Gene ontology ID
GO:0006915
Definition
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died
Synonyms
1. activation of apoptosis
2. apoptosis
3. apoptosis activator activity
4. apoptosis signaling
5. apoptotic cell death
6. apoptotic program
7. apoptotic programmed cell death
8. caspase-dependent programmed cell death
9. cell suicide
10. cellular suicide
11. commitment to apoptosis
12. induction of apoptosis
13. induction of apoptosis by p53
14. programmed cell death by apoptosis
15. signaling (initiator) caspase activity
16. type I programmed cell death
References
1. GOC: cjm
2. GOC: dhl
3. GOC: ecd
4. GOC: go curators
5. GOC: mtg apoptosis
6. GOC: tb
7. ISBN 01985067328. PMID 188461079. PMID 2149426310. Wikipedia: Apoptosis
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA