Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Saccharomyces cerevisiae | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | an essential peripheral membrane protein, Tim44, tethers mtHsp70, the core of the import motor, to the translocon. The presequence translocase-associated motor complex, PAM, acts as a functional unit to couple the action of mitochondrial Hsp70 chaperone Ssc1 to the movement of preproteins through the Tim23 translocon into the mitochondrial matrix. Tim44-mtHsp70 interaction is destabilized by binding of mtHsp70 to a substrate polypeptide. The N-terminal 167-amino-acid segment of mature Tim44 is suf?cient for both interaction with mtHsp70 and destabilization of a Tim44-mtHsp70 complex caused by client protein binding, mutational interaction analysis, overview | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | an essential peripheral membrane protein, Tim44, tethers mtHsp70, the core of the import motor, to the translocon. The presequence translocase-associated motor complex, PAM, acts as a functional unit to couple the action of mitochondrial Hsp70 chaperone Ssc1 to the movement of preproteins through the Tim23 translocon into the mitochondrial matrix. Tim44-mtHsp70 interaction is destabilized by binding of mtHsp70 to a substrate polypeptide. The N-terminal 167-amino-acid segment of mature Tim44 is suf?cient for both interaction with mtHsp70 and destabilization of a Tim44-mtHsp70 complex caused by client protein binding, mutational interaction analysis, overview | Saccharomyces cerevisiae | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
mitochondrial hsp70 | - |
Saccharomyces cerevisiae |