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xylitol + NADP+ = L-xylulose + NADPH + H+
xylitol + NADP+ = L-xylulose + NADPH + H+
probably identical with EC 1.1.1.5 diacetyl reductase
-
xylitol + NADP+ = L-xylulose + NADPH + H+
active site structure
-
xylitol + NADP+ = L-xylulose + NADPH + H+
active site residues are Cys138, Val143, His146, Trp191, and Met200, the catalytic tetrad is formed by Asn107, Ser136, Tyr149, and Lys153, substrate binding site structure, enzyme with dual function showing L-xylulose reductase activity and dicarbonyl reductase activity, EC 1.1.1.5
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
-
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
-
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5, the amino acid residues Ser136, Tyr149, and Lys153 form the catalytic triad
-
xylitol + NADP+ = L-xylulose + NADPH + H+
immunological analysis revealed that the dicarbonyl/L-xylulose reductase is not identical with the sperm protein P26h
-
xylitol + NADP+ = L-xylulose + NADPH + H+
-
-
-
-
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1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
1,4-dibromo-2,3-butanedione + NADPH
? + NADP+
-
Substrates: dicarbonyl reductase activity
Products: -
r
D-erythrose + NADPH + H+
? + NADP+
Substrates: -
Products: -
ir
D-fructose + NADPH + H+
? + NADP+
Substrates: low activity
Products: -
?
D-ribulose + NADH
D-arabinitol + NAD+
Substrates: -
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
D-ribulose + NADPH + H+
? + NADP+
Substrates: -
Products: -
?
D-ribulose + NADPH + H+
D-ribitol + NADP+
-
Substrates: -
Products: -
?
D-sorbitol + NADP+
?
-
Substrates: -
Products: -
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
D-threose + NADPH
D-threitol + NADP+
D-threose + NADPH + H+
? + NADP+
Substrates: -
Products: -
ir
D-xylulose + NADH + H+
D-arabinitol + NAD+
D-xylulose + NADPH + H+
D-xylitol + NADP+
D-xylulose + NADPH + H+
xylitol + NADP+
diacetyl + NAD(P)H
acetoin + NAD(P)+
diacetyl + NADPH + H+
acetoin + NADP+
Substrates: -
Products: -
?
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
DL-threitol + NAD+
D-threose + NADH
DL-threitol + NADP+
D-erythrulose + NADPH
-
Substrates: probably identical with erythrulose reductase, EC 1.1.1.162 and diacetyl reductase, EC 1.1.1.5
Products: -
r
L-erythrulose + NADPH + H+
? + NADP+
Substrates: -
Products: -
ir
L-ribulose + NADPH + H+
? + NADP+
Substrates: low activity
Products: -
?
L-sorbose + NADPH + H+
L-sorbitol + NADP+
L-threose + NADPH
L-threitol + NADP+
L-xylulose + NADH
L-xylitol + NAD+
L-xylulose + NADH + H+
xylitol + NAD+
L-xylulose + NADPH + H+
L-xylitol + NADP+
L-xylulose + NADPH + H+
xylitol + NADP+
xylitol + NAD+
L-xylulose + NADH + H+
xylitol + NADP+
L-xylulose + NADPH + H+
xylitol + NADP+
xylulose + NADPH + H+
Substrates: -
Products: -
?
additional information
?
-
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
Substrates: dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
Products: -
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
Substrates: dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
Products: -
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
Substrates: dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
Products: -
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
Substrates: dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
Products: -
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
Substrates: dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
Products: -
r
D-erythrose + NADPH
?
Substrates: reductase activity
Products: -
r
D-erythrose + NADPH
?
Substrates: reductase activity
Products: -
r
D-erythrose + NADPH
?
Substrates: reductase activity
Products: -
r
D-erythrose + NADPH
?
Substrates: reductase activity
Products: -
r
D-erythrose + NADPH
?
Substrates: reductase activity
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
Substrates: reductase activity
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
Substrates: reductase activity
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
Substrates: reductase activity
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
Substrates: reductase activity
Products: -
r
D-ribulose + NADPH
D-ribitol + NADP+
-
Substrates: -
Products: -
?
D-ribulose + NADPH
D-ribitol + NADP+
Substrates: reductase activity
Products: -
r
D-sorbitol + NADP+
D-sorbose + NADPH + H+
Substrates: -
Products: -
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
Substrates: -
Products: -
?
D-threose + NADPH
D-threitol + NADP+
Substrates: reductase activity
Products: -
r
D-threose + NADPH
D-threitol + NADP+
Substrates: reductase activity
Products: -
r
D-threose + NADPH
D-threitol + NADP+
Substrates: reductase activity
Products: -
r
D-threose + NADPH
D-threitol + NADP+
Substrates: reductase activity
Products: -
r
D-threose + NADPH
D-threitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADH + H+
D-arabinitol + NAD+
Substrates: about 100fold lower activity compared to L-xylulose
Products: -
r
D-xylulose + NADH + H+
D-arabinitol + NAD+
Substrates: -
Products: -
?
D-xylulose + NADPH + H+
D-xylitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
Substrates: reductase activity
Products: -
r
D-xylulose + NADPH + H+
xylitol + NADP+
Substrates: -
Products: -
?
D-xylulose + NADPH + H+
xylitol + NADP+
Substrates: low activity
Products: -
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity, NADPH is the preferred cofactor
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
Substrates: dicarbonyl reductase activity
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity, NADPH is the preferred cofactor
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity, NADPH is the preferred cofactor
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: -
Products: -
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
Substrates: dicarbonyl reductase activity
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity, NADPH is the preferred cofactor
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: -
Products: -
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
Substrates: detoxification of alpha-dicarbonyl compounds
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
Substrates: dicarbonyl reductase activity
Products: -
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
Substrates: dicarbonyl reductase activity, NADPH is the preferred cofactor
Products: -
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
Substrates: reductase activity, forward reaction is highly preferred
Products: -
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
Substrates: reductase activity, forward reaction is highly preferred
Products: -
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
Substrates: reductase activity, forward reaction is highly preferred
Products: -
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
Substrates: reductase activity, forward reaction is highly preferred
Products: -
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
Substrates: reductase activity, forward reaction is highly preferred
Products: -
r
DL-threitol + NAD+
D-threose + NADH
Substrates: -
Products: -
?
DL-threitol + NAD+
D-threose + NADH
Substrates: -
Products: -
?
DL-threitol + NAD+
D-threose + NADH
Substrates: -
Products: -
?
DL-threitol + NAD+
D-threose + NADH
-
Substrates: -
Products: -
r
L-erythrulose + NADPH
?
Substrates: reductase activity
Products: -
r
L-erythrulose + NADPH
?
Substrates: reductase activity
Products: -
r
L-erythrulose + NADPH
?
Substrates: reductase activity
Products: -
r
L-erythrulose + NADPH
?
Substrates: reductase activity
Products: -
r
L-erythrulose + NADPH
?
Substrates: reductase activity
Products: -
r
L-sorbose + NADPH + H+
L-sorbitol + NADP+
Substrates: low activity
Products: -
?
L-sorbose + NADPH + H+
L-sorbitol + NADP+
Substrates: low activity
Products: -
?
