EC Number   |
Natural Substrates |
|---|
   7.4.2.3 | ATP + H2O |
- |
| 7.4.2.3 | ATP + H2O |
preprotein transport across the mitochondrial inner membrane |
| 7.4.2.3 | ATP + H2O |
Hsp70 escort proteins are essential for maintaining the function of yeast mitochondrial hsp70 molecular chaperones(mtHsp70) |
| 7.4.2.3 | ATP + H2O |
mtHsp70 exhibits limited solubility due to aggregation mediated by its ATPase domain, residues 47-440, but human escort protein Hep directly enhances chaperone solubility through interactions with this domain |
| 7.4.2.3 | ATP + H2O |
the essential mitochondrial Hsp70 is required for the import of mitochondrial preproteins into the matrix compartment. The translocation, specific activity of mitochondrial Hsp70 is coordinated by its interaction with specific partner proteins, forming the import motor complex that provides the energy for unfolding and complete translocation of precursor polypeptide chains. Impaired interdomain communication in mitochondrial Hsp70 results in the loss of inward-directed translocation force |
| 7.4.2.3 | ATP + H2O |
preprotein import-driving ATPase activity of mtHsp70 |
| 7.4.2.3 | ATP + H2O + heat shock protein 70[side 1] |
- |
| 7.4.2.3 | ATP + H2O + mitochondrial-protein[side 1] |
- |
| 7.4.2.3 | ATP + H2O + protein/out |
- |
| 7.4.2.3 | ATP + H2O + protein/out |
mitochondrial preproteins synthesized in the cytosol are imported through the mitochondrial outer membrane by the translocase of the outer mitochondrial membrane, TOM, complex |
