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Literature summary for 3.4.24.B10 extracted from

  • Mori, S.; Tanaka, M.; Nanba, D.; Nishiwaki, E.; Ishiguro, H.; Higashiyama, S.; Matsuura, N.
    PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (2003), J. Biol. Chem., 278, 46029-46034.
    View publication on PubMed
Search for more literature for 3.4.24.B10

Activating Compound

Activating Compound Comment Organism Structure
PACSIN3 protein that interacts with the enzyme via its proline-rich region, amino acid residues 829-840, at the cytoplasmic domain, interaction is necessary for the upregulation of proHB-EGF shedding Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in a yeast two-hybrid system as GT-tagged enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Homo sapiens key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein + H2O
-
 Homo sapiens peptides
-
 ?
protein + H2O key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease 12
-
 Homo sapiens
ADAM12
-
 Homo sapiens
ADAM12/meltrin alpha
-
 Homo sapiens
M12.212 Merops-ID Homo sapiens
meltrin alpha
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens