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(2-fluoro-4-hydroxyphenyl)pyruvate + O2
(3-fluoro-2,5-dihydroxyphenyl)pyruvate + CO2
(4-hydroxyphenyl)-pyruvate + O2
homogentisate + CO2
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-
-
-
?
2-thienylpyruvate + O2
? + CO2
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-
-
-
?
3,4-dihydroxyphenylpyruvate + O2
? + CO2
3-thienylpyruvate + O2
3-carboxymethyl-3-thiolene-2-one + CO2
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-
-
?
4-fluorophenylpyruvate + O2
4-fluoro-2-hydroxyphenylacetate + CO2
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?
4-hydroxyphenylpyruvate + O2
2,5-dihydroxyphenylacetate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
4-hydroxyphenylpyruvate + O2
homogentisate + CO2 + 4-hydroxyphenylacetate
4-hydroxytetrafluorophenylpyruvate + O2
? + CO2
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?
4-methylphenylpyruvate + O2
? + CO2
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poor substrate
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
[(4-hydroxyphenyl)thio]pyruvate + O2
[(4-hydroxyphenyl)sulfinyl]acetate + CO2
additional information
?
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(2-fluoro-4-hydroxyphenyl)pyruvate + O2
(3-fluoro-2,5-dihydroxyphenyl)pyruvate + CO2
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?
(2-fluoro-4-hydroxyphenyl)pyruvate + O2
(3-fluoro-2,5-dihydroxyphenyl)pyruvate + CO2
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-
?
3,4-dihydroxyphenylpyruvate + O2
? + CO2
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-
-
?
3,4-dihydroxyphenylpyruvate + O2
? + CO2
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-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
4-hydroxyphenylpyruvate dioxygenase does not use phenolpyruvate as a substrate in normal plant metabolism
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
evidence against participation of a quinol as a free intermediate
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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enzyme is involved in production of homogentisate, the aromatic precursor of all phenylquinones
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
Frog
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
activity with the keto-form of 4-hydroxyphenylpyruvate is 40times higher than with the enol tautomer
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
the conversion of 4-hydroxyphenyl-pyruvate to homogentisate involves oxidative decarboxylation, side-chain migration and aromatic hydroxylation in a single catalytic cycle. The 4-HPPD reaction is unusual in that the 2-oxoacid and prime substrate moieties are contained within the same molecule
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
second step of oxidative tyrosine catabolism
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
second step of oxidative tyrosine catabolism
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
homogentisate is an intermediate of the tyrosine degradation pathway, and a precursor of a redox-cycling metabolite, pyomelanin
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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homogentisate is an intermediate of the tyrosine degradation pathway, and a precursor of a redox-cycling metabolite, pyomelanin
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
-
-
?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
-
hppD is transcriptionally activated by HpdA and repressed by HpdR
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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best substrate
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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enzyme participates in catabolism of tyrosine
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2 + 4-hydroxyphenylacetate
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the wild-type enzyme produces 85% homogentisate and 15% 4-hydroxyphenylacetate
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?
4-hydroxyphenylpyruvate + O2
homogentisate + CO2 + 4-hydroxyphenylacetate
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the wild-type enzyme produces 90% homogentisate, 1% quinolacetate, and 9% 4-hydroxyphenylacetate
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
-
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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-
?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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-
?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
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-
?
phenylpyruvate + O2
2-hydroxyphenylacetate + CO2
-
at 10% of the activity with 4-hydroxyphenylpyruvate
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?
[(4-hydroxyphenyl)thio]pyruvate + O2
[(4-hydroxyphenyl)sulfinyl]acetate + CO2
-
substrate undergoes oxidative decarboxylation and sulfoxidation to give [(4-hydroxyphenyl)sulfinyl]acetate, ring oxidation is not observed
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?
[(4-hydroxyphenyl)thio]pyruvate + O2
[(4-hydroxyphenyl)sulfinyl]acetate + CO2
-
substrate undergoes oxidative decarboxylation and sulfoxidation to give [(4-hydroxyphenyl)sulfinyl]acetate, ring oxidation is not observed
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?
additional information
?
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no activity is observed for 3-hydroxyphenylpyruvate, 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylglyoxylate, phenylpyruvate, 2-oxoglutarate, glyoxylate, pyruvate, oxaloacetate or oxobutyrate
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?
additional information
?
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no activity is observed for 3-hydroxyphenylpyruvate, 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylglyoxylate, phenylpyruvate, 2-oxoglutarate, glyoxylate, pyruvate, oxaloacetate or oxobutyrate
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?
additional information
?
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no activity is observed for 3-hydroxyphenylpyruvate, 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylglyoxylate, phenylpyruvate, 2-oxoglutarate, glyoxylate, pyruvate, oxaloacetate or oxobutyrate
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?
additional information
?
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HpdR positively regulates hpdA expression through direct binding to the HpdA promoter within a region containing two conserved direct repeat sequences. HpdR-dependent hpdA transcription occurs in the presence of 4-hydroxyphenylpyruvate, tyrosine, and phenylalanine, as well as during starvation
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?
additional information
?
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Single turnover kinetics are observed spectrophotometrically by mixing equal volumes of the anaerobic enzyme-substrate complex and solutions containing molecular oxygen in the presence of saturating HPP using a stopped-flow spectrophotometer. k1 = 7.4 x 100000 /M/s, k2 = 74 /s, k3 = 13.2 /s, k4 = 1.6 /s, indicating the accumulation of three catalytic intermediates. The kinetic data observed with substrate substituted with deutererons for aromatic protons are not significantly different from those observed with the proteo substrate. The final phase in catalysis (k4), decreases to 0.7 /s in the presence of deuterium oxide solvent, indicating the involvement of a solvent-derived proton in this step.
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?