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Gene ontology
Version 2014-12-22
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Details for S100A9 complex
Gene ontology ID
GO:1990662
Definition
A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility
Comment
An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay).
Synonyms
1. S100A9 homodimer
References
1. GOC: bhm
2. PMID 15642721
3. IntAct: EBI-10099500
4. IntAct: EBI-10099571
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