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Literature summary for 3.4.24.B10 extracted from
- Cellular roles of ADAM12 in health and disease (2008), Int. J. Biochem. Cell Biol., 40, 1685-1702.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| tissue growth factor beta | potent inducer of ADAM12 expression | Mus musculus | |
| tissue growth factor beta | potent inducer of ADAM12 expression | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | N-TIMP-3 variants that lack MMP inhibitory activity but retain the ability to inhibit ADAM17/TACE fail to inhibit ADAM12 | Homo sapiens | |
| additional information | N-TIMP-3 variants that lack MMP inhibitory activity but retain the ability to inhibit ADAM17/TACE fail to inhibit ADAM12 | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Mus musculus | - |
| adipocyte | - |
Homo sapiens | - |
| C2C12 cell | - |
Mus musculus | - |
| chondroblast | - |
Mus musculus | - |
| chondroblast | - |
Homo sapiens | - |
| hepatic stellate cell | - |
Mus musculus | - |
| hepatic stellate cell | - |
Homo sapiens | - |
| oligodendrocyte | - |
Mus musculus | - |
| oligodendrocyte | - |
Homo sapiens | - |
| osteoclast | - |
Mus musculus | - |
| osteoclast | - |
Homo sapiens | - |
| placenta | - |
Mus musculus | - |
| placenta | - |
Homo sapiens | - |
| trophoblast | - |
Mus musculus | - |
| trophoblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betacellulin + H2O | - |
Mus musculus | ? | - |
? |  |
| betacellulin + H2O | - |
Homo sapiens | ? | - |
? | |
| delta-like 1 + H2O | - |
Mus musculus | ? | - |
? | |
| delta-like 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| epidermal growth factor + H2O | - |
Mus musculus | ? | - |
? | |
| epidermal growth factor + H2O | - |
Homo sapiens | ? | - |
? | |
| heparin-binding epidermal growth factor + H2O | - |
Mus musculus | ? | - |
? | |
| heparin-binding epidermal growth factor + H2O | - |
Homo sapiens | ? | - |
? | |
| insulin-like growth factor binding protein-3 + H2O | - |
Mus musculus | ? | - |
? | |
| insulin-like growth factor binding protein-3 + H2O | - |
Homo sapiens | ? | - |
? | |
| insulin-like growth factor binding protein-5 + H2O | - |
Mus musculus | ? | - |
? | |
| insulin-like growth factor binding protein-5 + H2O | - |
Homo sapiens | ? | - |
? | |
| placental leucine aminopeptidase + H2O | - |
Mus musculus | ? | - |
? | |
| placental leucine aminopeptidase + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM12 | - |
Mus musculus |
| ADAM12 | - |
Homo sapiens |
| ADAM12-L | splice variant, transmembrane protein | Mus musculus |
| ADAM12-L | splice variant, transmembrane protein | Homo sapiens |
| ADAM12-S | splice variant, soluble protein | Mus musculus |
| ADAM12-S | splice variant, soluble protein | Homo sapiens |
| meltrin alpha | - |
Mus musculus |
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