Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania major | primary enzyme mediating pteridine salvage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Biopterin + NADPH | activity with NADH is less than 5% of the activity with NADPH | Leishmania major | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
Dihydrobiopterin + NADPH | - |
Leishmania major | ? | - |
? | |
Dihydrofolate + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrofolate + NADP+ | - |
? | |
folate + NADPH | - |
Leishmania major | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
additional information | no activity with quinoid dihydrobiopterin | Leishmania major | ? | - |
? | |
additional information | primary enzyme mediating pteridine salvage | Leishmania major | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
biopterin as substrate | Leishmania major |
4.7 | - |
dihydrobiopterin as substrate | Leishmania major |
6 | - |
dihydrofolate as substrate | Leishmania major |
6 | - |
folate as substrate | Leishmania major |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Leishmania major |