L-threose + NADPH
L-threitol + NADP+
Substrates: reductase activity
Products: -
r
L-threose + NADPH
L-threitol + NADP+
Substrates: reductase activity
Products: -
r
L-threose + NADPH
L-threitol + NADP+
Substrates: reductase activity
Products: -
r
L-threose + NADPH
L-threitol + NADP+
Substrates: reductase activity
Products: -
r
L-threose + NADPH
L-threitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADH
L-xylitol + NAD+
Substrates: -
Products: -
r
L-xylulose + NADH
L-xylitol + NAD+
Substrates: part of the L-arabinose catabolism
Products: -
r
L-xylulose + NADH + H+
xylitol + NAD+
Substrates: -
Products: -
r
L-xylulose + NADH + H+
xylitol + NAD+
Substrates: -
Products: -
r
L-xylulose + NADH + H+
xylitol + NAD+
Substrates: -
Products: -
r
L-xylulose + NADH + H+
xylitol + NAD+
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: also reduces 2,3-butadione
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: the enzyme is involved in the uronate cycle of glucose metabolism
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: L-xylulose reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: uronate cycle of glucose metabolism
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: uronate cycle of glucose metabolism
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: part of the uronate cycle, involved in osmoregulation in the kidney
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: L-xylulose reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
Substrates: reductase activity
Products: -
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: uronate cycle of glucose metabolism
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: xylulose reductase has about 50% higher activity during xylose consumption than during the coconsumption of glucose and xylose
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: uronate cycle of glucose metabolism
Products: -
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
Substrates: -
Products: -
?
L-xylulose + NADPH + H+
xylitol + NADP+
Substrates: -
Products: -
ir
L-xylulose + NADPH + H+
xylitol + NADP+
Substrates: -
Products: -
r
L-xylulose + NADPH + H+
xylitol + NADP+
Substrates: preferred substrate
Products: -
r
L-xylulose + NADPH + H+
xylitol + NADP+
Substrates: preferred substrate
Products: -
r
xylitol + NAD+
L-xylulose + NADH + H+
Substrates: -
Products: -
r
xylitol + NAD+
L-xylulose + NADH + H+
Substrates: -
Products: -
r
xylitol + NAD+
L-xylulose + NADH + H+
Substrates: -
Products: -
r
xylitol + NAD+
L-xylulose + NADH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: strain DM101 and DM122, product identification is not exact, could also be D-xylulose
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: -
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
Substrates: engineered enzyme with altered cofactor specificity
Products: -
?
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
xylitol + NADP+
L-xylulose + NADPH + H+
Substrates: -
Products: -
r
additional information
?
-
Substrates: NADH-linked enzyme form, no activity with NADPH and NADP+, no activity with L-arabinitol, adonitol or ribitol, dulcitol or galactitol, D-mannitol, and D-sorbitol, no activity with D-sorbose, L-sorbose, D-psicose, and D-fructose
Products: -
?
additional information
?
-
-
Substrates: NADH-linked enzyme form, no activity with NADPH and NADP+, no activity with L-arabinitol, adonitol or ribitol, dulcitol or galactitol, D-mannitol, and D-sorbitol, no activity with D-sorbose, L-sorbose, D-psicose, and D-fructose
Products: -
?
additional information
?
-
-
Substrates: minimal reductive activity also with D-xylulose, D-erythrose and dihydroxyacetone
Products: -
?
additional information
?
-
-
Substrates: no substrate: D-fructose, D-sorbose, L-sorbose, xylitol, D-arabitol, L-arabitol, ribitol, D-sorbitol and galactitol
Products: -
?
additional information
?
-
Substrates: substrate specificity, overview
Products: -
?
additional information
?
-
-
Substrates: substrate specificity, overview
Products: -
?
additional information
?
-
Substrates: dicarbonyl/L-xylulose reductase is bifunctional
Products: -
?
additional information
?
-
-
Substrates: dicarbonyl/L-xylulose reductase is bifunctional
Products: -
?
additional information
?
-
-
Substrates: no activity in the mitochondrial fraction with D-xylulose, D-sorbose, L-sorbose, L-erythrulose, D-fructose, D-sorbitol, L-arabitol, D-gulitol, D-talitol
Products: -
?
additional information
?
-
Substrates: substrate specificity for dicarbonyl reductase activity, overview
Products: -
?
additional information
?
-
-
Substrates: substrate specificity for dicarbonyl reductase activity, overview
Products: -
?
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