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Version 2014-12-22
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Details for ATPase-coupled transmembrane transporter activity
7.2.2
Gene ontology ID
GO:0042626
Definition
Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source
Synonyms
1. ATP-coupled transmembrane transporter activity
2. ATP-dependent transmembrane transporter activity
3. ATPase activity, coupled to transmembrane movement of substances
4. hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
5. P-P-bond-hydrolysis-driven transmembrane transporter activity
6. P-P-bond-hydrolysis-driven transporter
References
1. GOC: mtg transport
2. ISBN 0815340729
3. EC 7.2.2
4. Reactome: R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1"
5. Reactome: R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol"
6. Reactome: R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol"
7. Reactome: R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner"
8. Reactome: R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol"
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