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Literature summary for 1.13.11.27 extracted from

  • Chiari, M.E.; Tosoni, L.; Joray, M.B.; Diaz Napal, G.N.; Palacios, S.M.; Ruiz, G.M.; Vera, D.M.; Carpinella, M.C.
    The inhibitory activity of plants from central Argentina on p-hydroxyphenylpyruvate dioxygenase. Isolation and mechanism of inhibition of a flavanone from Flourensia oolepis (2015), Planta Med., 81, 1382-1391 .
    View publication on PubMed
Search for more literature for 1.13.11.27

Inhibitors

Inhibitors Comment Organism Structure
pinocembrin 5,7-dihydroxyflavanone, isolation from Flourensia oolepis ethanol extract, inhibition mechanism. Pinocembrin is a reversible inhibitor of the enzyme and acts as a noncompetitive inhibitor, molecular modeling studies and binding mode, overview. Comparison to other HPPD enzyme-inhibitor complexes Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ an iron-dependent, nonheme oxygenase enzyme Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxyphenylpyruvate + O2 Sus scrofa
-
 homogentisate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Sus scrofa
-
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxyphenylpyruvate + O2
-
 Sus scrofa homogentisate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HPPD
-
 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0137
-
 pinocembrin pH and temperature not specified in the publication Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0731
-
 pH and temperature not specified in the publication Sus scrofa pinocembrin

General Information

General Information Comment Organism
metabolism the enzyme is involved in the second step of the tyrosine degradation pathway, catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate Sus scrofa