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Literature summary for 7.4.2.3 extracted from

  • Mokranjac, D.; Berg, A.; Adam, A.; Neupert, W.; Hell, K.
    Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor (2007), J. Biol. Chem., 282, 18037-18045.
    View publication on PubMed
Search for more literature for 7.4.2.3

Activating Compound

Activating Compound Comment Organism Structure
TIM14
-
 Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
Tim16
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Saccharomyces cerevisiae 5743
-
mitochondrial matrix
-
 Saccharomyces cerevisiae 5759
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + protein/out Saccharomyces cerevisiae Tim14 and Tim16 are essential components of the import motor of the mitochondrial TIM23 preprotein translocase, the J and J-like domains of Tim14 and 16 function in the regulation of the ATPase activity of the Hsp70 chaperone of the import motor, with the help of Tim44, Tim14, Tim16 and Mge1 mtHsp70 converts the energy of ATP hydrolysis into vectorial movement of the unfolded polypeptide chain across the translocation pore ADP + phosphate + protein/in
-
 ir

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + protein/out Tim14 and Tim16 are essential components of the import motor of the mitochondrial TIM23 preprotein translocase, the J and J-like domains of Tim14 and 16 function in the regulation of the ATPase activity of the Hsp70 chaperone of the import motor, with the help of Tim44, Tim14, Tim16 and Mge1 mtHsp70 converts the energy of ATP hydrolysis into vectorial movement of the unfolded polypeptide chain across the translocation pore Saccharomyces cerevisiae ADP + phosphate + protein/in
-
 ir

Synonyms

Synonyms Comment Organism
mitochondrial TIM23 preprotein translocase
-
 Saccharomyces cerevisiae
mtHSP70
-
 Saccharomyces cerevisiae
TIM protein complex
-
 Saccharomyces cerevisiae