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Gene ontology
Version 2014-12-22
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Details for histone methyltransferase activity (H3-K4 specific)
Gene ontology ID
GO:0042800
Definition
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein
Comment
Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies.
Synonyms
1. histone H3 lysine 4-specific methyltransferase activity
2. histone lysine N-methyltransferase activity (H3-K4 specific)
3. histone methylase activity (H3-K4 specific)
References
1. PMID 12086618
2. Reactome: R-HSA-1214188 "PRDM9 trimethylates histone H3"
3. Reactome: R-HSA-3364026 "SET1 complex trimethylates H3K4 at the MYC gene"
4. Reactome: R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark"
5. Reactome: R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter"
6. Reactome: R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter"
7. Reactome: R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter"
8. Reactome: R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter"
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