Information on EC 3.4.21.4 - trypsin

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.21.4
-
RECOMMENDED NAME
GeneOntology No.
trypsin
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential cleavage: Arg-/-, Lys-/-
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide hydrolysis
-
-
hydrolysis of peptide bond
-
-
endopeptidase
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
nocardicin A biosynthesis
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9002-07-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Cambarus affinis
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Sugarcane rootstalk borer weevil
UniProt
Manually annotated by BRENDA team
sharpsnout sea bream
-
-
Manually annotated by BRENDA team
isoform EFE-b
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
putative trypsin
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
tobacco hornworm moth
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
diamondback moth
-
-
Manually annotated by BRENDA team
red palm weevil
-
-
Manually annotated by BRENDA team
salmon
-
-
-
Manually annotated by BRENDA team
Atlantic bonito
-
-
Manually annotated by BRENDA team
trypsin isozymes A, B and C
-
-
Manually annotated by BRENDA team
isoform TR-S
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
insecticide-resistant and -susceptible strains, serine proteinases with trypsin-like activity
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
yellowfin tuna
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Triops sp.
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(benzyloxycarbonyl-L-alanyl-L-arginine)2-rhodamine-110 + 2 H2O
2 benzyloxycarbonyl-L-alanyl-L-arginine + rhodamine-110
show the reaction diagram
-
specific trypsin substrate
-
-
?
4-methylumbelliferyl-4-guanidinobenzoate + H2O
4-methylumbelliferol + 4-guanidinobenzoate
show the reaction diagram
-
-
-
-
?
Abz-ERFK-EDDnp + H2O
Abz-ER + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-FRFK-EDDnp + H2O
Abz-FR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-GRFK-EDDnp + H2O
Abz-GR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-HRFK-EDDnp + H2O
Abz-HR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-KRFK-EDDnp + H2O
Abz-KR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-LRFK-EDDnp + H2O
Abz-LR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-NRFK-EDDnp + H2O
Abz-NR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-QRFK-EDDnp + H2O
Abz-QR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RDFK-EDDnp + H2O
Abz-R + DFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-REFK-EDDnp + H2O
Abz-R + EFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RGFK-EDDnp + H2O
Abz-R + GFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RHFK-EDDnp + H2O
Abz-R + HFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RNFK-EDDnp + H2O
Abz-R + NFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RPFK-EDDnp + H2O
Abz-R + PFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RQFK-EDDnp + H2O
Abz-R + QFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RRFK-EDDnp + H2O
Abz-R + RFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RSFK-EDDnp + H2O
Abz-R + SFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RTFK-EDDnp + H2O
Abz-R + TFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RVFK-EDDnp + H2O
Abz-R + VFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-RYFK-EDDnp + H2O
Abz-R + YFK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-VRFK-EDDnp + H2O
Abz-VR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-WRFK-EDDnp + H2O
Abz-WR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
Abz-YRFK-EDDnp + H2O
Abz-YR + FK-EDDnp
show the reaction diagram
-
-
-
-
?
acetyl-Ala-Val-(L-alpha-aminobutyryl)-Pro-Arg(NO2)-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
acetyl-Ala-Val-(L-alpha-aminobutyryl)-Pro-Lys-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
acetyl-Ala-Val-(L-alpha-aminobutyryl)-Pro-N-omega-hydroxy-L-arginine-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
acetyl-Ala-Val-(L-alpha-aminobutyryl)-Pro-Phe(p-CN)-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
acetyl-Ala-Val-(L-alpha-aminobutyryl)-Pro-Phe(p-NH2)-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
acetyl-L-Phe-L-Ala-L-Thr-(4-guanidino)-L-Phe-NH-(3-carbamoyl-4-nitrophenol) + H2O
acetyl-L-Phe-L-Ala-L-Thr-(4-guanidino)-L-Phe + 5-amino-2-nitrobenzamide
show the reaction diagram
-
-
-
-
?
AGPYAHSS + H2O
?
show the reaction diagram
-
trypsin N143H/E151H hydrolyzes the peptide exclusively in presence of Ni2+ or Zn2+ with high levels of catalytic efficiency
-
-
?
alpha-amylase + H2O
?
show the reaction diagram
-
-
-
?
alpha-casein + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-N-p-tosyl-L-arginine methyl ester + H2O
alpha-N-p-tosyl-L-arginine + methanol
show the reaction diagram
-
-
-
-
?
