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ADP + phosphate + succinyl-CoA
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
ATP + adipate + CoA
ADP + phosphate + adipyl-CoA
-
59% activity compared to succinate
-
-
r
ATP + ATP
adenosine 5'-tetraphosphate + ADP
-
-
-
?
ATP + butyrate + CoA
ADP + phosphate + butyryl-CoA
-
48% activity compared to succinate
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
ATP + glutarate + CoA
ADP + phosphate + glutaryl-CoA
-
121% activity compared to succinate
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
ATP + oxalate + CoA
ADP + phosphate + oxalyl-CoA
-
9% activity compared to succinate
-
-
r
ATP + propionate + CoA
ADP + phosphate + propionyl-CoA
-
10% activity compared to succinate
-
-
r
ATP + succinate + CoA
?
-
generation of succinyl-CoA from succinate for anabolic purposes when the route from 2-oxoglutarate is repressed, e.g. under anaerobic conditions
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
beta,gamma-methylene-adenosine 5'-triphosphate
beta,gamma-methylene-adenosine 5'-tetraphosphate + ?
-
-
alpha,gamma-methylene adenosine tetraphosphate
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
UTP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
additional information
?
-
ADP + phosphate + succinyl-CoA

?
-
the enzyme plays an essential role in the citric acid cycle, where the conversion of succinyl-CoA into succinate represents an important site of substrate level phosphorylation
-
-
?
ADP + phosphate + succinyl-CoA
?
-
-
-
-
?
ADP + phosphate + succinyl-CoA
?
-
catalyzes the formation of ATP via substrate-level phosphorylation
-
-
?
ADP + phosphate + succinyl-CoA

ATP + succinate + CoA
-
-
-
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
the enzyme carries out the substrate-level phosphorylation in the citric acid cycle
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
-
r
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
r
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
r
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
generation of ATP is critical for the beta-cell mitochondrial metabolism
-
?
ADP + phosphate + succinyl-CoA
ATP + succinate + CoA
-
-
-
?
ATP + 3-sulfinopropionate + CoA

ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
SucCDAm is unspecific regarding ATP or GTP
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
?
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + 3-sulfinopropionate + CoA
ADP + phosphate + 3-sulfinopropionyl-CoA
-
-
-
r
ATP + acetate + CoA

ADP + phosphate + acetyl-CoA
-
-
-
r
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
-
Blastocystis succinyl-CoA synthetase is a tricarboxylic acid cycle enzyme that conserves energy by substrate-level phosphorylation. In the absence of a classic mitochondrial electron transport chain, it is likely to be one of the main ATP producing enzymes in this parasite
-
-
r
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
-
Blastocystis SCS is ATP-specific, while both ATP and GTP fit into the Blastocystis SCS active site, GTP is destabilizes by electrostatic dipole interactions with Lys42 and Lys110, the side-chains of which lie outside the nucleotide-binding cavity, an electrostatic gatekeeper controls which ligands can enter the binding site, overview
three reaction steps in the reverse direction: 1. formation of a non-covalent enzyme-succinyl-phosphate complex and cocomitant release of CoA, 2. formation of a covalent phosphoryl-enzyme intermediate with the release of succinate, and 3. phosphorylation of ADP forming ATP
-
r
ATP + acetate + CoA
ADP + phosphate + acetyl-CoA
-
-
-
-
?
ATP + D-malate + CoA

ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + D-malate + CoA
ADP + phosphate + D-malyl-CoA
-
-
-
r
ATP + itaconate + CoA

ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + itaconate + CoA
ADP + phosphate + itaconyl-CoA
-
-
-
r
ATP + L-malate + CoA

ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + L-malate + CoA
ADP + phosphate + L-malyl-CoA
-
-
-
r
ATP + succinate + CoA

ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
AarC is succinyl-CoA:acetate CoA-transferase, which replaces succinyl-CoA synthetase in a variant CAC, this new bypass appears to reduce metabolic demand for free CoA, reliance upon nucleotide pools, and the likely effect of variable cytoplasmic pH upon CAC flux, the enzyme is required for the citric acid cycle, overview
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
SucCDAm is unspecific regarding ATP or GTP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
802, 804, 806, 807, 809, 810, 811, 812, 813, 815, 820, 821, 823, 824 -
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
r
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
during the reaction a His residue at the alpha-subunit is transiently phosphorylated. Glu208alpha and Glu197beta, are crucial for phosphorylation and dephosphorylation of the active-site His
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
ATP is the preferred cosubstrate
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for ATP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for succinate
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
the enzyme is part of the Krebs cycle
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for ATP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
Pigeon
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for ATP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
specific for succinate
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
no activity with GTP/GDP
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
r
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
?
ATP + succinate + CoA
ADP + phosphate + succinyl-CoA
-
-
-
-
?
GTP + succinate + CoA

GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
r
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
r
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
-
-
r
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has no activity with GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km value for ADP and for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
enzyme has a low Km-value for ADP and a high Km-value for GDP
-
-
?
GTP + succinate + CoA
GDP + phosphate + succinyl-CoA
-
no activity with GDP/GTP
-
-
?