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Literature summary for 1.13.11.27 extracted from

  • Wojcik, A.; Broclawik, E.; Siegbahn, P.E.; Lundberg, M.; Moran, G.; Borowski, T.
    Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase - a QM/MM study (2014), J. Am. Chem. Soc., 136, 14472-14485 .
    View publication on PubMed
Search for more literature for 1.13.11.27

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis of HPPD-Fe(II)-acetate complex, PDB ID 1CJX Pseudomonas fluorescens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe Fe(II), Fe(III), and Fe(IV) during oxygenation and hydroxylation, overview. The iron ion is coordinated by a His-His-Glu triad, structure of HPPD-Fe(II)-acetate complex, overview Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylpyruvate + O2 Pseudomonas fluorescens
-
 homogentisate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2 Pseudomonas fluorescens ATCC 13525
-
 homogentisate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-
Pseudomonas fluorescens ATCC 13525
-
-
-

Reaction

Reaction Comment Organism Reaction ID
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 reaction mechanism, quantum mechanics/molecular mechanics calculations and simulations, detailed overview Pseudomonas fluorescens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
 Pseudomonas fluorescens homogentisate + CO2
-
 ?
4-hydroxyphenylpyruvate + O2
-
 Pseudomonas fluorescens ATCC 13525 homogentisate + CO2
-
 ?

Subunits

Subunits Comment Organism
More enzyme structure comparisons, structure homology modeling, overview Pseudomonas fluorescens

Synonyms

Synonyms Comment Organism
HPPD
-
 Pseudomonas fluorescens

General Information

General Information Comment Organism
metabolism suggested hydroxylation mechanisms for HMS and HPPD and pathways leading to alternative products: oxepinone and quinolacetate Pseudomonas fluorescens
additional information molecular dynamics simulations are performed for the HPPD-Fe(IV)=O-hydroxyphenylacetate complex in order to obtain a reliable starting structure for quantum mechanics/molecular mechanics calculations of ring hydroxylation and coupled rearrangement reactions catalyzed by the enzyme HPPD, structure of HPPD-Fe(II)-acetate complex, structure homology modeling, overview Pseudomonas fluorescens