Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxyphenylpyruvate | enzyme form 2 and 3, no substrate inhibition is observed for enzyme form 1 | Homo sapiens | |
bathophenanthroline | - |
Homo sapiens | |
diethyldithiocarbamate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
4-hydroxyphenylpyruvate | enzyme form 1 | Homo sapiens | |
0.027 | - |
4-hydroxyphenylpyruvate | enzyme form 2 | Homo sapiens | |
0.029 | - |
4-hydroxyphenylpyruvate | enzyme form 3 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63000 | 67000 | enzyme forms 1, 2, and 3, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
enzyme form 1, 2, and 3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.51 | 1.1 | enzyme forms 1, 2, and 3 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | - |
Homo sapiens | homogentisate + CO2 | - |
? | |
phenylpyruvate + O2 | - |
Homo sapiens | 2-hydroxyphenylacetate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the multiple enzyme forms are not interconvertible by oxidation, reduction, pyridine inactivation, metal chelator treatment, or treatment with neuraminidase | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.6 | - |
and a second optimum at pH 7.4, enzyme form 3 | Homo sapiens |
5.1 | - |
and a second optimum at pH 7.4, enzyme form 1 and 2 | Homo sapiens |
7.4 | - |
and a second optimum at pH 5.1 for enzyme form 1 and 2, and at pH 4.6 for enzyme form 3 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
4-hydroxyphenylpyruvate | about, enzyme form 3 | Homo sapiens | |
0.7 | - |
4-hydroxyphenylpyruvate | about, enzyme form 2 | Homo sapiens |