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Information on EC 1.8.1.2 - assimilatory sulfite reductase (NADPH)

for references in articles please use BRENDA:EC1.8.1.2

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IUBMB Comments

Contains siroheme, [4Fe-4S] cluster, FAD and FMN. The enzyme, which catalyses the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. Different from EC 1.8.99.5, dissimilatory sulfite reductase, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin).

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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hydrogen sulfide
+
3
NADP+
+
3
H2O
=
sulfite
+
3
NADPH
+
3
H+
+
3
+
3
=
+
3
+
3

Synonyms
sulfite reductase, met10, sir-fp, sir-hp, nadph-sulfite reductase, sirhp, desulforubidin, cysij, nadph-dependent sulfite reductase, coenzyme f420-dependent sulfite reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
assimilatory sulfate reduction I, assimilatory sulfate reduction III