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Literature summary for 1.5.1.33 extracted from

  • de Souza Moreira, D.; Ferreira, R.F.; Murta, S.M.
    Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines (2016), Exp. Parasitol., 160, 60-66 .
    View publication on PubMed
Search for more literature for 1.5.1.33

Cloned(Commentary)

Cloned (Comment) Organism
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts Leishmania guyanensis
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts Leishmania amazonensis
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts. Overexpression of ptr1 gene in the wild-type Leishmania braziliensis lines increases 2fold the SbIII-resistance phenotype compared to the non-transfected counterpart Leishmania braziliensis
gene ptr1 from wild-type and SbIII-resistant lines, DNA and amino acid sequenc determination, analysis, and comparison, chromosomal localization, enzyme expression analysis. PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts. Overexpression of ptr1 gene in the wild-type Leishmania infantum lines does not change the SbIII-resistance phenotype Leishmania infantum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biopterin + 2 NADPH + 2 H+ Leishmania guyanensis
-
 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+ Leishmania amazonensis
-
 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+ Leishmania braziliensis
-
 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+ Leishmania infantum
-
 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania amazonensis O09352 wild-type (WTS) and SbIII-resistant (SbR) lines
-
Leishmania braziliensis A4HCP1 wild-type (WTS) and SbIII-resistant (SbR) lines
-
Leishmania guyanensis A0A1E1IZ95 wild-type (WTS) and SbIII-resistant (SbR) lines
-
Leishmania infantum A4I067 wild-type (WTS) and SbIII-resistant (SbR) lines
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biopterin + 2 NADPH + 2 H+
-
 Leishmania guyanensis 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+
-
 Leishmania amazonensis 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+
-
 Leishmania braziliensis 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?
biopterin + 2 NADPH + 2 H+
-
 Leishmania infantum 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
 ?

Synonyms

Synonyms Comment Organism
PTR1
-
 Leishmania guyanensis
PTR1
-
 Leishmania amazonensis
PTR1
-
 Leishmania braziliensis
PTR1
-
 Leishmania infantum

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Leishmania guyanensis
NADPH dependent on Leishmania amazonensis
NADPH dependent on Leishmania braziliensis
NADPH dependent on Leishmania infantum

Expression

Organism Comment Expression
Leishmania guyanensis PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts additional information
Leishmania amazonensis PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts additional information
Leishmania braziliensis PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts additional information
Leishmania infantum PTR1 protein is more expressed in the Sb-resistant lines compared to their respective wild-type counterparts additional information

General Information

General Information Comment Organism
physiological function the enzyme participates in the salvage of pteridines, which are essential to maintain growth of Leishmania Leishmania guyanensis
physiological function the enzyme participates in the salvage of pteridines, which are essential to maintain growth of Leishmania Leishmania amazonensis
physiological function the enzyme participates in the salvage of pteridines, which are essential to maintain growth of Leishmania Leishmania braziliensis
physiological function the enzyme participates in the salvage of pteridines, which are essential to maintain growth of Leishmania Leishmania infantum