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Information on EC 6.2.1.5 - succinate-CoA ligase (ADP-forming)
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6.2.1.5 succinate-CoA ligase (ADP-forming)Specify your search results
Word Map
- 6.2.1.5
- mtdna
- suclg1
-
methylmalonic
-
aciduria
- dguok
-
encephalomyopathic
- c10orf2
- mimigardefordensis
- twinkle
-
c4-dicarboxylic
- thiokinase
-
faroe
-
gtp-forming
-
hepatocerebral
-
3,3'-dithiodipropionic
- molecular biology
The enzyme appears in viruses and cellular organisms
Synonyms
sucla2, succd, a-scs, cg11963, scact, adp-forming succinyl-coa synthetase, scs-betaa, a-stk, succinyl-coa synthetase (adp-forming), succinyl-coa ligase (atp-forming), 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-SCS
A-STK
-
-
-
-
A-SUCL
SCS
SCS-alpha
SCS-beta
-
-
-
-
SCS-betaA
-
-
-
-
STK
-
-
-
-
SucCD
succinate coenzyme A ligase
Succinate thiokinase
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-
-
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succinate-CoA ligase
Succinic thiokinase
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-
-
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Succinyl coenzyme A synthetase
Succinyl coenzyme A synthetase (adenosine diphosphate-forming)
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-
-
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Succinyl-CoA synthetase
Succinyl-CoA synthetase (ADP-forming)
SUCLA2
Synthetase, succinyl coenzyme A (adenosine diphosphate-forming)
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-
-
-
Tneu_1463
Tneu_1464
VEG239
-
-
-
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VEG63
-
-
-
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Vegetative protein 239
-
-
-
-
Vegetative protein 63
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-
-
-
additional information
AarC is predicted to be a class I CoAtransferase
A-SCS
-
-
-
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SCS-alpha
-
-
-
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Succinyl coenzyme A synthetase
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-
-
-
Succinyl-CoA synthetase
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-
-
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Succinyl-CoA synthetase (ADP-forming)
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
reaction mechanism, Glu435 is a key active site residue, overview. Class I CoA-transferases first bind the acyl-CoA substrate, forming a carboxylate product and an enzyme-CoA thioester intermediate, which accounts for the observed ping-pong kinetics and susceptibility to borohydride inactivation
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acid-thiol ligation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
succinate:CoA ligase (ADP-forming)
-
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CAS REGISTRY NUMBER
COMMENTARY
9080-33-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + adipate + CoA
ADP + phosphate + adipyl-CoA
-
59% activity compared to succinate
-
-
r
ATP + butyrate + CoA
ADP + phosphate + butyryl-CoA
-
48% activity compared to succinate
-
-
r
ATP + glutarate + CoA
ADP + phosphate + glutaryl-CoA
-
121% activity compared to succinate
-
-
r
ATP + oxalate + CoA
ADP + phosphate + oxalyl-CoA
-
9% activity compared to succinate
-
-
r
ATP + propionate + CoA
ADP + phosphate + propionyl-CoA
-
10% activity compared to succinate
-
-
r
ATP + succinate + CoA
?
-
generation of succinyl-CoA from succinate for anabolic purposes when the route from 2-oxoglutarate is repressed, e.g. under anaerobic conditions
-
-
?
beta,gamma-methylene-adenosine 5'-triphosphate
beta,gamma-methylene-adenosine 5'-tetraphosphate + ?
-
-
alpha,gamma-methylene adenosine tetraphosphate
?
ADP + phosphate + succinyl-CoA
?
-
the enzyme plays an essential role in the citric acid cycle, where the conversion of succinyl-CoA into succinate represents an important site of substrate level phosphorylation
-
-
?
ADP + phosphate + succinyl-CoA
?
-
catalyzes the formation of ATP via substrate-level phosphorylation
-
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
generation of ATP is critical for the beta-cell mitochondrial metabolism
-
?
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
SucCDAm is unspecific regarding ATP or GTP
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
?
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
-
Blastocystis succinyl-CoA synthetase is a tricarboxylic acid cycle enzyme that conserves energy by substrate-level phosphorylation. In the absence of a classic mitochondrial electron transport chain, it is likely to be one of the main ATP producing enzymes in this parasite
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-
r
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
-
Blastocystis SCS is ATP-specific, while both ATP and GTP fit into the Blastocystis SCS active site, GTP is destabilizes by electrostatic dipole interactions with Lys42 and Lys110, the side-chains of which lie outside the nucleotide-binding cavity, an electrostatic gatekeeper controls which ligands can enter the binding site, overview
three reaction steps in the reverse direction: 1. formation of a non-covalent enzyme-succinyl-phosphate complex and cocomitant release of CoA, 2. formation of a covalent phosphoryl-enzyme intermediate with the release of succinate, and 3. phosphorylation of ADP forming ATP
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
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r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
AarC is succinyl-CoA:acetate CoA-transferase, which replaces succinyl-CoA synthetase in a variant CAC, this new bypass appears to reduce metabolic demand for free CoA, reliance upon nucleotide pools, and the likely effect of variable cytoplasmic pH upon CAC flux, the enzyme is required for the citric acid cycle, overview
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-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
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r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
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r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
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?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
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no activity with GTP/GDP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
during the reaction a His residue at the alpha-subunit is transiently phosphorylated. Glu208alpha and Glu197beta, are crucial for phosphorylation and dephosphorylation of the active-site His
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
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-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
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-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
the enzyme is part of the Krebs cycle
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for ATP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for succinate
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
r
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
r
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP