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Literature summary for 6.2.1.5 extracted from

  • Luis, P.; Ruiter, J.; IJlst, L.; De Almeida, I.; Duran, M.; Wanders, R.; Silva, M.
    Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate CoA ligases (2014), J. Inherit. Metab. Dis., 37, 353-357 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by valproic acid Homo sapiens
valproyl-CoA 45-55% inhibition at 1 mM Homo sapiens
ZnCl2 complete inhibition at 1mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
ATP at pH 8.0 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + succinyl-CoA Homo sapiens
-
ATP + succinate + CoA
-
r
ATP + succinate + CoA Homo sapiens
-
ADP + phosphate + succinyl-CoA
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + succinyl-CoA
-
Homo sapiens ATP + succinate + CoA
-
r
ATP + succinate + CoA
-
Homo sapiens ADP + phosphate + succinyl-CoA
-
r

Synonyms

Synonyms Comment Organism
A-SUCL
-
Homo sapiens
ATP-dependent succinate:CoA ligase
-
Homo sapiens
ATP-specific succinate:CoA ligase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens