Literature summary for 7.4.2.3 extracted from

Wadhwa, R.; Takano, S.; Kaur, K.; Aida, S.; Yaguchi, T.; Kaul, Z.; Hirano, T.; Taira, K.; Kaul, S.C.
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60 (2005), Biochem. J., 391, 185-190.

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Application

Application	Comment	Organism
medicine	in vivo binding of mortalin/mtHsp70 with HSP60, involvment in tumorigenesis, functional distinction in pathways involved in senescence	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	recombinant GST-tagged mortalin/mtHsp70 deletion mutants, which demonstrate binding of mortalin via its N-terminal region	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	TIG-1 cell, overexpression of mortalin extends the in vitro lifespan of the fibroblasts	Homo sapiens	-
additional information	NARF cell, stably transfected with isopropyl beta-D-thiogalactoside-inducible p14ARF	Homo sapiens	-
osteosarcoma cell line	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
mitochondrial hsp70	-	Homo sapiens
mortalin/mtHsp70	-	Homo sapiens

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Release 2023.1 (January 2023)