Literature summary for 1.5.1.33 extracted from

Kaur, J.; Singh, B.K.; Tripathi, R.P.; Singh, P.; Singh, N.
Leishmania donovani: a glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes (2009), Exp. Parasitol., 123, 258-264.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,6-dimethyl-4-(3-O-benzyl-1,2-ortho-isopropylidene-beta-L-threopentofuranos-4-yl)-1-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester	treatment with 90 microM GDA resulted in reduction of viable cells from 94.2% (control) to 77.1%, 76.8%, 74.9%, 35.3% and 24.9% at 18, 24, 48, 72 and 96 h, respectively	Leishmania donovani

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	Q6QDB5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
pteridine reductase 1	-	Leishmania donovani
PTR1	-	Leishmania donovani

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Release 2023.1 (January 2023)