysts by reverse transcription-PCR of heat shock-inducible hsp70 gene.
Levels of heat shock protein transcripts in normal follicles and ovarian follicular cysts.
Profiling and quantifying differential gene transcription in Phytophthora infestans prior to and during the early stages of potato infection.
Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii.
The consensus Nglyco -X-S/T motif and a previously unknown Nglyco -N-linked glycosylation are necessary for growth and pathogenicity of Phytophthora.
Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease.
[Heat shock protein of HSP70 family revealed in some contemporary freshwater Amoebae and in Acanthamoeba sp. from cysts isolated from permafrost samples]
Death, Sudden, Cardiac
Oxidative parameters and expression of 70kDa heat shock proteins in pig heart tissue after transport and slaughter.
Dehydration
Bioinformatics and protein expression analyses implicate LEA proteins in the drought response of Collembola.
Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats.
Erianthus arundinaceus HSP70 (EaHSP70) overexpression increases drought and salinity tolerance in sugarcane (Saccharum spp. hybrid).
Heat shock proteins contribute to mosquito dehydration tolerance.
Molecular biomarkers in grey seals (Halichoerus grypus) to evaluate pollutant exposure, health and immune status.
Physiological responses to fluctuating thermal and hydration regimes in the chill susceptible insect, Thaumatotibia leucotreta.
Responses of the bed bug, Cimex lectularius, to temperature extremes and dehydration: levels of tolerance, rapid cold hardening and expression of heat shock proteins.
Targeting conserved co-opted host factors to block virus replication: Using allosteric inhibitors of the cytosolic Hsp70s to interfere with tomato bushy stunt virus replication.
The regulation of heat shock proteins in response to dehydration in Xenopus laevis.
Transcriptional regulation and stress-defensive key genes induced by ?-aminobutyric acid in association with tolerance to water stress in creeping bentgrass.
Dementia
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
Curcumin Increases HSP70 Expression in Primary Rat Cortical Neuronal Apoptosis Induced by gp120 V3 Loop Peptide.
Dementia, Vascular
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the Alzheimer type.
Demyelinating Diseases
A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
Induction of Heat Shock Protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.
Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis.
The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA.
Dengue
A synthetic dengue virus antigen elicits enhanced antibody titers when linked to, but not mixed with, Mycobacterium tuberculosis HSP70 domain II.
Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.
Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70.
Dengue virus infection activates cellular chaperone Hsp70 in THP-1 cells: downregulation of Hsp70 by siRNA revealed decreased viral replication.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Mitochondrial Import of Dengue Virus NS3 Protease and Cleavage of GrpEL1, a Cochaperone of Mitochondrial Hsp70.
The significance of Hsp70 subnetwork for Dengue virus lifecycle.
Dentigerous Cyst
HSP70 expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma.
Dermatitis
Bacterial infection and tissue-specific Hsp72, -73 and -90 expression in western painted turtles.
Dermatitis Herpetiformis
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Dermatitis, Atopic
High positive frequency of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy.
Dermatitis, Contact
Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma.
Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity.
Dermatomyositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Diabetes Complications
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-?B and STAT Signaling Pathways in Diabetic Mice.
Diabetes Mellitus
Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus.
Heat Shock Protein 70 Gene Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus, with and without Nephropathy.
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study.
Increased serum levels of IgA antibodies to hsp70 protein in patients with diabetes mellitus: their relationship with vascular complications.
Participation of Hsp70 and Hsp90? Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus.
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.
[The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus]
Diabetes Mellitus, Type 1
Chaperones may cause the focus of diabetes autoimmunity on distinct (pro)insulin peptides.
Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.
Heat-Shock Protein 70-Mediated Heat Preconditioning Attenuates Hepatic Carbohydrate and Oxidative Disturbances in Rats With Type 1 Diabetes.
No independent association between HSP70 gene polymorphism and IDDM.
Participation of Hsp70 and Hsp90? Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus.
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese.
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
T cells and autoantibodies to human HSP70 in type 1 diabetes in children.
The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70?kDa Heat Shock Protein DnaK in Macrophage Stimulation.
Diabetes Mellitus, Type 2
Appearance of leptin-HSP70 correlation, in type 2 diabetes.
Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus.
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes.
Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis.
Folate supplementation reduces serum hsp70 levels in patients with type 2 diabetes.
Heat Shock Protein 70 Gene Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus, with and without Nephropathy.
Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response.
Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?
Serum HSP70 level in patients with endometrial cancer with and without diabetes.
The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.
The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes.
Diabetes, Gestational
Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study.
Diabetic Foot
Meta-analysis for assessing the healing process of ulcers among diabetic patients: Cases of HbA1c, lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, 25-hydroxy vitamin D.
Diphtheria
Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine.
Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins.
SKOV-3 and Me45 cell response to cisplatin-based chemotherapy: an in vitro study.
The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells.
Disseminated Intravascular Coagulation
Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Down Syndrome
Evidence for apoptosis in the fetal Down syndrome brain.
Duodenogastric Reflux
Injury to the gastric mucosa and cellular dynamics in a rat model of duodenogastric reflux: the possible significance of gastrin induction and a heat shock protein.
Dyskinesias
Initiation of stress protein synthesis in the myocardium of coronary patients.
Dyslexia
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
Dyslipidemias
Effect of dyslipidemia on intima-media thickness of intra- and extracranial atherosclerosis by regulating the expression of hsp70 in rabbits.
Dystonia
Heterogeneous clinical spectrum of DNAJC12-deficient hyperphenylalaninemia: from attention deficit to severe dystonia and intellectual disability.
Echovirus Infections
Hsp70 Is a Potential Therapeutic Target for Echovirus 9 Infection.
Encephalitis
Brain-derived heat shock protein 70-Peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Encephalitis, Japanese
An hsp70 fusion protein vaccine potentiates the immune response against Japanese encephalitis virus.
Fusion expression of major antigenic segment of JEV E protein-hsp70 and the identification of domain acting as adjuvant in hsp70.
Identification of Heat Shock Protein 90 Beta in JEV-Induced Secretion Proteins.
Japanese encephalitis protein vaccine candidates expressing neutralizing epitope and M.T hsp70 induce virus-specific memory B cells and long-lasting antibodies in swine.
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
Encephalitis, Tick-Borne
Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of Yersinia pseudotuberculosis as an Antigen for the TI-Complexes.
Encephalomyelitis
Down-regulated miR-374c and Hsp70 promote Th17 cell differentiation by inducing Fas expression in experimental autoimmune encephalomyelitis.
Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.
Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains.
Heat Shock Protein 70: Roles in Multiple Sclerosis.
HINT1 peptide/Hsp70 complex induces NK-cell-dependent immunoregulation in a model of autoimmune demyelination.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.
Encephalomyelitis, Autoimmune, Experimental
Down-regulated miR-374c and Hsp70 promote Th17 cell differentiation by inducing Fas expression in experimental autoimmune encephalomyelitis.
Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.
Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains.
Heat Shock Protein 70: Roles in Multiple Sclerosis.
HINT1 peptide/Hsp70 complex induces NK-cell-dependent immunoregulation in a model of autoimmune demyelination.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.
Endocarditis
Enhanced levels of Staphylococcus aureus stress protein GroEL and DnaK homologs early in infection of human epithelial cells.
Endolymphatic Hydrops
Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex.
Endometrial Hyperplasia
Over-expression of heat shock proteins in carcinogenic endometrium.
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
Endometrial Neoplasms
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?
Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.
Over-expression of heat shock proteins in carcinogenic endometrium.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
Proteomics reveals protein profile changes in cyclooxygenase-2 inhibitor-treated endometrial cancer cells.
Serum HSP70 level in patients with endometrial cancer with and without diabetes.
Silencing of heat shock protein 70 expression enhances radiotherapy efficacy and inhibits cell invasion in endometrial cancer cell line.
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression of heat shock protein (HSP70) in normal endometrium and endometrial carcinomas]
[Heat shock proteins and malignancies of the female genital tract]
Endometriosis
Effect of GnRH agonist therapy on the expression of human heat shock protein 70 in eutopic and ectopic endometria of women with endometriosis.
Proteolytic tailoring of the heat shock protein 70 and its implications in the pathogenesis of endometriosis.
Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70.
[Inhibition effect and mechanisms of quercetin on surgically induced endometriosis]
Endotoxemia
In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade.
Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia.
Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats.
Protection against endotoxemia by HSP70 in rodent cardiomyocytes.
Protective effects of glutamine in a rat model of endotoxemia.
Epilepsy
A new comorbidity model and the common pathological mechanisms of migraine and epilepsy.
Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.
Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy.
Effects of ferulic acid on oxidative stress, heat shock protein 70, connexin 43, and monoamines in the hippocampus of pentylenetetrazole-kindled rats.
Effects of metformin on apoptosis and ?-synuclein in a rat model of pentylenetetrazole-induced epilepsy.
Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model.
Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An MRI volumetric and histopathological study.
Genetic Modulation of HSPA1A Accelerates Kindling Progression and Exerts Pro-convulsant Effects.
Heat shock protein 70 expression in epilepsy suggests stress rather than protection.
Hippocampal expression of heat shock proteins in mesial temporal lobe epilepsy with psychiatric comorbidities and their relation to seizure outcome.
Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
[Chaperones in regulation and restoration of physiological functions].
Epilepsy, Temporal Lobe
Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model.
Heat shock protein 70 expression in epilepsy suggests stress rather than protection.
Esophageal Neoplasms
Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma.
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis.
Esophageal Squamous Cell Carcinoma
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer.
Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma.
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis.
[Expression and significance of heat shock proteins in esophageal squamous cell carcinoma]
[Prognostic significances of natural killer cells and dendritic cells infiltrations in esophageal squamous cell carcinoma]
Esophagitis
Prevalence and Pathogenesis of Barrett's Esophagus in Luoyang, China.
Essential Hypertension
An allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression.
Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory Markers in Essential Hypertension.
Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension.
Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity.
The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension.
Exfoliation Syndrome
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Fabry Disease
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Fanconi Anemia
HSP90 Shapes the Consequences of Human Genetic Variation.
The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.
Fatty Liver
Vulnerability of experimentally induced fatty liver to heat stress in rats.
Fatty Liver, Alcoholic
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Fetal Growth Retardation
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
The Role of Hsp70 in the Regulation of Autophagy in Gametogenesis, Pregnancy, and Parturition.
Fibroma
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis.
Fibrosarcoma
Characterization of novel hsp70 in mammalian cells.
Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy.
Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release.
HSP27 and HSP70 increase the survival of WEHI-S cells exposed to hyperthermia.
Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells.
p27Cip/Kip Is Involved in Hsp25 or Inducible Hsp70 Mediated Adaptive Response by Low Dose Radiation.
Flavivirus Infections
Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.
Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections.
Foot-and-Mouth Disease
Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus.
The expressions of HSP70 and ?B-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
[Fusion expression of O type foot-and-mouth diseases virus VP1 gene and HSP70 gene and induction of immune responses in mice]
Frontotemporal Dementia
Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.
Gastritis, Atrophic
Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats.
Gastroesophageal Reflux
Altered expression of HSP27 and HSP70 in distal oesophageal mucosa in patients with gastro-oesophageal reflux disease subjected to fundoplication.
Barrett's Esophagus and ?-carotene Therapy: Symptomatic Improvement in GERD and Enhanced HSP70 Expression in Esophageal Mucosa.
Gastrointestinal Diseases
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach.
Protective role of HSF1 and HSP70 against gastrointestinal diseases.
Protective role of HSP70 against various gastrointestinal diseases.
Gastrointestinal Neoplasms
Heat shock proteins are differentially expressed in human gastrointestinal cancers.
Gaucher Disease
Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
Genetic Diseases, Inborn
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
Connecting Hsp70, sphingolipid metabolism and lysosomal stability.
Mitochondrial HSP70 Chaperone System-The Influence of Post-Translational Modifications and Involvement in Human Diseases.
Gingivitis
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers.
Glaucoma
Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival.
HSP70 expression before and after treatment and its clinical value in patients with acute angle-closure glaucoma.
Hsp70 protects human trabecular meshwork cells injury induced by UVB through Smad pathway.
Hsp70.1 and related lysosomal factors for necrotic neuronal death.
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Molecular Genetics of Glaucoma: Subtype and Ethnicity Considerations.
Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model.
[The GG genotype of the HSPA1B gene is associated with increased risk of glaucoma in northern Iran].
Glaucoma, Angle-Closure
HSP70 expression before and after treatment and its clinical value in patients with acute angle-closure glaucoma.
Molecular Genetics of Glaucoma: Subtype and Ethnicity Considerations.
Glioblastoma
BAG3 Expression in Glioblastoma Cells Promotes Accumulation of Ubiquitinated Clients in an Hsp70-dependent Manner.
Cell death forms and HSP70 expression in U87 cells after ionizing radiation and/or chemotherapy.
Correction: Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma.
Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma.
Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.
Effects of single or combined treatments with radiation and chemotherapy on survival and danger signals expression in glioblastoma cell lines.
Efficacy of Anti-Epileptic Drugs in the Treatment of Tumor and Its Associated Epilepsy: An in vitro Perspective.
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Erratum to: Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Flower-like Mn-Doped Magnetic Nanoparticles Functionalized with ? v ?3-Integrin-Ligand to Efficiently Induce Intracellular Heat after Alternating Magnetic Field Exposition, Triggering Glioma Cell Death.
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines.
Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.
Induction of heat shock proteins and its effects on glial differentiation in rat C6 glioblastoma cells.
Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.
Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients.
Primary glioblastoma multiforme tumors and recurrence : Comparative analysis of the danger signals HMGB1, HSP70, and calreticulin.
Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines.
Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr.
The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D.
[Alterations in cytokinetics and heat shock protein (70 kDa) expression of glial cell by hyperthermia]
Glioma
A peptide derived from apoptin inhibits glioma growth.
Autophagic Inhibition via Lysosomal Integrity Dysfunction Leads to Antitumor Activity in Glioma Treatment.
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours.
Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization.
Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter.
Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells.
Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells.
Exposure to 2.45 GHz electromagnetic fields induces hsp70 at a high SAR of more than 20 W/kg but not at 5W/kg in human glioma MO54 cells.
Expression of heat shock proteins in brain tumors.
Glioma Pathophysiology: Insights Emerging from Proteomics.
Heat shock protein expression in human gliomas.
Hsp27 (HSPB1): a possible surrogate molecular marker for loss of heterozygosity (LOH) of chromosome 1p in oligodendrogliomas but not in astrocytomas.
Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.
HSP70 induction and oxidative stress protection mediated by a subtoxic dose of NMDA in the retinoic acid-differentiated C6 glioma cell line.
HSP70 inhibition suppressed glioma cell viability during hypoxia/reoxygenation by inhibiting the ERK1/2 and PI3K/AKT signaling pathways.
HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation.
HSP70-based anti-cancer immunotherapy.
In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance.
Inhibition of Heat Shock Protein Response Enhances PS-341-Mediated Glioma Cell Death.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
Modulation of the arsenite-induced expression of stress proteins by reducing agents.
Modulation of the stress-induced synthesis of hsp27 and alpha B-crystallin by cyclic AMP in C6 rat glioma cells.
Molecular mechanisms of paraptosis induction: implications for a non-genetically modified tumor vaccine.
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model.
Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients.
Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation.
Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr.
Reliability of HSP70 (HSPA) expression as a prognostic marker in glioma.
The Effects of Venlafaxine and Dexamethasone on the Expression of HSP70 in Rat C6 Glioma Cells.
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma.
[Alterations in cytokinetics and heat shock protein (70 kDa) expression of glial cell by hyperthermia]
[Chaperone therapy in the rat model of intracranial glioblastoma].
Glomerulonephritis
IL-1beta depresses expression of the 70-kilodalton heat shock protein and sensitizes glomerular cells to oxidant-initiated apoptosis.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Glomerulonephritis, IGA
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Goiter
Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics.
Graft vs Host Disease
Reduced levels of Hsp70 result in a therapeutic effect of 15-deoxyspergualin on acute graft-versus-host disease in (DA x LEW)F1 rats.
Granuloma
Expression of heat shock protein 70 (HSP70) at the interface of polymer-implants in vivo.
Graves Disease
An allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression.
Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease.
Hantavirus Infections
HSP70 induced by Hantavirus infection interacts with viral nucleocapsid protein and its overexpression suppresses virus infection in Vero E6 cells.
[Expression of HSP70 in human umbilical vein endothelial cells induced by Hantavirus]
Head and Neck Neoplasms
DeltaNp63alpha up-regulates the Hsp70 gene in human cancer.
Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells.
Evaluating erythropoietin-associated tumor progression using archival tissues from a phase III clinical trial.
Proteins and single nucleotide polymorphisms involved in apoptosis, growth control, and DNA repair predict cisplatin sensitivity in head and neck cancer cell lines.
Tetraploid arrest with overexpressed non-mutated p53 in germ cell cancers.
Hearing Loss
An ELISA serum assay for autoantibodies to HSP70 in immune-mediated hearing loss.
Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death.
Stress pathways in the rat cochlea and potential for protection from acquired deafness.
Tinnitus, hearing loss and inflammatory processes in an older Portuguese population.
Hearing Loss, Noise-Induced
Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.
Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis.
Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations.
Hearing Loss, Sensorineural
Dexamethasone Regulates Cochlear Expression of Deafness-associated Proteins Myelin Protein Zero and Heat Shock Protein 70, as Revealed by iTRAQ Proteomics.
Serum antibodies to heat shock protein 70 in sensorineural hearing loss.
Serum heat shock protein 70 and its correlation with clinical characteristics in patients with sudden sensorineural hearing loss.
Heart Arrest
Persistently elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker in post-cardiac-arrest patients.
Heart Defects, Congenital
[Expression of the heat shock protein-70 in the myocardial cells of cyanosis congenital heart diseases]
Heart Diseases
HSP70: therapeutic potential in acute and chronic cardiac disease settings.
Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.
The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease.
Heart Failure
Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions.
Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction.
Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure.
Hsp70 regulates the doxorubicin-mediated heart failure in Hsp70-transgenic mice.
Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarction.
Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure.
Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.
Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.
The increased expression of the inducible Hsp70 (HSP70A1A) in serum of patients with heart failure and its protective effect against the cardiotoxic agent doxorubicin.
HELLP Syndrome
Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Hematologic Diseases
The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance.
Hematologic Neoplasms
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Hemorrhagic Septicemia, Viral
Quantitative expression profiling of immune response genes in rainbow trout following infectious haematopoietic necrosis virus (IHNV) infection or DNA vaccination.
Hemorrhagic Stroke
[Protective and antiedema effect of heat shock protein hsp70 studied in vitro on hemorrhagic stroke model in nervous tissue].
Hepatitis
Mitochondrial HSP70, HSP40, and HSP60 bind to the 3' untranslated region of the Murine hepatitis virus genome.
Telomerase repeat amplification protocol (TRAP) activity upon recombinant expression and purification of human telomerase in a bacterial system.
Ursodeoxycholic acid reduces expression of heat shock proteins in primary biliary cirrhosis.
[Enhancement of cellular and humoral immune responses of HBV DNA vaccine by HSP70 and gp96].
Hepatitis B
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine.
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70.
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
Hepatitis B, Chronic
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
[Expression and significance of HSP27, HSP70 and HSP90 alpha in the livers of chronic hepatitis B patients]
Hepatitis C
Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A.
The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle.
[Detection of serum heat shock protein 70 level in patients with hepatitis C infection and its role in cytotoxicity of CTLs induced by HSP70-HCV peptide complex]
Hepatitis C, Chronic
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
Hepatitis, Autoimmune
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
Hepatitis, Chronic
Expression of aldo-keto reductase family 1 member b10 in the early stages of human hepatocarcinogenesis.
Expression of P53 and HSP70 in Chronic Hepatitis, Liver Cirrhosis, and Early and Advanced Hepatocellular Carcinoma Tissues and Their Diagnostic Value in Hepatocellular Carcinoma: An Immunohistochemical Study.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Hepatoblastoma
Is HSP70 involved in nitric oxide-induced protection of the heart?
Herpes Simplex
Antigenic peptides complexed to phylogenically diverse Hsp70s induce differential immune responses.
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.
Identification of sequences involved in the transcriptional control of a Drosophila heat-shock gene.
Neuroprotective effects of virally delivered HSPs in experimental stroke.
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Protective effect of post-ischaemic viral delivery of heat shock proteins in vivo.
The bovine viral diarrhea virus (BVDV) NS3 protein, when expressed alone in mammalian cells, induces apoptosis which correlates with caspase-8 and caspase-9 activation.
The effect of matrix attached regions (MAR) and specialized chromatin structure (SCS) on the expression of gene constructs in cultured cells and in transgenic mice.
The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.
Tissue-specific DNA binding of nuclear proteins that bind to the adenovirus inverted terminal repeat.
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter.
Herpes Zoster
Analysis of immune-related ESTs and differential expression analysis of few important genes in lines of rohu (Labeo rohita) selected for resistance and susceptibility to Aeromonas hydrophila infection.
Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.
Transcriptional responses in juvenile Atlantic cod (Gadus morhua) after exposure to mercury-contaminated sediments obtained near the wreck of the German WW2 submarine U-864, and from Bergen Harbor, Western Norway.
Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease.
[Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70.]
Histoplasmosis
Stress proteins in fungal diseases.
HIV Infections
Elevated levels of antibodies against 70 kDa heat shock proteins in the sera of patients with HIV infection.
Heat shock protein-based therapeutic strategies against human immunodeficiency virus type 1 infection.
Hodgkin Disease
[Expression of heat shock proteins HSP72 and HSP73 in Colombian patients with Hodgkin lymphoma positive and negative for Epstein Barr virus]
Huntington Disease
Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.
Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment.
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease.
Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease.
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Hyperalgesia
Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents.
Hypercholesterolemia
Soy isoflavones reduce heat shock proteins in experimental atherosclerosis.
Hyperemia
Nitric oxide releasing aspirin protects the gastric mucosa against stress and promotes healing of stress-induced gastric mucosal damage: role of heat shock protein 70.
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
Hyperglycemia
Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats.
Heat shock protein 70: A promising therapeutic target for myocardial ischemia-reperfusion injury.
Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice.
Induction of heat shock proteins by hyperglycemic cerebral ischemia.
KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons.
Maternal Type 1 diabetes activates stress response in early placenta.
Restoring HSP70 Deficiencies Improves Glucose Tolerance in Diabetic Monkeys.
Hyperkalemia
High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter.
Hyperlipidemias
Heat shock protein 70: A promising therapeutic target for myocardial ischemia-reperfusion injury.
Hyperlipidemia induced by high cholesterol diet inhibits heat shock response in rat hearts.
Hypersensitivity
Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma.
Deletion of the Hsp70 chaperone gene SSB causes hypersensitivity to guanidine toxicity and curing of the [PSI+] prion by increasing guanidine uptake in yeast.
Displacement of sequence-specific transcription factors from mitotic chromatin.
DNA distortion and multimerization: novel functions of the glutamine-rich domain of GAGA factor.
Exogenous HSP70 attenuates nitroglycerin-induced migraine-like symptoms in mice.
High positive frequency of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy.
HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing.
Identification of a Mycobacterium leprae-specific T cell epitope on the 70 kDa heat shock protein.
Immune responses to abacavir in antigen-presenting cells from hypersensitive patients.
Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children.
Preinduced intestinal HSP70 improves visceral hypersensitivity and abnormal intestinal motility in PI-IBS mouse model.
Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster.
Yge1p, a eukaryotic Grp-E homolog, is localized in the mitochondrial matrix and interacts with mitochondrial Hsp70.
Hypertension
Abnormal hsp70 gene expression: its potential key role in metabolic defects in hypertension.