ANVIPFKVHFRAAFC + H2O
ANVIPFK + VHFR + AAFC
show the reaction diagram
-
-
-
-
?
apomyoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
-
-
?
benzoyl-Arg 4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
benzoyl-Arg ethyl ester + H2O
benzoyl-Arg + ethanol
show the reaction diagram
-
-
-
?
benzoyl-Arg ethyl ester + leucinamide
benzoyl-Arg leucinamide + ethanol
show the reaction diagram
-
-
-
?
benzoyl-Arg-4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
?
benzoyl-Arg-p-nitroanilide + H2O
benzoyl-Arg + p-nitroaniline
show the reaction diagram
benzoyl-DL-Arg-4-nitroanilide + H2O
benzoyl-DL-Arg + 4-nitroaniline
show the reaction diagram
benzoyl-DL-Arg-7-amido-4-methylcoumarin + H2O
benzoyl-DL-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
benzoyl-DL-arginine-p-nitroanilide + H2O
benzoyl-DL-arginine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
benzoyl-L-Arg amide + H2O
?
show the reaction diagram
-
beta-trypsin is about 40% more active than alpha trypsin
-
-
?
benzoyl-L-Arg-4-nitroanilide + H2O
benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
benzoyl-L-arginine-p-nitroanilide + H2O
benzoyl-L-arginine + p-nitroaniline
show the reaction diagram
benzyloxycarbonyl-Arg-4-nitroanilide + H2O
benzyloxycarbonyl-Arg + 4-nitrolaniline
show the reaction diagram
-
-
?
benzyloxycarbonyl-Arg-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
?
benzyloxycarbonyl-Arg-thiobenzyl ester + H2O
benzyloxycarbonyl-Arg + phenylmethanethiol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
94.8% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Glu-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Glu-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
75.2% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Glu-Lys-Lys-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
14.8% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Gly-Pro-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-glutaminyl-L-arginyl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-glutaminyl-L-arginyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-glutamyl-L-lysyl-L-lysine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-glutamyl-L-lysyl-L-lysine + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity
-
-
?
benzyloxycarbonyl-L-leucyl-L-arginyl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-leucyl-L-arginyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-leucyl-L-lysyl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-leucyl-L-lysyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-phenylalaninyl-L-seryl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-phenylalaninyl-L-seryl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-valyl-L-leucyl-L-lysine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-valyl-L-leucyl-L-lysine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-valyl-L-prolyl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-L-valyl-L-prolyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
51.4% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
44.5% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
Benzyloxycarbonyl-Lys methyl ester + H2O
Benzyloxycarbonyl-Lys + methanol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Lys p-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + p-nitrophenol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
benzyloxycarbonyl-Lys + phenylmethanethiol
show the reaction diagram
benzyloxycarbonyl-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
27.1% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
33.5% of the activtiy with benzyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonylglycyl-L-prolyl-L-arginine-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonylglycyl-L-prolyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
benzyloxycarbopnyl-L-Lys benzoyl ester + H2O
benzyloxycarbopnyl-L-Lys + benzoate
show the reaction diagram
-
-
-
-
?
beta-crystallin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-lactoglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
bovine heart cytochrome c + H2O
?
show the reaction diagram
-
-
-
-
?
bovine M-proinsulin + H2O
?
show the reaction diagram
-
insulin containing methionine at the N-terminus
cleaved at the K59R60-G61 bond of the C/A junction, but at the B/C junction cleavage occurs at the R31R32-E33 as well as the R31-R32E33 bond. Cleavage at the B/C junction is preferred (65%) over that at the C/A junction (35%)
-
?
Bovine serum albumin + H2O
?
show the reaction diagram
bovine serum albumin + H2O
LVVSTQTALA + ?
show the reaction diagram
-
-
-
-
?
bovine skin DQ-collagen type I + H2O
?
show the reaction diagram
calmodulin + H2O
?
show the reaction diagram
-
-
-
-
?
carbobenzoxy-L-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
carbonic anhydrase + H2O
?
show the reaction diagram
-
-
-
?
casein + H2O
?
show the reaction diagram
Cbz-L-Arg-7-amido-4-methylcoumarin + H2O
Cbz-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Collagen + H2O
?
show the reaction diagram
-
trypsin has little activity against collagen
-
-
?
