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BRENDA support

Ligand H+

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Basic Ligand Information

Molecular Structure
Picture of H+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
+p
H+
GPRLSGONYQIRFK-UHFFFAOYSA-N
Synonyms:
H+[side 1], H+[side1], H+ [side 1], H+[side 2], H+[side2], H+ [side 2], proton
Pathway Source
Pathways
BRENDA
(S)-reticuline biosynthesis, 3-phenylpropionate degradation, 4-hydroxymandelate degradation, 4-hydroxyphenylacetate degradation, acetoin degradation more
KEGG
Adrenergic signaling in cardiomyocytes, Apelin signaling pathway, Bile secretion, cAMP signaling pathway, Cardiac muscle contraction more
MetaCyc
(+)-camphor biosynthesis, (+)-pisatin biosynthesis, (+)-secoisolariciresinol diglucoside biosynthesis, (-)-camphor biosynthesis, (-)-dehydrodiconiferyl alcohol degradation more


Show all pahtways known for Show all BRENDA pathways known for H+

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1806 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alkyldihydroxyacetone phosphate + NADPH + H+ = 1-alkyl-sn-glycerol 3-phosphate + NADP+
show the reaction diagram
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D-ribulose + NADH + H+ = D-arabinitol + NAD+
show the reaction diagram
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dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ = dTDP-beta-L-rhamnose + NADP+
show the reaction diagram
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2-hydroxyacetophenone + NADH + H+ = (S)-1-phenyl-1,2-ethanediol + NAD+
show the reaction diagram
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D-fructose 6-phosphate + NADH + H+ = D-sorbitol 6-phosphate + NAD+
show the reaction diagram
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dehydroepiandrosterone + NADH + H+ = androsterone + NAD+
show the reaction diagram
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2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
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D-xylono-1,4-lactone + NADH + H+ = D-xylose + NAD+
show the reaction diagram
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D-glucuronate + NADPH + H+ = ? + NADP+
show the reaction diagram
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+ = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
show the reaction diagram
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(+)-camphor + NADH + H+ = (+)-borneol + NAD+
show the reaction diagram
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D-glucose 6-phosphate + NADPH + H+ = D-sorbitol 6-phosphate + NADP+
show the reaction diagram
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D-galacturonate + NADPH + H+ = L-galactonate + NADP+
show the reaction diagram
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2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
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2 benzyl 2-methyl-3-oxobutyrate + 2 NADPH + 2 H+ = benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + benzyl (2S,3S)-2-methyl-3-hydroxybutanoate + 2 NADP+
show the reaction diagram
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daunorubicin + NADPH + H+ = daunorubicinol + NADP+
show the reaction diagram
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formaldehyde + NADH + H+ = methanol + NAD+
show the reaction diagram
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2,5-didehydro-D-gluconate + NADPH + H+ = 2-dehydro-D-gluconate + NADP+
show the reaction diagram
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GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+ = GDP-D-rhamnose + NAD(P)+
show the reaction diagram
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3''-deamino-3''-oxonicotianamine + NAD(P)H + H+ = 2'-deoxymugineic acid + NAD(P)+
show the reaction diagram
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hydroxypyruvate + NADH + H+ = D-glycerate + NAD+
show the reaction diagram
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2-formylglutarate + NADH + H+ = 2-hydroxymethylglutarate + NAD+
show the reaction diagram
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1,5-anhydro-D-fructose + NADPH + H+ = 1,5-anhydro-D-mannitol + NADP+
show the reaction diagram
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diacetyl + NADH + H+ = (R)-acetoin + NAD+
show the reaction diagram
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phosphonoacetaldehyde + NADH + H+ = 2-hydroxyethylphosphonate + NAD+
show the reaction diagram
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2-sulfoacetaldehyde + NADPH + H+ = isethionate + NADP+
show the reaction diagram
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perakine + NADPH + H+ = raucaffrinoline + NADP+
show the reaction diagram
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benzil + NADPH + H+ = (S)-benzoin + NADP+
show the reaction diagram
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a very-long-chain 3-oxoacyl-CoA + NADPH + H+ = a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+
show the reaction diagram
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methyl ecgonone + NADPH + H+ = methyl ecgonine + NADP+
show the reaction diagram
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(3R)-vestitone + NADPH + H+ = (3R,4R)-4'-methoxyisoflavan-2',4,7-triol + NADP+
show the reaction diagram
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norsolorinic acid + NADPH + H+ = (1'S)-averantin + NADP+
show the reaction diagram
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2'-dehydrokanamycin A + NADPH + H+ = kanamycin A + NADP+
show the reaction diagram
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GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+ = GDP-beta-L-colitose + NAD(P)+
show the reaction diagram
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2-dehydropantolactone + NADPH + H+ = (R)-pantolactone + NADP+
show the reaction diagram
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aklaviketone + NADPH + H+ = aklavinone + NADP+
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+ = dTDP-6-deoxy-alpha-D-allopyranose + NAD+
show the reaction diagram
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D-galacturonate + NADPH + H+ = L-galactonate + NADP+
show the reaction diagram
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5-dehydro-D-gluconate + NADH + H+ = L-idonate + NAD+
show the reaction diagram
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L-epi-2-inosose + NADH + H+ = myo-inositol + NAD+
show the reaction diagram
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3-sulfopyruvate + NADPH + H+ = (2S)-3-sulfolactate + NADP+
show the reaction diagram
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phenylglyoxylate + NADH + H+ = (R)-mandelate + NAD+
show the reaction diagram
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pyruvate + CO2 + NADH + H+ = (S)-malate + NAD+
show the reaction diagram
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12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+ = 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
show the reaction diagram
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2-oxoglutarate + NADH + H+ = (R)-2-hydroxyglutarate + NAD+
show the reaction diagram
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pyruvate + CO2 + NADPH + H+ = (S)-malate + NADP+
show the reaction diagram
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2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ = 2,3,5,6-tetrachlorohydroquinone + NAD+
show the reaction diagram
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(R)-2-alkyl-3-oxoalkanoate + NADPH + H+ = (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+
show the reaction diagram
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6-dehydro-Virginiae butanolide-A + NADPH + H+ = (2R,3R,6S)-Virginiae butanolide-A + NADP+
show the reaction diagram
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2-oxoglutarate + CO2 + NADPH + H+ = isocitrate + NADP+
show the reaction diagram
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D-apiose + NADH + H+ = D-apiitol + NAD+
show the reaction diagram
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1-phenylpropan-1,2-dione + NADH + H+ = (S)-phenylacetylcarbinol + NAD+
show the reaction diagram
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3-dehydrolevoglucosan + NADH + H+ = levoglucosan + NAD+
show the reaction diagram
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4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ = (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
show the reaction diagram
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(S)-2-benzoylsuccinyl-CoA + NADH + H+ = (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD+
show the reaction diagram
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17alpha-hydroxyprogesterone + NADPH + H+ = 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
show the reaction diagram
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L-lactaldehyde + NADPH + H+ = propane-1,2-diol + NADP+
show the reaction diagram
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androstenedione + NADPH + H+ = testosterone + NADP+
show the reaction diagram
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D-fructose + NADH + H+ = D-mannitol + NAD+
show the reaction diagram
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D-glyceraldehyde + NADPH + H+ = glycerol + NADP+
show the reaction diagram
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(2S)-acetoin + NADH + H+ = (2S,3S)-butane-2,3-diol + NAD+
show the reaction diagram
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oxaloacetate + NADPH + H+ = (S)-malate + NADP+
show the reaction diagram
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D-xylulose + NADH + H+ = xylitol + NAD+
show the reaction diagram
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benzaldehyde + NAD(P)H + H+ = benzyl alcohol + NAD(P)+
show the reaction diagram
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glycerone phosphate + NAD(P)H + H+ = sn-glycerol 3-phosphate + NAD(P)+
show the reaction diagram
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(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ = (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
show the reaction diagram
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cortisone + NADPH + H+ = cortisol + NADP+
show the reaction diagram
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3-quinuclidinone + NADPH + H+ = (R)-3-quinuclidinol + NADP+
show the reaction diagram
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3-quinuclidinone + NADH + H+ = (R)-3-quinuclidinol + NAD+
show the reaction diagram
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3-quinuclidinone + NADPH + H+ = (S)-3-quinuclidinol + NADP+
show the reaction diagram
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pyruvate + 2 ferrocytochrome c + 2 H+ = (S)-lactate + 2 ferricytochrome c
show the reaction diagram
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2 L-ascorbate + O2 + 4 H+ = 2 monodehydroascorbate + 2 H2O
show the reaction diagram
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2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O
show the reaction diagram
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2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
show the reaction diagram
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2 D-erythroascorbic acid + H2O2 + 2 H+ = ?
show the reaction diagram
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3-methyl-L-tyrosine + H2O2 + H+ = 3-hydroxy-5-methyl-L-tyrosine + H2O
show the reaction diagram
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NADH + H+ + reduced ferredoxin = H2 + NAD+ + oxidized ferredoxin
show the reaction diagram
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5 sulfur + 2 O2 + 2 H2O + 4 H+ = sulfite + thiosulfate + 2 sulfide
show the reaction diagram
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2 arachidonate + 2 O2 + 2 H+ = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate + (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate + H2O
show the reaction diagram
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2 arachidonate + 2 O2 + H+ = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O
show the reaction diagram
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anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3
show the reaction diagram
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naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+
show the reaction diagram
