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Literature summary for 1.5.1.33 extracted from
- Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase (2010), Anal. Biochem., 396, 194-203.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as N-terminal His6-tagged protein in Spodoptera frugiperda 21 cells | Trypanosoma brucei |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Trypanosoma brucei |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methotrexate | - |
Trypanosoma brucei |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | O76290 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Trypanosoma brucei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrobiopterin + NADPH | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pteridine reductase 1 | - |
Trypanosoma brucei |
| PTR1 | - |
Trypanosoma brucei |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000111 | - |
methotrexate | - |
Trypanosoma brucei | |
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Release 2023.1 (January 2023)
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