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Gene ontology
Version 2014-12-22
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Details for oxoglutarate dehydrogenase complex
oxoglutarate dehydrogenase complex
Gene ontology ID
GO:0045252
Definition
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)
Comment
See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
Synonyms
1. dihydrolipoamide S-succinyltransferase complex
References
1. MetaCyc CPLX66-42
2. PMID 10848975
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is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
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Condensed Tree View
Gene ontology
biological_process is a
negative regulation of natural killer cell differentiation is a
negative regulation of natural killer cell differentiation involved in immune response is a
positive regulation of neutrophil activation is a
positive regulation of thrombin-activated receptor signaling pathway is a
positive regulation of histone H3-K9 dimethylation is a
DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization is a
positive regulation of inward rectifier potassium channel activity is a
positive regulation of voltage-gated sodium channel activity is a
protein kinase C deactivation is a
regulation of SNARE complex disassembly is a
regulation of postsynaptic neurotransmitter receptor diffusion trapping is a
excitatory chemical synaptic transmission
modulation by host of viral RNA genome replication is a
regulation of single stranded viral RNA replication via double stranded DNA intermediate is a
modulation by host of viral release from host cell is a
regulation of lipid localization is a
regulation of fatty acid transport is a
ubiquitin recycling is a
detection of reduced oxygen by carotid body chemoreceptor signaling part of
regulation of systemic arterial blood pressure by neurotransmitter is a
norepinephrine-epinephrine catabolic process in blood stream part of
renal system process involved in regulation of blood volume is a
ectoderm and mesoderm interaction is a
endocrine signaling is a
interferon-epsilon secretion is a
chromosome organization involved in meiotic cell cycle is a
kinetochore disassembly involved in meiotic chromosome organization is a
vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly part of
mitotic spindle pole body duplication is a
muscle cell apoptotic process is a
cell division is a
asymmetric neuroblast division resulting in ganglion mother cell formation is a
glial cell growth is a
synoviocyte proliferation is a
cell wall mannoprotein biosynthetic process is a
structural constituent of postsynapse part of
chromatin remodeling in response to cation stress is a
histone H3-K9 methylation is a
histone H3-K4 methylation is a
histone H3-K4 monomethylation is a
histone methyltransferase activity (H3-K4 specific) part of
vitellogenesis is a
tRNA-containing ribonucleoprotein complex export from nucleus is a
establishment of protein localization to mitochondrion is a
heme B biosynthetic process is a
heme O biosynthetic process is a
trinitrotoluene catabolic process is a
gallate metabolic process is a
iprodione metabolic process is a
phenylmercury acetate metabolic process is a
resolution of mitotic recombination intermediates part of
gap filling involved in double-strand break repair via nonhomologous end joining part of
cellular response to endothelin is a
cellular response to glucagon stimulus is a
sinoatrial valve morphogenesis is a
ventriculo bulbo valve morphogenesis is a
inferior olivary nucleus morphogenesis part of
pons morphogenesis part of
branch fusion, open tracheal system part of
terminal branching, open tracheal system is a
lateral root morphogenesis is a
trabecula morphogenesis is a
bone trabecula morphogenesis is a
pulmonary vein morphogenesis is a
cochlear nucleus development part of
ventral tegmental area development part of
Harderian gland development is a
salivary gland development is a
female gonad development is a
endocardium development part of
ADP transport is a
taurine transport is a
bicarbonate transport is a
cAMP transport is a
carboxylic acid transport is a
histidine transport is a
protoporphyrinogen oxidase activity is a
3-oxosteroid 1-dehydrogenase activity is a
1-pyrroline-5-carboxylate dehydrogenase activity is a
folate reductase activity is a
formyltetrahydrofolate dehydrogenase activity is a
L-galactose dehydrogenase activity is a
methylenetetrahydrofolate dehydrogenase (NAD+) activity is a
riboflavin reductase (NADPH) activity is a
saccharopine dehydrogenase activity is a
cellular_component is a
cellular anatomical entity is a
peg and socket contact is a
inner dense plaque of desmosome part of
cytoplasm is a427 BRENDA localization in branch, click for list of all
osmiophilic body is a
B875 antenna complex part of
light-harvesting complex, peripheral complex is a
B800-820 antenna complex part of
eukaryotic 43S preinitiation complex
diamine N-acetyltransferase complex part of
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex is a
thioglucosidase complex part of
translation initiation complex part of19 BRENDA localization in branch, click for list of all
translation initiation ternary complex part of
translation preinitiation complex part of
translation release factor complex part of