Cry1Ab protoxin + H2O
Cry1Ab toxin
show the reaction diagram
-
-
-
-
?
Cytochrome c + H2O
?
show the reaction diagram
D-Phe-Pip-Arg 4-nitroanilide + H2O
D-Phe-Pip-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
D-Phe-piperidinyl-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
D-Val-Leu-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
D-Val-Leu-Lys-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
D-Val-Leu-Lys-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
DrmSP8-36 + H2O
?
show the reaction diagram
-
trypsin is the major endopeptidase regulating N-terminal truncated sex peptide DrmSP8-36 in hemolymph, the trypsin cleavage site R7-K8 is essential for release of the C-terminal fragment SP8-36 from sperm tail, the protein is cleaved more rapidly and completely in mated female hemolymph
-
-
?
enhanced green fluorescent protein-T1 + H2O
?
show the reaction diagram
-
enhanced green fluorescent protein-T1 is specifically cleaved into two major fragments by trypsin at the grafted cleavage site, approximately 20 and 8 kDa
-
-
?
enhanced green fluorescent protein-T1nb + H2O
?
show the reaction diagram
-
-
-
-
?
enhanced green fluorescent protein-T2 + H2O
?
show the reaction diagram
-
enhanced green fluorescent protein-T2 is specifically cleaved into two major fragments by trypsin at the grafted cleavage site, approximately 18 and 10 kDa
-
-
?
epithelial sodium channel + H2O
?
show the reaction diagram
factor Xa + H2O
?
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
FITC-casein + H2O
?
show the reaction diagram
-
fluorescence-labeled casein
-
-
?
gamma-crystallin + H2O
?
show the reaction diagram
-
-
-
-
?
GDDSTPSILPAPRGYPGQV + H2O
GDDSTPSILPAPR + GYPGQV
show the reaction diagram
-
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
-
-
-
-
?
GERGFFYTPKT + H2O
?
show the reaction diagram
-
insulin-derived peptide
cleavage at bond K-T
-
?
GERGFFYTPKTRR + H2O
?
show the reaction diagram
-
insulin-derived peptide
cleavage at bond K-T
-
?
Glu-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
glucose oxidase + H2O
?
show the reaction diagram
-
-
-
?
Gly-Pro-Arg-p-nitroanilide + H2O
Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
glycogen phosphorylase b + H2O
?
show the reaction diagram
-
-
-
?
GPNSKGRSLIGRLDTPYGGC + H2O
GPNSKGR + SLIGRLDTPYGGC
show the reaction diagram
-
-
-
-
?
Hemoglobin + H2O
?
show the reaction diagram
high pathogenic hemagglutinin + H2O
?
show the reaction diagram
-
-
-
-
?
human cartilage collagen type II + H2O
?
show the reaction diagram
human M-proinsulin + H2O
?
show the reaction diagram
-
insulin containing methionine at the N-terminus
cleavage at the R31R32-E33 and K64R65-G66 bonds, i.e. B/C and C/A junctions. Cleavage at the B/C junction is preferred (65%) over that at the C/A junction (35%)
-
?
human placenta DQ-collagen type IV + H2O
?
show the reaction diagram
insulin
?
show the reaction diagram
-
-
cleavage at bond K29-T30
-
?
insulin + H2O
?
show the reaction diagram
inter-alpha-trypsin inhibitor heavy chain H4 + H2O
?
show the reaction diagram
-
inter-alpha-trypsin inhibitor heavy chain H4 is also a marker of acute ischemic stroke
-
-
?
intestinal alkaline sphingomyelinase bound to mucosa + H2O
free intestinal alkaline sphingomyelinase
show the reaction diagram
L-Phe-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
L-Phe-L-Pro-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Phe-L-Val-L-Ile-N-(3-carbamoyl-4-nitrophenyl)-L-Arg-amide + H2O
L-Phe-L-Val-L-Ile-L-Arg + 5-amino-2-nitrobenzamide
show the reaction diagram
-
-
-
-
?
L-Phe-L-Val-L-Ile-N-(3-carbamoyl-4-nitrophenyl)-L-Lys-amide + H2O
L-Phe-L-Val-L-Ile-L-Lys + 5-amino-2-nitrobenzamide
show the reaction diagram
-
-
-
-
?
