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Literature summary for 6.2.1.5 extracted from
- Site-directed mutagenesis of Escherichia coli succinyl-CoA synthetase. beta-Cys325 is a nonessential active site residue (1989), J. Biol. Chem., 264, 1457-1460.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C325E | Cys325Glu mutant is 83% as active as the wild type enzyme. The mutant enzyme is refractory to chemical modification by CoA disulfide-S,S-dioxide and methyl methane thiosulfonate. It is less reactive with NEM | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
wild type and Cys325Glu mutant | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + succinate + CoA | - |
Escherichia coli | ADP + phosphate + succinyl-CoA | - |
? |  |
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