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Literature summary for 2.6.1.1 extracted from

  • Artigues, A.; Crawford, D.L.; Iriarte, A.; Martinez-Carrion, M.
    Divergent Hsc70 binding properties of mitochondrial and cytosolic aspartate aminotransferase. Implications for their segregation to different cellular compartments (1998), J. Biol. Chem., 273, 33130-33134.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cytosolic Hsp70, from bovine brain, protein exclusively binds to the mitochondrial isozyme, regulatory function Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mature isozyme mAAT Rattus norvegicus 5739
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mitochondrion mitochondrial isoenzyme Rattus norvegicus 5739
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additional information cytosolic and mitochondrial isozymes bind differently to the 70 kDa heat shock protein Hsp70, which regulates the folding and aggregation process of polypeptides, sequence and distribution of Hsp70-binding regions allow the classification of isozymes into a phylogenetic tree, overview Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate + 2-oxoglutarate Rattus norvegicus
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oxaloacetate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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purified premature mitochondrial isozyme pmAAT
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Rattus norvegicus P00507 mature mitochondrial isozyme mAAT
-

Source Tissue

Source Tissue Comment Organism Textmining
liver premature and mature mitochondrial isozyme Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate + 2-oxoglutarate
-
Rattus norvegicus oxaloacetate + L-glutamate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal 5'-phosphate protein Rattus norvegicus