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Literature summary for 7.4.2.3 extracted from
- Protein import into mitochondria (2005), Biochem. Soc. Trans., 33, 1019-1023.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TIM14 | stimulates | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | TIM44 binds to the peptide-binding domain of Hsp70 and thereby recruits it to the outlet of the translocation pore, so that mtHsp70 can bind to the incoming polypeptide chain as soon as it emerges from the channel | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | matrix | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | several rounds of ATP-dependent binding to and release from mtHsp70 lead to complete translocation of polypeptides into the mitochondrial matrix | Homo sapiens | ADP + phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitochondrial heat-shock protein 70 | - |
Homo sapiens |
| mtHSP70 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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