Information on EC 2.6.1.1 - aspartate transaminase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
2.6.1.1
-
RECOMMENDED NAME
GeneOntology No.
aspartate transaminase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
(R)-cysteate degradation
-
Alanine, aspartate and glutamate metabolism
-
anaerobic energy metabolism (invertebrates, cytosol)
-
Arginine and proline metabolism
-
aspartate biosynthesis
-
aspartate degradation I
-
aspartate degradation II
-
Biosynthesis of secondary metabolites
-
C4 photosynthetic carbon assimilation cycle, NAD-ME type
-
C4 photosynthetic carbon assimilation cycle, PEPCK type
-
Carbon fixation in photosynthetic organisms
-
coenzyme M biosynthesis II
-
Cysteine and methionine metabolism
-
glutamate degradation II
-
Isoquinoline alkaloid biosynthesis
-
Metabolic pathways
-
Microbial metabolism in diverse environments
-
Novobiocin biosynthesis
-
phenylalanine degradation IV (mammalian, via side chain)
-
Phenylalanine metabolism
-
Phenylalanine, tyrosine and tryptophan biosynthesis
-
sulfolactate degradation III
-
TCA cycle VI (obligate autotrophs)
-
Tropane, piperidine and pyridine alkaloid biosynthesis
-
Tyrosine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-aspartate:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. Aspartate transaminase activity can be formed from the aromatic-amino-acid transaminase (EC 2.6.1.57) of Escherichia coli by controlled proteolysis [7], some EC 2.6.1.57 activity can be found in this enzyme from other sources [8]; indeed the enzymes are identical in Trichomonas vaginalis [6].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2-oxoglutarate-glutamate aminotransferase
-
-
-
-
AAT
-
-
-
-
AAT
Q4LDF8
-
AAT
P00509
-
AAT
Q5F4K8
-
AAT
Spirodela polyrhiza SJ
-
-
-
AAT
-
-
aatB3
Q939C9
-
aminotransferase, aspartate
-
-
-
-
AsAT
-
-
aspartate alpha-ketoglutarate transaminase
-
-
-
-
aspartate aminotransferase
-
-
-
-
aspartate aminotransferase
Q9SIE1
-
aspartate aminotransferase
-
-
aspartate aminotransferase
Q4LDF8
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
Q5F4K8
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
Spirodela polyrhiza SJ
-
-
-
aspartate aminotransferase
-
-
aspartate aminotransferase
P14909
-
aspartate aminotransferase
-
-
aspartate aminotransferase
Q7ZTK9
-
aspartate transaminase
-
-
aspartate, 2-oxoglutarate aminotransferase
-
-
aspartate-2-oxoglutarate transaminase
-
-
-
-
aspartate/(R)-cysteate:2-oxoglutarate aminotransferase
-
-
aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase
-
-
aspartate:2-oxoglutarate amino-transferase
-
-
aspartate:2-oxoglutarate aminotransferase
-
-
-
-
aspartic acid aminotransferase
-
-
-
-
aspartic aminotransferase
-
-
-
-
aspartyl aminotransferase
-
-
-
-
AspAT
P00509
-
AspAT
-
-
AspAT
Haloferax mediterranei R-4
-
-
-
AspAT
-
-
AspAT
O96142
-
AspAT
Pseudoalteromonas haloplanktis TAC 125
-
-
-
AspATSs
P14909
-
AspATSs
Sulfolobus solfataricus MT-4
-
-
-
AspT
-
-
-
-
AST
-
-
-
-
AST
Q4LDF8
-
AST
P00507
-
AST
-
-
AST-Bb
-
-
C-S lyase
P00507
-
EcAspAT
P00509
wild-type enzyme shows weak desulfination activity and decarboxylation activity
glutamate oxaloacetate transaminase
-
-
-
-
glutamate-oxalacetate aminotransferase
-
-
-
-
glutamate-oxalate transaminase
-
-
-
-
glutamic oxalic transaminase
-
-
-
-
glutamic oxaloacetic transaminase
-
-
glutamic-aspartic aminotransferase
-
-
-
-
glutamic-aspartic transaminase
-
-
-
-
glutamic-oxalacetic transaminase
-
-
-
-
glutamic-oxaloacetic transaminase
-
-
-
-
GOT
Q4LDF8
-
GOT
P00507
-
GOT
-
-
GOT (enzyme)
-
-
-
-
L-aspartate aminotransferase
-
-
L-aspartate aminotransferase
Escherichia coli TY103
-
-
-
L-aspartate transaminase
-
-
-
-
L-aspartate-2-ketoglutarate aminotransferase
-
-
-
-
L-aspartate-2-oxoglutarate aminotransferase
-
-
-
-
L-aspartate-2-oxoglutarate-transaminase
-
-
-
-
L-aspartate-alpha-ketoglutarate transaminase
-
-
-
-
L-aspartate:2-oxoglutarate aminotransferase
-
-
L-aspartateartate aminotransferase
P00509
-
L-aspartic aminotransferase
-
-
-
-
L-AspAT
D3H0F7
-
oxaloacetate transferase
-
-
-
-
oxaloacetate-aspartate aminotransferase
-
-
-
-
plastid aspartate aminotransferase
-
-
protein TT0402
-
-
SsAspAT
-, P14909
-
transaminase A
-
-
-
-
additional information
-
aspartate aminotransferases are divided into 2 subgroups: subgroup Ia, inclusive the enzyme of Escherichia coli, posses Arg292 for substrate binding and show a specificity for acidic substrates only, subgroup Ib, inclusive the enzyme of Thermus thermophilus, can utilize acidic as well as neutral substrates
additional information
-
EC 2.6.1.57 may be converted to EC 2.6.1.1 by controlled proteolysis with subtilisin, the 2 enzymes are encoded by 2 different genes with high sequence homology
additional information
-
aspartate aminotransferases are divided into 2 subgroups: subgroup Ia, inclusive the enzyme of Escherichia coli, posses Arg292 for substrate binding and show a specificity for acidic substrates only, subgroup Ib, inclusive the enzyme of Thermus thermophilus, can utilize acidic as well as neutral substrates
CAS REGISTRY NUMBER
COMMENTARY
9000-97-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
2 genotypes
-
-
Manually annotated by BRENDA team
3 genes encoding 3 different isozymes: asp1 is mitochondrial, asp3 is amyloplastidic and asp2 is cytosolic
-
-
Manually annotated by BRENDA team
2 major isozymes: Asp-DEAE-1 and Asp-DEAE-2
-
-
Manually annotated by BRENDA team
2 isozymes; var. Lodi
-
-
Manually annotated by BRENDA team
strain YM-2
-
-
Manually annotated by BRENDA team
strain YM-2
-
-
Manually annotated by BRENDA team
Bradyrhizobium japonicum 392
strain 392
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozymes; mongrel dogs
-
-
Manually annotated by BRENDA team
Chlamydomonas reinhardtii 6145c
strain 6145c
-
-
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
cytosolic form I, and mitochondrial forms II and III
-
-
Manually annotated by BRENDA team
dolphin
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
isoenzymes: AspAT-1, AspAT-2, AspAT-3
-
-
Manually annotated by BRENDA team
B; isoenzymes A and B
-
-
Manually annotated by BRENDA team
mutant K258A
-
-
Manually annotated by BRENDA team
mutant V39L
-
-
Manually annotated by BRENDA team
Escherichia coli TY103
-
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozymes
-
-
Manually annotated by BRENDA team
different molecular forms: alpha, beta, gamma, delta, epsilon
-
-
Manually annotated by BRENDA team
3 isozymes: 2 cytosolic, 1 mitochondrial
-
-
Manually annotated by BRENDA team
strain R-4, ATCC 33500
-
-
Manually annotated by BRENDA team
Haloferax mediterranei R-4
strain R-4, ATCC 33500
-
-
Manually annotated by BRENDA team
cytosolic isozyme
-
-
Manually annotated by BRENDA team
4 isozymes: AST I , AST II, AST III, AST IV; camel tick
