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Information on EC 1.11.1.21 - catalase-peroxidase

for references in articles please use BRENDA:EC1.11.1.21

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IUBMB Comments

Differs from EC 1.11.1.7, peroxidase in having a relatively high catalase (EC 1.11.1.6) activity with H2O2 as donor, releasing O2; both activities use the same heme active site. In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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donor
+
H2O2
=
oxidized donor
+
2
H2O
+
=
+
2
2
H2O2
=
O2
+
2
H2O
2
=
+
2

Synonyms
catalase-peroxidase, catalase peroxidase, catalase/peroxidase, hydroperoxidase i, katx2, katg2, katg1, fvcp02, fvcp01, afkatg, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 H2O2 = O2 + 2 H2O
show the reaction diagram
donor + H2O2 = oxidized donor + 2 H2O
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
methanol oxidation to formaldehyde IV, reactive oxygen species degradation, superoxide radicals degradation