Reference on EC 1.5.1.33 - pteridine reductase
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Nare, B.; Hardy, L.W.; Beverley, S.M.
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
J. Biol. Chem.
272
13883-13891
1997
Leishmania major, Leishmania tarentolae
Robello, C.; Navarro, P.; Castanys, S.; Gamarro, F.
A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi
Mol. Biochem. Parasitol.
90
525-535
1997
Trypanosoma cruzi, Trypanosoma cruzi Y
Nare, B.; Luba, J.; Hardy, L.W.; Beverley, S.
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
Parasitology
114
101-110
1997
Leishmania major
-
Hardy, L.W.; Matthews, W.; Nare, B.; Beverley, S.M.
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways
Exp. Parasitol.
87
157-169
1997
Leishmania major
Leblanc, E.; Papadopoulou, B.; Bernatchez, C.; Ouellette, M.
Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania
Eur. J. Biochem.
251
768-774
1998
Leishmania tarentolae
Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
Proc. Natl. Acad. Sci. USA
91
11442-11446
1994
Leishmania major
Wang, J.; Leblanc, E.; Chang, C.F.; Papadopoulou, B.; Bray, T.; Witheley, J.M.; Lin, S.X.; Quellette, M.
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1
Arch. Biochem. Biophys.
342
197-202
1997
Leishmania tarentolae
Luba, J.; Nare, B.; Liang, P.H.; Anderson, K.S.; Beverley, S.M.; Hardy, L.W.
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence
Biochemistry
37
4093-4104
1998
Leishmania major
Zhao, H.; Bray, T.; Ouellette, M.; Zhao, M.; Ferre, R.A.; Matthews, D.; Whiteley, J.M.; Varughese, K.I.
Structure of pteridine reductase (PTR1) from Leishmania tarentolae
Acta Crystallogr. Sect. D
59
1539-1544
2003
Leishmania tarentolae (P42556), Leishmania tarentolae
McLuskey, K.; Gibellini, F.; Carvalho, P.; Avery, M.A.; Hunter, W.N.
Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex
Acta Crystallogr. Sect. D
60
1780-1785
2004
Leishmania major (Q01782), Leishmania major
Kumar, P.; Kothari, H.; Singh, N.
Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani
Protein Expr. Purif.
38
228-236
2004
Leishmania donovani (Q6QDB5), Leishmania donovani
Schuettelkopf, A.W.; Hardy, L.W.; Beverley, S.M.; Hunter, W.N.
Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design
J. Mol. Biol.
352
105-116
2005
Leishmania major
Dawson, A.; Gibellini, F.; Sienkiewicz, N.; Tulloch, L.B.; Fyfe, P.K.; McLuskey, K.; Fairlamb, A.H.; Hunter, W.N.
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
Mol. Microbiol.
61
1457-1468
2006
Trypanosoma brucei
Kumar, P.; Sundar, S.; Singh, N.
Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani
Exp. Parasitol.
116
182-189
2007
Leishmania donovani (Q6QDB5), Leishmania donovani
Kumar, P.; Kumar, A.; Verma, S.S.; Dwivedi, N.; Singh, N.; Siddiqi, M.I.; Tripathi, R.P.; Dube, A.; Singh, N.
Leishmania donovani pteridine reductase 1: biochemical properties and structure-modeling studies
Exp. Parasitol.
120
73-79
2008
Leishmania donovani
Cavazzuti, A.; Paglietti, G.; Hunter, W.N.; Gamarro, F.; Piras, S.; Loriga, M.; Allecca, S.; Corona, P.; McLuskey, K.; Tulloch, L.; Gibellini, F.; Ferrari, S.; Costi, M.P.
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Proc. Natl. Acad. Sci. USA
105
1448-1453
2008
Trypanosoma cruzi, Leishmania major (Q01782), Leishmania major
Shanks, E.J.; Ong, H.B.; Robinson, D.A.; Thompson, S.; Sienkiewicz, N.; Fairlamb, A.H.; Frearson, J.A.
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
Anal. Biochem.
396
194-203
2010
Trypanosoma brucei (O76290), Trypanosoma brucei
Kaur, J.; Singh, B.K.; Tripathi, R.P.; Singh, P.; Singh, N.
