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Information on EC - phosphoglucosamine mutase

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
       phosphoglucosamine mutase
IUBMB Comments
The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, alpha-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of alpha-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate.
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The enzyme appears in viruses and cellular organisms
phosphoglucosamine mutase, aq1627, mmp1077, more
alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate
show the reaction diagram