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Literature summary for 5.4.2.10 extracted from
- Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans (2009), Oral Microbiol. Immunol., 24, 272-277.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the glmM gene may have a constructive role in the virulence properties of Streptococcus mutans | Streptococcus mutans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pFW5 (Spec_r) Escherichia coli - streptococcus shuttle plasmid to create the mutant glmM gene, into the shuttle vector pDL289 to complement the glmM-deficient mutant strain | Streptococcus mutans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| glmM mutant | mutant shows an altered general phenotype, reduced growth rate and increased autolysis, mutation results in defect biofilm formation | Streptococcus mutans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucosamine 1-phosphate | Streptococcus mutans | - |
D-glucosamine 6-phosphate | - |
? |  |
| alpha-D-glucosamine 1-phosphate | Streptococcus mutans UA159 | - |
D-glucosamine 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus mutans | Q8DTC6 | - |
- |
| Streptococcus mutans UA159 | Q8DTC6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucosamine 1-phosphate | - |
Streptococcus mutans | D-glucosamine 6-phosphate | - |
? | |
| alpha-D-glucosamine 1-phosphate | - |
Streptococcus mutans UA159 | D-glucosamine 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlmM | - |
Streptococcus mutans |
| phosphoglucosamine mutase | - |
Streptococcus mutans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Streptococcus mutans | a glmM-deficient Streptococcus mutans strain is used | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | phosphoglucosamine mutase functions in the biosynthesis of peptidoglycan | Streptococcus mutans |
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Release 2023.1 (January 2023)
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