Literature summary for 3.4.24.B10 extracted from

Stautz, D.; Sanjay, A.; Hansen, M.T.; Albrechtsen, R.; Wewer, U.M.; Kveiborg, M.
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity (2010), Exp. Cell Res., 316, 55-67.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in 293-VnR cell (derived from HEK-293 cell)	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E351Q	catalytically inactive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	c-Src kinase activity regulates ADAM12-L phosphorylation (tyrosine phosphorylation) and the c-Src-ADAM12-L interaction, the cytoplasmic tail of ADAM12-L has two Src SH3-binding sites, the high-affinity c-Src binding site is important for its cellular localization with c-Src to actin-rich structures at the cell periphery	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ADAM12-L	long transmembrane form	Homo sapiens

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Release 2023.1 (January 2023)