Cloned (Comment) | Organism |
---|---|
- |
Trypanosoma brucei |
Crystallization (Comment) | Organism |
---|---|
- |
Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dihydrobiopterin | substrate inhibition | Trypanosoma brucei | |
methotrexate | - |
Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0109 | - |
dihydrobiopterin | pH 3.7 | Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.1 | - |
pH 3.7, substrate dihydrofolate | Trypanosoma brucei |
0.1 | - |
pH 3.7, substrate folate | Trypanosoma brucei |
2 | - |
pH 3.7, substrate biopterin | Trypanosoma brucei |
2.3 | - |
pH 3.7, substrate dihydrobiopterin | Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Biopterin + NADPH | - |
Trypanosoma brucei | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
dihydrobiopterin + NADPH | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + NADP+ | - |
? | |
Dihydrofolate + NADPH | - |
Trypanosoma brucei | 5,6,7,8-Tetrahydrofolate + NADP+ | - |
? | |
folate + NADPH | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | crystallization data | Trypanosoma brucei |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.7 | - |
dihydrobiopterin | pH 3.7 | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.7 | - |
- |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000152 | - |
methotrexate | pH 3.7 | Trypanosoma brucei | |
0.0038 | - |
dihydrobiopterin | pH 3.7 | Trypanosoma brucei |