Acute hypertension induces heat-shock protein 70 gene expression in rat aorta.
Adrenergic regulation of adrenal and aortic heat shock protein.
Altered temporal profile of heat shock factor 1 phosphorylation and heat shock protein 70 expression induced by heat shock in nucleus tractus solitarii of spontaneously hypertensive rats.
Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study.
Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions.
Autoimmunity in the pathogenesis of hypertension.
Blood pressure and heat shock protein expression in response to acute and chronic stress.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Circulating heat shock protein and heat shock protein antibody levels in established hypertension.
Effects of Taurine on ACE, ACE2 and HSP70 Expression of Hypothalamic-Pituitary-Adrenal Axis in Stress-Induced Hypertensive Rats.
Environmental stress and genes of hypertension.
Experimental induction of salt-sensitive hypertension is associated with lymphocyte proliferative response to HSP70.
Expression of hsp70 gene in lymphocytes from normotensive and hypertensive humans.
Genes of stress in experimental hypertension.
Genetic hypertension is characterized by the abnormal expression of a gene localized in major histocompatibility complex HSP70.
Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.
Heat stress genes in hypertension.
HSP70 Family in the Renal Inflammatory Response.
Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension.
Increased serum HSP70 levels are associated with the duration of diabetes.
Interaction between hypertension and HSP70 variants increase the risk of cerebral ischemia in Chinese Han population: an association study.
Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers.
Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice.
Losartan through Hsp70 Avoids Angiotensin II Induced Mesenchymal Epithelial Transition in Proximal Tubule Cells from Spontaneously Hypertensive Rats.
Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II.
Restriction fragment length polymorphism of hsp70 gene, localized in the RT1 complex, is associated with hypertension in spontaneously hypertensive rats.
Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension.
Vitamin D receptor-modulated Hsp70/AT1 expression may protect the kidneys of SHRs at the structural and functional levels.
[Content of the major heat shock protein HSP70 in rats with hereditary stress-induced arterial hypertension]
[Polymorphism of the gene of heat shock protein hsp70 in lines of rats with normal and hypertensive status]
[Relation of HSP70 gene and spontaneously hypertension in rats]
[Study of genetic polymorphism of heat shock protein 70-1 associated with susceptibility to ischemic stroke]
[Study of heat shock protein gene 70 (HSP70) expression and its polymorphous marker (+ 1267A> G) in women under exposure to a long-term stress.]
[Study on plasma antibodies against heat shock protein 70 in the hypertensive patients with cerebral infarction]
[The stress gene in hypertension]
Hypertension, Portal
Elevated serum heat shock protein 70 and liver stiffness reflect hepatic dysfunction and severity in postoperative biliary atresia.
Hypertension, Pregnancy-Induced
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Hypertension, Pulmonary
Diminished gene expression of cardiac heat shock proteins in pulmonary hypertensive chickens.
Proteomic analysis of the lung in rats with hypobaric hypoxia-induced pulmonary hypertension.
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension.
Variation of heat shock protein gene expression in the brain of cold-induced pulmonary hypertensive chickens.
Hyperthyroidism
Effect of thyroid hormone on mtHsp70 expression, mitochondrial import and processing in cardiac muscle.
Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease.
Long-term thyroxine administration increases heat stress protein-70 mRNA expression and attenuates p38 MAP kinase activity in response to ischaemia.
Hypertrophy, Left Ventricular
[Heat shock proteins 70 kD as a new marker of lesions to target organs in hypertension]
Hypoglycemia
Amelioration of hypoxic and hypoglycemic damage to cerebral endothelial cells. Effects of heat shock pretreatment.
Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line.
Hypokinesia
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.
Hypotension
Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats.
Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions.
Hypobaric Hypoxia Preconditioning Attenuates Experimental Heatstroke Syndromes via Preinduction of Heat Shock Protein 70.
Neuroprotective role of heat shock protein 70 in the rostral ventrolateral medulla during acute mevinphos intoxication in the rat.
Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke.
Renal expression of heat shock proteins after brain death induction in rats.
[Adaptation to heat activates synthesis of HSP70, limits hyperproduction of nitric oxide, and protects organism against acute hypotension during heat shock]
Ileus
Morphological data indicate a stress response at the oral border of strangulated small intestine in horses.
Immunoglobulin Light-chain Amyloidosis
C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia.
Infarction, Middle Cerebral Artery
Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke.
Dynamic expression changes of Bcl-2, Caspase-3 and Hsp70 in middle cerebral artery occlusion rats.
Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat.
Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion.
Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways.
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia--an MRI study.
Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia.
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Protective effects of focal ischemic preconditioning and HSP70 expression on middle cerebral artery occlusion in rats.
Quantitation of multiple gene expression by in situ hybridization autoradiography: accurate normalization using Bayes classifier.
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
[Effect of dl-3-N-butylphthalide on the expression of hsp70 mRNA and c-fos in transient cerebral ischemic and reperfused rat brain]
Infections
A furoviral replicase recruits host HSP70 to membranes for viral RNA replication.
A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70.
Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.
Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses.
Anaplasma phagocytophilum MSP4 and HSP70 Proteins Are Involved in Interactions with Host Cells during Pathogen Infection.
Anti-HSP70 autoantibody formation by B-1 cells in Toxoplasma gondii-infected mice.
Anti-hypoxia effect of adenovirus-mediated expression of heat shock protein 70 (HSP70) on primary cultured neurons.
Antibodies specific for heat shock proteins in human and murine malaria.
Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction.
Antiviral effect of hyperthermic treatment in rhinovirus infection.
Antiviral effect of short hyperthermic treatment at specific stages of vesicular stomatitis virus replication cycle.
Aquareovirus NS31 protein serves as a specific inducer for host heat shock 70-kDa protein.
Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb.
Assessment of the levels of serum Hsp 70 and ghrelin in children with simple febrile convulsions.
Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells.
Association of HSP70 with the adenovirus type 5 fiber protein in infected HEp-2 cells.
Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.
Baculovirus replication induces the expression of heat shock proteins in vivo and in vitro.
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.
Biphasic translocation of a 70 kDa heat shock protein in human cytomegalovirus-infected cells.
Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains.
CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.
Chaperone-mediated in vitro disassembly of polyoma- and papillomaviruses.
Characterization of a wheat HSP70 gene and its expression in response to stripe rust infection and abiotic stresses.
Characterization of four heat-shock protein genes from Nile tilapia (Oreochromis niloticus) and demonstration of the inducible transcriptional activity of Hsp70 promoter.
Chicken Heat Shock Protein 70 Is an Essential Host Protein for Infectious Bursal Disease Virus Infection In Vitro.
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection.
Cloning and expression analysis of a HSP70 gene from Pacific abalone (Haliotis discus hannai).
Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells.
Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection.
Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma.
Cutaneous leishmaniasis caused by Leishmania donovani in the tribal population of the Agasthyamala Biosphere Reserve forest, Western Ghats, Kerala, India.
Cytokine gene expression profiles of bovine dendritic cells after interaction with Mycobacterium avium ssp. paratuberculosis (M.a.p.), Escherichia coli (E. coli) or recombinant M.a.p. heat shock protein 70.
Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.
Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis.
Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70.
Detection of natural infection of Leishmania donovani (Kinetoplastida: Trypanosomatidae) in Phlebotomus argentipes (Diptera: Psychodidae) from a forest ecosystem in the Western Ghats, India, endemic for cutaneous leishmaniasis.
Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells.
Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori.
DRACO inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Dual Recognition of Sialic Acid and ?Gal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains.
During canine viscero-cutaneous leishmaniasis the anti-Hsp70 antibodies are specifically elicited by the parasite protein.
Dynamics of heat shock protein 70 concentrations in peripheral blood lymphocyte lysates during pregnancy in lactating Holstein-Friesian cows.
Early antibody response and clinical outcome in experimental canine leishmaniasis.
Early infection dynamics after experimental challenge with Mycobacterium avium subspecies paratuberculosis in calves reveal limited calf-to-calf transmission and no impact of Hsp70 vaccination.
Ecological aspects and molecular detection of Leishmania DNA Ross (Kinetoplastida: Trypanosomatidae) in phlebotomine sandflies (Diptera: Psychodidae) in terra firme and várzea environments in the Middle Solimões Region, Amazonas State, Brazil.
Ectromelia virus upregulates the expression of heat shock protein 70 to promote viral replication.
Effect of Staphylococcus aureus infection on the heat stress protein 70 (HSP70) level in chicken embryo tissues.
Effects of anthraquinone extract from Rheum officinale Bail on the physiological responses and HSP70 gene expression of Megalobrama amblycephala under Aeromonas hydrophila infection.
Effects of mannan oligosaccharide on the physiological responses, HSP70 gene expression and disease resistance of Allogynogenetic crucian carp (Carassius auratus gibelio) under Aeromonas hydrophila infection.
Effects of turnip crinkle virus infection on the structure and function of mitochondria and expression of stress proteins in turnips
Efficient activation of human T cells of both CD4 and CD8 subsets by urease-deficient recombinant Mycobacterium bovis BCG that produced a heat shock protein 70-M. tuberculosis-derived major membrane protein II fusion protein.
Eimeria tenella: hsp70 expression during sporogony.
ELISA and western blotting for the detection of Hsp70 and Hsp83 antigens of Leishmania donovani.
Enhanced Activation of T Lymphocytes by Urease-Deficient Recombinant Bacillus Calmette-Guerin Producing Heat Shock Protein 70-Major Membrane Protein-II Fusion Protein.
Epidemiological monitoring of American tegumentary leishmaniasis: molecular characterization of a peridomestic transmission cycle in the Amazonian lowlands of Bolivia.
Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection.
Evidence for disruption of Na(+)-K(+)-ATPase and hsp70 during vibriosis of sea bream, Sparus (=Rhabdosargus) sarba Forsskål.
Evidence that Hsc70 Is Associated with Cucumber Necrosis Virus Particles and Plays a Role in Particle Disassembly.
Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria.
Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean.
Exposure of gnotobiotic Artemia franciscana larvae to abiotic stress promotes heat shock protein 70 synthesis and enhances resistance to pathogenic Vibrio campbellii.
Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78.
Expression of 65- and 67-kilodalton heat-regulated proteins and a 70-kilodalton heat shock cognate protein of Leishmania donovani in macrophages.
Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury.
Expression of heat shock proteins and subolesin affects stress responses, Anaplasma phagocytophilum infection and questing behaviour in the tick, Ixodes scapularis.
Extracellular heat-shock protein 70 aggravates cerulein-induced pancreatitis through toll-like receptor-4 in mice.
Formation of aggresome-like structures in herpes simplex virus type 2-infected cells and a potential role in virus assembly.
Functional defects of the DnaK756 mutant chaperone of Escherichia coli indicate distinct roles for amino- and carboxyl-terminal residues in substrate and co-chaperone interaction and interdomain communication.
Further Evidence of an Association between the Presence of Leishmania RNA Virus 1 and the Mucosal Manifestations in Tegumentary Leishmaniasis Patients.
Glycolipid receptors for verotoxin and Helicobacter pylori: role in pathology.
Heat shock protein 70 (HSP70) in gastric adaptation to aspirin in Helicobacter pylori infection.
Heat shock protein (hsp70) expression and thermal tolerance in sublethally heat-shocked eastern oysters Crassostrea virginica infected with the parasite Perkinsus marinus.
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells.
Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle.
Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide.
Heat shock protein 70 is associated with CSFV NS5A protein and enhances viral RNA replication.
Heat Shock Protein 70 Is Associated with Replicase Complex of Japanese Encephalitis Virus and Positively Regulates Viral Genome Replication.
Heat shock protein 70 is necessary for Rice stripe virus infection in plants.
Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis.
Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Heat Shock Protein A6, a Novel HSP70, Is Induced During Enterovirus A71 Infection to Facilitate Internal Ribosomal Entry Site-Mediated Translation.
Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages.
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis.
Heat shock protein expression in target cells infected with low levels of replication-competent virus contributes to the immunogenicity of adenoviral vectors.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Heat shock protein profiles on the protein and gene expression levels in olive flounder kidney infected with Streptococcus parauberis.
Heat shock protein70 is implicated in modulating NF-?B activation in alveolar macrophages of patients with active pulmonary tuberculosis.
Heat shock proteins (HSP 90, 70, 60, and 27) in Galleria mellonella (Lepidoptera) hemolymph are affected by infection with Conidiobolus coronatus (Entomophthorales).
Heat shock proteins and infection: interactions of pathogen and host.
Heat shock proteins on the human sperm surface.
Heat shock-induced cardioprotection activates cytoskeletal-based cell survival pathways.
Heat-shock protein 70 acts as an effective adjuvant in neonatal mice and confers protection against challenge with herpes simplex virus.
Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages.
Heat-shock protein 70 is associated with the entry of Marek's disease virus into fibroblast.
Herpes simplex virus-induced expression of 70 kDa heat shock protein (HSP70) requires early protein synthesis but not viral DNA replication.
High resolution melting analysis as an accurate method for identifying Leishmania infantum in canine serum samples.
hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.
HSP70 and its cochaperone CPIP promote potyvirus infection in Nicotiana benthamiana by regulating viral coat protein functions.
Hsp70 expression in shrimp Litopenaeus vannamei in response to IHHNV and WSSV infection.
HSP70 induced by Hantavirus infection interacts with viral nucleocapsid protein and its overexpression suppresses virus infection in Vero E6 cells.
Hsp70 Is a Potential Therapeutic Target for Echovirus 9 Infection.
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.
HSP70 Overexpression in Response to Ureaplasma urealyticum-Mediated Oxidative Stress In Preeclamptic Placenta.
Hsp70 positively regulates porcine circovirus type 2 replication in vitro.
HSP70 production and inhibition of cell proliferation in Molt-4 T-cells after cell-to-cell transmission of HTLV-I: effect of PGA1.
Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death.
hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.
Hsp70-1: upregulation via selective phosphorylation of heat shock factor 1 during coxsackieviral infection and promotion of viral replication via the AU-rich element.
hsp70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus.
Human humoral immunity to hsp70 during Trypanosoma cruzi infection.
Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.
Human stress protein hsp70: overexpression in E coli, purification and characterization.
Hybridization improved bacteria resistance in abalone: Evidence from physiological and molecular responses.
Identification of chikungunya virus interacting proteins in mammalian cells.
Identification of proteins in excretory/secretory extracts of Echinostoma friedi (Trematoda) from chronic and acute infections.
IL17A-deficient mice are highly susceptible to Toxoplasma gondii infection due to excessively induced T. gondii HSP70 and IFN-? production.
Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection.
Immunomodulatory effects of hyperthermia on resisting WSSV infection in Procambarus clarkii.
Implication of heat shock proteins in rotavirus entry into Reh cells.
In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.
Increased expression of 70 kD heat shock protein in cultured primary human keratinocytes induced by human papillomavirus 16 E6/E7 gene.
Increased expression of Hsp70 and co-localization with nuclear protein in cells infected with the Hantaan virus.
Induced expression and localization to nuclear-inclusion bodies of hsp70 in varicella-zoster virus-infected human diploid fibroblasts.
Induction of cellular hsp70 expression by human cytomegalovirus.
Induction of pro-viral grass carp Ctenopharyngodon idella Hsp70 instead of Hsc70 during infection of grass carp reovirus.
Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1.
Influence of the cestode Ligula intestinalis and the acanthocephalan Polymorphus minutus on levels of heat shock proteins (HSP70) and metallothioneins in their fish and crustacean intermediate hosts.
Ingestion of bacteria overproducing DnaK attenuates Vibrio infection of Artemia franciscana larvae.
Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro.
Inhibition of human immunodeficiency virus type 1 infection of human CD4+ T cells by microbial HSP70 and the peptide epitope 407-426.
Inhibition of poliovirus replication by prostaglandins A and J in human cells.
Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors.
Inner ear supporting cells protect hair cells by secreting HSP70.
Interaction between the CCR5 chemokine receptors and microbial HSP70.
Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.
Interactive Responses of Potato (Solanum tuberosum L.) Plants to Heat Stress and Infection With Potato Virus Y.
Intraperitoneal immunization of recombinant HSP70 (DnaK) of Salmonella Typhi induces a predominant Th2 response and protective immunity in mice against lethal Salmonella infection.
Involvement of apoptosis in host-parasite interactions in the zebra mussel.
Larval excretory-secretory products from the parasite Schistosoma mansoni modulate HSP70 protein expression in defence cells of its snail host, Biomphalaria glabrata.
Leishmaniasis epidemiology: all down to the DNA.
Major histocompatibility complex haplotype determines hsp70-dependent protection against measles virus neurovirulence.
Megalocytivirus-induced proteins of turbot (Scophthalmus maximus): Identification and antiviral potential.
Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKK?.
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression.
Modulation of macrophage heat shock proteins (HSPs) expression in response to intracellular infection by virulent and avirulent strains of Leishmania donovani.
Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1.
Modulation of the level of expression of cellular genes in adenovirus 12-infected and transformed human cells.
Molecular chaperone function of stress inducible Hsp70 is critical for intracellular multiplication of Toxoplasma gondii.
Molecular characterization of heat shock protein 70 gene transcripts during Vibrio harveyi infection of humphead snapper, Lutjanus sanguineus.
Molecular cloning of HSP70 in Mycoplasma ovipneumoniae and comparison with that of other mycoplasmas.
Molecular cloning, expression HSP70 and its response to bacterial challenge and heat stress in Microptenus salmoides.
mRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cells.
Multifaceted capsid proteins: multiple interactions suggest multiple roles for Pepino mosaic virus capsid protein.
Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis.
Negative effect of heat shock on feline calicivirus release from infected cells is associated with the control of apoptosis.
Non-lethal heat shock increased hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp.
Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells.
Pathogenic infection and immune-related gene expression of Chinese sturgeon (Acipenser sinensis) challenged by Citrobacter freundii.
Pathogenicity of non-O1/ O139 Vibrio cholerae and its induced immune response in Macrobrachium rosenbergii.
Patterns of the innate immune response in tambaqui Colossoma macropomum: Modulation of gene expression in haemorrhagic septicaemia caused by Aeromonas hydrophila.
Persistent borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.
Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.
Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-?B and NOS/NO signaling pathways.
Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens.
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
Production and preliminary evaluation of Trypanosoma evansi HSP70 for antibody detection in Equids.
Production of stress-inducible form of heat-shock protein 70 in mouse peritoneal adherent cells after in vivo infection by Francisella tularensis.
Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection.
Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response.
Proteomic analysis reveals differentially abundant proteins probably involved in the virulence of amastigote and promastigote forms of Leishmania infantum.
Putative Roles for Metallothionein and HSP70 Genes in Relation with Heavy Metal Accumulation and Parasitic Cymothoid in the Fish Nemipterus furcosus.
Real-time polymerase chain reaction based algorithm for differential diagnosis of Kinetoplastidean species of zoonotic relevance.
Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70.
Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of Yersinia pseudotuberculosis as an Antigen for the TI-Complexes.
Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels.
Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs.
Recruitment of the host plant heat shock protein 70 by Tomato yellow leaf curl virus coat protein is required for virus infection.
Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1).
Response of epithelial cells infected by Treponema denticola.
Responses of HSP70 Gene to Vibrio parahaemolyticus Infection and Thermal Stress and Its Transcriptional Regulation Analysis in Haliotis diversicolor.
Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori.
Role and mechanism of the Hsp70 molecular chaperone machines in bacterial pathogens.
ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells.
Salicylic acid-mediated potentiation of Hsp70 induction correlates with reduced apoptosis in tobacco protoplasts.
Selective induction of chromosomal gene expression by human cytomegalovirus.
Serological reactivity to heat shock protein 70 in patients with hydatid disease.
Shock response induced in rat brain and spleen during primary infection with Trichinella spiralis larvae.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections.
Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes.
Suppression of virus replication by prostaglandin A is associated with heat shock protein synthesis.
Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection.
The Capsid Protein VP1 of Coxsackievirus B Induces Cell Cycle Arrest by Up-Regulating Heat Shock Protein 70.
The cellular stress response of the scleractinian coral Goniopora columna during the progression of the black band disease.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.
The endosymbiotic bacterium Holospora obtusa enhances heat-shock gene expression of the host Paramecium caudatum.
The ER Lumenal Hsp70 Protein FpLhs1 Is Important for Conidiation and Plant Infection in Fusarium pseudograminearum.
The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection.
The heat shock protein (Hsp) 70 of Cryptococcus neoformans is associated with the fungal cell surface and influences the interaction between yeast and host cells.
The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life Cycle.
The humoral response to heat shock protein 70 in human and murine Schistosomiasis mansoni.
The immunization of A2/K(b) transgenic mice with the KMP11-HSP70 fusion protein induces CTL response against human cells expressing the T. cruzi KMP11 antigen: identification of A2-restricted epitopes.
The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity.
The production of a 70 kDa heat shock protein by Toxoplasma gondii RH strain in immunocompromised mice.
The Role of Heat Shock Proteins in Leukemia.
The stable 2-kb LAT intron of herpes simplex stimulates the expression of heat shock proteins and protects cells from stress.
Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin.
Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice.
Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70.
Transient transfection of Theileria annulata.
Trypanosoma cruzi heat-shock protein-70 kDa,alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells.
Unusual cryptosporidium species recovered from human faeces: first description of Cryptosporidium felis and Cryptosporidium 'dog type' from patients in England.
Urine heat shock protein 70 levels as a marker of urinary tract infection in children.
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus: influence of species, isolate source, and Leishmania RNA virus-1.
Virus-heat shock protein interaction and a novel axis for innate antiviral immunity.
Wuchereria bancrofti: cloning and characterization of heat shock protein 70 from the human lymphatic filarial parasite.
Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.
Zoonotic potential of Giardia duodenalis and Cryptosporidium spp. and prevalence of intestinal parasites in young dogs from different populations on Prince Edward Island, Canada.
[A study of participation of Hdj1 co-chaperone in the modulation of sleep and behavior using micro RNA technology in vivo].
[Amniotic fluid heat shock protein 70 concentration in preterm premature rupture of membranes]
[Construction of replication-deficient recombinant adenoviral vector carrying HBsAg and HSP70 chimeric gene and its expression in vitro]
[Detection of serum heat shock protein 70 level in patients with hepatitis C infection and its role in cytotoxicity of CTLs induced by HSP70-HCV peptide complex]
[Development of a novel recombinant BCG for tuberculosis vaccine].
[Effects of lentivirus-mediated heat shock protein 70 gene on endoplasmic reticulum calcium homeostasis and calcium channels of PC12 cells induced by ischemia and hypoxia].
[Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein].
[Relationship between Pi-Wei damp-heat syndrome with expressions of nuclear factor-kappaBmRNA and heat shock protein 70 mRNA in patients with chronic gastritis]
Infertility
Comparative Expression Analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor Gene between Varicocele-Induced and Non-Varicocele Testes of Dog.
Inflammatory Bowel Diseases
Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
The Role of HSP70 Heat Shock Proteins in the Pathogenesis and Treatment of Inflammatory Bowel Diseases.
Influenza in Birds
Fusion of HSP70 gene of Mycobacterium tuberculosis to hemagglutinin (H5) gene of avian influenza virus in DNA vaccine enhances its potency.
Influenza, Human
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice.
Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.
AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.
Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway.
Cloning, expression and purification of the influenza A (H9N2) virus M2e antigen and truncated Mycobacterium tuberculosis HSP70 as a fusion protein in Pichia pastoris.
DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.
Heat shock protein 70 modulates influenza a virus polymerase activity.
Heterologous expression, purification and characterization of the influenza A virus M2e gene fused to Mycobacterium tuberculosis HSP70(359-610) in prokaryotic system as a fusion protein.
