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Information on EC - pteridine reductase

for references in articles please use BRENDA:EC1.5.1.33
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EC Tree
     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
       pteridine reductase
IUBMB Comments
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC (dihydrofolate reductase) and EC (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC (dihydrofolate reductase) in being specific for the Si-face of NADPH.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
pteridine reductase, pteridine reductase 1, tbptr1, lmptr1, ldptr1, nadph-dihydropteridine reductase, more
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+
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