L-Phe-L-Val-L-Pro-N-(3-carbamoyl-4-nitrophenyl)-L-Arg-amide + H2O
L-Phe-L-Val-L-Pro-L-Arg + 5-amino-2-nitrobenzamide
show the reaction diagram
-
-
-
-
?
L-Phe-L-Val-L-Pro-N-(3-carbamoyl-4-nitrophenyl)-L-Lys-amide + H2O
L-Phe-L-Val-L-Pro-L-Lys + 5-amino-2-nitrobenzamide
show the reaction diagram
-
-
-
-
?
L-Tat (47-58) + H2O
?
show the reaction diagram
-
trypsin significantly inactivates L-Tat (47-58)
-
-
?
low pathogenic hemagglutinin + H2O
?
show the reaction diagram
-
-
-
-
?
lubricin + H2O
?
show the reaction diagram
-
-
-
-
?
Lysozyme + H2O
?
show the reaction diagram
-
-
-
?
M-diarginyl insulin + H2O
?
show the reaction diagram
-
insulin containing methionine at the N-terminus
cleavage at bond K29-T30
-
?
M-insulin
?
show the reaction diagram
-
insulin containing methionine at the N-terminus
cleavage at bond K29-T30
-
?
MeOSuc-Ala-Ala-Ala-Arg 4-nitroanilide + H2O
MeOSuc-Ala-Ala-Ala-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
MeOSuc-Ala-Ala-Arg 4-nitroanilide + H2O
MeOSuc-Ala-Ala-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
MeOSuc-Ala-Arg 4-nitroanilide + H2O
MeOSuc-Ala-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Myoglobin + H2O
?
show the reaction diagram
-
-
-
?
N-(p-tosyl)-Gly-Pro-Arg 4-nitroanilide + H2O
N-(p-tosyl)-Gly-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-acetyl-GTNRSSKGRSLIGKVDGTSHVTGKGVT-amide + H2O
SLIGKVDGTSHVTGKGVT-amide + N-acetyl-GTNRSSKGR
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-DL-Arg-4-nitroanilide + H2O
N-alpha-benzoyl-DL-Arg + 4-nitroaniline
show the reaction diagram
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
N-alpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
N-alpha-benzoyl-DL-arginine-p-nitroanilide + H2O
N-alpha-benzoyl-DL-arginine + p-nitroaniline
show the reaction diagram
N-alpha-benzoyl-L-Arg ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
show the reaction diagram
N-alpha-benzoyl-L-Arg methyl ester + H2O
N-alpha-benzoyl-L-Arg + methanol
show the reaction diagram
N-alpha-benzoyl-L-Arg-2-naphthylamide + H2O
N-alpha-benzoyl-L-Arg + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-L-Arg-4-nitroanilide + H2O
N-alpha-benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
N-alpha-benzoyl-L-Arg-ethyl ester + H2O
N-alpha-benzoyl-L-Arg + ethanol
show the reaction diagram
N-alpha-benzoyl-L-arginine 4-nitroanilide + H2O
N-alpha-benzoyl-L-arginine + 4-nitroanilide
show the reaction diagram
-
-
-
?
N-alpha-benzoyl-L-arginine ethyl ester + H2O
?
show the reaction diagram
N-alpha-benzoyl-L-arginine ethyl ester + H2O
N-alpha-benzoyl-L-arginine + ethanol
show the reaction diagram
N-alpha-benzoyl-L-arginine-p-nitroanilide + H2O
N-alpha-benzoyl-L-arginine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-L-Lys-p-nitroanilide + H2O
N-alpha-benzoyl-L-Lys + p-nitroaniline
show the reaction diagram
N-alpha-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
N-alpha-benzoyl-L-Phe-L-Val-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-alpha-benzoyl-L-Pro-L-Phe-L-Arg-4-nitroanilide + H2O
N-alpha-benzoyl-L-Pro-L-Phe-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-alpha-p-tosyl-L-Arg methyl ester + H2O
N-alpha-p-tosyl-L-Arg + methanol
show the reaction diagram
-
-
-
-
?
N-alpha-p-tosyl-L-arginine methyl ester + H2O
N-alpha-p-tosyl-L-arginine + ?
show the reaction diagram
-
-
-
-
?