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2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2
show the reaction diagram
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terephthalate + NADH + O2 + H+ = (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+
show the reaction diagram
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2,4-dinitrotoluene + NADH + H+ + O2 = 4-methyl-5-nitrocatechol + nitrite + NAD+
show the reaction diagram
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phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+
show the reaction diagram
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6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2
show the reaction diagram
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3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
show the reaction diagram
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pyrrole-2-carboxylate + NADH + H+ + O2 = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O
show the reaction diagram
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N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O
show the reaction diagram
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(+)-sabinene + NADPH + H+ + O2 = (+)-cis-sabinol + NADP+ + H2O
show the reaction diagram
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erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O
show the reaction diagram
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cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O
show the reaction diagram
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[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + O2 + NADPH + H+ = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + NADP+ + H2O
show the reaction diagram
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4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
show the reaction diagram
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4-nitrocatechol + NAD(P)H + H+ + O2 = 2-hydroxy-1,4-benzoquinone + nitrite + NAD(P)+ + H2O
show the reaction diagram
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(indol-3-yl)pyruvate + NADPH + H+ + O2 = (indol-3-yl)acetate + NADP+ + H2O + CO2
show the reaction diagram
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aklavinone + NADPH + H+ + O2 = epsilon-rhodomycinone + NADP+ + H2O
show the reaction diagram
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2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
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dTDP-beta-L-evernosamine + 2 NADPH + 2 H+ + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 NADP+ + 3 H2O
show the reaction diagram
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5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O
show the reaction diagram
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taxifolin + NADPH + H+ + O2 = 2,3-dihydrogossypetin + NADP+ + H2O
show the reaction diagram
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2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O
show the reaction diagram
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2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O
show the reaction diagram
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4-methyl-5-nitrocatechol + O2 + NADPH + H+ = 2-hydroxy-5-methylquinone + nitrite + H2O + NADP+
show the reaction diagram
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1,3,7-trimethylurate + NADH + H+ + O2 = 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O
show the reaction diagram
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protoasukamycin + NADH + H+ + O2 = 4-hydroxyprotoasukamycin + NAD+ + H2O
show the reaction diagram
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resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O
show the reaction diagram
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resorcinol + NADH + H+ + O2 = hydroxyquinol + NAD+ + H2O
show the reaction diagram
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[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
show the reaction diagram
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acetone + NADPH + H+ + O2 = methyl acetate + NADP+ + H2O
show the reaction diagram
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butane + NADH + H+ + O2 = butan-1-ol + NAD+ + H2O
show the reaction diagram
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4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 = 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O
show the reaction diagram
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dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O
show the reaction diagram
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phenol + NADH + H+ + O2 = catechol + NAD+ + H2O
show the reaction diagram
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a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O
show the reaction diagram
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3-amino-4-hydroxybenzoate + NADPH + H+ + O2 = 3-amino-2,4-dihydroxybenzoate + NADP+ + H2O
show the reaction diagram
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2-nitrophenol + NADPH + H+ + O2 = catechol + NADP+ + H2O + nitrite
show the reaction diagram
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anhydrotetracycline + NADPH + H+ + O2 = 12-dehydrotetracycline + NADP+ + H2O
show the reaction diagram
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anthraniloyl-CoA + 2 NAD(P)H + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+
show the reaction diagram
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questin + NADPH + H+ + O2 = demethylsulochrin + NADP+
show the reaction diagram
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2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O
show the reaction diagram
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progesterone + NADPH + H+ + O2 = Testosterone acetate + NADP+ + H2O
show the reaction diagram
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4-hydroxyacetophenone + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O
show the reaction diagram
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phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O
show the reaction diagram
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