tricarboxylic acid cycle enzyme complex part of
dihydrolipoyl dehydrogenase complex is a
oxoglutarate dehydrogenase complex is a
type II site-specific deoxyribonuclease complex part of
type IV site-specific deoxyribonuclease complex part of
autolysosome is a
autophagosome membrane part of
amphisome membrane is a
lytic vacuole is a12 BRENDA localization in branch, click for list of all
laminin-7 complex is a
potassium channel complex is a
mitochondrial ATP-gated potassium channel complex is a
sodium channel complex is a
S100A9 complex is a
outer membrane protein complex is a14 BRENDA localization in branch, click for list of all
proton-transporting ATP synthase, stator stalk is a
proton-transporting two-sector ATPase complex is a
archaeal proton-transporting A-type ATPase complex is a
platelet dense tubular network membrane is a
magnetosome membrane is a
CENP-A containing nucleosome binding is a
nucleosomal histone binding is a
bacteriochlorophyll c binding is a
hydroquinone binding is a
carbon monoxide sensor activity is a
[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
negative regulation of 3'-UTR-mediated mRNA stabilization is a
negative regulation of action potential is a
negative regulation of asexual reproduction is a
negative regulation of biomineralization is a
negative regulation of cellular process is a
negative regulation of actin filament severing is a
negative regulation of amino acid uptake involved in synaptic transmission is a
negative regulation of binding of sperm to zona pellucida is a
negative regulation of calcium ion transport into cytosol is a
negative regulation of cartilage condensation is a
negative regulation of catecholamine uptake involved in synaptic transmission is a
negative regulation of cell activation is a
negative regulation of natural killer cell differentiation involved in immune response is a
negative regulation of cell adhesion molecule production is a
negative regulation of cell aging is a
negative regulation of cell communication is a
negative regulation of cell cycle is a
negative regulation of cell death is a
negative regulation of cell differentiation is a
negative regulation of cell division is a
negative regulation of cell growth is a
negative regulation of cell killing is a
negative regulation of cell population proliferation is a
negative regulation of cell wall organization or biogenesis is a
negative regulation of cellular component movement is a
negative regulation of cellular component organization is a
negative regulation of adherens junction organization is a
negative regulation of barbed-end actin filament capping is a
negative regulation of blood microparticle formation is a
negative regulation of capsule organization is a
negative regulation of cell junction assembly is a
negative regulation of cell projection organization is a
negative regulation of cell-substrate junction organization is a
negative regulation of cholesterol transporter activity is a
negative regulation of clathrin-coated pit assembly is a
negative regulation of endocytosis is a
negative regulation of extracellular matrix organization is a
negative regulation of fusion of sperm to egg plasma membrane is a
negative regulation of fusion of virus membrane with host plasma membrane is a
negative regulation of hyaluranon cable assembly is a
negative regulation of inclusion body assembly is a
negative regulation of integrin biosynthetic process is a
negative regulation of iron-sulfur cluster assembly is a
negative regulation of membrane invagination is a
negative regulation of membrane tubulation is a
negative regulation of organelle organization is a
negative regulation of cargo loading into COPII-coated vesicle is a
negative regulation of chloroplast fission is a
negative regulation of chromosome organization is a
negative regulation of cytoskeleton organization is a
negative regulation of endoplasmic reticulum tubular network organization is a
negative regulation of endosome organization is a
negative regulation of lysosome organization is a
negative regulation of melanosome organization is a
negative regulation of mitochondrion organization is a
negative regulation of nuclear division is a
negative regulation of organelle assembly is a
negative regulation of phagosome maturation is a
negative regulation of postsynaptic density organization is a
negative regulation of secretory granule organization is a
negative regulation of synaptic vesicle lumen acidification is a
negative regulation of vacuole fusion, non-autophagic is a
negative regulation of vesicle fusion is a
negative regulation of phospholipid translocation is a
negative regulation of plasma lipoprotein oxidation is a
negative regulation of plasma membrane raft polarization is a
negative regulation of plasma membrane repair is a
negative regulation of protein-containing complex assembly is a
negative regulation of protein-containing complex disassembly is a
negative regulation of supramolecular fiber organization is a
negative regulation of synapse organization is a
negative regulation of synapse structural plasticity is a
negative regulation of synaptic vesicle membrane organization is a
negative regulation of syncytium formation by plasma membrane fusion is a
negative regulation of tight junction disassembly is a
negative regulation of very-low-density lipoprotein particle remodeling is a
negative regulation of vitellogenesis is a
negative regulation of cellular hyperosmotic salinity response is a
negative regulation of cellular metabolic process is a
negative regulation of cellular pH reduction is a
negative regulation of cellular protein localization is a
negative regulation of cellular response to alcohol is a
negative regulation of cellular response to alkaline pH is a
negative regulation of cellular response to drug is a
negative regulation of cellular response to gamma radiation is a
negative regulation of cellular response to growth factor stimulus is a
negative regulation of cellular response to heat is a
negative regulation of cellular response to hypoxia is a
negative regulation of cellular response to insulin stimulus is a
negative regulation of cellular response to macrophage colony-stimulating factor stimulus is a
negative regulation of cellular response to manganese ion is a
negative regulation of cellular response to oxidative stress is a
negative regulation of cellular response to oxidopamine is a
negative regulation of cellular response to testosterone stimulus is a
negative regulation of cellular response to thapsigargin is a
negative regulation of cellular response to tunicamycin is a
negative regulation of cellular response to very-low-density lipoprotein particle stimulus is a
negative regulation of cellular response to X-ray is a
negative regulation of chromosome segregation is a
negative regulation of conjugation is a
negative regulation of cytolysis is a
negative regulation of dense core granule biogenesis is a
negative regulation of establishment of bipolar cell polarity is a
negative regulation of establishment or maintenance of cell polarity regulating cell shape is a
negative regulation of gene silencing is a
negative regulation of horizontal cell localization is a
negative regulation of interphase mitotic telomere clustering is a
negative regulation of intracellular mRNA localization is a
negative regulation of intracellular transport is a
negative regulation of melanosome transport is a
negative regulation of mitotic telomere tethering at nuclear periphery is a
negative regulation of myelination is a
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization is a
negative regulation of peroxidase activity is a
negative regulation of phagocytosis is a
negative regulation of phenotypic switching is a
negative regulation of protein folding is a
negative regulation of response to DNA damage stimulus is a
negative regulation of response to endoplasmic reticulum stress is a
negative regulation of ribonucleoprotein complex localization is a
negative regulation of ribosome biogenesis is a
negative regulation of secretion by cell is a
negative regulation of sequestering of calcium ion is a
negative regulation of sequestering of zinc ion is a
negative regulation of serotonin uptake is a
negative regulation of single-species biofilm formation is a
negative regulation of stomatal opening is a
negative regulation of synaptic vesicle clustering is a
negative regulation of synaptic vesicle recycling is a
negative regulation of synaptic vesicle transport is a
negative regulation of transcytosis is a
negative regulation of transmembrane transport is a
negative regulation of transposition is a
negative regulation of vacuolar transport is a
negative regulation of vesicle docking is a
negative regulation of circadian rhythm is a
negative regulation of coflocculation is a
negative regulation of developmental pigmentation is a
negative regulation of developmental process is a
negative regulation of DNA-binding transcription factor activity is a
negative regulation of dosage compensation by inactivation of X chromosome is a
negative regulation of entry of bacterium into host cell is a
negative regulation of establishment of protein localization is a
negative regulation of establishment of RNA localization to telomere is a
negative regulation of fibrinolysis is a
negative regulation of growth is a
negative regulation of GTPase activity is a
negative regulation of guanyl-nucleotide exchange factor activity is a
negative regulation of hemostasis is a
negative regulation of immune system process is a
negative regulation of lipid localization is a
negative regulation of locomotion is a
negative regulation of long-term synaptic potentiation is a
negative regulation of membrane depolarization is a
negative regulation of membrane hyperpolarization is a
negative regulation of metabolic process is a
negative regulation of multi-organism process is a
negative regulation of multicellular organismal process is a
negative regulation of nitrogen utilization is a
negative regulation of nuclear receptor transcription coactivator activity is a
negative regulation of phosphorus utilization is a
negative regulation of posttranscriptional gene silencing is a
negative regulation of proteasome-activating ATPase activity is a
negative regulation of protein localization to cell-cell junction is a
negative regulation of protein localization to presynapse is a
negative regulation of receptor localization to synapse is a
negative regulation of reproductive process is a
negative regulation of response to stimulus is a
negative regulation of short-term synaptic potentiation is a
negative regulation of signaling is a
negative regulation of sulfur utilization is a
negative regulation of telomerase RNA localization to Cajal body is a
negative regulation of transport is a
negative regulation of viral process is a
positive regulation of biological process is a
positive regulation by symbiont of entry into host is a
positive regulation of action potential is a
positive regulation of asexual reproduction is a
positive regulation of biomineralization is a
positive regulation of cellular process is a
positive regulation of actin filament severing is a
positive regulation of amino acid uptake involved in synaptic transmission is a
positive regulation of calcium ion transport into cytosol is a
positive regulation of cartilage condensation is a
positive regulation of catecholamine uptake involved in synaptic transmission is a
positive regulation of cell activation is a
positive regulation of neutrophil degranulation is a
positive regulation of cell adhesion molecule production is a
positive regulation of cell aging is a
positive regulation of cell communication is a
positive regulation of cell cycle is a
positive regulation of cell death is a
positive regulation of cell differentiation is a
positive regulation of cell division is a
positive regulation of cell growth is a
positive regulation of cell killing is a
positive regulation of cell population proliferation is a
positive regulation of cell wall organization or biogenesis is a
positive regulation of cellular component biogenesis is a
positive regulation of cellular component movement is a
positive regulation of cellular component organization is a
positive regulation of adherens junction organization is a
positive regulation of blood microparticle formation is a
positive regulation of capsule organization is a
positive regulation of cell projection organization is a
positive regulation of cell-substrate junction organization is a
positive regulation of chylomicron remodeling is a
positive regulation of endocytosis is a
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation is a
positive regulation of extracellular matrix organization is a
positive regulation of integrin biosynthetic process is a
positive regulation of membrane invagination is a
positive regulation of membrane tubulation is a
positive regulation of neuromuscular junction development is a
positive regulation of organelle organization is a
positive regulation of autophagosome maturation is a
positive regulation of chloroplast fission is a
positive regulation of chromosome organization is a
positive regulation of cytoskeleton organization is a
positive regulation of endoplasmic reticulum tubular network organization is a
positive regulation of endosome organization is a
positive regulation of melanosome organization is a
positive regulation of mitochondrion organization is a
positive regulation of nuclear division is a
positive regulation of peroxisome organization is a
positive regulation of phagosome maturation is a
positive regulation of postsynaptic density organization is a
positive regulation of secretory granule organization is a
positive regulation of synaptic vesicle lumen acidification is a
positive regulation of vacuole organization is a
positive regulation of vesicle fusion is a
positive regulation of phospholipid translocation is a
positive regulation of plasma membrane raft polarization is a
positive regulation of plasma membrane repair is a
positive regulation of postsynaptic membrane organization is a
positive regulation of presynaptic membrane organization is a
positive regulation of protein-containing complex disassembly is a
positive regulation of supramolecular fiber organization is a
positive regulation of synapse maturation is a
positive regulation of synapse pruning is a
positive regulation of synapse structural plasticity is a
positive regulation of synaptic vesicle membrane organization is a
positive regulation of syncytium formation by plasma membrane fusion is a
positive regulation of terminal button organization is a
positive regulation of tight junction disassembly is a
positive regulation of very-low-density lipoprotein particle remodeling is a
positive regulation of vitellogenesis is a
positive regulation of cellular metabolic process is a
positive regulation of cellular pH reduction is a
positive regulation of cellular protein localization is a
positive regulation of establishment of protein localization to mitochondrion is a
positive regulation of intracellular protein transport is a
positive regulation of endosome to plasma membrane protein transport is a
positive regulation of protein exit from endoplasmic reticulum is a
positive regulation of protein export from nucleus is a
positive regulation of protein import into chloroplast stroma is a
positive regulation of protein import into nucleus is a
positive regulation of protein targeting to membrane is a
positive regulation of protein localization to cell leading edge is a
positive regulation of protein localization to cell periphery is a
positive regulation of protein localization to cell surface is a
positive regulation of protein localization to cell tip is a
positive regulation of protein localization to centrosome is a
positive regulation of protein localization to chromatin is a
positive regulation of protein localization to chromosome, telomeric region is a
positive regulation of protein localization to cilium is a
positive regulation of protein localization to endoplasmic reticulum is a
positive regulation of protein localization to endosome is a
positive regulation of protein localization to kinetochore is a
positive regulation of protein localization to lysosome is a
positive regulation of protein localization to membrane is a
positive regulation of protein localization to nucleus is a
positive regulation of protein localization to phagocytic vesicle is a
positive regulation of protein localization to spindle pole body is a
positive regulation of cellular response to alcohol is a
positive regulation of cellular response to drug is a
positive regulation of cellular response to gamma radiation is a
positive regulation of cellular response to heat is a
positive regulation of cellular response to hepatocyte growth factor stimulus is a
positive regulation of cellular response to hypoxia is a
positive regulation of cellular response to insulin stimulus is a
positive regulation of cellular response to macrophage colony-stimulating factor stimulus is a
positive regulation of cellular response to manganese ion is a
positive regulation of cellular response to oxidative stress is a
positive regulation of cellular response to oxidopamine is a
positive regulation of cellular response to thapsigargin is a
positive regulation of cellular response to transforming growth factor beta stimulus is a
positive regulation of cellular response to tunicamycin is a
positive regulation of cellular response to very-low-density lipoprotein particle stimulus is a
positive regulation of cellular response to X-ray is a
positive regulation of chromosome segregation is a
positive regulation of conjugation is a
positive regulation of cytolysis is a
positive regulation of establishment of bipolar cell polarity is a
positive regulation of establishment or maintenance of cell polarity regulating cell shape is a
positive regulation of horizontal cell localization is a
positive regulation of intracellular mRNA localization is a
positive regulation of intracellular transport is a
positive regulation of melanosome transport is a
positive regulation of myelination is a
positive regulation of peroxidase activity is a
positive regulation of phagocytosis is a
positive regulation of phenotypic switching is a
positive regulation of protein folding is a
positive regulation of response to cell cycle checkpoint signaling is a
positive regulation of response to DNA damage stimulus is a
positive regulation of response to endoplasmic reticulum stress is a
positive regulation of ribonucleoprotein complex localization is a
positive regulation of secretion by cell is a
positive regulation of sequestering of calcium ion is a
positive regulation of sequestering of zinc ion is a
positive regulation of serotonin uptake is a
positive regulation of single-species biofilm formation is a
positive regulation of stomatal opening is a
positive regulation of synaptic vesicle clustering is a
positive regulation of synaptic vesicle recycling is a
positive regulation of synaptic vesicle transport is a
positive regulation of transcytosis is a
positive regulation of transmembrane transport is a
positive regulation of G-protein activated inward rectifier potassium channel activity is a
positive regulation of transposition is a
positive regulation of vacuolar transport is a
positive regulation of vesicle docking is a
positive regulation of circadian rhythm is a
positive regulation of developmental pigmentation is a
positive regulation of developmental process is a
positive regulation of DNA-binding transcription factor activity is a
positive regulation of dosage compensation by inactivation of X chromosome is a
positive regulation of establishment of protein localization is a
positive regulation of establishment of RNA localization to telomere is a
positive regulation of growth is a
positive regulation of guanyl-nucleotide exchange factor activity is a
positive regulation of hemostasis is a
positive regulation of immune system process is a
positive regulation of lipid localization is a
positive regulation of locomotion is a
positive regulation of membrane depolarization is a
positive regulation of membrane hyperpolarization is a
positive regulation of metabolic process is a
positive regulation of mRNA alternative polyadenylation is a
positive regulation of multi-organism process is a
positive regulation of multicellular organismal process is a
positive regulation of nitrogen utilization is a
positive regulation of phosphorus utilization is a
positive regulation of posttranscriptional gene silencing is a
positive regulation of protein localization to cell-cell junction is a
positive regulation of protein localization to synapse is a
positive regulation of reproductive process is a
positive regulation of response to stimulus is a
positive regulation of short-term synaptic potentiation is a
positive regulation of signaling is a
positive regulation of sulfur utilization is a
positive regulation of telomerase RNA localization to Cajal body is a
positive regulation of transport is a
positive regulation of viral process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a