N-alpha-p-tosyl-L-arginine methyl ester + H2O
N-alpha-p-tosyl-L-arginine + ethanol
show the reaction diagram
-
-
-
-
?
N-alpha-p-tosyl-L-arginine methyl ester + H2O
N-alpha-p-tosyl-L-arginine + methanol
show the reaction diagram
-
-
-
-
?
N-benzoyl-DL-Arg-4-nitroanilide + H2O
N-benzoyl-DL-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-DL-Arg-4-nitroanilide + H2O
N-benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-DL-arginine 4-nitroanilide + H2O
N-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
N-benzoyl-DL-arginine-4-nitroanilide + H2O
N-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzoyl-DL-arginyl-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
?
N-Benzoyl-L-Arg ethyl ester + H2O
?
show the reaction diagram
N-benzoyl-L-Arg-4-nitroanilide + H2O
N-benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-arginine 4-nitroanilide + H2O
N-benzoyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
the trypsin-like proteinases from the resistant strains exhibited higher affinity for the substrate than the enzymes from the susceptible strains
-
-
?
N-benzoyl-L-arginine ethyl ester + H2O
N-benzoyl-L-arginine + ethanol
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-arginine-p-nitroanilide + H2O
N-benzoyl-L-arginine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine methyl ester + H2O
N-benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine + methanol
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine-4-nitroanilide + H2O
N-benzoyl-L-isoleucyl-L-glutamyl-glycyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
N-benzyloxycarbonyl-Gly-L-Pro-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide + H2O
N-benzyloxycarbonyl-Gly-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-carbobenzyloxy-Gly-Pro-Arg-p-nitroanilide + H2O
N-carbobenzyloxy-Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
Nafamostat + H2O
?
show the reaction diagram
-
extremely poor substrate
-
?
Nalpha-(tert-butoxycarbonyl)-L-alanyl-L-alanine-4-nitroanilide + H2O
Nalpha-(tert-butoxycarbonyl)-L-alanyl-L-alanine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-4-tosyl-L-Arg methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-4-tosyl-L-arginine methyl ester + H2O
Nalpha-4-tosyl-L-arginine + methanol
show the reaction diagram
Nalpha-benzoyl-DL-Arg 2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-Benzoyl-DL-Arg 4-nitroanilide + H2O
Nalpha-Benzoyl-DL-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-Arg-p-nitroanilide + H2O
?
show the reaction diagram
Nalpha-benzoyl-DL-arginine 4-nitroanilide + H2O
Nalpha-benzoyl-DL-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-arginine 4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
Nalpha-benzoyl-L-arginine + ethanol
show the reaction diagram
Nalpha-Boc-D-Ala-(p-amidino)phenyl ester + D-Ala-4-nitroanilide
Nalpha-Boc-D-Ala-D-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Ala-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Ala-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Ala-Gly-(4-carbamido)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Ala-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Leu-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Leu-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Leu-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Leu-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Phe-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Phe-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-D-Phe-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-D-Phe-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-Gly-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-Gly-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-Gly-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-Gly-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Ala-(p-amidino)phenyl ester + D-Ala-4-nitroanilide
Nalpha-Boc-L-Ala-D-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Ala-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Ala-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Ala-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Ala-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Leu-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Leu-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Leu-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Leu-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Phe-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Phe-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nalpha-Boc-L-Phe-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nalpha-Boc-L-Phe-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nalpha-p-tosyl-L-Arg methyl ester + H2O
?
show the reaction diagram
Nalpha-p-tosyl-L-arginine methyl ester + H2O
?
show the reaction diagram
NATLDPRSFLLRNPNDKYE + H2O
NATLDPR + SFLLRNPNDKYE
show the reaction diagram
-
-
-
-
?
Nbeta-Boc-beta-Ala-(p-amidino)phenyl ester + L-Ala-4-nitroanilide
Nbeta-Boc-beta-Ala-L-Ala-4-nitroanilide + 4-hydroxybenzimidamide
show the reaction diagram
-
-
-
-
?
Nbeta-Boc-beta-Ala-(p-guanidino)phenyl ester + beta-Ala-4-nitroanilide
Nbeta-Boc-beta-Ala-beta-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
Nbeta-Boc-beta-Ala-(p-guanidino)phenyl ester + L-Ala-4-nitroanilide
Nbeta-Boc-beta-Ala-L-Ala-4-nitroanilide + 1-(4-hydroxyphenyl)guanidine
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AAGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AAGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AAGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-ADGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-ADGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-ADGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AEGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AEGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AEGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AFGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AFGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AFGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGARGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGAR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGARGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGDRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGDR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGDRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGERGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGER + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGERGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGFRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGFR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGFRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGGKGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGGRAAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRDAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GDGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGREAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GEGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRFAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GFGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GGGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGGRGDGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGEGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGFGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGGGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGHGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGIGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGKGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGLGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGMGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGNGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGQGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGSGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGTGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGVGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRGYGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGGRHAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GHGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRIAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GIGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRKAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GKGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRLAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GLGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRMAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GMGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRNAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GNGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRQAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GQGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRSAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GSGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRTAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GTGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRVAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GVGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGGRYAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGGR + GYGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGHRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGHR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGHRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGIRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGIR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGIRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGKRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGKR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGKRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGLRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGLR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGLRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGMRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGMR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGMRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGNRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGNR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGNRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGQRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGQR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGQRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGSRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGSR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGSRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGTRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGTR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGTRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AGVRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGVR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGVRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AGYRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AGYR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AGYRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AHGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AHGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AHGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AIGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AIGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AIGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AKGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AKGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AKGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-ALGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-ALGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-ALGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AMGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AMGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AMGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-ANGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-ANGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-ANGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AQGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AQGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AQGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-ASGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-ASGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-ASGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-ATGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-ATGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-ATGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-AVGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AVGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AVGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
o-aminobenzoyl-AYGRGAGQ-(2,3-dinitrophenyl-ethylene diamine) + H2O
o-aminobenzoyl-AYGR + GAGQ-(2,3-dinitrophenyl-ethylene diamine)
show the reaction diagram
-
-
-
?
o-aminobenzoyl-AYGRGAGQ-(2,4-dinitrophenyl-ethylene diamine) + H2O
?
show the reaction diagram
ovalbumin + H2O
?
show the reaction diagram
-
-
-
?
p-amidinophenyl acetate + H2O
p-amidinophenol + acetate
show the reaction diagram
-
-
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
-
-
-
-
?
p-nitrophenyl p'-guanidinobenzoate + H2O
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl-p'-guanidino benzoate + H2O
p-nitrophenol + p-guanidinobenzoate
show the reaction diagram
p-tosyl-L-Arg methyl ester + H2O
?
show the reaction diagram
Pefachrome + H2O
?
show the reaction diagram
-
-
-
?
Pefachrome tPA + H2O
?
show the reaction diagram
-
-
-
?
peroxidase + H2O
?
show the reaction diagram
-
-
-
?
pre-Pro-Arg-insulin + H2O
mono/di-Arg insulin + ?
show the reaction diagram
-
-
-
-
-
Pro-Arg-insulin + H2O
mono/di-Arg insulin + ?
show the reaction diagram
-
-
-
-
-
pro-human defensin-5 + H2O
human defensin-5 + pro-human defensin-5 propeptide
show the reaction diagram
-
pro-human defensin-5 in the intestinal lumen is processed by trypsin in a complex in which chymotrypsinogen is also cleaved for activation
-
-
?
pro-insulin + H2O
human insulin-threonine-ester
show the reaction diagram
-
-
-
-
-
pro-matrix metalloproteinase-2 + H2O
matrix metalloproteinase-2 + pro-peptide
show the reaction diagram
-
activation by trypsin depends on various factors such as the level of exogenously added Ca2+ and Brij-35, temperature, and trypsin concentration. Activation occurs as sequential processing, initially generating an active 62 kDa species followed by successive truncation of the C-terminal domain leading to active species of 56 kDa, 52 kDa and 50kDa. Comparison with activation of pro-matrix metalloproteinase-2 by membrane-type 1 metalloproteinase or 4-aminophenylmercuric acetate
-
-
?
protease-activated receptor-1 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-2 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-3 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-4 + H2O
?
show the reaction diagram
-
activation
-
-
?
proteinase-activated receptor 1 + H2O
?
show the reaction diagram
-
-
-
-
?
