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Literature summary for 1.13.11.27 extracted from

  • Lin, Y.L.; Huang, J.L.; Wu, C.S.; Liu, H.G.; Yang, D.Y.
    Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (2002), Bioorg. Med. Chem. Lett., 12, 1709-1713.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione potent linear competitive inhibitor Echinochloa crus-galli
3-hydroxy-4-phenyl-2-furanone 0.0005 mM, 50% inhibition, may serve as a lead compound for further design of more potent inhibitors Sus scrofa
additional information neither epoxybenzoaquinone ester nor 2-hydroxy-3-phenyl-3-butenoic acid is an inhibitor Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
 4-hydroxyphenylpyruvate
-
 Echinochloa crus-galli

Organism

Organism UniProt Comment Textmining
Echinochloa crus-galli
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Echinochloa crus-galli

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
 Sus scrofa homogentisate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2
-
 Echinochloa crus-galli homogentisate + CO2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000098
-
 2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione
-
 Echinochloa crus-galli