Leishmania donovani: a glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes
Exp. Parasitol.
123
258-264
2009
Leishmania donovani (Q6QDB5), Leishmania donovani
Mpamhanga, C.P.; Spinks, D.; Tulloch, L.B.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Fairlamb, A.H.; Wyatt, P.G.; Frearson, J.A.; Hunter, W.N.; Gilbert, I.H.; Brenk, R.
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening
J. Med. Chem.
52
4454-4465
2009
Trypanosoma brucei (O76290)
Singh, N.; Kaur, J.; Kumar, P.; Gupta, S.; Singh, N.; Ghosal, A.; Dutta, A.; Kumar, A.; Tripathi, R.; Siddiqi, M.I.; Mandal, C.; Dube, A.
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
Parasitol. Res.
105
1317-1325
2009
Leishmania donovani
Nare, B.; Garraway, L.A.; Vickers, T.J.; Beverley, S.M.
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major
Curr. Genet.
55
287-299
2009
Leishmania major
Kaur, J.; Singh, N.; Singh, B.K.; Dube, A.; Tripathi, R.P.; Singh, P.; Singh, N.
Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes
Exp. Parasitol.
125
310-314
2010
Leishmania major
Kaur, J.; Sundar, S.; Singh, N.
Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani
J. Antimicrob. Chemother.
65
1742-1748
2010
Leishmania donovani
Tulloch, L.B.; Martini, V.P.; Iulek, J.; Huggan, J.K.; Lee, J.H.; Gibson, C.L.; Smith, T.K.; Suckling, C.J.; Hunter, W.N.
Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases
J. Med. Chem.
53
221-229
2010
Leishmania major, Trypanosoma brucei (Q581W1), Trypanosoma brucei
Sienkiewicz, N.; Ong, H.B.; Fairlamb, A.H.
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice
Mol. Microbiol.
77
658-671
2010
Trypanosoma brucei
Barrack, K.L.; Tulloch, L.B.; Burke, L.A.; Fyfe, P.K.; Hunter, W.N.
Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site
Acta Crystallogr. Sect. F
67
33-37
2011
Leishmania donovani (Q6QDB5), Leishmania donovani
Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R.; Fairlamb, A.H.; Gilbert, I.H.
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1
ChemMedChem
6
302-308
2011
Trypanosoma brucei
Kazemi, B.; Tohidi, F.; Bandehpour, M.; Yarian, F.
Molecular cloning, expression and enzymatic assay of pteridine reductase 1 from Iranian lizard Leishmania
Iran. Biomed. J.
14
97-102
2010
Leishmania sp. (A2TEY0), Leishmania sp. BK-2007 (A2TEY0)
Ong, H.B.; Sienkiewicz, N.; Wyllie, S.; Fairlamb, A.H.
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major
J. Biol. Chem.
286
10429-10438
2011
Leishmania major, Trypanosoma brucei
Sahi, S.; Tewatia, P.; Ghosal, S.
Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum
J. Mol. Model.
18
5065-5073
2012
Leishmania donovani
Leite, F.H.A.; Froes, T.Q.; da Silva, S.G.; de Souza, E.I.M.; Vital-Fujii, D.G.; Trossini, G.H.G.; Pita, S.S.D.R.; Castilho, M.S.
An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors
Eur. J. Med. Chem.
132
322-332
2017
Leishmania major
de Souza Moreira, D.; Ferreira, R.F.; Murta, S.M.
Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines
Exp. Parasitol.
160
60-66
2016
Leishmania amazonensis (O09352), Leishmania amazonensis, Leishmania braziliensis (A4HCP1), Leishmania braziliensis, Leishmania guyanensis (A0A1E1IZ95), Leishmania guyanensis, Leishmania infantum (A4I067), Leishmania infantum
Khalaf, A.I.; Huggan, J.K.; Suckling, C.J.; Gibson, C.L.; Stewart, K.; Giordani, F.; Barrett, M.P.; Wong, P.E.; Barrack, K.L.; Hunter, W.N.