proteinase-activated receptor PAR-1 + H2O
activated proteinase-activated receptor PAR-1
show the reaction diagram
-
no activation by mesotrypsin in epithelial cells, but mesotrypsin activates PAR-1 in astrocytoma cells. Half-maximal response for both cationic and anionic trypsin at about 10-20 nM
-
-
?
proteinase-activated receptor PAR-2 + H2O
activated proteinase-activated receptor PAR-2
show the reaction diagram
-
no activation by mesotrypsin in epithelial cells. Half-maximal response for both cationic and anionic trypsin at about 5 nM
-
-
?
proteinase-activated receptor PAR-3 + H2O
activated proteinase-activated receptor PAR-3
show the reaction diagram
-
no activation by mesotrypsin in epithelial cells. Half-maximal response for both cationic and anionic trypsin at about 10-20 nM
-
-
?
S-2222 + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Arg-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Pro-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Leu-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Pro-Lys-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Pro-Lys-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Pro-Trp-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Trp + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-Ala-Ala-Pro-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Ala-Ala-Pro-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Leu-7-amido-4-methylcoumarin + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Lys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
superoxide dismutase 1 + H2O
?
show the reaction diagram
-
-
-
-
?
tert-butoxycarbonyl-L-Gln-L-Ala-L-Arg-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-L-Gln-L-Ala-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-Gln-Arg-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-Gln-Gly-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
Tos-L-Arg-OMe + H2O
?
show the reaction diagram
tosyl-Gly-Pro-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
?
show the reaction diagram
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
?
tosyl-Gly-Pro-Lys-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
?
tosyl-GPK-p-nitroanilide + H2O
tosyl-GPK + p-nitroaniline
show the reaction diagram
tosyl-GPR-p-nitroanilide + H2O
tosyl-GPR + p-nitroaniline
show the reaction diagram
ubiquitin + H2O
?
show the reaction diagram
-
-
-
-
?
VP4 + H2O
fragments VP8* and VP5*
show the reaction diagram
-
outer layer protein of rotavirus capsid
-
-
?
Z-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Ala-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
low amidolytic activity
-
-
?
Z-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
low amidolytic activity
-
-
?
Z-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
Z-Gly-Gly-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
low amidolytic activity
-
-
?
Z-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Z-Gly-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Gly-Pro-Arg-p-nitroanilide + H2O
Z-Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Z-Phe-Arg-4-methylcoumaryl-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
low activity
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
high amidolytic activity
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
DrmSP8-36 + H2O
?
show the reaction diagram
-
trypsin is the major endopeptidase regulating N-terminal truncated sex peptide DrmSP8-36 in hemolymph, the trypsin cleavage site R7-K8 is essential for release of the C-terminal fragment SP8-36 from sperm tail, the protein is cleaved more rapidly and completely in mated female hemolymph
-
-
?
enhanced green fluorescent protein-T1 + H2O
?
show the reaction diagram
-
enhanced green fluorescent protein-T1 is specifically cleaved into two major fragments by trypsin at the grafted cleavage site, approximately 20 and 8 kDa
-
-
?
enhanced green fluorescent protein-T2 + H2O
?
show the reaction diagram
-
enhanced green fluorescent protein-T2 is specifically cleaved into two major fragments by trypsin at the grafted cleavage site, approximately 18 and 10 kDa
-
-
?
Gelatin + H2O
?
show the reaction diagram
-
-
-
-
?
human cartilage collagen type II + H2O
?
show the reaction diagram
-
use of enzyme and its regulators as markers of prognosis and disease activity in rheumatoid arthritis
-
-
?
intestinal alkaline sphingomyelinase bound to mucosa + H2O
free intestinal alkaline sphingomyelinase
show the reaction diagram
-
cleavage at R440, first tryptic site upstream of signal anchor. Physiological role of enzyme in sphingomyelin digestion
-
-
?
protease-activated receptor-1 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-2 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-3 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-4 + H2O
?
show the reaction diagram
-
activation
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Na+
-
Na+ activation is interwoven with substrate selectivity in the trypsin scaffold
Ni2+
-
trypsin N143H/E151H hydrolyzes the peptide AGPYAHSS exclusively in presence of Ni2+ or Zn2+ with high levels of catalytic efficiency
Zn2+
-
trypsin N143H/E151H hydrolyzes the peptide AGPYAHSS exclusively in presence of Ni2+ or Zn2+ with high levels of catalytic efficiency
additional information