Ligand succinate

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C4H6O4
succinate
KDYFGRWQOYBRFD-UHFFFAOYSA-N
Synonyms:
a dicarboxylate, butanedioic acid, dihydrofumarate, reduced fumarate, succinate buffer, succinic acid
Pathway Source
Pathways
BRENDA
(5R)-carbapenem carboxylate biosynthesis, 3-phenylpropionate degradation, 4-hydroxymandelate degradation, arginine metabolism, carnitine metabolism more
KEGG
Alanine, aspartate and glutamate metabolism, Biosynthesis of alkaloids derived from histidine and purine, Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid, Biosynthesis of alkaloids derived from shikimate pathway, Biosynthesis of alkaloids derived from terpenoid and polyketide more
MetaCyc
(-)-4'-demethyl-epipodophyllotoxin biosynthesis, (2-trimethylamino)ethylphosphonate degradation, (5R)-carbapenem carboxylate biosynthesis, (Kdo)2-lipid A biosynthesis II (P. putida), (S)-lactate fermentation to propanoate, acetate and hydrogen more


Show all pahtways known for Show all BRENDA pathways known for succinate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (20 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propionyl-CoA + succinate = propanoate + succinoyl-CoA
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succinate + (S)-(+)-citramalyl-CoA = succinyl-CoA + citramalate
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succinate + acetyl-CoA = acetate + succinyl-CoA
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In Vivo Product in Enzyme-catalyzed Reactions (486 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
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4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
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2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
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gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
show the reaction diagram
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taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2
show the reaction diagram
phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2
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deacetoxyvindoline + 2-oxoglutarate + O2 = deacetylvindoline + succinate + CO2
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L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2
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hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
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L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2
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L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2
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7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2
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(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2
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[50S ribosomal protein L16]-L-Arg81 + 2-oxoglutarate + O2 = [50S ribosomal protein L16]-(3R)-3-hydroxy-L-Arg81 + succinate + CO2
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xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2
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UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate
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N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
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validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2
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L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2
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scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
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trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
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a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
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methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2
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[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2
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L-isoleucine + 2-oxoglutarate + O2 = (3S)-3'-hydroxy-L-isoleucine + succinate + CO2
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(3S)-3'-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (3S,4R)-3',4-dihydroxy-L-isoleucine + succinate + CO2
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S-(L-glutamyl)-[peptidyl-carrier protein of nonribosomal peptide synthetase KtzH] + 2-oxoglutarate + O2 = S-(erythro-3-hydroxy-L-glutamyl)-[peptidyl-carrier-protein of nonribosomal peptide synthetase KtzH] + succinate + CO2
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S-(L-glutamyl)-[peptidyl-carrier protein of nonribosomal peptide synthetase KtzH] + 2-oxoglutarate + O2 = S-(threo-3-hydroxy-L-glutamyl)-[peptidyl-carrier-protein of nonribosomal peptide synthetase KtzH] + succinate + CO2
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(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
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(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(E)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
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L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl- = 4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O
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2R,3S,4S-cis-leucoanthocyanidin + 2-oxoglutarate + O2 = cis- and trans-dihydroquercetins + succinate + CO2 + 2 H2O
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(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O
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(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O
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fumarate + CoM + CoB = succinate + CoM-S-S-CoB
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succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA
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succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA
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succinyl-CoA + acetate = acetyl-CoA + succinate
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succinyl-CoA + oxalate = succinate + oxalyl-CoA
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succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA
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succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA
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mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
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succinamic acid + H2O = succinic acid + NH3
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succinonitrile + 2 H2O = succinic acid + NH3
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Substrate in Enzyme-catalyzed Reactions (102 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinate + NAD(P)+ = succinic acid anhydride + NAD(P)H
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succinate + 2,6-dichlorophenolindophenol = ?
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succinate + O2 = ?
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(6S)-hydroxyhyoscyamine + succinate + CO2 = L-hyoscyamine + 2-oxoglutarate + O2
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methane + succinate + O2 = methanol + fumarate + H2O
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succinate + NADH = succinic semialdehyde + NAD+ + H2O
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succinate + acetyl-CoA = acetate + succinyl-CoA
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1,4-cyclohexanedimethanol + succinic acid = ?
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succinate = ?
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Dihydrofumarate = Tartronate semialdehyde + CO2
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succinate + glyoxylate = isocitrate
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
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ATP + succinate + (2S)-2,3-diaminopropionate = ?
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succinate + O2 + NAD+ = NADH + ?
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Product in Enzyme-catalyzed Reactions (1419 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + fumarate = succinate
show the reaction diagram
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3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
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gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
show the reaction diagram
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