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
J. Med. Chem.
57
6479-6494
2014
Trypanosoma brucei
Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-Da-Silva, A.; Moraes, C.; Alcantara, L.; Fontana, V.; Freitas-Junior, L.; Gul, S.; Kuzikov, M.; Behrens, B.; Poehner, I.; Wade, R.; Costi,
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
Molecules
22
E426
2017
no activity in Homo sapiens, Trypanosoma brucei (O76290), Leishmania major (Q01782)
Landi, G.; Linciano, P.; Tassone, G.; Costi, M.P.; Mangani, S.; Pozzi, C.
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
Acta Crystallogr. Sect. D
76
558-564
2020
Trypanosoma brucei brucei (O76290)
Shamshad, H.; Hafiz, A.; Althagafi, I.I.; Saeed, M.; Mirza, A.Z.
Characterization of the Trypanosoma brucei pteridine reductase active-site using computational docking and virtual screening techniques
Curr. Comput. aided Drug Des.
16
583-598
2020
Trypanosoma brucei brucei (O76290), Leishmania major (Q01782), Leishmania major
Linciano, P.; Cullia, G.; Borsari, C.; Santucci, M.; Ferrari, S.; Witt, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Santarem, N.; Cordeiro da Silva, A.; Conti, P.; Bolognesi, M.L.; Roberti, M.; Prati, F.; Bartoccini, F.; Retini, M.; Piersanti, G.; Cavalli, A.; Goldoni, L.; Bertozzi, S.M.; Bertozzi, F.; , B.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Eur. J. Med. Chem.
189
112047
2020
Trypanosoma brucei brucei (O76290), Leishmania major (Q01782), Leishmania major
Phadke, S.; Somani, R.; Pathak, D.
New benzimidazole derivatives as inhibitors of Pteridine reductase 1 design, molecular docking study and ADMET prediction
J. Appl. Pharm. Sci.
10
30-39
2020
Leishmania major (Q01782)
-
Labine, M.; DePledge, L.; Feirer, N.; Greenwich, J.; Fuqua, C.; Allen, K.
Enzymatic and mutational analysis of the PruA pteridine reductase required for pterin-dependent control of biofilm formation in Agrobacterium tumefaciens
J. Bacteriol.
202
e00098-20
2020
Leishmania major (Q01782), Agrobacterium fabrum (Q7CZX3), Agrobacterium fabrum C58 (Q7CZX3), Agrobacterium fabrum ATCC 33970 (Q7CZX3)
Herrmann, F.C.; Sivakumar, N.; Jose, J.; Costi, M.P.; Pozzi, C.; Schmidt, T.J.
In silico identification and in vitro evaluation of natural inhibitors of Leishmania major pteridine reductase I
Molecules
22
2166
2017
Leishmania major (Q01782), Leishmania major
Kimuda, M.P.; Laming, D.; Hoppe, H.C.; Tastan Bishop, Oe.
Identification of novel potential inhibitors of pteridine reductase 1 in Trypanosoma brucei via computational structure-based approaches and in vitro inhibition assays
Molecules
24
142
2019
Trypanosoma cruzi (O44029), Trypanosoma brucei brucei (O76290)
Herrera-Acevedo, C.; Flores-Gaspar, A.; Scotti, L.; Mendonca-Junior, F.J.B.; Scotti, M.T.; Coy-Barrera, E.
Identification of kaurane-type diterpenes as inhibitors of Leishmania pteridine reductase I
Molecules
26
0000
2021
Leishmania panamensis (A0A088SA10), Leishmania panamensis, Leishmania braziliensis (A4HCP1), Leishmania amazonensis (O09352), Leishmania major (Q01782), Leishmania major
Tassone, G.; Landi, G.; Linciano, P.; Francesconi, V.; Tonelli, M.; Tagliazucchi, L.; Costi, M.P.; Mangani, S.; Pozzi, C.
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of Trypanosoma brucei pteridine reductase and dihydrofolate reductase
Pharmaceuticals
14
636
2021
Trypanosoma brucei brucei (O76290)
Bhattacharya, A.; Leprohon, P.; Ouellette, M.
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
PLoS Negl. Trop. Dis.
15
e0009377
2021
Leishmania infantum (A4I067), Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263 (A4I067)
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