Immunogenicity and protective efficacy of recombinant M2e.Hsp70c (Hsp70(359-610)) fusion protein against influenza virus infection in mice.
In contrast to conventional inactivated influenza vaccines, 4xM2e.HSP70c fusion protein fully protected mice against lethal dose of H1, H3 and H9 influenza A isolates circulating in Iran.
In Vitro Evaluation of Influenza M2 and Leishmania major HSP70 (221-604) Chimer Protein.
Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site.
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
PBP74, a new member of the mammalian 70-kDa heat shock protein family, is a mitochondrial protein.
The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.
Vaccination with recombinant 4 × M2e.HSP70c fusion protein as a universal vaccine candidate enhances both humoral and cell-mediated immune responses and decreases viral shedding against experimental challenge of H9N2 influenza in chickens.
Vaccination with three tandem repeats of M2 extracellular domain fused to Leismania major HSP70 protects mice against influenza A virus challenge.
[Relationship of HSP70 to temperature-dependency of influenza viral infection]
Insulin Resistance
Aging Does Not Reduce Heat Shock Protein 70 in the Absence of Chronic Insulin Resistance.
Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice.
Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus.
Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways.
Exercise reduces cellular stress related to skeletal muscle insulin resistance.
Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice.
Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice.
Metabolic surgery improves insulin resistance through the reduction of gut-secreted heat shock proteins.
Muscle Heat Shock Protein 70 Predicts Insulin Resistance With Aging.
Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.
Periapical Lesions Increase Macrophage Infiltration and Inflammatory Signaling in Muscle Tissue of Rats.
Plasma HSP70 Levels Correlate with Health Risk Factors and Insulin Resistance in African American Subjects.
Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.
Restoring HSP70 Deficiencies Improves Glucose Tolerance in Diabetic Monkeys.
The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.
Insulinoma
Heat shock protein hsp70 overexpression confers resistance against nitric oxide.
Intellectual Disability
Heterogeneous clinical spectrum of DNAJC12-deficient hyperphenylalaninemia: from attention deficit to severe dystonia and intellectual disability.
Intestinal Volvulus
The Onchocerca volvulus mRNAs for a hsp70, a collagen-like protein and a ribosomal protein possess a 5' spliced leader sequence.
Intracranial Arteriosclerosis
Proteomic analysis and comparison of intra? and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits.
Intracranial Hemorrhages
The 70 kDa heat shock protein protects against experimental traumatic brain injury.
Intracranial Hypertension
Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.
Iron Overload
2016 Clinical trials update in new treatments of ?-thalassemia.
Ischemic Attack, Transient
Coexpression of c-fos and hsp70 mRNAs in gerbil brain after ischemia: induction threshold, distribution and time course evaluated by in situ hybridization.
Immunoelectron microscopic study of c-Fos, c-Jun and heat shock protein after transient cerebral ischemia in gerbils.
Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein.
[Induction of HSP70 and neuronal damage following transient cerebral ischemia in rats]
Ischemic Stroke
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke.
Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases.
Interaction between hypertension and HSP70 variants increase the risk of cerebral ischemia in Chinese Han population: an association study.
L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70.
Multimodal Rehabilitation Program Promotes Motor Function Recovery of Rats After Ischemic Stroke by Upregulating Expressions of GAP-43, SYN, HSP70, and C-MYC.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
[Amantadine sulfate (PK-Merz) in the treatment of ischemic stroke: a clinical-experimental study]
[Study of genetic polymorphism of heat shock protein 70-1 associated with susceptibility to ischemic stroke]
Keloid
Heat shock proteins modulate keloid formation.
Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts.
Proteomic profiling reveals upregulated protein expression of hsp70 in keloids.
Keratitis
Heat-shock protein 70 expression in the equine cornea.
Keratoconjunctivitis
Heat shock protein expression in human conjunctiva.
Keratosis, Actinic
Cytoplasmic Increase in Hsp70 Protein: A Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis.
Kidney Calculi
Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.
Kidney Diseases, Cystic
A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector.
Labyrinth Diseases
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease.
Utility of laboratory testing in autoimmune inner ear disease.
[The role of heat shock protein 70 and its autoantibody in experimental autoimmune inner ear disease]
Laryngeal Neoplasms
Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease.
[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues]
[Expression of heat shock proteins in laryngeal carcinoma]
Laryngopharyngeal Reflux
Expression of CAIII and Hsp70 Is Increased the Mucous Membrane of the Posterior Commissure in Laryngopharyngeal Reflux Disease.
Leishmaniasis
Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
Characterisation of a monoclonal antibody recognising specifically the HSP70 from Leishmania.
Comparison and clinical validation of qPCR assays targeting Leishmania 18S rDNA and HSP70 genes in patients with American Tegumentary Leishmaniasis.
Development and validation of PCR-based assays for diagnosis of American cutaneous leishmaniasis and identificatio nof the parasite species.
Distinct genetic profiles of Leishmania (Viannia) braziliensis associate with clinical variations in cutaneous-leishmaniasis patients from an endemic area in Brazil.
Epidemiological monitoring of American tegumentary leishmaniasis: molecular characterization of a peridomestic transmission cycle in the Amazonian lowlands of Bolivia.
Heat-shock protein 70 gene sequencing for Leishmania species typing in European tropical infectious disease clinics.
High Resolution Melting Analysis Targeting hsp70 as a Fast and Efficient Method for the Discrimination of Leishmania Species.
Identification of Leishmania (Viannia) species and clinical isolates of Leishmania (Leishmania) amazonensis from Brazil using PCR-RFLP of the heat-shock protein 70 gene reveals some unexpected observations.
Identification of proteins interacting with HSP70 mRNAs in Leishmania braziliensis.
Imported leishmaniasis cases in Cuba (2006-2016): what have we learned.
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Mapping of the linear antigenic determinants of the Leishmania infantum hsp70 recognized by leishmaniasis sera.
Phylogeny of Leishmania species based on the heat-shock protein 70 gene.
Sequence analysis and PCR-RFLP profiling of the hsp70 gene as a valuable tool for identifying Leishmania species associated with human leishmaniasis in Brazil.
[Molecular typing of Leishmania (Leishmania) amazonensis and species of the subgenus Viannia associated with cutaneous and mucosal leishmaniasis in Colombia: A concordance study].
Leishmaniasis, Cutaneous
Canine cutaneous leishmaniasis caused by neotropical Leishmania infantum despite of systemic disease: A case report.
DNA immunization with the gene encoding P4 nuclease of Leishmania amazonensis protects mice against cutaneous Leishmaniasis.
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Leishmania tropica isolates from non-healed and healed patients in Iran: A molecular typing and phylogenetic analysis.
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
Leishmaniasis, Mucocutaneous
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World.
Leishmaniasis, Visceral
Characterisation of the Leishmania donovani/L. infantum Hybrid Isolated from an Autochothonous Kala-Azar Patient: Preliminary Results of an In Vivo Model
Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in normal and nu/nu BALB/c mice.
Effects of the disruption of the HSP70-II gene on the growth, morphology, and virulence of Leishmania infantum promastigotes.
Expression of recombinant heat-shock protein 70 of MCAN/IR/96/LON-49, a tool for diagnosis and future vaccine research.
Immunogenicity and efficacy of single antigen Gp63, polytope and polytopeHSP70 DNA vaccines against visceral Leishmaniasis in experimental mouse model.
Immunogenicity and protective efficacy of DNA vaccine against visceral leishmaniasis in BALB/c mice.
Lack of serological specificity of recombinant heat shock protein of Leishmania donovani.
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Mapping of the linear antigenic determinants of the Leishmania infantum hsp70 recognized by leishmaniasis sera.
Protective immunity using MPL-A and autoclaved Leishmania donovani as adjuvants along with a cocktail vaccine in murine model of visceral leishmaniasis.
Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients.
RFLPs of ITS, ITS1 and hsp70 amplicons and sequencing of ITS1 of recent clinical isolates of Kala-azar from India and Bangladesh confirms the association of L. tropica with the disease.
Lentivirus Infections
[Effects of lentivirus-mediated heat shock protein 70 gene on calcium homeostasis in PC12 cells undergone ischemia and hypoxia].
Leprosy
Identification of a Mycobacterium leprae-specific T cell epitope on the 70 kDa heat shock protein.
Identification of human T cell epitopes in the Mycobacterium leprae heat shock protein 70-kD antigen.
Individuals from different populations identify multiple and diverse T-cell determinants on mycobacterial HSP70.
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
Nerve and skin damage in leprosy is associated with increased intralesional heat shock protein.
Short-term Follow-up of Chagasic Patients after Benznidazole Treatment Using Multiple Serological Markers.
Leprosy, Lepromatous
Individuals from different populations identify multiple and diverse T-cell determinants on mycobacterial HSP70.
The variable C-terminal region of the Mycobacterium leprae 70-kilodalton heat shock protein is the target for humoral immune responses.
Leprosy, Tuberculoid
The variable C-terminal region of the Mycobacterium leprae 70-kilodalton heat shock protein is the target for humoral immune responses.
Leukemia
Analysis of cell surface and relative gene expression of heat shock protein 70 in human leukemia cell lines.
Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules.
Antileukemic activity of the HSP70 inhibitor pifithrin-? in acute leukemia.
ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity.
Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70.
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity.
Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70.
Combined use of dendritic cells enhances specific antileukemia immunity by leukemia cell-derived heat shock protein 70 in a mouse model with minimal residual leukemia cells.
Effect of hyperthermia on selective expression of HL-60 heat shock proteins.
Efficient Induction of Nuclear Aggresomes by Specific Single Missense Mutations in the DNA-binding Domain of a Viral AP-1 Homolog.
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
Heat-shock protein expression in leukemia.
Heat-shock proteins expressed on the surface of human T cell leukemia virus type I-infected cell lines induce autoantibodies in rabbits.
Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements.
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Immunotherapy using heat-shock protein preparations of leukemia cells after syngeneic bone marrow transplantation in mice.
Inducement of specific CTLs by antigen-peptides from human leukemia cells and their cytotoxicity to leukemia cells.
Induction of leukemia-specific antibodies by immunotherapy with leukemia-cell-derived heat shock protein 70.
Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death: implications for acute myeloid leukemia.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
JWA as a novel molecule involved in oxidative stress-associated signal pathway in myelogenous leukemia cells.
Kinase-Addiction and Bi-Phasic Sensitivity-Resistance of Bcr-Abl-and Raf-1-Expressing Cells to Imatinib and Geldanamycin.
Kinetics of chaperone activity of proteins Hsp70 and Hdj1 in human leukemia u-937 cells after preconditioning with thermal shock or compound u-133.
Modulating Heat Shock Proteins 70 and 90 Expression by Low Power Laser Irradiation (635nm and 780nm) in Jurkat E6.1 T-lymphocyte Leukemia Cell Line.
Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells.
PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins.
Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response.
Quercetin affects Hsp70/IRE1? mediated protection from death induced by endoplasmic reticulum stress.
Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.
Stably expressed FIPV peplomer protein induces cell fusion and elicits neutralizing antibodies in mice.
Study of heat shock protein HSP90 alpha, HSP70, HSP27 mRNA expression in human acute leukemia cells.
Study on amino acid composition of HSP70 and the level of plasma free amino acids of workers with long-term exposure to harmful factors.
Synergistic cytotoxic effect of quercetin and heat treatment in a lymphoid cell line (OZ) with low HSP70 expression.
Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells.
The preparation of leukemia cell vaccine expressing BCG heat shock protein 70 and anti-leukemia effect in vitro.
The prognostic impact of anti-heat shock protein 70 and its antigen on survival of patients with intermediate and unfavorable cytogenetic risk acute myeloid leukemia.
Transduction of Schistosoma mansoni by vesicular stomatitis virus glycoprotein-pseudotyped Moloney murine leukemia retrovirus.
Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity.
Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide.
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3.
VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines.
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
[Expression of HSP70 mRNA and MDR1 mRNA in K562 cells induced by heat shock and ADM]
[In vitro anti-tumor effect of CTL induced by HSP70-Id complex-modified dendritic cells]
[The mechanism of apoptosis of chronic myeloid leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine]
[The role of Hsp70 chaperone in the reaction of human leukemic cells to anticancer drugs]
Leukemia, B-Cell
Combined use of dendritic cells enhances specific antileukemia immunity by leukemia cell-derived heat shock protein 70 in a mouse model with minimal residual leukemia cells.
[In vitro anti-tumor effect of CTL induced by HSP70-Id complex-modified dendritic cells]
Leukemia, Erythroblastic, Acute
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.
Antiproliferative prostaglandins activate heat shock transcription factor.
Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines.
Contribution of heat shock proteins to cell protection from complement-mediated lysis.
DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells.
Heat shock factor 1 mediates hemin-induced hsp70 gene transcription in K562 erythroleukemia cells.
Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1.
Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.
Reduction of Thermotolerance by Heat Shock Protein 90 Inhibitors in Murine Erythroleukemia Cells.
Study of heat shock protein HSP90 alpha, HSP70, HSP27 mRNA expression in human acute leukemia cells.
The discovery of Hsp70 domain with cell-penetrating activity.
[Novel compounds increasing chaperone Hsp70 expression and their biological activity]
[The balance between Hsp70 and its cochaperones Hdj1 and Bag1 determines its substrate-binding activity]
Leukemia, Lymphocytic, Chronic, B-Cell
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
CAMKII?, HSP70 and HSP90 transcripts are differentially expressed in chronic myeloid leukemia cells from patients with resistant mutated disease.
Hsp90 - a potential prognostic marker in CML.
Induction of heat shock response by curcumin in human leukemia cells.
Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70.
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
Leukemia, Myeloid
Expression and phosphorylation of BiP/GRP78, a molecular chaperone in the endoplasmic reticulum, during the differentiation of a mouse myeloblastic cell line.
Weak electromagnetic fields (50 Hz) elicit a stress response in human cells.
Leukemia, Myeloid, Acute
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.
Antileukemic activity of the HSP70 inhibitor pifithrin-? in acute leukemia.
Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment.
Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines.
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors.
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.
Study of heat shock protein HSP90 alpha, HSP70, HSP27 mRNA expression in human acute leukemia cells.
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia.
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
Leukemia, T-Cell
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Leukoencephalopathies
Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.
Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.
Leukoplakia
Heat Shock Protein 70 Membrane Expression in Oral Cancer: A Possible New Target in Antineoplastic Therapy?
Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex.
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Lichen Planus
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Lichen Planus, Oral
Altered expression of HSP70 in oral lichen planus.
Expression of heat shock protein (HSP70) in oral lichen planus and non-dysplastic oral leucoplakia.
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis.
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Liver Abscess, Amebic
Cloning and characterization of Entamoeba histolytica antigens recognized by human secretory IgA antibodies.
Liver Cirrhosis
Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
Expression of P53 and HSP70 in Chronic Hepatitis, Liver Cirrhosis, and Early and Advanced Hepatocellular Carcinoma Tissues and Their Diagnostic Value in Hepatocellular Carcinoma: An Immunohistochemical Study.
Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation.
Liver Cirrhosis, Biliary
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
Liver Diseases
Carbon monoxide induces hypothermia tolerance in kupffer cells and attenuates liver schemia/reperfusion injury in rats.
Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The effects of long-duration, low-temperature ground transportation on physiological and biochemical indicators of stress in mice.
Liver Failure, Acute
Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats.
Induction of heat shock protein 27 by bicyclol attenuates d-galactosamine/lipopolysaccharide-induced liver injury.
Prostaglandin E1 improves survival rate after 95% hepatectomy in rats.
Liver Neoplasms
Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
Expression of HSP70 and JNK-related proteins in human liver cancer: Potential effects on clinical outcome.
Gel-based proteomics of liver cancer progression in rat.
Heat shock protein 70 positively regulates transforming growth factor-?-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.
The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways.
Long QT Syndrome
The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels.
Lung Diseases
[Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]
Lung Injury
A protective Hsp70-TLR4 pathway in lethal oxidant lung injury.
Aerobic exercise ameliorates particulate matter-induced lung injury in aging rats.
Alanyl?glutamine prophylactically protects against lipopolysaccharide?induced acute lung injury by enhancing the expression of HSP70.
Effects of Chai-Qin-Cheng-Qi decoction () on acute pancreatitis-associated lung injury in mice with acute necrotizing pancreatitis.
Effects of HSP70.1/3 gene knockout on NF-kappaB mediated and cytokine induced reduction in alveolar ion and fluid transport - Response.
Enhanced Hsp70 expression protects against acute lung injury by modulating apoptotic pathways.
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.
Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins.
Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model.
Protective Effect of Hesperidin Against Sepsis-Induced Lung Injury by Inducing the Heat-Stable Protein 70 (Hsp70)/Toll-Like Receptor 4 (TLR4)/ Myeloid Differentiation Primary Response 88 (MyD88) Pathway.
Pyrrolidine dithiocarbamate reduces lung reperfusion injury.
TAT-HSP70 Attenuates Experimental Lung Injury.
Lung Neoplasms
Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients.
Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC).
Circulating Heat Shock Protein 70 Is a Novel Biomarker for Early Diagnosis of Lung Cancer.
Co-expression of CD24 and Hsp70 as a prognostic biomarker for lung cancer.
Concentrations of SP-A and HSP70 are associated with polarization of macrophages in pleural effusions of non-small cell lung cancer.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line.
Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study.
Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin.
Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549.
EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790?M resistant mutation in lung cancer cells.
Expression of heat shock protein 70 and p53 in human lung cancer.
Expression of Hsp27 and Hsp70 in lymphocytes and plasma in healthy workers and coal miners with lung cancer.
Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells.
Heat shock protein antagonists in early stage clinical trials for NSCLC.
Heat shock proteins as biomarkers of lung cancer.
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.
Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation.
Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells.
Microbial HSP70 peptide epitope 407-426 as adjuvant in tumor-derived autophagosome vaccine therapy of mouse lung cancer.
Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study.
Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-?B activation and HSP70 up-regulation.
Postoperative psychological stress and expression of stress-related factors HSP70 and IFN-? in patients with early lung cancer.
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression.
Serum heat shock protein 70 levels and lung cancer risk: a case-control study nested in a large cohort study.
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption.
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions.
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer.
The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.
The relationship between three heat shock protein 70 gene polymorphisms and susceptibility to lung cancer.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines.
[Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]
[Differentially expressed genes in human giant-cell lung cancer lines with different metastatic potentials]
[Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM]
[Role of microRNA-155 in Brain Metastasis of Hypoxic Lung Cancer].
Lupus Erythematosus, Discoid
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Lupus Erythematosus, Systemic
Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.
Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.
Elevated levels of the 70 kD heat shock protein in patients with systemic lupus erythematosus are not dependent on enhanced transcription of the hsp70 gene.
Hsp70 Gene Polymorphisms Are Associated With Disease Susceptibility and HRQOL Improvement in Chinese Han Population With Systemic Lupus Erythematosus.
Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.
Possible role of Hsp70 in autoantigen shuttling to the dermo-epidermal junction in systemic lupus erythematosus.
Relationship between heat shock protein induction and the binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes.
Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with systemic lupus erythematosus (SLE).
Lyme Disease
Borrelia burgdorferi HSP70 homolog: characterization of an immunoreactive stress protein.
Evaluation of genetic divergence among Borrelia burgdorferi isolates by use of OspA, fla, HSP60, and HSP70 gene probes.
Lymphadenitis
HSP70 is selectively over-expressed in the blast cells of the germinal centres and paracortex in reactive lymph nodes.
Lymphatic Metastasis
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Co-expression of CD24 and Hsp70 as a prognostic biomarker for lung cancer.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors.
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
HSP70 as a Diagnostic and Prognostic Marker in Egyptian Women With Breast Cancer.
Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma.
Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Prognostic significance of heat shock proteins 70 and p27 protein in patients with mucoepidermoid carcinoma]
Lymphedema
Temporal and spatial patterns of endogenous danger signal expression after wound healing and in response to lymphedema.
Lymphocytic Choriomeningitis
Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes.
Lymphoma
Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma.
Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas.
Effect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgaris.
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.
Methyl Jasmonate Cytotoxicity and Chemosensitization of T Cell Lymphoma In Vitro Is Facilitated by HK 2, HIF-1?, and Hsp70: Implication of Altered Regulation of Cell Survival, pH Homeostasis, Mitochondrial Functions.
Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.
Morphological effects of autologous hsp70 on peritoneal macrophages in a murine T cell lymphoma.
Mycobacterial HSP70 as an adjuvant in the design of an idiotype vaccine against a murine lymphoma.
Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells.
Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse lymphoma cells.
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.
[Purification of hsp70 and its immunoprotective effect against mouse hepatoma]
Lymphoma, B-Cell
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy.
Donepezil delays photoreceptor apoptosis induced by N-methyl-N-nitrosourea in mice.
Evaluation of the effect of heat shock protein 70 targeted drugs on cirrhotic cardiomyopathy in biliary cirrhotic rats.
Mitochondrial HSP70 cognate-mediated differential expression of JNK1/2 in the pollution stressed grey mullets, Mugil cephalus.
PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure.
Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol.
Lymphoma, Large B-Cell, Diffuse
Regulation of hsc70 expression in the human histiocytic lymphoma cell line, U937.
Lymphoma, Non-Hodgkin
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Lymphoma, Primary Effusion
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Lymphoma, T-Cell
Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma.
Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas.
Hsp70 induces Th1 polarization through tumor-associated macrophages in a T-cell lymphoma.
Methyl Jasmonate Cytotoxicity and Chemosensitization of T Cell Lymphoma In Vitro Is Facilitated by HK 2, HIF-1?, and Hsp70: Implication of Altered Regulation of Cell Survival, pH Homeostasis, Mitochondrial Functions.
Morphological effects of autologous hsp70 on peritoneal macrophages in a murine T cell lymphoma.
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.
Lymphoma, T-Cell, Cutaneous
Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas.
Lysosomal Storage Diseases
Lysosomal storage diseases: HSP70 reverses lysosomal pathology.
Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
Macular Degeneration
Unravelling the Role of HSP70 as the Unexplored Molecular Target in Age-Related Macular Degeneration.
Malaria
Antibodies specific for heat shock proteins in human and murine malaria.
Cellular and antibody responses to the Plasmodium falciparum heat shock protein Pf72/HSP70 during and after acute malaria in individuals from an endemic area of Brazil.
Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins.
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
Molecular cloning and sequencing of the circumsporozoite protein gene from Plasmodium falciparum strain FCC-1/HN and expression of the gene in Mycobacteria.
Molecular cloning and sequencing of the merozoite surface antigen 2 gene from Plasmodium falciparum strain FCC-1/HN and expression of the gene in mycobacteria.
Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.
Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3.
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion.
Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70.
Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-?B activation.
Short-term Follow-up of Chagasic Patients after Benznidazole Treatment Using Multiple Serological Markers.
Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria.
Structural insights into the binding mechanism of Plasmodium falciparum exported Hsp40-Hsp70 chaperone pair.
The Hsp70 heat-shock gene family of the mosquito Anopheles albimanus.
Malnutrition
A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats.
Heat shock proteins in porcine ovary: synthesis, accumulation and regulation by stress and hormones.
Honey can repairing damage of liver tissue due to protein energy malnutrition through induction of endogenous stem cells.
The relationship between the degree of malnutrition and changes in selected parameters of the immune response in critically ill patients.
Mastitis
Use of primers based on the heat shock protein genes hsp70, hsp40, and hsp10, for the detection of bovine mastitis pathogens Streptococcus agalactiae, Streptococcus uberis and Streptococcus bovis.
Measles
Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperone.
hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.
Modulation of Measles Virus NTAIL Interactions through Fuzziness and Sequence Features of Disordered Binding Sites.
Melanoma
2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90.
7Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors.
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo.
Acute extracellular acidification reduces intracellular pH, 42 degrees C-induction of heat shock proteins and clonal survival of human melanoma cells grown at pH 6.7.
Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma.
Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells.
Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells.
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.
Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line.
Differential effect of acute and permanent heat shock protein 70 overexpression in tumor cells on lysability by cytotoxic T lymphocytes.
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70.
Effect of antiangiogenic therapy on luciferase activity in a cytomegalovirus- or HSP70-promoter-transfected M21 tumor model.
Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.
Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock protein 70 in target cells.
Enhanced T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma cells.
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas.
Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles.
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Heat shock protein expression in the eye and in uveal melanoma.
Heterogeneous patterns of constitutive and heat shock induced expression of HLA-linked HSP70-1 and HSP70-2 heat shock genes in human melanoma cell lines.
Hsp70 chaperone-based gel composition as a novel immunotherapeutic anti-tumor tool.
HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors.
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
HSP70-based anti-cancer immunotherapy.
Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells.
Hyperthermia enhances CTL cross-priming.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Immunohistochemical expression of C-myc oncogene, heat shock protein 70 and HLA-DR molecules in malignant cutaneous melanoma.
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach.
Interaction of human heat shock protein 70 with tumor-associated peptides.
Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response.
Isocordoin analogues promote apoptosis in human melanoma cells via Hsp70.
Isolated Limb Perfusion With Melphalan Triggers Immune Activation in Melanoma Patients.
Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Melanoma-reactive class I-restricted cytotoxic T cell clones are stimulated by dendritic cells loaded with synthetic peptides, but fail to respond to dendritic cells pulsed with melanoma-derived heat shock proteins in vitro.
Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells.
Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line.
Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
Recent Patents on Heat Shock Proteins Targeting Antibodies.
Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate.
SKOV-3 and Me45 cell response to cisplatin-based chemotherapy: an in vitro study.
Stress-induced proteins in immune response to cancer.
Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects.
Suppression of melanin production by expression of HSP70.
The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms.
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.
[Construction of the eukaryotic coexpression vector containing Mycobacterium tuberculosis heat shock protein 70 and green fluorescent protein.]
Melanoma, Experimental
Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles.
Heat shock protein derived from a non-autologous tumour can be used as an anti-tumour vaccine.
Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma.
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma.
Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma.
MELAS Syndrome
Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects.
[Immunostaining of mitochondrial heat shock proteins (mtHSPs) in skeletal muscle fibers of mitochondrial cytopathy]
Memory Disorders
17-AAG improves cognitive process and increases heat shock protein response in a model lesion with A?25-35.
Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learning.
Effects of batroxobin on spatial learning and memory disorder of rats with temporal ischemia and the expression of HSP32 and HSP70.
Meniere Disease
Anti-heat shock protein 70 antibodies in Meniere's disease.
HSP70 antibodies in 80 patients with "clinically certain" Meniere's disease.
Recognition of a dominant epitope in bovine heat-shock protein 70 in inner ear disease.
Meningeal Neoplasms
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Meningioma
Expression of heat shock proteins in brain tumors.
[Changes in the cytokine profile in patients with supratentorial meningiomas].
Meningitis
Effect of chronic heat stress on some physiological and immunological parameters in different breed of broilers.
[Significance of heat shock protein 70 in cerebrospinal fluid in differential diagnosis of central nervous system infection in children]
Meningitis, Viral
[Significance of heat shock protein 70 in cerebrospinal fluid in differential diagnosis of central nervous system infection in children]
Mesothelioma
Functional inhibition of heat shock protein 70 by VER-155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism.
Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor.
Mesothelioma cells escape heat stress by upregulating Hsp40/Hsp70 expression via mitogen-activated protein kinases.
Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma.
Mesothelioma, Malignant
Pifithrin-? induces necroptosis through oxidative mitochondrial damage but accompanies epithelial-mesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosis.
Metabolic Diseases
Plasma HSP70 Levels Correlate with Health Risk Factors and Insulin Resistance in African American Subjects.
Migraine Disorders
Exogenous HSP70 attenuates nitroglycerin-induced migraine-like symptoms in mice.
mitochondrial protein-transporting atpase deficiency
A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen.
Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.
Central role of 70-kDa heat shock protein in adaptation of plants to drought stress.
Deletion of one of the duplicated Hsp70 genes causes hereditary myopathy of diaphragmatic muscles in Holstein-Friesian cattle.
Exercise preconditioning reduces acute ischemic renal injury in Hsp70.1 knockout mouse.
Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.
Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.
HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis.
HSP70 is a negative regulator of NLRP3 inflammasome activation.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
Hyperthermic pre-treatment protects rat IPC-81 leukaemia cells against heat- and hydrogen peroxide-induced apoptosis.
Restoring HSP70 Deficiencies Improves Glucose Tolerance in Diabetic Monkeys.
Motor Neuron Disease
Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis.
Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells.
Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barré syndrome.
Mouth Neoplasms
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells.
Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity.
Expression of Heat Shock Protein 70 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells.
Prognosis and predictive value of heat-shock proteins expression in oral cancer: A PRISMA-compliant meta-analysis.
Recent Progress of Biomarkers in Oral Cancers.
Mucocutaneous Lymph Node Syndrome
HSP60, HSP70 in the pathogenesis of Kawasaki disease: implication and action.
Multiple Myeloma
Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma.
Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma.
HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma.
Human DKK1 and human HSP70 fusion DNA vaccine induces an effective anti-tumor efficacy in murine multiple myeloma.
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma.
The PI3K/Akt signalling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.
Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d.
Multiple Sclerosis
Aberrant stress-induced Hsp70 expression in immune cells in multiple sclerosis.
Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis.
Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?
Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
Identification of antibodies as biological markers in serum from multiple sclerosis patients by immunoproteomic approach.
T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kDa heat shock proteins in multiple sclerosis.
Multiple System Atrophy
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.
Mumps
Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1.
Muscular Atrophy
Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation.
Differential response of heat shock proteins to hindlimb unloading and reloading in the soleus.
FOXO Signaling is Required for Disuse Muscle Atrophy and is Directly Regulated by Hsp70.
Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats.
HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
Hsp70 prevents disuse muscle atrophy in senescent rats.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Idesolide, an isolate of Idesia polycarpa, inhibits apoptosis through induction of intracellular heat shock protein 70 in C2C12 muscle cells.
Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy.
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders.
Muscular Diseases
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.
Deletion of one of the duplicated Hsp70 genes causes hereditary myopathy of diaphragmatic muscles in Holstein-Friesian cattle.
Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids.
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.
Muscular Disorders, Atrophic
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy.
Muscular Dystrophies
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Chaperoning heat shock proteins: Proteomic analysis and relevance for normal and dystrophin-deficient muscle.
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders.
Muscular Dystrophies, Limb-Girdle
Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
Muscular Dystrophy, Oculopharyngeal
Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy.
Mycoses
Heat shock proteins (HSP 90, 70, 60, and 27) in Galleria mellonella (Lepidoptera) hemolymph are affected by infection with Conidiobolus coronatus (Entomophthorales).
Pathogen-induced AdDjSKI of the wild peanut, Arachis diogoi, potentiates tolerance of multiple stresses in E. coli and tobacco.
Myelitis
Administration of carnosine in the treatment of acute spinal cord injury.
PPARgamma agonist rosiglitazone is neuroprotective after traumatic spinal cord injury via anti-inflammatory in adult rats.
Myelodysplastic Syndromes
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.
Expression and prognostic significance of heat-shock proteins in myelodysplastic syndromes.
Hsp70 Trap Assay for Detection of Misfolded Subproteome Related to Myelodysplastic Syndromes.
Understanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components.
Myocardial Infarction
Effects and Mechanism of Noninvasive Positive-Pressure Ventilation in a Rat Model of Heart Failure Due to Myocardial Infarction.
Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70.
Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases.
Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.
HSP70 stress proteins, nitric oxide, and resistance of August and Wistar rats to myocardial infarction.
Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction.
Ozone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HPS70) expression through activating the JAK2/STAT3 Pathway.
Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB.
Regional distribution of HSP70 proteins after myocardial infarction.
[The role of heat shock proteins on the disordered tissues: implication for the pathogenesis and diagnostics in the forensic practice]
[The role of stress proteins HSP70 and the adrenergic system in different resistance to myocardial infarction of August and Wistar genetic rat strains]
[Transplantation of bone marrow cells up-regulated the expressions of HSP32 and HSP70 in the acute ischemic myocardium]
Myocardial Ischemia
Adenovirus-mediated gene transfer of a heat shock protein 70 (hsp 70i) protects against simulated ischemia.
Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.
Heat shock proteins as emerging therapeutic targets.
Heat shock proteins in myocardial stress.
Quantification of cardioprotective gene expression in porcine short-term hibernating myocardium.
The use of transgenic mice to study cytoprotection by the stress proteins.
[Antiarrhythmic effect of oligonucleotides accompanied by activation of HSP70 protein in the heart of rats].
Myocardial Stunning
Quantification of cardioprotective gene expression in porcine short-term hibernating myocardium.
Myocarditis
The expressions of HSP70 and ?B-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
Myoclonic Epilepsies, Progressive
Insights in progressive myoclonus epilepsy: HSP70 promotes cystatin B polymerization.
Myoma
Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.
Myositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Myositis, Inclusion Body
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Nasal Polyps
Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis.
Heat shock protein 70 and anti-heat shock protein 70 antibodies in nasal secretions of patients with chronic rhinosinusitis.
Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis.
Nasopharyngeal Carcinoma
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Intracell Heat Shock Protein 70 Expression and Nasopharyngeal Carcinoma Stage.
[Expression of main heat stress proteins and p53 in nasopharyngeal carcinoma]
[Study on the expression of HSP70 and HSP90beta in nasopharyngeal carcinoma and the clinical significance]
Nasopharyngeal Neoplasms
Co-Inhibition of HSP70/HSP90 Synergistically Sensitizes Nasopharyngeal Carcinoma Cells to Thermotherapy.
Neoplasm Metastasis
AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo.
Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics.
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens.
Co-expression of CD24 and Hsp70 as a prognostic biomarker for lung cancer.
Comparison of the expression of 5 heat shock proteins in benign and malignant salivary gland tumor tissues.
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma.
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma.
Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance.
General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors.
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor.
Heat-shocked tumor cell lysate-pulsed dendritic cells induce effective anti-tumor immune response in vivo.
Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells.
HSP70 as a Diagnostic and Prognostic Marker in Egyptian Women With Breast Cancer.
HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors.
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein.
Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma.
Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Inducible HSP70 antagonizes cisplatin?induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC?27 cells.
Intracell Heat Shock Protein 70 Expression and Nasopharyngeal Carcinoma Stage.
Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition.
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.
Patterns of heat shock protein (HSP70) expression and Kupffer cell activity following thermal ablation of liver and colorectal liver metastases.
Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone.
Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.
Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation.
Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.
Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.
The complex function of hsp70 in metastatic cancer.
The human HSP70 family of chaperones: where do we stand?
The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Tid1-S regulates the mitochondrial localization of EGFR in non-small cell lung carcinoma.
[Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]
[Differentially expressed genes in human giant-cell lung cancer lines with different metastatic potentials]
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression of HSP70/HSP27 protein in residual lesion after NPC radiotherapy]
[Prognostic significance of heat shock proteins 70 and p27 protein in patients with mucoepidermoid carcinoma]
Neoplasm, Residual
Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice.
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
Radiofrequency ablation in combination with an mTOR inhibitor restrains pancreatic cancer growth induced by intrinsic HSP70.
SerpinB3, a new prognostic tool in breast cancer patients treated with neoadjuvant chemotherapy.
Transcatheter arterial embolization combined with radiofrequency ablation activates CD8(+) T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors.
Neoplasms
(1)H, (15)N and (13)C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1.
15-deoxyspergualin inhibits eukaryotic protein synthesis through eIF2alpha phosphorylation.
17-(allylamino)-17-demethoxygeldanamycin drives Hsp70 expression, but fails to improve morphological or functional recovery in injured skeletal muscle.
2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90.
2-phenylethynesulphonamide (PFT-?) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels.
4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.
5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor.
7Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors.
?-Cyano-4-hydroxycinnamate induces apoptosis in Dalton's lymphoma cells: role of altered cell survival-regulatory mechanisms.
?-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-?B and Hsp70 protein modulation in vitro, and tumor reduction in vivo.
A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death.
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity.
A 14-mer peptide from HSP70 protein is the critical epitope which enhances NK activity against tumor cells in vivo.
A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.
A broadly applicable, personalized heat shock protein-mediated oncolytic tumor vaccine.
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
A hsp70-2 mutation recognized by CTL on a human renal cell carcinoma.
A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells.
A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent.
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
A non-receptor-mediated mechanism for internalization of molecular chaperones.
A novel anticancer approach: SEA-anchored tumor cells expressing heat shock protein 70 onto the surface elicit strong anticancer efficacy.
A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells.
A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.
A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.
A Novel Function of Molecular Chaperone HSP70: SUPPRESSION OF ONCOGENIC FOXM1 AFTER PROTEOTOXIC STRESS.
A Novel Heat Shock Protein 70-based Vaccine Prepared from DC-Tumor Fusion Cells.
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction.
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
A novel method to assay molecular chaperone activity of HSP70: evaluation of drug resistance in cancer treatment.
A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens.
A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif.
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
A novel sulfamethoxazole derivative as an inhibitory agent against HSP70: A combination of computational with in vitro studies.
A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis.
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
A peptide derived from apoptin inhibits glioma growth.
A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients.
A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer.
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma.
A simple method to cure established tumors by inflammatory killing of normal cells.
A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities.
A small molecule inhibitor of inducible heat shock protein 70.
A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation.
A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.
A tumour stage-dependent evolution of drug resistant T cell lymphoma: Role of soluble mediators of tumour and host origin.
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo.
Aberrant expression of stress-induced phosphoprotein 1 in colorectal cancer and its clinicopathologic significance.
Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy.
Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.
Active immunotherapy for mouse breast cancer with irradiated whole-cell vaccine expressing VEGFR2.
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines.
Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo.
Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
Alleviative effect of selenium on inflammatory damage caused by lead via inhibiting inflammatory factors and heat shock proteins in chicken testes.
Allosteric Inhibition of the Tumor-Promoting Interaction between AIMP2-DX2 and HSP70.
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group.
Allostery in the Hsp70 Chaperone Proteins.
Alterations in trace element levels and mRNA expression of Hsps and inflammatory cytokines in livers of duck exposed to molybdenum or/and cadmium.
Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.
Altered expression of HSP27 and HSP70 in distal oesophageal mucosa in patients with gastro-oesophageal reflux disease subjected to fundoplication.
An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer.
An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
An RNA Aptamer Specific to Hsp70-ATP Conformation Inhibits its ATPase Activity Independent of Hsp40.
Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model.
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis.
Andrographolide induces degradation of mutant p53 via activation of Hsp70.
Anti-cancer effects of targeting Hsp70 in tumor stromal cells.
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages.
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
Anti-neoplastic action of aspirin against a T cell lymphoma involves alteration in tumor microenvironment and regulation of tumor cell survival.
Antibodies to the 70 kDa heat shock protein in midtrimester amniotic fluid and intraamniotic immunity.
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.
Antigenic Hsp70-peptide upregulate altered cell surface MHC class I expression in TAMs and increases anti-tumor function in Dalton's lymphoma bearing mice.
Antimetabolic Agent 3-Bromopyruvate Exerts Myelopotentiating Action in a Murine Host Bearing a Progressively Growing Ascitic Thymoma.
Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction.
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.
Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.
Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma.
Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.
Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70.
Arginine-Arginine-Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging.
Arsenic-induced testicular toxicity in Gallus gallus: Expressions of inflammatory cytokines and heat shock proteins.
Assessment of heat shock protein 70 induction by heat in alfalfa varieties and constitutive overexpression in transgenic plants.
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Attenuation of contact hypersensitivity by cell-permeable heat shock protein 70 in BALB/c mouse model.
Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70.
Augmentation of immune cell activity against tumor cells by Rauwolfia radix.
Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia.
Author Correction: Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.
Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics.
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
BAG-1: a multifunctional regulator of cell growth and survival.
BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy.
Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer.
Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET.
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis.
Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells.
Biochemical analysis of heat-resistant mouse tumor cell strains: a new member of the HSP70 family.
Biochemical changes of plasma in paratroops after parachuting: a preliminary investigation.
Biomarkers That Predict Sensitivity to Heat Shock Protein 90 Inhibitors.
Boldo prevents UV light and nitric oxide-mediated plasmid DNA damage and reduces the expression of Hsp70 protein in melanoma cancer cells.
C-terminal domain of p42 Ebp1 is essential for down regulation of p85 subunit of PI3K, inhibiting tumor growth.
C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.
Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours.
Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.
Cancer genesis: stem tumour cells as an MHC-null/HSP70 - very high 'primordial self' escaping both MHC-restricted and MHC-non- restricted immunesurveillance.
Cancer immunotherapy using irradiated tumor cells secreting heat shock protein 70.
Cancer Takes a Toll on Skeletal Muscle by Releasing Heat Shock Proteins-An Emerging Mechanism of Cancer-Induced Cachexia.
Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells.
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
CD28-mediated T cell response is upregulated by exogenous application of autologous Hsp70-peptide complex in a tumor-bearing host.
CD91-dependent programming of T-helper cell responses following heat shock protein immunization.
CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity.
CEA promoter-regulated oncolytic adenovirus-mediated Hsp70 expression in immune gene therapy for pancreatic cancer.
Cell density-dependent alterations in tumorigenic potential of a murine T-cell lymphoma: implication in the evolution of multidrug resistance in tumor cells.
Cell stress proteins: novel immunotherapeutics.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Cell surface heat shock protein-mediated entry of tumor cell-adapted rotavirus into U-937 cells.
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
Cell-surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity.
Cellular and molecular chaperone fusion vaccines: targeting resistant cancer cell populations.
Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens.
Chaperone substrate provides missing link for cancer drug discovery.
Chaperone-dependent stabilization and degradation of p53 mutants.
Chaperones and slow death--a recipe for tumor immunotherapy.
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model.
Chronic electromagnetic field exposure decreases HSP70 levels and lowers cytoprotection.
Circulating Heat Shock Protein 70 in Health, Aging and Disease.
Circulating Heat Shock Protein 70 Is a Novel Biomarker for Early Diagnosis of Lung Cancer.
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers.
Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer.
Clusterin Inhibition using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate Resistant Prostate Cancer.
Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Comparative study of stress and immune-related transcript outcomes triggered by Vibrio anguillarum bacterin and air exposure stress in liver and spleen of gilthead seabream (Sparus aurata), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss).
Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 function.
Comparison of the anti-tumor effects of various whole-body hyperthermia protocols: Correlation with HSP 70 expression and composition of splenic lymphocytes.
Comparison of the expression of 5 heat shock proteins in benign and malignant salivary gland tumor tissues.
Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue.
Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.
Complement upregulation in photodynamic therapy-treated tumors: Role of Toll-like receptor pathway and NFkappaB.
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging.
Computational aided mechanistic understanding of Camellia sinensis bioactive compounds against co-chaperone p23 as potential anticancer agent.
Concomitant overexpression of heat-shock protein 70 and HLA class-I in hepatitis C virus-related hepatocellular carcinoma.
Conservation of the central MHC genome: PFGE mapping and RFLP analysis of complement, HSP70, and TNF genes in the goat.
Construction of human liver cancer vascular endothelium cDNA expression library and screening of the endothelium-associated antigen genes.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Control of transgene expression using local hyperthermia in combination with a heat-sensitive promoter.
Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries.
Correction to: Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.
Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-?. In Vitro Synergy Quantification of Pifithrin-? Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949.
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
Correlation of heat shock protein (HSP70) expression with cell proliferation (MIB1), estrogen receptors (ER) and clinicopathological variables in invasive ductal breast carcinomas.
Correlation of heat shock protein 70 expression with estrogen receptor levels in invasive human breast cancer.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment.
Cross-presentation of the oncofoetal tumor antigen 5T4 from irradiated prostate cancer cells - a key role for heat shock protein 70 and receptor CD91.
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.
Curcumin Combined with Oxaliplatin Effectively Suppress Colorectal Carcinoma in vivo Through Inducing Apoptosis.
Cytokine effects and cellular signaling pathways of grass carp HSP70 in head kidney leukocytes.
Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma.
Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation.
Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing.
Cytotoxicity of demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, to melanoma cells.
Daboialectin, a C-type lectin from Russell's viper venom induces cytoskeletal damage and apoptosis in human lung cancer cells in vitro.
Death by chaperone: HSP90, HSP70 or both?
Decrease of heat shock protein levels and cell populations by wine phenolic extracts.
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.
DeltaNp63alpha up-regulates the Hsp70 gene in human cancer.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity.
Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors.
Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators.
Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N'-disubstituted thiourea derivatives.
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
Designing Specific HSP70 Substrate Binding Domain Inhibitor for Perturbing Protein Folding Pathways to Inhibit Cancer Mechanism.
Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment.
Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.
Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis.
Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men.
Differential effect of acute and permanent heat shock protein 70 overexpression in tumor cells on lysability by cytotoxic T lymphocytes.
Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis.
Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas.
Differential expression of heat shock protein 70 (hsp70) in human monocytes rendered apoptotic by IL-4 or serum deprivation.
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix.
Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas.
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.
Differential Nasal Expression of Heat Shock Proteins 27 and 70 by Aerobic Exercise: A Preliminary Study.
Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs.
Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.
Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone hsp70.
Doxorubicin hydrochloric increases tumour coagulation and end-point survival in percutaneous microwave ablation of tumours in a VX2 rabbit tumour model.
Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy.
Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70.
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Dual role of heat shock proteins as regulators of apoptosis and innate immunity.
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer.
Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin.
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
Effect of antiangiogenic therapy on luciferase activity in a cytomegalovirus- or HSP70-promoter-transfected M21 tumor model.
Effect of glucocorticoid depletion on heat-induced Hsp70, IL-1beta and TNF-alpha gene expression.
Effect of Lead on Antioxidant Ability and Immune Responses of Crucian Carp.
Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in Solid Ehrlich Carcinoma-bearing mice.
Effect of radiation and hyperthermia on prostate tumor cells with induced thermal tolerance and the correlation with HSP70 accumulation.
Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies.
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.
Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels.
Effects of chronic nitrate exposure on the intestinal morphology, immune status, barrier function, and microbiota of juvenile turbot (Scophthalmus maximus).
Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells.
Effects of low-power laser radiation on mice immunity.
Effects of Molybdenum or/and Cadmium on mRNA Expression Levels of Inflammatory Cytokines and HSPs in Duck Spleens.
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver.
Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma.
Efficient CTL productivity of modified fusion cells by increase of heat shock protein 70.
Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction.
Elevated serum levels of heat shock protein 70 are associated with breast cancer.
Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNF? in human phagocytes.
Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy.
Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70.
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation.
Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis.
Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
Enhancement of immunogenicity of murine lymphocytic leukemia cells by transfection with BCG heat shock protein 70 gene.
Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium tuberculosis heat shock protein 70 gene to an antigen gene.
Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia.
Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo.
Epithelial ovarian cancer: feasibility of image-guided intratumoral radiofrequency hyperthermia-enhanced direct gene therapy.
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
Erratum to: Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin.
Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours.
Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3.
Evaluating erythropoietin-associated tumor progression using archival tissues from a phase III clinical trial.
Evaluation of HER2, p53, bcl-2, topoisomerase II-alpha, heat shock proteins 27 and 70 in primary breast cancer and metastatic ipsilateral axillary lymph nodes.
Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI.
Evidence for hSNM1B/Apollo functioning in the HSP70 mediated DNA damage response.