-
-
Manually annotated by BRENDA team
Leptosphaeria michotii
2 isozymes A and B
-
-
Manually annotated by BRENDA team
grey mullet, Osteichthyes
-
-
Manually annotated by BRENDA team
2 isozymes: AAT1 and AAT2; cv. Estoril
-
-
Manually annotated by BRENDA team
2 cytosolic isozymes: AAT-P1 and AAT-P2; cv. Uniharvest
-
-
Manually annotated by BRENDA team
2 cytosolic isozymes: AAT-1 and AAT-2, the latter has the 3 forms AAT-2a, AAT-2b, AAT-2c
-
-
Manually annotated by BRENDA team
2 isozymes; Jacq. var. trichoglume Eyles
-
-
Manually annotated by BRENDA team
DSM 6457; strain SF-4; strains FTF-INRA, DSM 3012
-
-
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicus SF-4
strain SF-4
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
2 isoenzymes: AAT-1, AAT-2; cv. Koganemasari
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozymes
-
-
Manually annotated by BRENDA team
cytosolic isozyme
-
-
Manually annotated by BRENDA team
at least 3 isozymes: inducible cytosolic cAspAT and mitochondrial mAspAT, and a constitutive minor plastidic pAspAT
-
-
Manually annotated by BRENDA team
; prokaryotic-type isoform
-
-
Manually annotated by BRENDA team
Pseudoalteromonas haloplanktis TAC 125
strain TAC 125
-
-
Manually annotated by BRENDA team
strain IFO 12996
-
-
Manually annotated by BRENDA team
Pseudomonas putida IFO 12996
strain IFO 12996
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozyme; male Wistar rats
-
-
Manually annotated by BRENDA team
male Wistar rats; purified cytosolic isozyme
-
-
Manually annotated by BRENDA team
mature mitochondrial isozyme mAAT
SwissProt
Manually annotated by BRENDA team
mitochondrial isozyme mAspAT
-
-
Manually annotated by BRENDA team
purified premature mitochondrial isozyme pmAAT
-
-
Manually annotated by BRENDA team
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
clam, mollusca: Bivalvia
-
-
Manually annotated by BRENDA team
strain SJ
-
-
Manually annotated by BRENDA team
Spirodela polyrhiza SJ
strain SJ
-
-
Manually annotated by BRENDA team
strain MT4
SwissProt
Manually annotated by BRENDA team
Sulfolobus solfataricus MT-4
-
-
-
Manually annotated by BRENDA team
Sulfolobus solfataricus MT4
strain MT4
SwissProt
Manually annotated by BRENDA team
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
mitochondrial isozyme
-
-
Manually annotated by BRENDA team
purified cytosolic isozyme
-
-
Manually annotated by BRENDA team
strain HB8
-
-
Manually annotated by BRENDA team
strain HB8
Uniprot
Manually annotated by BRENDA team
Torulopsis candida
cytosolic and mitochondrial isozyme
-
-
Manually annotated by BRENDA team
Bushby strain
-
-
Manually annotated by BRENDA team
Trichomonas vaginalis Bushby
Bushby strain
-
-
Manually annotated by BRENDA team
cytosolic isoform
UniProt
Manually annotated by BRENDA team
mitochondrial isoform
Q964F0
UniProt
Manually annotated by BRENDA team
cytosolic isoform
UniProt
Manually annotated by BRENDA team
mitochondrial isoform
UniProt
Manually annotated by BRENDA team
-
Q7ZTK9
UniProt
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli O44:H18 (strain 042 / EAEC)
Escherichia coli O44:H18 (strain 042 / EAEC)
Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Plasmodium falciparum (isolate 3D7)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Staphylococcus aureus (strain NCTC 8325)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)