Literature summary for 7.4.2.3 extracted from

Mokranjac, D.; Sichting, M.; Popov-Celeketi?, D.; Berg, A.; Hell, K.; Neupert, W.
The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2 (2005), J. Biol. Chem., 280, 31608-31614.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Mdj2	stimulates ATPase activity of mtHsp70 to the same extent as TIM14, forms a complex with TIM16, which does not interfer with the TIM16-TIM14 complex and cannot support cell growth, but overexpression of Mdj2 fully restores growth of cells lacking TIM14	Saccharomyces cerevisiae
TIM14	stimulates ATPase activity of mtHsp70 and thereby enables efficient binding of mtHsp70 to incoming preproteins, stimulates to the same extent as Mdj2, forms a complex with TIM16, which recruits it to the translocase, the TIM16-TIM14 complex does not interfer with the TIM16-Mdj2 complex	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	strains YPH499 and YPH501	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	Saccharomyces cerevisiae	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
mtHSP70	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)