Evidence of multimeric forms of HSP70 with phosphorylation on serine and tyrosine residues--implications for roles of HSP70 in detection of GI cancers.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Exercise, vascular wall and cardiovascular diseases: an update (Part 1).
Exhaustion of Protective Heat Shock Response Induces Significant Tumor Damage by Apoptosis after Modulated Electro-Hyperthermia Treatment of Triple Negative Breast Cancer Isografts in Mice.
Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity.
Exosomes from plasmacytoma cells as a tumor vaccine.
Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma.
Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma.
Expression and roles of heat shock proteins in human breast cancer.
Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity.
Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines.
Expression of cyclooxygenase-2 in neoplasms of the mammary gland in bitches.
Expression of heat shock protein 70 (HSP70) and EBV latent membrane protein 1 (LMP1) in Reed-Sternberg cells of Hodgkin's disease.
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Expression of heat shock protein 70 and c-myc protein in human breast cancer: an immunohistochemical study.
Expression of heat shock protein 70 and p53 in human lung cancer.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis.
Expression of Heat Shock Protein 70 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study.
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
Expression of HSP70 and Its Relation with Other Cytokines in Human Middle Ear Effusion.
Expression of human HSP70 during the synthetic phase of the cell cycle.
Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia.
Expression of mutant protein p53 and Hsp70 and Hsp90 chaperones in cockles Cerastoderma edule affected by neoplasia.
Expression of p53 and hsp70 in relation to apoptosis during Meckel's cartilage development in the mouse.
Expressions of HSP70 and HSP27 in hepatocellular carcinoma.
Extracellular cell stress (heat shock) proteins-immune responses and disease: an overview.
Extracellular heat shock protein (Hsp)70 and Hsp90? assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells.
Extracellular HSPA1A promotes the growth of hepatocarcinoma by augmenting tumor cell proliferation and apoptosis-resistance.
Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma.
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.
Fluorescent-Linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors.
Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth.
From protein-protein interaction to therapy response: molecular imaging of heat shock proteins.
Function and Chemotypes of Human Hsp70 Chaperones.
Functional analysis of Hsp70 inhibitors.
Functional inhibition of Hsp70 by Pifithrin-? switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.
Fusion of Hsp70 to Mage-a1 enhances the potency of vaccine-specific immune responses.
Fusion protein of ATPase domain of Hsc70 with TRP2 acting as a tumor vaccine against B16 melanoma.
Fusion proteins of Hsp70 with tumor-associated antigen acting as a potent tumor vaccine and the C-terminal peptide-binding domain of Hsp70 being essential in inducing antigen-independent anti-tumor response in vivo.
gammadelta T cells lyse autologous and allogenic oesophageal tumours: involvement of heat-shock proteins in the tumour cell lysis.
Ganetespib for small cell lung cancer.
Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60).
General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors.
Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy.
Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype.
Genomic organization and expression of the human tumorous imaginal disc (TID1) gene.
Glutamine preserves skeletal muscle force during an inflammatory insult.
Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors.
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.
Graphene oxide based electrochemical label free immunosensor for rapid and highly sensitive determination of tumor marker HSP70.
Graphitic carbon nitride nanosheets as a multifunctional nanoplatform for photochemical internalization-enhanced photodynamic therapy.
GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.
Haematoporphyrin based photodynamic therapy combined with hyperthermia provided effective therapeutic vaccine effect against colon cancer growth in mice.
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
Heat induced expression of CD95 and its correlation with the activation of apoptosis upon heat shock in rat histiocytic tumor cells.
Heat shock (hsp70) and resistance proteins in non-small cell lung carcinomas.
Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.
Heat shock protein (HSP70) expression in septic patients.
Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver.
Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer.
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.
Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells.
Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo.
Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells.
Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results - Short communication.
Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901.
Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles.
Heat shock protein 70 gene polymorphisms and cancer risk: a meta-analysis.
Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles.
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.
Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake.
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.
Heat shock protein 70 is a useful marker for predicting colorectal cancer.
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.
Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice.
Heat shock protein 70 is required for the survival of cancer cells.
Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes.
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.
Heat shock protein 70 positively regulates transforming growth factor-?-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG(2) cells.
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway.
Heat shock protein 70-associated peptides elicit specific cancer immunity.
Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells.
Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase.
Heat shock protein 70: role in antigen presentation and immune stimulation.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
Heat shock protein derived from a non-autologous tumour can be used as an anti-tumour vaccine.
Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy.
Heat shock protein expression in the eye and in uveal melanoma.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications.
Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro.
Heat shock protein-antigen fusions lose their enhanced immunostimulatory capacity after endotoxin depletion.
Heat shock proteins (HSP70 and HSP27) as markers of epithelial dysplasia in oral leukoplakia.
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties.
Heat Shock Proteins 27, 70, and 110: Expression and Prognostic Significance in Colorectal Cancer.
Heat shock proteins and cell proliferation in human breast cancer biopsy samples.
Heat shock proteins and infection: interactions of pathogen and host.
Heat shock proteins as prognostic markers of cancer.
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor.
Heat shock proteins in cancer.
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
Heat shock proteins in immune response to cancer: the Fourth Paradigm.
Heat shock proteins in immunity.
Heat shock proteins in pancreatic diseases.
Heat shock proteins in renal cell carcinomas.
Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia.
Heat shock proteins: conditional mediators of inflammation in tumor immunity.
Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.
Heat Stress and Feed Restriction Distinctly Affect Performance, Carcass and Meat Yield, Intestinal Integrity, and Inflammatory (Chemo)Cytokines in Broiler Chickens.
Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment.
Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion.
Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha.
Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.
Heat-shock proteins: new keys to the development of cytoprotective therapies.
Heat-shocked tumor cell lysate-pulsed dendritic cells induce effective anti-tumor immune response in vivo.
Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity.
Hemidesmus indicus induces immunogenic death in human colorectal cancer cells.
Hepatocellular dysplastic nodules.
Heterogeneous patterns of constitutive and heat shock induced expression of HLA-linked HSP70-1 and HSP70-2 heat shock genes in human melanoma cell lines.
High expression of heat shock proteins and heat shock factor-1 distinguishes an aggressive subset of clear cell renal cell carcinoma.
High levels of heat shock protein 70 are associated with pro-inflammatory cytokines and may differentiate early- from late-onset preeclampsia.
High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort.
High-throughput screening identifies small molecule inhibitors of molecular chaperones.
Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1{gamma}
HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family.
HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines.
Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.
Hsp27 and Hsp70 Expression in Esophageal Squamous
HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).
Hsp27, Hsp70 and mismatch repair proteins hMLH1 and hMSH2 expression in peripheral blood lymphocytes from healthy subjects and cancer patients.
HSP47 as a possible marker for malignancy of tumors in vivo.
Hsp60 is actively secreted by human tumor cells.
Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells.
Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.
Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells.
Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ?Np63 ubiquitination and degradation.
HSP70 and ER expression in cervical intraepithelial neoplasia and cervical cancer.
HSP70 and genomic stability.
Hsp70 and Hsp90--a relay team for protein folding.
HSP70 and modified HPV 16 E7 fusion gene without the addition of a signal peptide gene sequence as a candidate therapeutic tumor vaccine.
Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line.
Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development.
HSP70 as a Diagnostic and Prognostic Marker in Egyptian Women With Breast Cancer.
HSP70 binding sites in the tumor suppressor protein p53.
Hsp70 chaperone as a survival factor in cell pathology.
Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.
Hsp70 chaperone-based gel composition as a novel immunotherapeutic anti-tumor tool.
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.
Hsp70 in cancer: A double agent in the battle between survival and death.
Hsp70 in cancer: back to the future.
Hsp70 in Cancer: Partner or Traitor to Immune System.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
Hsp70 induces Th1 polarization through tumor-associated macrophages in a T-cell lymphoma.
HSP70 induction by ING proteins sensitizes cells to tumor necrosis factor alpha receptor-mediated apoptosis.
HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells.
HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors.
HSP70 inhibitor combined with cisplatin suppresses the cervical cancer proliferation in vitro and transplanted tumor growth: An experimental study.
HSP70 inhibitor VER155008 suppresses pheochromocytoma cell and xenograft growth by inhibition of PI3K/AKT/mTOR and MEK/ERK pathways.
Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Hsp70 interactions with the p53 tumour suppressor protein.
Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells.
HSP70 modified response against HPV based tumor.
Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions.
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.
HSP70 Multi-Functionality in Cancer.
HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope.
HSP70 overexpression increases resistance of V79 cells to cytotoxicity of airborne pollutants, but does not protect the mitotic spindle against damage caused by airborne toxins.
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells.
HSP70 protects against TNF-induced lethal inflammatory shock.
Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death.
HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors.
HSP70 silencing combined with AIF: A novel therapeutic approach for cancer.
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
Hsp70, an immunological actor playing with the intracellular self under oxidative stress.
Hsp70- and p53-reponses after heat treatment and/or X-irradiation mediate the susceptibility of hematopoietic cells to undergo apoptosis.
Hsp70--a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck.
Hsp70-2 is required for tumor cell growth and survival.
Hsp70-bag3 interactions regulate cancer-related signaling networks.
HSP70-based anti-cancer immunotherapy.
HSP70-eIF4G Interaction Promotes Protein Synthesis and Cell Proliferation in Hepatocellular Carcinoma.
Hsp70: A Cancer Target Inside and Outside the Cell.
HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin.
Hsp70: anti-apoptotic and tumorigenic protein.
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.
Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevis.
HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein.
HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms.
HSP90 Shapes the Consequences of Human Genetic Variation.
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.
Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling.
Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells.
Human Inducible Hsp70: Structures, Dynamics, and Interdomain Communication from All-Atom Molecular Dynamics Simulations.
Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.
Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
Human prostate stem cell antigen and HSP70 fusion protein vaccine inhibits prostate stem cell antigen-expressing tumor growth in mice.
Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin.
Hyperthermia classic article commentary: 'Re-induction of hsp70 synthesis: an assay for thermotolerance' by Gloria C. Li and Johnson Y. Mak, International Journal of Hyperthermia 1989;5:389-403.
Hyperthermia, inducing pancreatic heat-shock proteins, fails to prevent cerulein-induced stress kinase activation.
Hyperthermia-associated carboplatin resistance: Differential role of p53, HSF1 and Hsp70 in hepatoma cells.
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.
Identification and functional characterization of nuclear mortalin in human carcinogenesis.
Identification of a Promiscuous Epitope Peptide Derived From HSP70.
Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Identification of diagnostic serum protein profiles of glioblastoma patients.
Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity.
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex.
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer.
Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes.
Identification of the active portion of the CCL3 derivative reported to induce antitumor abscopal effect.
IgA antibodies to the 27-kDa heat-shock protein in the genital tracts of women with gynecologic cancers.
Image-Guided Radiofrequency Hyperthermia (RFH)-Enhanced Direct Chemotherapy of Hepatic Tumors: The Underlying Biomolecular Mechanisms.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles.
Immunization of protein HPV16 E7 in fusion with mouse HSP70 inhibits the growth of TC-1 cells in tumor bearing mice.
Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses.
Immunoexpression of Heat Shock Protein 70, Glypican 3, Glutamine Synthetase, and Beta-Catenin in Hepatocellular Carcinoma After Liver Transplantation: Association Between Positive Glypican 3 and Beta-Catenin With the Presence of Larger Nodules.
Immunogenetic effects of low dose (CEM43 30) magnetic nanoparticle hyperthermia and radiation in melanoma cells.
Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy.
Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.
Immunohistochemical detection of estrogen receptor in invasive human breast cancer: correlation with heat shock proteins, pS2 and oncogene products.
Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma.
Immunomodulatory effects of radiofrequency ablation in a breast cancer model.
Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.
Immunostimulatory functions of membrane-bound and exported heat shock protein 70.
Immunotherapy of cancer using heat shock proteins.
Immunotherapy of Epstein-Barr virus associated malignancies using mycobacterial HSP70 and LMP2A356-364 epitope fusion protein.
Implication of heat shock proteins in rotavirus entry into Reh cells.
Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432.
Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy.
In silico Analysis of Molecular Mechanisms of Galanthus nivalis Agglutinin-Related Lectin-Induced Cancer Cell Death from Carbohydrate-Binding Motif Evolution Hypothesis.
In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells.
In Silico Molecular Modeling and Docking Studies on Novel Mutants (E229V, H225P and D230C) of the Nucleotide-Binding Domain of Homo sapiens Hsp70.
In vitro effect of focused ultrasound or thermal stress on HSP70 expression and cell viability in three tumor cell lines.
In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody.
In vivo monitoring of antiangiogenic therapy by magnetic resonance and bioluminescence imaging in an M21 tumor model through activation of an hsp70 promoter-luciferase reporter construct.
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors.
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway.
Increased expression of the Hsp70 cochaperone HspBP1 in tumors.
Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?
Increased Levels of Interleukin-17A Exosomes in Psoriasis.
Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3.
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Inducible HSP70 antagonizes cisplatin?induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC?27 cells.
Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes.
Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity.
Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells.
Induction of apoptosis by quercetin: involvement of heat shock protein.
Induction of autologous tumor killing by heat treatment of fresh human tumor cells: involvement of gamma delta T cells and heat shock protein 70.
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70.
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.
Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.
Induction of Luciferase Activity under the Control of an hsp70 Promoter Using High-Intensity Focused Ultrasound: Combination of Bioluminescence and MRI Imaging in Three Different Tumour Models.
Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide.
Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: role of reactive oxygen intermediates.
Induction of systemic antitumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ.
Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia.
Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines.
Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice.
Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.
Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells.
Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells.
Influence of induction of HSP70 on the cytotoxicity of oxazaphosphorine compounds and cisplatin.
Influence of sex on cytokines, heat shock protein and oxidative stress markers in response to an acute total body resistance exercise protocol.
Inhibition of apoptosis via CHIP-mediated proteasomal degradation of TAp73?.
Inhibition of HIV-1 transcription by cyclopentenone prostaglandin A1 in Jurkat T lymphocytes.
Inhibition of HSP70: A challenging anti-cancer strategy.
Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells.
Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.
Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach.
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells.
Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase.
Inhibitors of the HSP90 molecular chaperone: current status.
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
Insulin-induced expression of human heat-shock protein gene hsp70.
Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53.
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC.
Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94.
Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.
Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.
Interleukin-6 and vascular endothelial growth factor release by renal cell carcinoma cells impedes lymphocyte-dendritic cell cross-talk.
Intracell Heat Shock Protein 70 Expression and Nasopharyngeal Carcinoma Stage.
Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy.
Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer.
Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-?B signaling via initiation of HSP70.
Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition.
Investigation on the effect of peptides mixture from tumor cells inducing anti-tumor specific immune response.
Involvement of heat shock protein-70 in the mechanism of hydrogen peroxide-induced DNA damage: the role of lysosomes and iron.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
Isocordoin analogues promote apoptosis in human melanoma cells via Hsp70.
Isolation and characterization of a novel scFv antibody fragments specific for Hsp70 as a tumor biomarker.
Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3.
Kinetic and structural characterization of human mortalin.
KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia.
Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.
Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells.
KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.
Label-Free Nondestructive Discrimination of Colon Carcinoma Sublines and Biomolecular Insights into their Differential Hsp70 Expression: DNA/RNA Nucleobase Specific Changes.
Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.
Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.
Long-term phosphodiesterase 5 inhibitor administration reduces inflammatory markers and heat-shock proteins in cavernous tissue of Zucker diabetic fatty rat (ZDF/fa/fa).
Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NF?B-TLR signaling pathway.
Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
Macrophage cell-derived exosomes/staphylococcal enterotoxin B against fibrosarcoma tumor.
Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy.
Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.
Mass culture and characterization of tumor cells from a naturally occurring invertebrate cancer model: applications for human and animal disease and environmental health.
Maternal Type 1 diabetes activates stress response in early placenta.
Mechanic effect of pulsed focused ultrasound in tumor and muscle tissue evaluated by MRI, histology, and microarray analysis.
Mechanochemical Disruption Suppresses Metastatic Phenotype and Pushes Prostate Cancer Cells toward Apoptosis.
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.
Membrane heat shock protein 70: a theranostic target for cancer therapy.
Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
Membrane-anchored heat-shock protein 70 (Hsp70) in cancer.
Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study.
Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8(+) CTL- and NK-mediated antitumor immunity than exosomes released from heat-shocked tumor cells expressing cytoplasmic HSP70.
Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity.
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models.
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.
Microwave-triggered/HSP-targeted gold nano-system for triple-negative breast cancer photothermal therapy.
MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer.
Modeling and docking studies on novel mutants (K71L and T204V) of the ATPase domain of human heat shock 70 kDa protein 1.
Moderate hyperthermic heating encountered during thermal ablation increases tumor cell activity.
Modulated Electro-Hyperthermia Facilitates NK-Cell Infiltration and Growth Arrest of Human A2058 Melanoma in a Xenograft Model.
Modulated Electro-Hyperthermia Induces a Prominent Local Stress Response and Growth Inhibition in Mouse Breast Cancer Isografts.
Modulating Heat Shock Proteins 70 and 90 Expression by Low Power Laser Irradiation (635nm and 780nm) in Jurkat E6.1 T-lymphocyte Leukemia Cell Line.
Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach.
Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.
Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol.
Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma.
Molecular Chaperones and Thyroid Cancer.
Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy.
Molecular cochaperones: tumor growth and cancer treatment.
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.
Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid.
Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study.
Monitoring the Induction of Heat Shock Factor 1/Heat Shock Protein 70 Expression following 17-Allylamino-Demethoxygeldanamycin Treatment by Positron Emission Tomography and Optical Reporter Gene Imaging.
Monitoring The Induction Of Heat Shock Factor 1/heat Shock Protein 70 Expression Following 17-allylamino-demethoxygeldanamycin Treatment By Positron Emission Tomography And Optical Reporter Gene Imaging.
Morphological effects of autologous hsp70 on peritoneal macrophages in a murine T cell lymphoma.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, induces apoptosis in melanoma cells.
Multi-panel assay of serum autoantibodies in colorectal cancer.
Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells.
Multiple hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity?
Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line.
Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature.
Mutant p53R175H promotes cancer initiation in the pancreas by stabilizing HSP70.
Mycobacterial HSP70 as an adjuvant in the design of an idiotype vaccine against a murine lymphoma.
N-acetylglucosamine biofunctionalized CdSeTe quantum dots as fluorescence probe for specific protein recognition.
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.
N-terminally fusion of Her2/neu to HSP70 decreases efficiency of Her2/neu DNA vaccine.
Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy.
Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination.
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality.
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.
New tricks for an old dog: the evolving world of Hsp70.
Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.
Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-?. In Vitro Synergy Quantification of Pifithrin-? Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.
Nuclear matrix as a target for hyperthermic killing of cancer cells.
Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.
Oligodendrogliomas in relation to astrocytes differentiation. Clinicopathologic and immunohistochemical study.
Oncogenic ras results in increased cell kill due to defective thermoprotection in lung cancer cells.
Opposite roles of metastasin (S100A4) in two potentially tumoricidal mechanisms involving human lymphocyte protein Tag7 and Hsp70.
Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models.
Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers.
Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death.
Over-expression of heat shock proteins in carcinogenic endometrium.
Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells.
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2.
Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer.
Overproduction and biophysical characterization of human HSP70 proteins.
p27 suppresses cyclooxygenase-2 expression by inhibiting p38? and p38?-mediated CREB phosphorylation upon arsenite exposure.
p300 mediates muscle wasting in Lewis lung carcinoma.
p53 as tumor marker for the early detection of reincidence in lung cancer.
p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer.
Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.
Patterns of heat shock protein (HSP70) expression and Kupffer cell activity following thermal ablation of liver and colorectal liver metastases.
Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells.
Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs.
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy.
Perturbation of HSP Network in MCF-7 Breast Cancer Cell Line Triggers Inducible HSP70 Expression and Leads to Tumor Suppression.
PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain.
pH-responsive Ag2S nanodots loaded with heat shock protein 70 inhibitor for photoacoustic imaging-guided photothermal cancer therapy.
Phage display biopanning identifies the translation initiation and elongation factors (IF1?-3 and eIF-3) as components of Hsp70-peptide complexes in breast tumour cells.
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts.
Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.
Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells.
Pharmacological Targeting of the Hsp70 Chaperone.
Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors.
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies.
Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma.
Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma.
Photodynamic therapy and the role of heat shock protein 70.
Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response.
Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70.
Pifithrin-? is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70.
Pifithrin-?, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.
Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children.
Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer.
Polymorphic analysis of MHClinked Heat Shock Protein 70 genes: Their susceptibility and prognostic implication in Kangri cancer cases of Kashmiri population.
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis.
Potent antitumor effect elicited by superantigen-linked tumor cells transduced with heat shock protein 70 gene.
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia.
Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms.
Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients.
Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG24-DFO[89Zr] for Tumor-Specific PET/CT Imaging.
Preconditioning with 1,25-dihydroxyvitamin D3 protects against subsequent ischemia-reperfusion injury in the rat kidney.
Preoperative treatment of rectal cancer with radiation, chemotherapy and hyperthermia: analysis of treatment efficacy and heat-shock response.
Preparation of multifunctional nanobubbles and their application in bimodal imaging and targeted combination therapy of early pancreatic cancer.
Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone.
Primary glioblastoma multiforme tumors and recurrence : Comparative analysis of the danger signals HMGB1, HSP70, and calreticulin.
Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.
Production and characterization of a monoclonal antibody specific to the human 70-kDa heat shock protein.
Production of heat shock proteins, cytokines, and nitric oxide in toxic stress.
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
Prognostic utility of autoantibodies to ?-enolase and Hsp70 for cancer of the gingivo-buccal complex using immunoproteomics.
Progressive tumor growth-associated altered tumor microenvironment: implications in a tumor stage-dependent modulation in survival of a murine T cell lymphoma.
Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.
Prophylactic Antitumor Effect of Mixed Heat Shock Proteins/Peptides in Mouse Sarcoma.
Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma.
Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
Protective effect of Ferula gummosa hydroalcoholic extract against nitric oxide deficiency-induced oxidative stress and inflammation in rats renal tissues.
Protective effects of dietary mannan oligosaccharide on heat stress-induced hepatic damage in broilers.
Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells.
Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA).
Proteomic analysis of the copper ion-induced stress response in a human embryonic carcinoma cell line.
Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.
ProteoMod: A new tool to quantitate protein post-translational modifications.
Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer.
Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70.
PS2 and HSP70 Expression in Rectal Adenocarcinomas: An Immunohistochemical Investigation of 45 cases.
Pseudomonas aeruginosa exotoxin A reduces chemoresistance of oral squamous carcinoma cell via inhibition of heat shock proteins 70 (HSP70).
Pu-erh Tea Inhibits Tumor Cell Growth by Down-Regulating Mutant p53.
Purification of multiple heat shock proteins from a single tumor sample.
Purification, preparation, and use of chaperone-peptide complexes for tumor immunotherapy.
Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.
Quercetin Liposome Sensitizes Colon Carcinoma to Thermotherapy and Thermochemotherapy in Mice Models.
Quercetin Mediated Reduction of Angiogenic Markers and Chaperones in DLA-Induced Solid Tumours.
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages.
Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.
Radiofrequency ablation (RFA)-induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins.
Radiofrequency ablation, heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers: a minireview.
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels.
Radiosynthesis of [(18)F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins.
Re-induction of hsp70 synthesis: an assay for thermotolerance.
Recent Patents on Heat Shock Proteins Targeting Antibodies.
Recent Progress of Biomarkers in Oral Cancers.
Recombinant Arabidopsis HSP70 sustains cell survival and metastatic potential of breast cancer cells.
Recombinant Lactaptin Induces Immunogenic Cell Death and Creates an Antitumor Vaccination Effect in Vivo with Enhancement by an IDO Inhibitor.
Recombinant Tumor Suppressor TSC1 Differentially Interacts with Escherichia coli DnaK and Human HSP70.
Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells.
Reconstituted complexes of mycobacterial HSP70 and EBV LMP2A-derived peptides elicit peptide-specific cytotoxic T lymphocyte responses and anti-tumor immunity.
Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.
Regional assignment of two genes of the human branched-chain alpha-keto acid dehydrogenase complex: the E1 beta gene (BCKDHB) to chromosome 6p21-22 and the E2 gene (DBT) to chromosome 1p31.
Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70.
Regulation of heat shock protein 70 gene expression by c-myc.
Relationship between codon 249 mutation in exon 7 of p53 gene and diagnosis of hepatocellular carcinoma.
Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes.
Report on the VIIth International Symposium on Heat Shock Proteins in Biology & Medicine.
Reproducibility of fluid-phase measurements in PBS-treated sputum supernatant of healthy and stable COPD subjects.
Response to hepatocarcinoma hca-f of mice immunized with heat shock protein 70 from elemene combo tumor cell vaccine.
Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer.
Retinoid- and sodium-butyrate--induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to natural killer cell lysis, growth delay, and altered growth morphology.
Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption: A Prospective Observational Study.
RNA interference-mediated silencing of the Hsp70 gene inhibits human gastric cancer cell growth and induces apoptosis in vitro and in vivo.
RNA polymerase II pausing and transcriptional regulation of the HSP70 expression.
Role of Hsp70 in cancer growth and survival.
Role of membrane Hsp70 in radiation sensitivity of tumor cells.
RP11-462C24.1 suppresses proliferation and invasion of colorectal carcinoma cells by regulating HSP70 through PI3K/AKT signaling pathway.
Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe.
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models.
Sensitizing tumor cells to radiation by targeting the heat shock response.
Sequence modification of heptapeptide selected by phage display as homing device for HT-29 colon cancer cells to improve the anti-tumour activity of drug delivery systems.
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
Serum p53 antibodies in patients with oral lesions: correlation with p53/HSP70 complexes.
Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells.
ShRNA-mediated gene silencing of Heat shock protein 70 inhibits human colon cancer cell growth in vitro and in vivo.
ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli.
Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells.
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo.
Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells.
Specific and Aspecific Molecular Checkpoints as Potential Targets for Dismantling Tumor Hierarchy and Preventing Relapse and Metastasis Through Shielded Cytolytic Treatments.
Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines.
Stress Proteins and Cytokines are Urinary Biomarkers for Diagnosis and Staging of Bladder Cancer.
Stress-induced proteins in immune response to cancer.
Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects.
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.
Study on amino acid composition of HSP70 and the level of plasma free amino acids of workers with long-term exposure to harmful factors.
Study on the preparation of recombinant human HSP70 and its presenting-antigen function.
Sub-lethal heat shock induces plasma membrane translocation of 70-kDa heat shock protein in viable, but not in apoptotic, U-937 leukaemia cells.
Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms.
Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance.
Suppressed expression of homotypic multinucleation, extracellular domains of CD172? (SIRP-?) and CD47 (IAP) receptor in TAMs up-regulated by Hsp70-peptide complex in Dalton's lymphoma.
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions.
Suppression of HSP70 inhibits the development of acute lymphoblastic leukemia via TAK1/Egr-1.
Surface expression of a C-terminal alpha-helix region in heat shock protein 72 on murine LL/2 lung carcinoma can be recognized by innate immune sentinels.
Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy.
Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.
Synergistic effect of muramyl dipeptide with heat shock protein 70 from Mycobacterium tuberculosis on immune activation.
Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells.
Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy.
Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization.
Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.
Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.
Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models.
Targeted Natural Killer Cell-Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial.
Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment.
Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Targeting Heat Shock Proteins 60 and 70 of Toxoplasma gondii as a Potential Drug Target: In Silico Approach.
Targeting heat shock proteins in cancer.
Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer.
Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy.
Targeting HSP70 for cancer therapy.
Targeting Hsp70: A possible therapy for cancer.
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody.
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Targeting the testis-specific heat-shock protein 70-2 (HSP70-2) reduces cellular growth, migration, and invasion in renal cell carcinoma cells.
Tetraploid arrest with overexpressed non-mutated p53 in germ cell cancers.
The 'peptidome' of tumour-derived chaperone-rich cell lysate anti-cancer vaccines reveals potential tumour antigens that stimulate tumour immunity.
The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue.
The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Proteins mRNA Expression in Chicken Livers.
The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth.
The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells.
The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma.
The complex function of hsp70 in metastatic cancer.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The development of modified human Hsp70 (HSPA1A) and its production in the milk of transgenic mice.
The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia.
The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A.
The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70.
The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.
The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer.
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
The Fate of Exogenous Human HSP70 Introduced into Animal Cells by Different Means.
The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.
The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90? and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth.
The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands.
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.
The Heat Shock-binding Protein (HspBP1) Protects Cells against the Cytotoxic Action of the Tag7-Hsp70 Complex.
The HSP70 and Autophagy Inhibitor Pifithrin-? Enhances the Antitumor Effects of TRAIL on Human Pancreatic Cancer.
The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex.
The HSP70 family and cancer.
The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.
The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models.
The HspA2 protein localizes in nucleoli and centrosomes of heat shocked cancer cells.
The immunobiology of heat shock proteins.
The immunosuppressive activity of heat shock protein 70.
The inducible Hsp70 as a marker of tumor immunogenicity.
The interaction of heat shock proteins with cellular membranes: a historical perspective.
The loss of CD44 and HSP70 overexpression is related to aggressive clinicopathologic factors in prostate cancer.
The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.
The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways.
The Novel Oral Hsp90 Inhibitor NVP-HSP990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo.
The PI3K/Akt signalling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.
The plant diterpene epoxysiderol targets Hsp70 in cancer cells, affecting its ATPase activity and reducing its translocation to plasma membrane.
The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats.
The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses.
The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells.
The production of a 70 kDa heat shock protein by Toxoplasma gondii RH strain in immunocompromised mice.
The prognostic impact of anti-heat shock protein 70 and its antigen on survival of patients with intermediate and unfavorable cytogenetic risk acute myeloid leukemia.
The Prognostic Significance of Hsp70 in Patients with Colorectal Cancer Patients: A PRISMA-Compliant Meta-Analysis.
The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: Expression of Hsps and inflammation-related genes and modulation of elements homeostasis.
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
The relationship between the degree of malnutrition and changes in selected parameters of the immune response in critically ill patients.
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge.
The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation.
The role of heat shock protein 70 in oxidant stress and inflammatory injury in quail spleen induced by cold stress.
The role of heat shock proteins in cancer.
The Role of Heat Shock Proteins in Leukemia.
The role of hsp70 in age-related diseases and the prevention of cancer.
The Role of HSP70 in Cancer and its Exploitation as a Therapeutic Target.
The structural and functional analysis of the human HSPA2 gene promoter region.
The study on the expression of membrane HSP70 protein in H22 cell and its immunoprotective mechanism against carcinoma.
The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.
The tumor-selective over-expression of the human Hsp70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription.
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
The versatile stress protein mortalin as a chaperone therapeutic agent.
Therapeutic efficacy of tumor-derived heat shock protein 70 immunotherapy combining interleukin-2 on tumor-bearing mice.
Therapeutic mechanism of treating SMMC-7721 liver cancer cells with magnetic fluid hyperthermia using Fe2O3 nanoparticles.
Therapeutic mechanism of treating SMMC-7721 liver cancer cells with magnetic fluid hyperthermia using Fe?O? nanoparticles.
Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer, current status and perspectives.
Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma.
Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies.
Thermal pretreatment promotes the protective effect of HSP70 against tendon adhesion in tendon healing by increasing HSP70 expression.
Thermodynamics and kinetics of Hsp70 association with A + U-rich mRNA-destabilizing sequences.
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model.
Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation.
Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein Complex.
Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells.
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death.
Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70.
Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol.
TRAIL-induced apoptosis is enhanced by heat shock protein 70 expression.
Transcatheter arterial embolization combined with radiofrequency ablation activates CD8(+) T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors.
Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d.
Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members.
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma.
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.
Treatment of ras-induced cancers by the F-actin-bundling drug MKT-077.
Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma.
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.
Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity.
Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.).
Tryptophan free diet delays healing of chronic gastric ulcers in rat.
Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex.
Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity.
Tumor Cell Surface Display of Immunoglobulin Heavy Chain Fc by Gene Transfer as a Means to Mimic Antibody Therapy.
Tumor cell surface display of immunoglobulin heavy chain Fc by gene transfer as a means to mimic antibody therapy.
Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide.
Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression.
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70.
Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma.
Tumor tissue characterization evaluating the luciferase activity under the control of a hsp70 promoter and MR imaging in three tumor cell lines.
Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers.
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.
Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity.
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3.
Tumor-specific therapeutic effect induced by an oncolytic adenoviral vector containing heat shock protein 70 and prodrug activation genes.
Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1?-VEGF signaling axis.
Ubiquitin-Associated (UBA) Domain in Human Fas Associated Factor 1 Inhibits Tumor Formation by Promoting Hsp70 Degradation.
Unexpected deeds of familiar proteins: Interplay of Hsp70, PGRP-S/Tag7 and S100A4/Mts1 in host vs. cancer combat.
Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised.
Up-regulation of heat shock protein 70 in adenocarcinomas of the lung in smokers.
Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.
Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer.
Use of in vivo bioluminescence and MRI to determine hyperthermia-induced changes in luciferase activity under the control of an hsp70 promoter.
Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice.
Vaccination with B16 tumor cell lysate plus recombinant Mycobacterium tuberculosis Hsp70 induces antimelanoma effect in mice.
Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models.
Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells.
Virus-Like Particle-Drug Conjugates Induce Protective, Long-lasting Adaptive Antitumor Immunity in the Absence of Specifically Targeted Tumor Antigens.
X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
Yeast Two-Hybrid and One-Hybrid Screenings Identify Regulators of hsp70 Gene Expression.
[A study of the inhibition effect of HIFU and its mechanism of action on the proliferation of human breast cancer cells]
[Alterations in cytokinetics and heat shock protein (70 kDa) expression of glial cell by hyperthermia]
[Antitumor therapeutic effect induced by intestine- carcinoma cells vaccine expressing membrane-bound heat shock protein 70]
[Construction of the eukaryotic coexpression vector containing Mycobacterium tuberculosis heat shock protein 70 and green fluorescent protein.]
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
[Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases]
[Expression of Hsp70 and Hdj1 chaperone proteins in human tumor cells]
[Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM]
[Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma]
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics.]
[Heat shock proteins and malignancies of the female genital tract]
[Heat shock proteins: new target in cytoprotective and tumor therapy]
[Hsp70 chaperone and the prospects of its application in anticancer therapy]
[Hsp70-H22 tumor antigen peptide complex activated dendritic cell in the induction of antitumor immunity]
[Immunoregulatory properties of Hsp70].
[In vitro anti-tumor effect of CTL induced by HSP70-Id complex-modified dendritic cells]
[Increase in thermosensitivity of cervical cancer and ovarian cancer cells by HSP70 antisense oligodeoxynucleotides]
[Induction and accumulation of HSP70 leads to formation of its complexes with other cell proteins]
[Influence of HSP70 on combined method of hyperthermia and immunologic effector cells to treat cancer]
[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy]
[Overexpression of heat shock protein 70 and spontaneous cancer cell apoptosis in hepatocellular carcinoma]
[Prognostic significance of heat shock proteins 70 and p27 protein in patients with mucoepidermoid carcinoma]
[Purification of hsp70 and its immunoprotective effect against mouse hepatoma]
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
[The role of extracellular chaperone Hsp70 in creating antitumor immunity in rat rhabdomyosarcoma RA-2 model]
[The role of heat shock proteins 27 and 70 in redox-dependent regulation of apoptosis in Jurkat tumor cells].
[The role of heat shock proteins HSP90 in the response of immune cells to centimeter microwaves]
[The role of Hsp70 chaperone in the reaction of human leukemic cells to anticancer drugs]
[The role of the heat shock protein in human breast cancer]
[The therapeutic efficacy of tumor-derived heat shock protein70 combining interleukin-2 on tumor-bearing mice]
[The virtuoueffect of heat shock protein 70 and evil effect of nuclear factor-kappa B in patients with chronic gastric disease of PI-Wie damp-heat syndrome type]
[Therapeutic effects of B and T lymphocyte attenuator extracellular domain and heat shock protein 70 antigen peptide on cervical cancer in mouse model.]
[Using Hsp70 promoter to regulate target gene expression in tumor]
Neoplasms, Germ Cell and Embryonal
Tetraploid arrest with overexpressed non-mutated p53 in germ cell cancers.
Neoplasms, Neuroepithelial
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Neoplastic Cells, Circulating
An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer.
Nephritis, Interstitial
T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.
Nephrosis, Lipoid
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Nephrotic Syndrome
Heat shock protein 70 and anti-heat shock protein 70 antibodies in patients with chronic glomerulonephritis.
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Nervous System Diseases
Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.
Hsp70 and its molecular role in nervous system diseases.
Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.
Mitochondrial HSP70 Chaperone System-The Influence of Post-Translational Modifications and Involvement in Human Diseases.
Overproduction and biophysical characterization of human HSP70 proteins.
Neuralgia
Proteomic analysis of differential proteins related to the neuropathic pain and neuroprotection in the dorsal root ganglion following its chronic compression in rats.
Neurilemmoma
Binding partners for curcumin in human schwannoma cells: biologic implications.
Combining curcumin (diferuloylmethane) and heat shock protein inhibition for neurofibromatosis 2 treatment: analysis of response and resistance pathways.
Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy.
Neuroblastoma
Activation of the heat shock response in familial amyloidotic polyneuropathy.
BAG-1L Protects SH-SY5Y Neuroblastoma Cells Against Hypoxia/Re-oxygenation Through Up-Regulating HSP70 and Activating PI3K/AKT Signaling Pathway.
Combining curcumin (diferuloylmethane) and heat shock protein inhibition for neurofibromatosis 2 treatment: analysis of response and resistance pathways.
Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation.
Effects of celastrol on Tau hyperphosphorylation and expression of HSF-1 and HSP70 in SH-SY5Y neuroblastoma cells induced by amyloid-? peptides.
Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts.
Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide.
Expression of HSP70 is impaired at the transcriptional level in stressed murine neuroblastoma cells.
Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.
Heat shock protein 70 induction by glutamine increases the ?-synuclein degradation in SH-SY5Y neuroblastoma cells.
High Glucose Content Abrogated the Normal Activity of Heat Shock Protein Signaling Pathway in Human Neuroblastoma Cells.
HSP70 protects human neuroblastoma cells from apoptosis and oxidative stress induced by amyloid peptide isoAsp7-A?(1-42).
In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance.
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells.
Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation.
miR-16-1 promotes the aberrant ?-synuclein accumulation in parkinson disease via targeting heat shock protein 70.
Neuronal cells show regulatory differences in the hsp70 gene response.
Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR.
Release of heat shock proteins from human neuroblastoma cells exposed to acrylamide.
Stress responses of mammalian cells to high hydrostatic pressure.
The discovery of Hsp70 domain with cell-penetrating activity.
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
[Effects of the Hydrogen Sulfide Donor GYY4137 and HSP70 Protein on the Activation of SH-SY5Y Cells by Lipopolysaccharide].
[Exogenous HSP70 and Signaling Pathways Involved in the Inhibition of LPS-Induced Neurotoxicity of Neuroblastoma Cells].
[Heat-shock protein HSP70 decreases activity of proteasomes in human neuroblastoma cells treated by amyloid-beta 1-42 with isomerized Asp7].
[Heat-shock protein HSP70 protects neuroblastoma cells SK-N-SH from the neurotoxic effects hydrogen peroxide and the ?-amyloid peptide].
[Heat-shock protein HSP70 reduces the secretion of TNF? by neuroblastoma cells and human monocytes induced with beta-amyloid peptides].
[Molecular chaperone Hsp70 protects neuroblastoma SK-N-SH cells from hypoxic stress]
[The Effect of Beta-Amyloid Peptides and Main Stress Protein HSP70 on Human SH-SY5Y Neuroblastoma Proteome].
Neurodegenerative Diseases
A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease.
AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury.
alphaB-crystallin (HspB5) in familial amyloidotic polyneuropathy.
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.
Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.
Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators.
Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons.
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis.
Factors Affecting Aggregate Formation in Cell Models of Huntington's Disease and Amyotrophic Lateral Sclerosis.
Formation of toxic oligomeric alpha-synuclein species in living cells.
Function and Chemotypes of Human Hsp70 Chaperones.
Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila.
Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.
Heat shock protein 70 suppresses neuroinflammation induced by ?-synuclein in astrocytes.
Heat shock protein 90: the cancer chaperone.
Heat shock proteins at the crossroads between cancer and Alzheimer's disease.
Heat shock proteins: a therapeutic target worth to consider.
Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease.
HSP70 and HSP90 in neurodegenerative diseases.
Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases.
Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.
Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells.
Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment.
J-domain proteins interaction with neurodegenerative disease-related proteins.
Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis.
Multiple hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity?
Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development.
Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response.
Overexpression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.
Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function.
Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection.
Roles of molecular chaperones in the nervous system.
Stimulatory effect of ?-synuclein on the tau-phosphorylation by GSK-3?.
Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway.
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.
The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
The development of modified human Hsp70 (HSPA1A) and its production in the milk of transgenic mice.
The Fate of Exogenous Human HSP70 Introduced into Animal Cells by Different Means.
The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease.
Therapeutic Effect of Exogenous Hsp70 in Mouse Models of Alzheimer's Disease.
Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies.
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and A? accumulation via enhancement of ERK phosphatase VHR activity.
[The role of heat shock protein 70 in regulating neuroinflammation].
[TRANSFORMATION OF MYASTHENIA GRAVIS INTO AMYOTROPHIC LATERAL SCLEROSIS, OR THEIR CONCOMITANCE? (CASE REVIEW)].
Neuroinflammatory Diseases
Heat shock protein 70 suppresses neuroinflammation induced by ?-synuclein in astrocytes.
Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.
Molecular mechanisms underlying hypothermia-induced neuroprotection.
Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-?B and STAT3.
SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-?B signaling.
Senkyunolide I attenuates oxygen-glucose deprivation/reoxygenation-induced inflammation in microglial cells.
[The role of heat shock protein 70 in regulating neuroinflammation].
Neurologic Manifestations
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Niemann-Pick Disease, Type C
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Niemann-Pick Diseases
Connecting Hsp70, sphingolipid metabolism and lysosomal stability.
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.
Non-alcoholic Fatty Liver Disease
Heat shock protein 70 promotes lipogenesis in HepG2 cells.
Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Obesity
17-DMAG, an Hsp90 inhibitor, ameliorates ovariectomy-induced obesity in rats.
Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein.
Effects of in vitro heat shock on immune cells in diet-induced obese mice.
Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity.
Heat shock response to exercise in pancreatic islets of obese mice.
Maternal obesity in mice not only affects fresh embryo quality but also aggravates injury due to vitrification.
Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats.
Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression.
Plasma HSP70 Levels Correlate with Health Risk Factors and Insulin Resistance in African American Subjects.
[Factors governing development of nonalcoholic fatty liver disease and insulin resistance in obesity].
Obstetric Labor, Premature
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy.
Ocular Hypertension
Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival.
Odontogenic Cysts
HSP70 expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma.
Odontogenic Tumors
HSP70 expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma.
Oligodendroglioma
Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours.
Heat shock protein expression in human gliomas.
Oligodendrogliomas in relation to astrocytes differentiation. Clinicopathologic and immunohistochemical study.
Optic Atrophy
Gene therapy with mitochondrial heat shock protein 70 suppresses visual loss and optic atrophy in experimental autoimmune encephalomyelitis.
Optic Nerve Diseases
AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury.
Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival.
Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Optic Nerve Injuries
HSP70 gene expression in the zebrafish retina after optic nerve injury: a comparative study under heat shock stresses.
HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: Its role in cell survival.
Unilateral optic nerve transection up-regulate Hsp70 protein expression in lateral geniculate nucleus of rats.
Optic Neuritis
Mitochondrial heat shock protein 70: new target for optic neuritis therapy.
Oral Submucous Fibrosis
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Osteoarthritis
Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model.
Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissue.
Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study.
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.
Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.
Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte.
Osteoarthritis, Knee
[Effect of HSP70 on apoptotic of cartilage cells in knee osteoarthritis].
Osteosarcoma
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress.
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell.
Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells.
Expression of heat shock proteins in osteosarcomas.
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis.
Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor.
Influence of ezrin-shRNA in combination with HSP70 on the apoptosis and proliferation of osteosarcoma cells.
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC.
Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.
Role of HSP70 in response to (thermo)radiotherapy: analysis of gene expression in canine osteosarcoma cells by RNA-seq.
Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells.
Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy.
The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells.
The Expression of HSPD1, SCUBE3, CXCL14 and Its Relations with the Prognosis in Osteosarcoma.
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model.
Triptolide reduces the viability of osteosarcoma cells by reducing MKP-1 and Hsp70 expression.
Otitis Media
Heat shock proteins in acute otitis media.
[HSP70 expression of middle ear mucosa in acute suppurative otitis media]
Otitis Media with Effusion
Expression of HSP70 and Its Relation with Other Cytokines in Human Middle Ear Effusion.
Otitis Media, Suppurative
[HSP70 expression of middle ear mucosa in acute suppurative otitis media]
Ototoxicity
17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro.
Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture.
Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise.
Heat shock protein 70 delays gentamicin-induced vestibular hair cell death.
Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death.
Ototoxicity-induced loss of hearing and inner hair cells is attenuated by HSP70 gene transfer.
Ovarian Neoplasms
BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
Bioactive Hexapeptide Reduced the Resistance of Ovarian Cancer Cells to DDP by Affecting HSF1/HSP70 Signaling Pathway.
Combined effects of curcumin and triptolide on an ovarian cancer cell line.
HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer.
Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells.
IgA antibodies to the 27-kDa heat-shock protein in the genital tracts of women with gynecologic cancers.
Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor.
Increased temperature-related adeno-associated virus vectors transduction of ovarian cancer cells - essential signatures of AAV receptor and heat shock proteins.
Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis.
NF-?B p65 promotes ovarian cancer cell proliferation and migration via regulating mortalin.
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models.
Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor.
Proteomic-based identification of HSP70 as a tumor-associated antigen in ovarian cancer.
The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer.
[Increase in thermosensitivity of cervical cancer and ovarian cancer cells by HSP70 antisense oligodeoxynucleotides]
Pancreatic Neoplasms
"Heat shock protein 70 in pancreatic diseases: Friend or foe".
CEA promoter-regulated oncolytic adenovirus-mediated Hsp70 expression in immune gene therapy for pancreatic cancer.
Evolution of novel therapeutic options for pancreatic cancer.
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.
Heat shock proteins in pancreatic diseases.
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics.
Pharmacokinetics and tissue distribution study in mice of triptolide-loaded lipid emulsion and accumulation effect on pancreas.
Possible involvement of HSP70 in pancreatic cancer cell proliferation after heat exposure and impact on RFA postoperative patient prognosis.
Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
Radiofrequency ablation in combination with an mTOR inhibitor restrains pancreatic cancer growth induced by intrinsic HSP70.
Radiofrequency ablation, heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers: a minireview.
Serum HSP70: A Novel Biomarker for Early Detection of Pancreatic Cancer.
The HSP70 and Autophagy Inhibitor Pifithrin-? Enhances the Antitumor Effects of TRAIL on Human Pancreatic Cancer.
