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Literature summary for 3.4.24.B10 extracted from

  • Leyme, A.; Bourd-Boittin, K.; Bonnier, D.; Falconer, A.; Arlot-Bonnemains, Y.; Theret, N.
    Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival (2012), Mol. Biol. Cell, 23, 3461-3472.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM12
-
 Homo sapiens
ADAM12L isoform Homo sapiens
disintegrin and metalloprotease 12
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction down-regulation of ADAM12L in hepatic stellate cells leads to cytoskeletal disorganization and loss of adhesion Homo sapiens
metabolism up-regulation of ADAM12L induces the Akt Ser-473 phosphorylation-dependent survival pathway via stimulation of beta1 integrins and activation of phosphoinositide 3-kinase, and promotes kinase activity from integrin-linked kinase immunoprecipitates Homo sapiens