Reference on EC 3.4.24.B10 - ADAM12 endopeptidase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loechel, F.; Fox, J.W.; Murphy, G.; Albrechtsen, R.; Wewer, U.M.
ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3
Biochem. Biophys. Res. Commun.
278
511-515
2000
Homo sapiens (O43184), Homo sapiens
Loechel, F.; Wewer, U.M.
Activation of ADAM 12 protease by copper
FEBS Lett.
506
65-68
2001
Homo sapiens (O43184)
Loechel, F.; Gilpin, B.J.; Engvall, E.; Albrechtsen, R.; Wewer, U.M.
Human ADAM 12 (meltrin alpha) is an active metalloprotease
J. Biol. Chem.
273
16993-16997
1998
Homo sapiens (O43184), Homo sapiens
Loechel, F.; Overgaard, M.T.; Oxvig, C.; Albrechtsen, R.; Wewer, U.M.
Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch
J. Biol. Chem.
274
13427-13433
1999
Homo sapiens (O43184), Homo sapiens
Shi, Z.; Xu, W.; Loechel, F.; Wewer, U.M.; Murphy, L.J.
ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3
J. Biol. Chem.
275
18574-18580
2000
Homo sapiens (O43184), Homo sapiens
Eto, K.; Puzon-McLaughlin, W.; Sheppard, D.; Sehara-Fujisawa, A.; Zhang, X.P.; Takada, Y.
RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction
J. Biol. Chem.
275
34922-34930
2000
Homo sapiens
Mori, S.; Tanaka, M.; Nanba, D.; Nishiwaki, E.; Ishiguro, H.; Higashiyama, S.; Matsuura, N.
PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor
J. Biol. Chem.
278
46029-46034
2003
Homo sapiens
McCulloch, D.R.; Harvey, M.; Herington, A.C.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
Mol. Cell. Endocrinol.
167
11-21
2000
Homo sapiens
Kodama, T.; Ikeda, E.; Okada, A.; Ohtsuka, T.; Shimoda, M.; Shiomi, T.; Yoshida, K.; Nakada, M.; Ohuchi, E.; Okada, Y.
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor
Am. J. Pathol.
165
1743-1753
2004
Homo sapiens
Oh, M.; Im, I.; Lee, Y.J.; Kim, Y.H.; Yoon, J.H.; Park, H.G.; Higashiyama, S.; Kim, Y.C.; Park, W.J.
Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors
Bioorg. Med. Chem. Lett.
14
6071-6074
2004
Homo sapiens
Zhao, Z.; Gruszczynska-Biegala, J.; Cheuvront, T.; Yi, H.; von der Mark, H.; von der Mark, K.; Kaufman, S.J.; Zolkiewska, A.
Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1
Exp. Cell Res.
298
28-37
2004
Homo sapiens
Thodeti, C.K.; Froehlich, C.; Nielsen, C.K.; Holck, P.; Sundberg, C.; Kveiborg, M.; Mahalingam, Y.; Albrechtsen, R.; Couchman, J.R.; Wewer, U.M.
Hierarchy of ADAM12 binding to integrins in tumor cells
Exp. Cell Res.
309
438-450
2005
Homo sapiens
Thodeti, C.K.; Froehlich, C.; Nielsen, C.K.; Takada, Y.; Faessler, R.; Albrechtsen, R.; Wewer, U.M.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins
FEBS Lett.
579
5589-5595
2005
Homo sapiens
Carl-McGrath, S.; Lendeckel, U.; Ebert, M.; Roessner, A.; Roecken, C.
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
Int. J. Oncol.
26
17-24
2005
Homo sapiens
Roy, R.; Wewer, U.M.; Zurakowski, D.; Pories, S.E.; Moses, M.A.
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage
J. Biol. Chem.
279
51323-51330
2004
Homo sapiens
Wewer, U.M.; Moergelin, M.; Holck, P.; Jacobsen, J.; Lydolph, M.C.; Johnsen, A.H.; Kveiborg, M.; Albrechtsen, R.
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme
J. Biol. Chem.
281
9418-9422
2006
Homo sapiens
Bernstein, H.G.; Keilhoff, G.; Bukowska, A.; Ziegeler, A.; Funke, S.; Dobrowolny, H.; Kanakis, D.; Bogerts, B.; Lendeckel, U.
ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes
J. Neurosci. Res.
75
353-360
2004
Homo sapiens, Rattus norvegicus
Lafuste, P.; Sonnet, C.; Chazaud, B.; Dreyfus, P.A.; Gherardi, R.K.; Wewer, U.M.; Authier, F.J.
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation
Mol. Biol. Cell
16
861-870
2005
Homo sapiens
Malinin, N.L.; Wright, S.; Seubert, P.; Schenk, D.; Griswold-Prenner, I.
Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity
Proc. Natl. Acad. Sci. USA
102
3058-3063
2005
Homo sapiens
Okada, A.; Mochizuki, S.; Yatabe, T.; Kimura, T.; Shiomi, T.; Fujita, Y.; Matsumoto, H.; Sehara-Fujisawa, A.; Iwamoto, Y.; Okada, Y.
ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage
Arthritis Rheum.
58
778-789
2008
Homo sapiens
Jacobsen, J.; Visse, R.; Sorensen, H.P.; Enghild, J.J.; Brew, K.; Wewer, U.M.; Nagase, H.
Catalytic properties of ADAM12 and its domain deletion mutants
Biochemistry
47
537-547
2008
Homo sapiens
Froehlich, C.; Albrechtsen, R.; Dyrskjot, L.; Rudkjaer, L.; Orntoft, T.F.; Wewer, U.M.
Molecular profiling of ADAM12 in human bladder cancer
Clin. Cancer Res.
12
7359-7368
2006
Homo sapiens (O43184), Homo sapiens
Kveiborg, M.; Albrechtsen, R.; Couchman, J.R.; Wewer, U.M.
Cellular roles of ADAM12 in health and disease
Int. J. Biochem. Cell Biol.
40
1685-1702
2008
Homo sapiens, Mus musculus
Atfi, A.; Dumont, E.; Colland, F.; Bonnier, D.; Lhelgoualch, A.; Prunier, C.; Ferrand, N.; Clement, B.; Wewer, U.M.; Theret, N.
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor
J. Cell Biol.
178
201-208
2007
Homo sapiens
Estrella, C.; Rocks, N.; Paulissen, G.; Quesada-Calvo, F.; Noel, A.; Vilain, E.; Lassalle, P.; Tillie-Leblond, I.; Cataldo, D.; Gosset, P.
Role of a disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium
Am. J. Respir. Cell Mol. Biol.
41
449-458
2009
Homo sapiens
Kveiborg, M.; Jacobsen, J.; Lee, M.H.; Nagase, H.; Wewer, U.M.; Murphy, G.
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)
Biochem. J.
430
79-86
2010
Homo sapiens (O43184)
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermato-endocrinology
1
46-53
2009
Homo sapiens
Stautz, D.; Sanjay, A.; Hansen, M.T.; Albrechtsen, R.; Wewer, U.M.; Kveiborg, M.
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity
Exp. Cell Res.
316
55-67
2010
Homo sapiens
Mino, N.; Miyahara, R.; Nakayama, E.; Takahashi, T.; Takahashi, A.; Iwakiri, S.; Sonobe, M.; Okubo, K.; Hirata, T.; Sehara, A.; Date, H.
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma
J. Surg. Oncol.
100
267-272
2009
Homo sapiens
Kerna, I.; Kisand, K.; Tamm, A.E.; Lintrop, M.; Veske, K.; Tamm, A.O.
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort
Osteoarthritis Cartilage
17
1093-1098
2009
Homo sapiens (O43184), Homo sapiens
Cowans, N.J.; Stamatopoulou, A.; Jaakohuhta, S.; Spencer, K.
ADAM-12 stability in first trimester maternal serum
Prenat. Diagn.
30
555-560
2010
Homo sapiens
Roy, R.; Rodig, S.; Bielenberg, D.; Zurakowski, D.; Moses, M.A.
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis
J. Biol. Chem.
286
20758-20768
2011
Homo sapiens
Beristain, A.; Zhu, H.; Leung, P.
Regulated expression of ADAMTS-12 in human trophoblastic cells: A role for ADAMTS-12 in epithelial cell invasion?
PLoS ONE
6
e18473
2011
Homo sapiens
Kotzsch, A.; Skovgaard, T.; Buus, U.; Andersen, S.; Devkota, K.; Berthelsen, J.
A substrate-optimized electrophoretic mobility shift assay for ADAM12
Anal. Biochem.
452
34-42
2014
Homo sapiens (O43184)
Aghababaei, M.; Hogg, K.; Perdu, S.; Robinson, W.P.; Beristain, A.G.
ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion
Cell Death Differ.
22
1970-1984
2015
Homo sapiens (O43184)
Wei, J.; Richbourgh, B.; Jia, T.; Liu, C.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation
Mediators Inflamm.
2014
649718
2014
Homo sapiens (O43184)
Leyme, A.; Bourd-Boittin, K.; Bonnier, D.; Falconer, A.; Arlot-Bonnemains, Y.; Theret, N.
Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival
Mol. Biol. Cell
23
3461-3472
2012
Homo sapiens (O43184), Homo sapiens
Stautz, D.; Wewer, U.M.; Kveiborg, M.
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12
PLoS ONE
7
e37628
2012
Homo sapiens (O43184)
Zhou, A.X.; El Hed, A.; Mercer, F.; Kozhaya, L.; Unutmaz, D.
The metalloprotease ADAM12 regulates the effector function of human Th17 cells
PLoS ONE
8
e81146
2013
Homo sapiens (O43184), Homo sapiens
Albrechtsen, R.; Wewer Albrechtsen, N.J.; Gnosa, S.; Schwarz, J.; Dyrskjot, L.; Kveiborg, M.
Identification of ADAM12 as a novel basigin sheddase
Int. J. Mol. Sci.
20
E1957
2019
Homo sapiens (O43184), Homo sapiens
Duhachek-Muggy, S.; Qi, Y.; Wise, R.; Alyahya, L.; Li, H.; Hodge, J.; Zolkiewska, A.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer
Mol. Cancer
16
32
2017
Homo sapiens (O43184), Homo sapiens
Roy, R.; Dagher, A.; Butterfield, C.; Moses, M.A.
ADAM12 is a novel regulator of tumor angiogenesis via STAT3 signaling
Mol. Cancer Res.
15
1608-1622
2017
Homo sapiens (O43184), Homo sapiens