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.
Pancreatitis
"Heat shock protein 70 in pancreatic diseases: Friend or foe".
Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1.
ANP preconditioning does not increase protection against experimental pancreatitis, observed after general anesthesia and jugular vein catheterization.
Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells.
Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas.
Dopamine D2 receptor activator quinpirole protects against trypsinogen activation during acute pancreatitis via upregulating HSP70.
Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis.
Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-?B in rats subjected to experimental pancreatitis - influence of HSP70.
Extracellular heat-shock protein 70 aggravates cerulein-induced pancreatitis through toll-like receptor-4 in mice.
Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells.
Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation.
Heat shock proteins in pancreatic diseases.
Heat shock response is associated with protection against acute interstitial pancreatitis in rats.
High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis.
Hyperthermia induces multiple pancreatic heat shock proteins and protects against subsequent arginine-induced acute pancreatitis in rats.
Prior peritoneal lavage with hot 0.9 % saline induces HSP70 expression and protects against cerulein-induced acute pancreatitis in rats.
Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation.
Spontaneous activation of pancreas trypsinogen in heat shock protein 70.1 knock-out mice.
Tethered Lipid Membranes as a Nanoscale Arrangement towards Non-Invasive Analysis of Acute Pancreatitis.
Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats.
Total parenteral nutrition attenuates cerulein-induced pancreatitis in rats.
[The expression of HSP-70 gene in exocrine pancreas of the rats suffering from acute necrotizing pancreatitis]
Pancreatitis, Acute Necrotizing
[The expression of HSP-70 gene in exocrine pancreas of the rats suffering from acute necrotizing pancreatitis]
Pancreatitis, Chronic
Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride.
Papilloma
Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy.
The effects of treated effluents on the intensity of papillomatosis and HSP70 expression in roach.
Papillomavirus Infections
An immunohistochemical analysis of heat shock protein 70, p53, and estrogen receptor status in carcinoma of the uterine cervix.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Paralysis
Heat shock proteins HSP70 and HSP27 in the cerebral spinal fluid of patients undergoing thoracic aneurysm repair correlate with the probability of postoperative paralysis.
In vivo modification of Na(+),K(+)-ATPase activity in Drosophila.
[Effect of electroacupuncture on expression of heat shock protein 70 in mice with amyotrophic lateral sclerosis].
Parasitic Diseases
The humoral response to heat shock protein 70 in human and murine Schistosomiasis mansoni.
Paratuberculosis
Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis.
Early infection dynamics after experimental challenge with Mycobacterium avium subspecies paratuberculosis in calves reveal limited calf-to-calf transmission and no impact of Hsp70 vaccination.
Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattle.
Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis.
Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis.
Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis.
Mycobacterial 70kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis.
Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells.
Parkinson Disease
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.
Applying chaperones to protein-misfolding disorders: molecular chaperones against ?-synuclein in Parkinson's disease.
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.
Chaperoning brain degeneration.
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.
Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease.
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
Exogenous protein HSP70 blocks neurodegeneration in the rat model of the clinical stage of Parkinson's disease.
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
Glutamine promotes Hsp70 and inhibits ?-Synuclein accumulation in pheochromocytoma PC12 cells.
Heat shock protein 70 induction by glutamine increases the ?-synuclein degradation in SH-SY5Y neuroblastoma cells.
Heat shock protein 70 reduces ?-synuclein-induced predegenerative neuronal dystrophy in the ?-synuclein viral gene transfer rat model of Parkinson's disease.
Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease.
Hsp70 molecular chaperones and Parkinson's disease.
Human Hsp70 Disaggregase Reverses Parkinson's-Linked ?-Synuclein Amyloid Fibrils.
Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.
Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment.
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Kinetic and structural characterization of human mortalin.
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.
Molecular Chaperones as Rational Drug Targets for Parkinson's Disease Therapeutics.
Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-?B and STAT3.
Retraction: DJ-1 Modulates ?-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70.
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.
[EFFECT OF QUERCETIN ON NEURODEGENERATIVE AND COMPENSATORY PROCESSES IN NIGROSTRIATAL SYSTEM IN A MODEL OF PRECLINICAL PARKINSON''S DISEASE STAGE IN RATS].
[The Major Human Stress Protein Hsp70 as a Factor of Protein Homeostasis and a Cytokine-Like Regulator].
Parkinsonian Disorders
Parkin mediates the degradation-independent ubiquitination of Hsp70.
Pemphigoid, Benign Mucous Membrane
Heat shock protein expression in human conjunctiva.
Pemphigoid, Bullous
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Pemphigus
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus?
Pemphigus serum and captopril induce heat shock protein 70 and inducible nitric oxide synthase overexpression, triggering apoptosis in human keratinocytes.
Peptic Ulcer
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
Periodontal Pocket
Effects of Initial Periodontal Therapy on Heat Shock Protein 70 Levels in Gingival Crevicular Fluid from Periodontitis Patients.
Putative heat shock protein 70 gene from Actinobacillus actinomycetemcomitans: molecular cloning and sequence analysis of its gene.
Periodontitis
Effects of Initial Periodontal Therapy on Heat Shock Protein 70 Levels in Gingival Crevicular Fluid from Periodontitis Patients.
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers.
[Serum, oral and gingival fluid levels of heat shock protein-70, cytokines and their autoantibodies by periodontal disease].
Peripheral Arterial Disease
Hsp70 expression in monocytes from patients with peripheral arterial disease and healthy controls : Monocyte Hsp70 in PAD.
Serum level of soluble Hsp70 is associated with vascular calcification.
Peripheral Nerve Injuries
Tanespimycin with bortezomib: activity in relapsed/refractory patients with multiple myeloma.
Peritoneal Fibrosis
HSP70 inhibits high glucose-induced Smad3 activation and attenuates epithelial-to-mesenchymal transition of peritoneal mesothelial cells.
Peritonitis
Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.
HSP70 is a negative regulator of NLRP3 inflammasome activation.
The immune response differentially regulates Hsp70 and glucocorticoid receptor expression in vitro and in vivo in common carp (Cyprinus carpio L.).
Persistent Infection
Dynamics of heat shock protein 70 concentrations in peripheral blood lymphocyte lysates during pregnancy in lactating Holstein-Friesian cows.
Pheochromocytoma
A standardized extract of Asparagus officinalis stem improves HSP70-mediated redox balance and cell functions in bovine cumulus-granulosa cells.
Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein.
Glutamine promotes Hsp70 and inhibits ?-Synuclein accumulation in pheochromocytoma PC12 cells.
HSP70 induction by bleomycin metal core analogs.
HSP70 inhibitor VER155008 suppresses pheochromocytoma cell and xenograft growth by inhibition of PI3K/AKT/mTOR and MEK/ERK pathways.
Neuroprotective effect of dipeptide AVP(4-5)-NH2 is associated with nerve growth factor and heat shock protein HSP70.
Silencing of Hsp70 Intensifies 6-OHDA-Induced Apoptosis and Hsp90 Upregulation in PC12 Cells.
Plasmacytoma
[Changes in the transcription activity of c-myc genes and heat shock proteins (HSP 70) after incubation of mouse plasmacytoma cells with dexamethasone]
Pleural Effusion
Concentrations of SP-A and HSP70 are associated with polarization of macrophages in pleural effusions of non-small cell lung cancer.
Pneumoconiosis
Polymorphisms in Heat-shock Protein 70 Genes Are Associated with Coal Workers' Pneumoconiosis in Southwestern China.
[Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker]
Pneumonia
Heat shock response and acute lung injury.
Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins.
Identification of Candidate Genes Downstream of TLR4 Signaling after Ozone Exposure in Mice: A Role for Heat-Shock Protein 70.
The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.
Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat.
Polymyositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Polyneuropathies
alphaB-crystallin (HspB5) in familial amyloidotic polyneuropathy.
Porcine Reproductive and Respiratory Syndrome
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication.
Encoded novel forms of HSP70 or a cytolytic protein increase DNA vaccine potency.
HSP70 fused with GP3 and GP5 of porcine reproductive and respiratory syndrome virus enhanced the immune responses and protective efficacy against virulent PRRSV challenge in pigs.
Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro.
Small interfering RNA based knock down of acute heat shock and or GGA inducible bovine heat shock protein 70 may interfere invitro expression pattern of TLR2/4 and NOD1/2.
Pre-Eclampsia
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Expression of heat shock protein 70 and endothelial nitric oxide synthase in placental tissue of preeclamptic and intrauterine growth-restricted pregnancies.
Genomic and proteomic investigation of preeclampsia.
Higher expression of HSP70 and LOX-1 in the placental tissues of pre-eclampsia pregnancies.
HSP70-mediated control of endothelial cell apoptosis during pre-eclampsia.
Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia.
Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia.
Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms?
Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia.
Over expression of HSP70 and HSF1 in endothelial cells during pre-eclamptic placental stress.
Serum heat shock protein 70 in preeclampsia and normal pregnancy: A systematic review and meta-analysis.
Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia.
SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death.
The Role of Hsp70 in the Regulation of Autophagy in Gametogenesis, Pregnancy, and Parturition.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antileukemic activity of the HSP70 inhibitor pifithrin-? in acute leukemia.
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity.
Suppression of HSP70 inhibits the development of acute lymphoblastic leukemia via TAK1/Egr-1.
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
Pregnancy Complications
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Premature Birth
Functional analysis of HSPA1A and HSPA8 in parturition.
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
HSP70: an alarmin that does not induce high rates of preterm birth but does cause adverse neonatal outcomes.
The Role of Hsp70 in the Regulation of Autophagy in Gametogenesis, Pregnancy, and Parturition.
Premenstrual Dysphoric Disorder
Luteal serum BDNF and HSP70 levels in women with premenstrual dysphoric disorder.
Primary Ovarian Insufficiency
The Role of Hsp70 in the Regulation of Autophagy in Gametogenesis, Pregnancy, and Parturition.
Prion Diseases
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
Prostatic Neoplasms
Abrogation of heat-shock protein (HSP)70 expression induced cell growth inhibition and apoptosis in human androgen-independent prostate cancer cell line PC-3m.
Association of HSP70-hom genetic variant with prostate cancer risk.
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR.
Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells.
Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells.
Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein.
Effects of dihydroartemisinin on HSP70 expression in human prostate cancer PC-3 cells.
Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells.
Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.
Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer.
Hsp70 binds to the androgen receptor N-terminal domain and modulates the receptor function in prostate cancer cells.
Human prostate stem cell antigen and HSP70 fusion protein vaccine inhibits prostate stem cell antigen-expressing tumor growth in mice.
Immunogenicity of 56 degrees C and UVC-treated prostate cancer is associated with release of HSP70 and HMGB1 from necrotic cells.
Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer.
Mechanochemical Disruption Suppresses Metastatic Phenotype and Pushes Prostate Cancer Cells toward Apoptosis.
Pifithrin-?, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.
Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer.
The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90? and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth.
The loss of CD44 and HSP70 overexpression is related to aggressive clinicopathologic factors in prostate cancer.
Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice.
[Anti-proliferative effects of heating on the human prostatic carcinoma cells in culture]
Prostatitis
Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome.
Protein-Energy Malnutrition
Honey can repairing damage of liver tissue due to protein energy malnutrition through induction of endogenous stem cells.
Proteinuria
Heat shock protein 70 and anti-heat shock protein 70 antibodies in patients with chronic glomerulonephritis.
Proteostasis Deficiencies
An RNA Aptamer Specific to Hsp70-ATP Conformation Inhibits its ATPase Activity Independent of Hsp40.
Hierarchical Functional Specificity of Cytosolic Heat Shock Protein 70 (Hsp70) Nucleotide Exchange Factors in Yeast.
Pseudorabies
Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression.
Effects of replacing the promoter of the immediate early gene with the promoter of Drosophila heat-shock gene HSP70 on the growth and virulence of pseudorabies virus.
Psoriasis
Effect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgaris.
Possible role of Malassezia furfur in psoriasis: modulation of TGF-beta1, integrin, and HSP70 expression in human keratinocytes and in the skin of psoriasis-affected patients.
Structure-Based Drug Designing and Simulation Studies for Finding Novel Inhibitors of Heat Shock Protein (HSP70) as Suppressors for Psoriasis.
Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation.
Pulmonary Arterial Hypertension
Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.
Pulmonary Disease, Chronic Obstructive
COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study.
Effects of extracellular Hsp70 and cigarette smoke on differentiated THP-1 cells and human monocyte-derived macrophages.
Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction.
Expression of heat stress protein 70 mRNA in patients with chronic obstructive pulmonary disease and its significance.
Extracellular Hsp70 induces inflammation and modulates LPS/LTA-stimulated inflammatory response in THP-1 cells.
Extracellular Hsp70 modulates the inflammatory response of CSE in NCI-H292 cells.
Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases.
Hsp27 and Hsp70 in chronic obstructive pulmonary disease: certainties vs doubts.
Increased HSP70 and TLR2 Gene Expression and Association of HSP70 rs6457452 Single Nucleotide Polymorphism with the Risk of Chronic Obstructive Pulmonary Disease in the Croatian Population.
Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids.
Pathogen-associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations.
Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients.
Pro-inflammatory effects of extracellular Hsp70 on NCI-H292 human bronchial epithelial cell line.
Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease.
Response to: Hsp27 and Hsp70 in chronic obstructive pulmonary disease.
Serum Heat Shock Protein Levels and the Relationship of Heat Shock Proteins with Various Parameters in Chronic Obstructive Pulmonary Disease Patients.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Pulmonary Edema
Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions.
Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters.
Pulmonary Embolism
Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
Pulmonary Fibrosis
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.
Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.
Serum levels of heat shock protein 70, a biomarker of cellular stress, are elevated in patients with systemic sclerosis: association with fibrosis and vascular damage.
Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.
Rabies
Hsp70 protein positively regulates Rabies Virus infection.
Rectal Diseases
Heat shock protein 70 is a useful marker for predicting colorectal cancer.
Rectal Neoplasms
Preoperative treatment of rectal cancer with radiation, chemotherapy and hyperthermia: analysis of treatment efficacy and heat-shock response.
Renal Insufficiency
Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Oxidative stress and cellular stress response in diabetic nephropathy.
Renal Insufficiency, Chronic
HSP27 and HSP70 serum and urine levels in patients suffering from chronic kidney disease.
The Ratio of Osteoprotegerin to Fetuin-A Is Independently Associated with Vascular Stiffness in Hemodialysis Patients.
Reperfusion Injury
Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1? synthesis.
CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.
Cyclic Helix B Peptide in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia-Reperfusion Injury in Isolated Porcine Kidneys.
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury.
Heat shock pretreatment protects pulmonary isografts from subsequent ischemia-reperfusion injury.
Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury.
Heat shock protein 70 induced by heat stress protects heterotopically transplanted hearts in rats.
Heat Shock Protein 70 Messenger RNA in Rat Leukocytes Elevates After Severe Intestinal Ischemia-Reperfusion.
How does moxibustion possibly work?
HSP70 silencing aggravates apoptosis induced by hypoxia/reoxygenation in vitro.
IL-17A mediates early post-transplant lesions after heterotopic trachea allotransplantation in Mice.
In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat.
Is HSP70 involved in nitric oxide-induced protection of the heart?
Knockdown of miR-384-3p Protects Against Myocardial Ischemia-Reperfusion Injury in Rats Through Targeting HSP70.
Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise.
Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats.
Plasma exosomes protect against cerebral ischemia/reperfusion injury via exosomal HSP70 mediated suppression of ROS.
Preconditioning somatothermal stimulation on right seventh intercostal nerve territory increases hepatic heat shock protein 70 and protects the liver from ischemia-reperfusion injury in rats.
Prior induction of heat shock proteins by a nitric oxide donor attenuates cardiac ischemia/reperfusion injury in the rat.
Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1.
Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice.
Role of priming stresses and Hsp70 in protection from ischemia-reperfusion injury in cardiac and skeletal muscle.
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.
TGF-beta1 release by volatile anesthetics mediates protection against renal proximal tubule cell necrosis.
The role of microRNA in modulating myocardial ischemia-reperfusion injury.
The use of transgenic mice to study cytoprotection by the stress proteins.
Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
[Antiarrhythmic effect of oligonucleotides accompanied by activation of HSP70 protein in the heart of rats].
[Effect of baicalin on HSP70 expression of hippocampal neurons in focal brain ischemia-reperfusion injury rats]
[Effect of electroacupuncture on free radical content and HSP70 expression in the brain tissue in rats with cerebral ischemia-reperfusion injury]
[Effects of Naomaitong Recipe on expressions of nuclear factor-kappaB and nitric-oxide synthases in brain tissue after focal cerebral ischemia reperfusion in aged rats.]
[Expression of the heat shock protein-70 in the myocardial cells of cyanosis congenital heart diseases]
Reproductive Tract Infections
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Heat shock proteins on the human sperm surface.
Respiratory Distress Syndrome
Inducibility of the 70 kD heat shock protein in peripheral blood monocytes is decreased in human acute respiratory distress syndrome and recovers over time.
Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid.
Retinal Degeneration
Divergent Effects of HSP70 Overexpression in Photoreceptors During Inherited Retinal Degeneration.
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins.
Retinal Detachment
Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase.
Retinoblastoma
Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.
Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation.
Rhabdomyosarcoma
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.
HSP70 dependence in rhabdomyosarcoma: Seed or soil?
[The role of extracellular chaperone Hsp70 in creating antitumor immunity in rat rhabdomyosarcoma RA-2 model]
Rheumatic Diseases
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases.
Rhinitis, Allergic
Correlations Between the Adenotonsillar Microbiome and Clinical Characteristics of Pediatric Patients With Snoring.
Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis.
Rotavirus Infections
Hsp70 negatively controls rotavirus protein bioavailability in caco-2 cells infected by the rotavirus RF strain.
Salmonella Infections
Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death.
Intraperitoneal immunization of recombinant HSP70 (DnaK) of Salmonella Typhi induces a predominant Th2 response and protective immunity in mice against lethal Salmonella infection.
Salpingitis
Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion.
Sandhoff Disease
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Sarcoidosis
Genetic polymorphisms of the TNFB and HSP70 genes located in the human major histocompatibility complex in sarcoidosis.
Sarcoidosis, Pulmonary
Antibodies to heat shock proteins in patients with pulmonary sarcoidosis.
Sarcoma
Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.
Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.
Prophylactic Antitumor Effect of Mixed Heat Shock Proteins/Peptides in Mouse Sarcoma.
Stress-induced proteins in immune response to cancer.
Sarcoma, Avian
Induction of hsp 72/73 by herbimycin A, an inhibitor of transformation by tyrosine kinase oncogenes.
The transcriptional inhibitors, actinomycin D and alpha-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain.
Sarcopenia
Cross-sectional associations among P3NP, HtrA, Hsp70, Apelin and sarcopenia in Taiwanese population.
Schistosomiasis
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
The humoral response to heat shock protein 70 in human and murine Schistosomiasis mansoni.
Schistosomiasis mansoni
A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70.
Scleroderma, Systemic
Serum levels of heat shock protein 70, a biomarker of cellular stress, are elevated in patients with systemic sclerosis: association with fibrosis and vascular damage.
Scrapie
Changes in HSP gene and protein expression in natural scrapie with brain damage.
Seizures
Assessment of the levels of serum Hsp 70 and ghrelin in children with simple febrile convulsions.
c-fos antisense oligonucleotide prevents delayed induction of hsp70 mRNA after soman-induced seizures.
cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain.
Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity.
Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade.
Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy.
DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase.
Ectopic expression of Miro 1 ameliorates seizure and inhibits hippocampal neurodegeneration in a mouse pilocarpine epilepsy model.
Effects of GLP-1 Receptor Activation on a Pentylenetetrazole-Kindling Rat Model.
Effects of metformin on apoptosis and ?-synuclein in a rat model of pentylenetetrazole-induced epilepsy.
Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo.
Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain.
Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.
Genetic Modulation of HSPA1A Accelerates Kindling Progression and Exerts Pro-convulsant Effects.
Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70.
Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-?B activation-induced nitric oxide synthase II expression.
Hippocampal expression of heat shock proteins in mesial temporal lobe epilepsy with psychiatric comorbidities and their relation to seizure outcome.
HSP70 heat shock gene regulation during ischemia.
HSP70 protects rats and hippocampal neurons from central nervous system oxygen toxicity by suppression of NO production and NF-?B activation.
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Induction of heat shock (stress) genes in the mammalian brain by hyperthermia and other traumatic events: a current perspective.
Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat.
Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.
l-Carnitine Modulates Epileptic Seizures in Pentylenetetrazole-Kindled Rats via Suppression of Apoptosis and Autophagy and Upregulation of Hsp70.
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Pentylenetetrazol-kindling in mice overexpressing heat shock protein 70.
Responses of heat shock proteins hsp27, alphaB-crystallin, and hsp70 in rat brain after kainic acid-induced seizure activity.
Stress proteins as molecular markers of neurotoxicity.
Time course and regional expression of C-FOS and HSP70 in hippocampus and piriform cortex following soman-induced seizures.
[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]
Seizures, Febrile
Assessment of the levels of serum Hsp 70 and ghrelin in children with simple febrile convulsions.
Sepsis
17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats.
An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators.
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis.
Cardiac and hepatic role of r-AtHSP70: basal effects and protection against ischemic and sepsis conditions.
Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo.
Damage-associated molecular patterns and immune activation in bipolar disorder.
Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis.
Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis.
Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis.
Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.
Glutamine's protection against brain damage in septic rats via increased protein oxygen-N-acetylglucosamine modification.
Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression.
Heat shock protein 70 expression protects against sepsis-associated cardiomyopathy by inhibiting autophagy.
Heat shock proteins: a history of study in Russia.
Immunoparalysis: Clinical and immunological associations in SIRS and severe sepsis patients.
Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats.
lncRNA RMRP Prevents Mitochondrial Dysfunction and Cardiomyocyte Apoptosis via the miR-1-5p/hsp70 Axis in LPS-Induced Sepsis Mice.
Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis.
Oxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target.
Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells.
Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels.
Serum HSP70 Levels, Oxidant Status and Mortality in Sepsis.
Soluble heat shock protein 70 members in patients undergoing allogeneic hematopoietic cell transplantation.
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
The effect of 2 mMol glutamine supplementation on HSP70 and TNF-? release by LPS stimulated blood from healthy children.
The Heat Shock Protein 70 Plays a Protective Role in Sepsis by Maintenance of the Endothelial Permeability.
The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.
The Role of HSP70 in the Protective Effects of NVP-AUY922 on Multiple Organ Dysfunction Syndrome in Endotoxemic Rats.
Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release.
Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.
[Effect of ketamine on endotoxin-induced septic shock in rats and its mechanism]
[Participation of heat shock proteins in modulation of NF-?B transcription factor activation during bacterial infections].
Severe Combined Immunodeficiency
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
Sezary Syndrome
Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity.
Shock, Septic
Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats.
Extracellular hsp70 levels in children with septic shock.
Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype.
Heat shock protein (HSP70) expression in septic patients.
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex.
[Effect of ketamine on endotoxin-induced septic shock in rats and its mechanism]
[The effect of ketamine on the expression of HSP70 induced by endotoxin in liver of rat]
Skin Diseases
Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis.
Pathogenic Cx31 is un/misfolded to cause skin abnormality via a Fos/JunB-mediated mechanism.
Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation.
Skin Neoplasms
Autoantibodies against p53, MMP-7, and Hsp70 as Potential Biomarkers for Detection of Nonmelanoma Skin Cancers.
Sleep Apnea, Obstructive
The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review.
Sleep Deprivation
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
[Chaperones in regulation and restoration of physiological functions].
[Protein 70 kDa in control of sleep and thermoregulation]
Small Cell Lung Carcinoma
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Spinal Cord Diseases
Quantitative assessment of hsp70, IL-1? and TNF-? in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy.
Spinal Cord Injuries
Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat.
Effects of glutamine supplementation on muscle function and stress responses in a mouse model of spinal cord injury.
Involvement of the choroid plexus in the inflammatory response after acute spinal cord injury in dogs: An immunohistochemical study.
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice.
Low?frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury.
Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury model in vitro.
Spinal cord trauma activates processing of xbp1 mRNA indicative of endoplasmic reticulum dysfunction.
Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression.
[An experimental research of hyperthermic preconditioning on the spinal cord injury]
Spinal Cord Ischemia
Tat-HSP70 protects neurons from oxidative damage in the NSC34?cells and ischemic damage in the ventral horn of rabbit spinal cord.
Spinocerebellar Ataxias
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7.
Mutant ?PKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity.
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
Spondylarthropathies
Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies.
Spondylitis, Ankylosing
Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.
HSP70 gene polymorphisms in ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Expression of 70-kDa heat shock protein in oral lesions: marker of biological stress or pathogenicity.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance.
Heat Shock Protein 70 Membrane Expression in Oral Cancer: A Possible New Target in Antineoplastic Therapy?
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC?3 cells.
HSP70 induces TLR4 signaling in oral squamous cell carcinoma: an immunohistochemical study.
Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells.
mRNA levels of molecular chaperones hsp27, hsp60 and hsp70 in cisplatin resistant squamous cell carcinomas.
[Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma]
Starvation
A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs.
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging.
CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation.
Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus.
Differential expression of heat shock proteins and antioxidant enzymes in response to temperature, starvation, and parasitism in the Carob moth larvae, Ectomyelois ceratoniae (Lepidoptera: Pyralidae).
Differential expression of insect and plant specific adhesin genes, Mad1 and Mad2, in Metarhizium robertsii.
Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults.
Effects of cyclical short-term food deprivation and refeeding on compensatory growth and gene expression of SOD, GPX and HSP70 in Schizothorax wangchiachii.
Exposure to a heat wave under food limitation makes an agricultural insecticide lethal: a mechanistic laboratory experiment.
Functional inhibition of heat shock protein 70 by VER-155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism.
Gene transcription during exposure to, and recovery from, cold and desiccation stress in Drosophila melanogaster.
Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Identification and expression analysis of a heat-shock protein 70 gene in Polycelis sp.
Metabolic modulation in Labeo rohita fingerlings during starvation: Hsp70 expression and oxygen consumption
Mutual exclusion of apoptosis and hsp70 in human vein intimal hyperplasia in vitro.
Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of Hsp70 by decreased mRNA stability.
Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy.
RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.
Role of Escherichia coli heat shock proteins DnaK and HtpG (C62.5) in response to nutritional deprivation.
Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells.
Temporal changes in superoxide dismutase, catalase, and heat shock protein 70 gene expression, cortisol and antioxidant enzymes activity of Labeo rohita fingerlings subjected to starvation and refeeding.
The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformans.
The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response.
The serum-induced phosphorylation of mammalian hsp27 correlates with changes in its intracellular localization and levels of oligomerization.
Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised.
Status Epilepticus
Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity.
Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model.
Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-?B activation-induced nitric oxide synthase II expression.
HSP70 heat shock gene regulation during ischemia.
Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat.
Stomach Neoplasms
Canine Gastric Carcinoma: Immunohistochemical Expression of Cell Cycle Proteins (p53, p21, and p16) and Heat Shock Proteins (Hsp27 and Hsp70).
Clinical significance of heat shock proteins in gastric cancer following hyperthermia stress: Indications for hyperthermic intraperitoneal chemoperfusion therapy.
Co-expression of heat shock protein 70 and glucose-regulated protein 94 in human gastric carcinoma cell line BGC-823.
Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.
Extracellular HSP70 blocks CD40L-induced apoptosis and tubular formation in endothelial cells.
Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901.
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis.
Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.
Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.
HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells.
Inducible HSP70 antagonizes cisplatin?induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC?27 cells.
Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients.
Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer.
Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.
Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation.
RNA interference-mediated silencing of the Hsp70 gene inhibits human gastric cancer cell growth and induces apoptosis in vitro and in vivo.
Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy.
[Preparation of chaperone-antigen peptide vaccine derived from human gastric cancer stem cells and its immune function].
Stomach Ulcer
Cholesteryl glucoside-induced protection against gastric ulcer.
Effect of jianpiyiqi prescription on the expression of heat shock proteins in acetic acid-induced chronic gastric ulcer rats.
Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells.
Effects of transportation on expression of Hsp90, Hsp70, Hsp27 and {alpha}B-crystallin in the pig stomach.
Expression and immunolocalization of heat shock proteins in the healing of gastric ulcers in rats.
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
Protective role of HSP70 against various gastrointestinal diseases.
Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing.
Role of heat shock proteins in gastric inflammation and ulcer healing.
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
Stimulation of gastric ulcer healing by heat shock protein 70.
Tryptophan free diet delays healing of chronic gastric ulcers in rat.
Stroke
A prospective evaluation of the heat shock protein 70 gene polymorphisms and the risk of stroke.
Alterations of Brain Quantitative Proteomics Profiling Revealed the Molecular Mechanisms of Diosgenin against Cerebral Ischemia Reperfusion Effects.
Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection.
C-Terminus of HSC70 Interacting Protein Increases Following Stroke and Impairs Survival Against Acute Oxidative Stress.
Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.
Cofilin-actin rod formation in experimental stroke is attenuated by therapeutic hypothermia and overexpression of the inducible 70 kD inducible heat shock protein (Hsp70).
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Delayed intervention in experimental stroke with TRC051384 - A small molecule HSP70 inducer.
Diazoxide increases liver and kidney HSP25 and HSP70 after shock and stroke.
Diazoxide, as a postconditioning and delayed preconditioning trigger, increases HSP25 and HSP70 in the central nervous system following combined cerebral stroke and hemorrhagic shock.
Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke.
Exploring molecular mechanism underlying Chinese medicine syndrome: A study on correlation between Chinese medicine syndrome and biomarkers for ischemic stroke.
Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.
Heat shock protein signaling in brain ischemia and injury.
Heat shock proteins: a history of study in Russia.
Hsp70 promotes synaptic transmission in brain slices damaged by contact with blood clot.
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Increased oxidative protein and DNA damage but decreased stress response in the aged brain following experimental stroke.
Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways.
Localization of 70-kDa stress protein induction in gerbil brain after ischemia.
Many mechanisms for hsp70 protection from cerebral ischemia.
Neuroprotective effects of heat shock protein70.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
The Antiapoptotic Actions of Mood Stabilizers: Molecular Mechanisms and Therapeutic Potentials.
[A study on relationship between plasma heat stress protein 70 and cytokine in patients with heat apoplexy]
[Distribution of 70kDa heat shock protein in rabbit brains after heat stress and heat stroke]
Stupor
[Role of heat-shock proteins of Hsp70 family in changes of narcotic activity of hyperbaric nitrogen during increasing hypoxic stimulus]
Subarachnoid Hemorrhage
Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood.
Hypothermia modulates induction of hsp70 and c-jun mRNA in the rat brain after subarachnoid hemorrhage.
Induction of HSP70 in rat brain following subarachnoid hemorrhage produced by endovascular perforation.
Subarachnoid hemorrhage induces c-fos, c-jun and hsp70 mRNA expression in rat brain.
Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain.
Synucleinopathies
Formation of toxic oligomeric alpha-synuclein species in living cells.
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy.
Tauopathies
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Hsp70 alters tau function and aggregation in an isoform specific manner.
Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases.
Tendinopathy
Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis.
Teratocarcinoma
Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival.
Tetanus
Generation and characterization of monoclonal antibodies specific for members of the mammalian 70-kDa heat shock protein family.
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells.
Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo.
The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.
Thrombosis
Heat shock protein 70 (Hsp70) regulates platelet integrin activation, granule secretion and aggregation.
Hsp70 preventing thrombosis: benefit without burden?
Hsp70 promotes synaptic transmission in brain slices damaged by contact with blood clot.
Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Inducing heat shock protein 70 expression provides a robust antithrombotic effect with minimal bleeding risk.
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling.
Thyroid Cancer, Papillary
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
Thyroid Carcinoma, Anaplastic
Hsp70 inhibition potentiates radicicol-induced cell death in anaplastic thyroid carcinoma cells.
The hsp70 inhibitor VER155008 induces paraptosis requiring de novo protein synthesis in anaplastic thyroid carcinoma cells.
Thyroid Neoplasms
Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment.
Tinnitus
Tinnitus, hearing loss and inflammatory processes in an older Portuguese population.
Tongue Neoplasms
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
Toxoplasmosis
Ginseng Stem-and-Leaf Saponin (GSLS)-Enhanced Protective Immune Responses Induced by Toxoplasma gondii Heat Shocked Protein 70 (HSP70) Against Toxoplasmosis in Mice.
IL17A-deficient mice are highly susceptible to Toxoplasma gondii infection due to excessively induced T. gondii HSP70 and IFN-? production.
Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70.
Use of immunological methods to the detection of toxoplasmosis and heat shock protein HSP70 in men.
Toxoplasmosis, Cerebral
Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis.
Trauma, Nervous System
Heat shock proteins and neuroprotection.
Hsp70 and its molecular role in nervous system diseases.
The neuroprotective potential of heat shock protein 70 (HSP70).
Triple Negative Breast Neoplasms
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Tuberculosis
A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice.
A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.
A novel vaccine strategy to induce mycobacterial antigen-specific Th1 responses by utilizing the C-terminal domain of heat shock protein 70.
A Recombinant Trivalent Fusion Protein F1-LcrV-HSP70(II) Augments Humoral and Cellular Immune Responses and Imparts Full Protection against Yersinia pestis.
A synthetic dengue virus antigen elicits enhanced antibody titers when linked to, but not mixed with, Mycobacterium tuberculosis HSP70 domain II.
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice.
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HBV DNA vaccine.
Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24.
An hsp70 fusion protein vaccine potentiates the immune response against Japanese encephalitis virus.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Biotechnology in the development of new vaccines and diagnostic reagents against tuberculosis.
C-terminal heat shock protein 70 of Mycobacterium tuberculosis as a molecular adjuvant for DNA vaccination with the porcine circovirus type 2 ORF2 (capsid) gene in mice.
CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.
Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70.
Chaperone-mediated inhibition of tubulin self-assembly.
Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement.
Cloning, expression and purification of the influenza A (H9N2) virus M2e antigen and truncated Mycobacterium tuberculosis HSP70 as a fusion protein in Pichia pastoris.
Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70.
Comparative study on the immunogenicity between Hsp70 DNA vaccine and Hsp65 DNA vaccine in human Mycobacterium tuberculosis.
Comparison of immunogenicity and vaccine efficacy between heat-shock proteins, HSP70 and GrpE, in the DnaK operon of Mycobacterium tuberculosis.
Comparison of PSA-specific CD8+ CTL responses and antitumor immunity generated by plasmid DNA vaccines encoding PSA-HSP chimeric proteins.
Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors.
Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.
Efficient activation of human T cells of both CD4 and CD8 subsets by urease-deficient recombinant Mycobacterium bovis BCG that produced a heat shock protein 70-M. tuberculosis-derived major membrane protein II fusion protein.
Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.
Evaluation of heat shock proteins for discriminating between latent tuberculosis infection and active tuberculosis: A preliminary report.
Expression of foreign gene in mycobacterium regulated by human Mycobacterium tuberculosis heat shock protein 70 promoter.
Flagellin contamination of recombinant heat shock protein 70 is responsible for its activity on T cells.
Fusion expression of major antigenic segment of JEV E protein-hsp70 and the identification of domain acting as adjuvant in hsp70.
Fusion of HSP70 gene of Mycobacterium tuberculosis to hemagglutinin (H5) gene of avian influenza virus in DNA vaccine enhances its potency.
Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo.
Heat shock protein 70/MAGE-3 fusion protein vaccine can enhance cellular and humoral immune responses to MAGE-3 in vivo.
Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.
Heterologous expression, purification and characterization of the influenza A virus M2e gene fused to Mycobacterium tuberculosis HSP70(359-610) in prokaryotic system as a fusion protein.
HSP70 domain II of Mycobacterium tuberculosis modulates immune response and protective potential of F1 and LcrV antigens of Yersinia pestis in a mouse model.
Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects.
Identification of human T cell epitopes in the Mycobacterium leprae heat shock protein 70-kD antigen.
Identification of mycobacterial HSP70 reactive human T cell clones discriminating between M. tuberculosis and M. leprae.
Immunogenicity and protective efficacy of recombinant M2e.Hsp70c (Hsp70(359-610)) fusion protein against influenza virus infection in mice.
In contrast to conventional inactivated influenza vaccines, 4xM2e.HSP70c fusion protein fully protected mice against lethal dose of H1, H3 and H9 influenza A isolates circulating in Iran.
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes.
Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone.
Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection.
Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.
Protective efficacy of a DNA vaccine construct encoding the VP2 gene of infectious bursal disease and a truncated HSP70 of Mycobacterium tuberculosis in chickens.
Short-term Follow-up of Chagasic Patients after Benznidazole Treatment Using Multiple Serological Markers.
The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo.
The construction of Schistosoma japonicum vaccine BCG-Sj26GST and its identification.
The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system.
The preparation of HL-60 cells vaccine expressing BCG heat shock protein 70 and detection of its immunogenicity in vitro.
The variable C-terminal region of the Mycobacterium leprae 70-kilodalton heat shock protein is the target for humoral immune responses.
Vaccination with B16 tumor cell lysate plus recombinant Mycobacterium tuberculosis Hsp70 induces antimelanoma effect in mice.
Vaccination with recombinant 4 × M2e.HSP70c fusion protein as a universal vaccine candidate enhances both humoral and cell-mediated immune responses and decreases viral shedding against experimental challenge of H9N2 influenza in chickens.
Vaccine Potential of a Recombinant Bivalent Fusion Protein LcrV-HSP70 Against Plague and Yersiniosis.
[Cloning and prokaryotic expression of heat shock protein 70 gene of Mycobacterium tuberculosis]
[Construction of recombinant BCG bearing S1 glycoprotein of nephropathogenic IBV and study on its immunogenicity on chickens]
[Construction of recombinant BCG bearing Schistosoma japonicum 26Ku antigen gene and study on its immunogenicity on mice]
[Development of a novel recombinant BCG for tuberculosis vaccine].
[Fusion expression of O type foot-and-mouth diseases virus VP1 gene and HSP70 gene and induction of immune responses in mice]
[Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70.]
[Influence of JEV E-HSP70 (Mycobacterium tuberculosis) fusion protein on immune response in BALB/c mice]
[Participation of heat shock proteins in modulation of NF-?B transcription factor activation during bacterial infections].
Tuberculosis, Bovine
The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis.
Tuberculosis, Meningeal
[Significance of heat shock protein 70 in cerebrospinal fluid in differential diagnosis of central nervous system infection in children]
Tuberculosis, Pulmonary
Heat shock protein70 is implicated in modulating NF-?B activation in alveolar macrophages of patients with active pulmonary tuberculosis.
Tuberous Sclerosis
N-Formyl-3,4-methylenedioxy-benzylidene-gamma-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells.
PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.
Uremia
Resveratrol Reduces Kidney Injury in a Rat Model of Uremia and is Associated with Increased Expression of Heat Shock Protein 70 (Hsp70).
Ureteral Obstruction
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy.
Growing evidence suggests WT1 effects in the kidney development are modulated by Hsp70/NO interaction.
WT-1 mRNA expression is modulated by nitric oxide availability and Hsp70 interaction after neonatal unilateral ureteral obstruction.
Urinary Bladder Neoplasms
Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines.
CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells.
Drug-induced keratin 9 interaction with Hsp70 in bladder cancer cells.
Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer.
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer.
Functional inhibition of Hsp70 by Pifithrin-? switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.
Heat shock protein expression independently predicts survival outcome in schistosomiasis-associated urinary bladder cancer.
HSP60 may predict good pathological response to neoadjuvant chemoradiotherapy in bladder cancer.
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells.
Tetraploid arrest with overexpressed non-mutated p53 in germ cell cancers.
The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer.
[The heat shock protein 70 antisense oligomers enhance the sensitivity of bladder cancer cell EJ to mitomycin C]
Urinary Tract Infections
Urine heat shock protein 70 levels as a marker of urinary tract infection in children.
Urticaria
Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria.
The pattern of HSP70 gene expression, flight activity and temperature in Apis mellifera meda colonies.
Uterine Cervical Neoplasms
An immunohistochemical analysis of heat shock protein 70, p53, and estrogen receptor status in carcinoma of the uterine cervix.
Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI.
HSP70 and ER expression in cervical intraepithelial neoplasia and cervical cancer.
HSP70 inhibitor combined with cisplatin suppresses the cervical cancer proliferation in vitro and transplanted tumor growth: An experimental study.
Inducible heat shock protein 70 enhances HPV31 viral genome replication and virion production during the differentiation-dependent life cycle in human keratinocytes.
Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression.
Proteomic identification of predictive tissue biomarkers of sensitive to neoadjuvant chemotherapy in squamous cervical cancer.
The Effect of Logotherapy on the Expressions of Cortisol, HSP70, Beck Depression Inventory (BDI), and Pain Scales in Advanced Cervical Cancer Patients.
[Heat-shock protein enhances immunogenicity of E7 oncoprotein of human papillomavirus included in chimeric construction (E7 HPV-HSP70)].
[Increase in thermosensitivity of cervical cancer and ovarian cancer cells by HSP70 antisense oligodeoxynucleotides]
[Inhibiting HSP70 expression enhances cisplatin sensitivity of cervical cancer cells].
Uterine Cervicitis
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Uveitis
Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis.
Vaccinia
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and A? accumulation via enhancement of ERK phosphatase VHR activity.
Vaginitis
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Vaginosis, Bacterial
Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: relation to microbial flora, vaginal pH, and method of contraception.
Varicocele
Comparative Expression Analysis of HSP70, HSP90, IL-4, TNF, KITLG and KIT-receptor Gene between Varicocele-Induced and Non-Varicocele Testes of Dog.
Effect of varicocelectomy treatment on spermatogenesis and apoptosis via the induction of heat shock protein 70 in varicocele?induced rats.
Vascular Calcification
Serum level of soluble Hsp70 is associated with vascular calcification.
Vascular Diseases
An additional physiological role for HSP70: Assistance of vascular reactivity.
Anti-heat-shock protein 70 kDa antibodies in vascular patients.
Dissecting the interaction between HSP70 and vascular contraction: role of [Formula: see text] handling mechanisms.
Effect of combined heat, ozonation and ultraviolet irradiation (VasoCare) on heat shock protein expression by peripheral blood leukocyte populations.
Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease.
Hsp70 expression in monocytes from patients with peripheral arterial disease and healthy controls : Monocyte Hsp70 in PAD.
HSP70 is associated with endothelial activation in placental vascular diseases.
YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.
Vascular System Injuries
Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age.
Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat.
Vector Borne Diseases
GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
Venereal Tumors, Veterinary
Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model.
Ventilator-Induced Lung Injury
Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation.
Ventricular Fibrillation
[Antiarrhythmic effect of oligonucleotides accompanied by activation of HSP70 protein in the heart of rats].
Vesicular Stomatitis
Antiviral effect of short hyperthermic treatment at specific stages of vesicular stomatitis virus replication cycle.
Vibrio Infections
Evidence for disruption of Na(+)-K(+)-ATPase and hsp70 during vibriosis of sea bream, Sparus (=Rhabdosargus) sarba Forsskål.
Non-lethal heat shock increased hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp.
Non-Lethal Heat Shock of the Asian Green Mussel, Perna viridis, Promotes Hsp70 Synthesis, Induces Thermotolerance and Protects Against Vibrio Infection.
Recombinant DnaK Orally Administered Protects Axenic European Sea Bass Against Vibriosis.
Virus Diseases
Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses.
Antiviral effect of short hyperthermic treatment at specific stages of vesicular stomatitis virus replication cycle.
Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.
Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells.
Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.
Cellular chaperones and folding enzymes are vital contributors to membrane bound replication and movement complexes during plant RNA virus infection.
Chaperone-mediated in vitro disassembly of polyoma- and papillomaviruses.
Dengue virus infection activates cellular chaperone Hsp70 in THP-1 cells: downregulation of Hsp70 by siRNA revealed decreased viral replication.
Effects of heat treatment on metabolism of tobacco plants infected with Potato virus Y.
Evidence for an association between heat shock protein 70 and the respiratory syncytial virus polymerase complex within lipid-raft membranes during virus infection.
HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70.
Heat shock protein 70 is necessary for Rice stripe virus infection in plants.
Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt-mTORC1 pathway depending on activation of p70S6K and Cdc2.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins.
HSP70 and its cochaperone CPIP promote potyvirus infection in Nicotiana benthamiana by regulating viral coat protein functions.
HSP70 homolog functions in cell-to-cell movement of a plant virus.
HSP70 induced by Hantavirus infection interacts with viral nucleocapsid protein and its overexpression suppresses virus infection in Vero E6 cells.
Hsp70 negatively controls rotavirus protein bioavailability in caco-2 cells infected by the rotavirus RF strain.
Hsp70 protein positively regulates Rabies Virus infection.
Increased expression of Hsp70 and co-localization with nuclear protein in cells infected with the Hantaan virus.
Induction by prostaglandin A1 of haem oxygenase in myoblastic cells: an effect independent of expression of the 70 kDa heat shock protein.
Induction of pro-viral grass carp Ctenopharyngodon idella Hsp70 instead of Hsc70 during infection of grass carp reovirus.
Influence of cytoplasmic heat shock protein 70 on viral infection of Nicotiana benthamiana.
Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site.
Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1.
Multifaceted capsid proteins: multiple interactions suggest multiple roles for Pepino mosaic virus capsid protein.
Persistent borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress.
Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection.
Specific binding of heat shock protein 70 with HN-protein inhibits the HN-protein assembly in Sendai virus-infected Vero cells.
Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response.
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
[Expression of HSP70 in human umbilical vein endothelial cells induced by Hantavirus]
[Relationship of HSP70 to temperature-dependency of influenza viral infection]
Vitiligo
4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.
HSP70 potentiates interferon-alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis.
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
HSP70iQ435A to subdue autoimmunity and support anti-tumor responses.
Immunohistochemical expression of heat shock protein 70 in vitiligo.
Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo.
Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.
The multi-target mechanism of Cyclosporin A in the treatment of vitiligo based on network pharmacology.
Vitreoretinopathy, Proliferative
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
Warts
Comparative proteomic analysis of resistant and susceptible potato cultivars during Synchytrium endobioticum infestation.
Whooping Cough
Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age.
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
Pertussis toxin expression in Drosophila alters the visual response and blocks eating behaviour.
Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels.
Wilms Tumor
Central nervous system, peripheral and hemodynamic effects of nanoformulated anandamide in hypertension.
Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas.
Growing evidence suggests WT1 effects in the kidney development are modulated by Hsp70/NO interaction.
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Wolff-Parkinson-White Syndrome
Initiation of stress protein synthesis in the myocardium of coronary patients.
Xeroderma Pigmentosum
Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene.
Yellow Fever
Green fluorescent protein as a genetic marker in transgenic Aedes aegypti.
Identification and characterization of heat shock 70 genes in Aedes aegypti (Diptera: Culicidae).
Yersinia Infections
Vaccine Potential of a Recombinant Bivalent Fusion Protein LcrV-HSP70 Against Plague and Yersiniosis.
Zika Virus Infection
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells.
HSP70 Copurifies with Zika Virus Particles.